M Kawashima, T Uemura, H Yamashita, A Hidano, T Matsukura
{"title":"[Molluscum contagiosum virus types found in Japan].","authors":"M Kawashima, T Uemura, H Yamashita, A Hidano, T Matsukura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Total DNAs obtained from Japanese patients with molluscum contagiosum (MC) were analyzed by agarose gel electrophoresis after digestion with Bam HI, Hind III or Cla I restriction enzymes, which revealed the presence of four different cleavage patterns of MC virus (MCV) DNAs. The comparison with previously reported MCV types clarified that two of them were identical with MCV-1 and -2, respectively. The other two isolates were considered as yet unrecognized types and named MCV-3 and -4, respectively.</p>","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 14","pages":"1457-60"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13237310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Nakamura, T Kageshita, S Hirai, T Kimura, A Yoshii, T Ono, T Arao
{"title":"[Expression of HLA-class I and II antigens on basal cell carcinoma].","authors":"T Nakamura, T Kageshita, S Hirai, T Kimura, A Yoshii, T Ono, T Arao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sixteen cases of Basal Cell Carcinoma have been tested with monoclonal antibodies to HLA-class I, beta 2-microglobulin, HLA-DR, DP and DQ antigens immunohistochemically using frozen tissues. HLA-class I antigens were expressed weakly on BCC in thirteen and fifteen out of sixteen cases using two different monoclonal antibodies respectively. beta 2-microglobulin was expressed differently with the same intensity as normal epidermis in 6 cases, weaker than normal epidermis in 8 cases and absent in 2 cases. There is no correlation with the expression of HLA-class I between histological type and lymphocyte infiltration. On the other hand, HLA-DR, DP and DQ antigens were positive in 4, 3 and 3 cases respectively. But the percentage of positive cells for HLA-class II were only 1-2%. The expression of HLA-DR antigen was most strongest among HLA-class II antigens.</p>","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 14","pages":"1431-5"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13237406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y Suzuki, K Otoyama, I Katayama, K Nishioka, S Nishiyana
{"title":"[Livedo with cerebrovascular thrombosis--correlation between clinical features, anti-cardiolopin antibodies, and cerebral microinfarction].","authors":"Y Suzuki, K Otoyama, I Katayama, K Nishioka, S Nishiyana","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty one patients with livedo racemosa (LRa) and periarteritis nodosa cutanea were screened for the presence of anti-cardiolipin antibody (aCL) by ELISA. 11 out of 21 revealed positive aCL whose clinical features could be divided into 3 groups: 4 patients with livedo with ulceration, 2 with pyoderma gangrenosum-like lesions, and 5 with extensive LRa. #1. The summer ulceration of leg of 4 patients were surrounded by several tiny petechiae where hyaline microthrombi of blood capillaries in the upper dermis were demonstrated. All had multiple cerebral microinfarctions on magnetic resonance imaging (MRI). #2. Pyoderma gangrenosum-like lesions of 2 patients consisted of painful punched-out ulcers on livedoid lesions where intravascular endothelial hyperplasia in a small artery was demonstrated. Both had multiple cerebral microinfarctions. #3. Another clinical manifestation of the patients with positive aCL was extensive form of LRa of 5 patients. All had positive ANA, however none of them exhibited cerebral microinfarctions on MRI. #4. The remaining 10 patients with negative aCL showed no relationship with such clinical and laboratory manifestations. These results indicate that there is a significant correlations between summer ulceration with petechiae, capillary microthrombi of the skin, positive aCL and cerebral microinfarctions on MRI.</p>","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 14","pages":"1437-44"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13237407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies].","authors":"M Asada, I Kurokawa, S Nishijima, Y Asada","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The expressions of several cytokeratins (CKs) in the outer root sheath (ORS) of the human anagen hair follicles were immunohistochemically studied using 11 antikeratin monoclonal antibodies (MoAbs) and 10 specimens from scalp. CKs 1, 10, 11, which are markers for differentiating keratinocytes, were exclusively found in the intermediate cells and the granular cells at the infundibulum. In cytokeratin expression, a distinct linear demarcation between the infundibulum and the isthmus was observed. Trichilemmal keratinization appeared to go in an inner-upward direction toward the hair canal. CK 19, a marker of undifferentiated stem cells, was found in outermost cells of the ORS at the isthmus and in some cells of the lower ORS. CK 16, a marker of hyperproliferative keratin, was detected in the outermost cells of the infundibulum and all the cells of the ORS below the isthmus. Therefore, the keratinocytes at the infundibulum may show a differentiation similar to that of the interfollicular epidermal keratinocytes. The ORS cells below the isthmus seem to move up to inner-upward direction along the hair axis with differentiation.</p>","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 14","pages":"1423-30"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12871063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[IL-2 responsiveness in antigen-specific lymphocyte proliferation test with sulfhydryl drug-sensitized murine lymphocytes--using rapid fluorochromasia assay].","authors":"J Osawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Response of murine lymphnode cells (LNC) sensitized with sulfhydryl drugs to recombinant interleukin 2 (rIL-2) was studied in antigen-specific lymphocyte proliferation test (LPT). Mice were primed with tiopronin (TP) and gold sodium thiomalate (GTM) and the secondary response to LNC was measured in a proliferative assay in vitro. Rapid fluorochromasia assay with propidium iodide (RFP) was used for the quantitative measurement of LPT instead of 3H-thymidine uptake. There was no difference in proliferative response to specific antigen between TP or GTM-primed LNC and control ones. In contrast, a significant proliferation was observed when LNC from sensitized mice were cultured with sensitizing antigen and rIL-2. The strength of response was dependent on the concentration of rIL-2. It was considered that adding rIL-2 to LPT of TP or GTM-sensitized mice enhanced antigen-specific lymphocyte proliferative response and the measurement of IL-2 responsiveness using RFP method might be useful to detect sulfhydryl drug allergy in man.</p>","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 12","pages":"1235-40"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12870878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Clinical and experimental study of glucocorticosteroids].","authors":"K Takeda","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 13","pages":"1297-310"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[New AIDS-virus receptor and AIDS-virus infection mechanism].","authors":"N Katsunuma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 13","pages":"1316-22"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Postherpetic neuralgia].","authors":"M Niimura","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 13","pages":"1352-4"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H Akiyama, T Yamada, K Shimoe, R Torigoe, H Kanzaki, J Arata
{"title":"[Combination effects of fosfomycin and other oral antimicrobial agents against methicillin-resistant Staphylococcus aureus].","authors":"H Akiyama, T Yamada, K Shimoe, R Torigoe, H Kanzaki, J Arata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Combination effects of fosfomycin (FOM) and other oral antimicrobial agents were studied against methicillin-resistant Staphylococcus aureus (MRSA) (methicillin: minimal inhibitory concentration (MIC) greater than or equal to 12.5 micrograms/ml) isolated from skin and skin structure infections. The fractional inhibitory concentration (FIC) index equal to or less than 0.5 was seen in 63.0% of 27 MRSA strains for FOM and minocycline combination, in 44.4% for FOM and cefatrizine, in 44.4% for FOM and cefaclor, in 40.7% for FOM and cefalexin, in 37.0% for FOM and doxycycline, in 29.6% for FOM and erythromycin, in 22.2% for FOM and rokitamycin, in 18.5% for FOM and ofloxacin, in 14.8% for FOM and sultamicillin, in 11.1% for FOM and clavulanic acid/amoxicillin. The combination effects of FOM and minocyclin, or FOM and cephalosporins were higher than other combinations with FOM. Combination of FOM with other antibiotics could be a useful way to treat MRSA skin and skin structure infections.</p>","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 12","pages":"1257-61"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13233133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Present status of sexually transmitted diseases].","authors":"S Okamoto","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19167,"journal":{"name":"Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology","volume":"100 13","pages":"1333-5"},"PeriodicalIF":0.0,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13235472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}