Neuroscience Research Communications最新文献_第4页

Laminar distribution of neurofilament inclusions and swollen achromatic neurons in neurofilament inclusion disease (NID) 神经丝包涵体病(NID)中神经丝包涵体的层流分布和肿胀的消色神经元

Neuroscience Research Communications Pub Date : 2004-03-01 DOI: 10.1002/NRC.20004

N. Cairns, E. Jaros, R. Perry, R. Armstrong

引用次数: 1

Treadmill exercise suppresses NPY expression in the hypothalamus of food-deprived rats 跑步机运动抑制食物剥夺大鼠下丘脑NPY表达

Neuroscience Research Communications Pub Date : 2004-03-01 DOI: 10.1002/NRC.20001

Sung-Soo Kim, Mal-Soon Shin, Hong Kim, Eun-Kyung Kim, Hee-Hyuk Lee, Hyun-kyung Chang, Taeck-Hyun Lee, M. Jang, M. Shin, Baek-Vin Lim, Chang-Ju Kim

引用次数: 4

Superoxide production and the activity of MnSOD in rat brain after intrahippocampal kainate-induced seizure 海马内盐诱导癫痫发作后大鼠脑内超氧化物产生及MnSOD活性的研究

Neuroscience Research Communications Pub Date : 2004-03-01 DOI: 10.1002/NRC.20003

L. Radenović, M. Jovanović, I. Vasiljević, V. Selaković

引用次数: 3

Stress‐ and cell cycle‐associated regulation of RGS2 mRNA levels 应激和细胞周期相关的RGS2 mRNA水平调控

Neuroscience Research Communications Pub Date : 2004-03-01 DOI: 10.1002/NRC.20000

J. Zmijewski, Ling Song, R. Jope

引用次数: 4

Aqueous carboyxfullerene analogue attenuated cerebral infarct and extracellular glutamate levels in anesthetized rat 水基富勒烯类似物减轻麻醉大鼠脑梗死和细胞外谷氨酸水平

Neuroscience Research Communications Pub Date : 2004-03-01 DOI: 10.1002/NRC.20005

P. Tsai, Wenyin Chen, T. Luh, Chung S. Yang

{"title":"Aqueous carboyxfullerene analogue attenuated cerebral infarct and extracellular glutamate levels in anesthetized rat","authors":"P. Tsai, Wenyin Chen, T. Luh, Chung S. Yang","doi":"10.1002/NRC.20005","DOIUrl":"https://doi.org/10.1002/NRC.20005","url":null,"abstract":"We have examined the effects of an aqueous-soluble carboxyfullerene analogue on the cerebral ischemia-induced infarct volume, and on extracellular glutamate accumulation, in an anesthetized rat brain cortex. A C3-symmetric carboxylic acid derivative of C60 (C3-C60), which contains three malonic acid groups per molecule, was administered intraventricularly (5 μL of a 30-μM solution of C3-C60 over a period of 40 min). Cerebral ischemia was induced by the ligation of bilateral common carotid arteries (CCA) and the unilateral middle cerebral artery (MCA). The infarct volume was calculated by analysis of 2-mm coronal sections of brain slices that were stained using TTC. We analyzed the glutamate concentrations in the cortex by microdialysis perfusion and on-line HPLC analysis. Administering C3-C60 significantly decreases the infarct volume (infarct percentage relative to total volume: 8 ± 1.4%) when compared with the vehicle (22 ± 2.6%; p < 0.01), which was similar to that of the control (22 ± 1.2%). Additionally, administering C3-C60 significantly decreases ischemia-induced extracellular glutamate accumulation when compared with the vehicle. These results suggest that an aqueous-soluble analogue of carboxyfullerene can protect a cerebral ischemia-induced infarct. This protective effect may be related to the attention of the accumulation of extracellular excitatory amino acids such as glutamate. The detailed mechanisms underlying the neuroprotective effects of C3-C60 require further investigation.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"1 1","pages":"112-119"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88877954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MODULATION OF BDNF EXPRESSION BY ELECTRICAL STIMULATION IN HINDLIMB MUSCLES OF RATS 电刺激对大鼠后肢肌肉BDNF表达的调节

Neuroscience Research Communications Pub Date : 2004-01-01 DOI: 10.1002/NRC.10101

B. Park, Ji Hyo Hwang, M. S. Kim, M. Lee, J. Rhee, S. Lee

引用次数: 6

Does whisker stimulation induce c‐Fos expression in the rat ipsilateral deafferented cerebral cortex? 须刺激能诱导大鼠同侧大脑皮层c - Fos表达吗?

Neuroscience Research Communications Pub Date : 2004-01-01 DOI: 10.1002/NRC.10106

Hyuk-Sang Jung, Hyun-Sam Lee, Jung-Won Shin, Doo-Jae Lee, R. Won, N. Sohn

引用次数: 0

A long‐term locomotor function and cognition study following middle cerebral artery occlusion in rats 大鼠大脑中动脉闭塞后的长期运动功能和认知研究

Neuroscience Research Communications Pub Date : 2004-01-01 DOI: 10.1002/NRC.10104

Hyuk-Sang Jung, Hyun-Sam Lee, Jung-Won Shin, Doo-Jae Lee, R. Won, N. Sohn

{"title":"A long‐term locomotor function and cognition study following middle cerebral artery occlusion in rats","authors":"Hyuk-Sang Jung, Hyun-Sam Lee, Jung-Won Shin, Doo-Jae Lee, R. Won, N. Sohn","doi":"10.1002/NRC.10104","DOIUrl":"https://doi.org/10.1002/NRC.10104","url":null,"abstract":"A long-term study of a cerebral ischemia model, considered valuable in developing better treatments of ischemia, was performed to understand the nature of the dysfunctions associated with stroke. This study focused on the behavioral recovery and cognitive learning and memory of rats over a 17-week period following middle cerebral artery occlusion (MCAO). The present study involved the design of a comprehensive guideline for clinical behavior evaluation. The behavior of ischemic rats was examined over 17 weeks from 4 different aspects: posture & balance tests (4 subtests), reflex tests (6 subtests), muscle-tone tests (3 subtests), and a foot-fault test. After the tests, the results were analyzed to reveal the relationship between hemispheric atrophy and functional evaluation scores. Each battery of behavioral tests revealed multiple recovery phases in the time courses. Also, in the passive avoidance test, the MCAO group differed significantly from the sham group until 8 weeks, at which point the latencies to the sham group levels had occurred and after which there was no significant difference until 17 weeks. Thus, the present study provides a valuable protocol in long-term neuroprotection studies and presents an important profile of motor function that will supplement standard histopathological analysis at a later stage of ischemia.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"63 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80872955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of low‐dose oxcarbazepine administration on developing cerebellum in newborn rat: A stereological study 低剂量奥卡西平对新生大鼠小脑发育的影响:一项体视学研究

Neuroscience Research Communications Pub Date : 2004-01-01 DOI: 10.1002/NRC.10103

E. Odacı, S. Kaplan, B. Sahin, O. Baş, F. Gevrek, D. Aygün, B. Unal, O. Sonmez, S. Çolakoğlu, S. Bilgiç

引用次数: 24

Effect of haloperidol on the numeric density of neurons and nuclear height in the rat hippocampus: A stereological and histopathological study 氟哌啶醇对大鼠海马神经元数量密度和核高度的影响:一项体视学和组织病理学研究

Neuroscience Research Communications Pub Date : 2004-01-01 DOI: 10.1002/NRC.10100

B. Unal, M. Özbek, Aydin, N. Aydın, Z. Bulucu, Ozgen Vuraler, E. Odacı, B. Sahin, S. Kaplan

{"title":"Effect of haloperidol on the numeric density of neurons and nuclear height in the rat hippocampus: A stereological and histopathological study","authors":"B. Unal, M. Özbek, Aydin, N. Aydın, Z. Bulucu, Ozgen Vuraler, E. Odacı, B. Sahin, S. Kaplan","doi":"10.1002/NRC.10100","DOIUrl":"https://doi.org/10.1002/NRC.10100","url":null,"abstract":"In recent studies, some neuroleptics have shown neurotoxic activities. Clinical and experimental studies have been carried out to investigate the effects of different neuroleptic drugs considered to affect the central nervous system. The aim of this study was to evaluate neurotoxic effects of halperidol on hippocampal neurons. The drug was given in daily doses of either 1 or 3 mg/kg for 6 weeks to adult male guinea pigs. After treatment, all animals were anaesthetized via short inhalation of ether, and then were fixed by a mixture of 2% glutaraldehyde and +2% paraformaldehyde in 0.1 M phosphate buffer. Brains were removed from the cranium and stored in the same fixative overnight. On the following day, the CA1 region of the hippocampus was dissected out. After embedding in araldite resin and obtaining semi-thin sections, the tissues were stained with toluidine blue. The physical dissector was used for measurements of nuclear height and numerical density of neurons and the sections were also evaluated histopathologically. The numerical density of neurons and nuclear height in the hippocampus for the low-dose (1 mg/kg) and high-dose (3 mg/kg) experimental groups were 12.4 mm3 and 3.6 μm and 7.14 mm3 and 3.56 μm, respectively. In contrast, the control group had a neuronal numerical density of 16.55 mm −3 and a nuclear height of 4.09 μm. There was a significant difference in both the mean density of neurons and the mean height of nuclei between haloperidol-treated and control groups (p < 0.05). There was also a statistical difference in the mean density of neurons (but not in nuclear height) when comparing the dosage of haloperidol (p < 0.05). These findings suggest that haloperidol treatment may lead to a loss of neurons as well as a decrease in the height of nuclei in the hippocampus.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"24 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84847121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24