Nihon Ika Daigaku zasshi最新文献

{"title":"[Genetic analysis of multifactorial cardiac diseases: idiopathic dilated cardiomyopathy and myocardial infarction].","authors":"A Kimura","doi":"10.1272/jnms.66.332","DOIUrl":"https://doi.org/10.1272/jnms.66.332","url":null,"abstract":"備考 原因遺伝子 原因遺伝子座 遺伝形式 心筋αアクチン 15q14 AD 不整脈を伴う 不明 CMD1A (CDCD1) 1p11 q11 不明 CMD1B (CMPD1) 9q13 q22 不明 CMD1C (CMPD3) 10q21 q22 不明 CMD1D (CMPD2) 1q32 不整脈を伴う 不明 CMD1E (CDCD2) 3p22 p25 不整脈と筋症状を伴う 不明 CMD1F 6q23 不明(タイチン?) CMD1G 2q31 筋症状のないもの ディストロフィン XLDCM Xq21.2 XR Barth 症候群(白血球減少を伴う乳児DCM) タファジン Xq28 筋症状を伴う乳児DCM CPTase 1p32 AR ミトコンドリア病 tRNA, rRNA ミトコンドリアDNA M #常染色体性優性遺伝(AD),常染色体劣性遺伝(AR),伴性劣性遺伝(XR),母系遺伝(M) はじめに","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 5","pages":"332-35"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21408953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Perspective of clinical genetics].","authors":"A Watanabe, M Migita, Y Watanabe, T Shimada","doi":"10.1272/jnms.66.340","DOIUrl":"https://doi.org/10.1272/jnms.66.340","url":null,"abstract":"","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 5","pages":"340-2"},"PeriodicalIF":0.0,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21408955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Kallmann syndrome: a failure of GnRH neuronal migration].","authors":"I S Parhar, Y Sakuma","doi":"10.1272/jnms.66.220","DOIUrl":"https://doi.org/10.1272/jnms.66.220","url":null,"abstract":"","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"220-1"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1272/jnms.66.220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Autoimmune fatigue syndrome and fibromyalgia syndrome].","authors":"Y Itoh,&nbsp;T Igarashi,&nbsp;N Tatsuma,&nbsp;T Imai,&nbsp;J Yoshida,&nbsp;M Tsuchiya,&nbsp;M Murakami,&nbsp;Y Fukunaga","doi":"10.1272/jnms.66.239","DOIUrl":"https://doi.org/10.1272/jnms.66.239","url":null,"abstract":"<p><p>We have encounted two patients with fibromyalgia (FM) initially diagnosed as having autoimmune fatigue syndrome (AIFS). To investigate the relationship between AIFS and FM, the distribution of the tender points in patients with AIFS was assessed according to the ACR criteria for FM. It was revealed that AIFS patients had 5.6 tender points on averages. Patients with headaches, digestive problems, or difficulty going to school had more tender points than patients without. Patients with ANA titers < 1: 160 had more tender points than patients with ANA > or = 1: 160. Anti-Sa negative patients had more tender points than positive patients. These results suggest a relationship between AIFS and FM in terms of the pathophysiologic mechanisms of the numerous tender points. In other words, ANA-positive FM patients could be one form of AIFS, as well as ANA-positive chronic fatigue syndrome patients. Thus, autoimmunity could explain the controversial disease entities of FM and/or CFS.</p>","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"239-44"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of bright light on cognitive disturbances in Alzheimer-type dementia].","authors":"T Ito,&nbsp;H Yamadera,&nbsp;R Ito,&nbsp;S Endo","doi":"10.1272/jnms.66.229","DOIUrl":"https://doi.org/10.1272/jnms.66.229","url":null,"abstract":"<p><p>We investigated the effectiveness of bright light therapy on cognitive disturbances and its effect on circadian (sleep-wake) rhythm in Alzheimer-type dementia (ATD). Twenty-seven patients with ATD were treated with bright light therapy in the morning for 4 consecutive weeks. We evaluated the cognitive functions and circadian rhythms of the patients as a whale, and as members of two groups (one: questionable and mild dementia: the other: moderate and severe dementia; both groups classified by the severity criteria of Clinical Dementia Rating). We assessed circadian rhythms by actigraphy and cognitive states by Mini-Mental-State Examination (MMSE) and Alzheimer's Disease Assessment Scale (ADAS) before and after light therapy. Bright light therapy improved circadian rhythm. Although bright light therapy had no Significant effect on the Severity of dementia, it improved the MMSE scores, cognitive functions of ADAS scores (memory > language) and non-cognitive functions of ADAS scores (behavior = mood), especially in the questionable and mild dementia group. These results suggest that bright light therapy improves cognitive functions with the modification of circadian rhythm, especially in the early stages of ATD.</p>","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"229-38"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1272/jnms.66.229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnosis and treatment of atopic dermatitis].","authors":"S Kawana","doi":"10.1272/jnms.66.279","DOIUrl":"https://doi.org/10.1272/jnms.66.279","url":null,"abstract":"","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"279-82"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical study of Helicobacter pylori infection].","authors":"T Matsuhisa,&nbsp;N Yamada","doi":"10.1272/jnms.66.222","DOIUrl":"https://doi.org/10.1272/jnms.66.222","url":null,"abstract":"","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"222-8"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis of acute massive fetomaternal hemorrhage.","authors":"T Ohshita,&nbsp;S Suzuki,&nbsp;R Sawa,&nbsp;Y Yoneyama,&nbsp;H Asakura,&nbsp;T Araki","doi":"10.1272/jnms.66.266","DOIUrl":"https://doi.org/10.1272/jnms.66.266","url":null,"abstract":"<p><p>We present here 2 cases of acute and 2 cases of chronic massive fetomaternal hemorrhage. A sinusoidal fetal heart rate pattern may indicate chronic fetomaternal hemorrhage, but, when increased variability is observed in fetal monitoring, maternal hemoglobin F should be measured to exclude acute fetomaternal hemorrhage.</p>","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"266-9"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of magnetization transfer contrast as a sensitive technique to reflect histopathological changes in the white matter adjacent to the frontal horns of lateral ventricles.","authors":"M Nakahara,&nbsp;H Hayashi,&nbsp;T Kumazaki,&nbsp;O Mori","doi":"10.1272/jnms.66.245","DOIUrl":"https://doi.org/10.1272/jnms.66.245","url":null,"abstract":"<p><p>The purpose of this study is to evaluate the usefulness of magnetization transfer contrast (MTC) as a technique to reflect histopathological changes in the white matter adjacent to the frontal horns of the lateral ventricles. Radiological-pathological correlation was performed in six patients who underwent Magnetic Resonance (MR) examination prior to death and in whom postmortem examinations of the brain were obtained. The extent and the severity of degeneration in the white matter adjacent to the frontal horns were evaluated histopathologically, and compared with those observed on the conventional proton density (PD) weighted MR images (Group 1). Changes in the white matter of another 35 patients were classified into three types according to the pattern of high signals adjacent to the frontal horns on conventional PD weighted MR images, and magnetization transfer ratio (MTR) in the white matter adjacent to the frontal horns was calculated from multi-slice and single-slice FSE images (Group 2). The relationship between signal intensities and MTR in the white matter adjacent to the frontal horns was evaluated. The extent of degeneration in the white matter adjacent to the frontal horns was classified into mild, moderate and severe types on the basis of stainin for myelins, axons and astrocytes. In Group 1, histopathological findings indicated a difference in severity of degeneration in the white matter adjacent to the frontal horns among the three types, while no significant differences were noted in the signals on PD weighted MR images. In Group 2, MTR showed significant differences in the signal intensities in the white matter adjacent to the frontal horns (p < 0.01) between the three types, while conventional PD weighted MR images failed to differentiate between them. In conclusion, MT imaging is a sensitive technique to evaluate the histopathological changes in the white matter adjacent to the frontal horns that cannot be detected by conventional MR imaging.</p>","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"245-52"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two types of peritoneal dissemination of pancreatic cancer cells in a hamster model.","authors":"S Yamamura,&nbsp;M Onda,&nbsp;E Uchida","doi":"10.1272/jnms.66.253","DOIUrl":"https://doi.org/10.1272/jnms.66.253","url":null,"abstract":"<p><p>Peritoneal dissemination has an unfavorable impact on the prognosis of pancreatic cancer, and a peritoneal dissemination model was created in hamsters by using an experimental pancreatic cancer to clarify its pathological characteristics. PGHAM-1, a cancer cell line we established from BOP induced pancreatic cancer in Syrian golden hamsters, was inoculated into the abdominal cavity of Syrian golden hamsters. After inoculation, sequential changes in the diaphragm, omentum, and parietal peritoneum, and the metastatic patterns of the PGHAM-1 cells were morphologically investigated by macroscopical, microscopical, and ultrastructural observation. The cancer cells were easily absorbed at the stomata in the diaphragm and milky spots in the omentum, which were absorptive lymphatic structures, and lymphatic metastasis occurred 4 days after inoculation. In the parietal peritoneum, however, the cancer cells attached to and proliferated on the parietal peritoneum where mesothelial cells had exfoliated and the basement membrane was exposed. This process was comparatively time-consuming, and metastasis occurred in the parietal peritoneum at 7 days after inoculation. This study suggested that there might be two patterns of peritoneal dissemination of hamster pancreatic cancer. One route is lymphatic metastasis via stomata in the diaphragm and milky spots in the omentum, and the other is direct metastasis on the parietal peritoneum; each metastasis forms independently.</p>","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"253-61"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1272/jnms.66.253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}