The Journal of surgical research最新文献

{"title":"Wound-edge protection devices in gastrointestinal surgery: a meta-analysis.","authors":"Qiang Chen, Lei Chen, Gang Chen, Yuwei Pu, C. Xing","doi":"10.1016/j.jss.2016.08.034","DOIUrl":"https://doi.org/10.1016/j.jss.2016.08.034","url":null,"abstract":"","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118000636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unused sterile instruments for closure prevent wound surgical site infection after pancreatic surgery.","authors":"D. Hashimoto, A. Chikamoto, K. Arima, K. Taki, Risa Inoue, K. Imai, Y. Yamashita, H. Baba","doi":"10.1016/j.jss.2016.02.044","DOIUrl":"https://doi.org/10.1016/j.jss.2016.02.044","url":null,"abstract":"","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118373881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive shock wave therapy improves muscular microcirculation.","authors":"T. Kisch, Waldemar Wuerfel, V. Forstmeier, E. Liodaki, F. Stang, K. Knobloch, P. Mailaender, R. Kraemer","doi":"10.1016/j.jss.2015.11.049","DOIUrl":"https://doi.org/10.1016/j.jss.2015.11.049","url":null,"abstract":"","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118172668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-fat enteral nutrition controls intestinal inflammation and improves intestinal motility after peritoneal air exposure.","authors":"Shanjun Tan, Chao Yu, Zhen Yu, Zhi-liang Lin, Guo-Hao Wu, Wen-kui Yu, Jie‐shou Li, Ning Li","doi":"10.1016/j.jss.2015.11.047","DOIUrl":"https://doi.org/10.1016/j.jss.2015.11.047","url":null,"abstract":"","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117809119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric burns: Kids' Inpatient Database vs the National Burn Repository.","authors":"Tahereh Soleimani, Tyler A. Evans, R. Sood, B. Hartman, I. Hadad, S. Tholpady","doi":"10.1016/j.jss.2015.11.034","DOIUrl":"https://doi.org/10.1016/j.jss.2015.11.034","url":null,"abstract":"","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118359339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of simulation to assess a statistically driven surgical scheduling system.","authors":"P. Kougias, V. Tiwari, D. Berger","doi":"10.1016/j.jss.2015.10.043","DOIUrl":"https://doi.org/10.1016/j.jss.2015.10.043","url":null,"abstract":"","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"118708013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications.","authors":"Swathi Balaji,&nbsp;Alice King,&nbsp;Yashu Dhamija,&nbsp;Louis D Le,&nbsp;Aimen F Shaaban,&nbsp;Timothy M Crombleholme,&nbsp;Sundeep G Keswani","doi":"10.1016/j.jss.2013.03.051","DOIUrl":"https://doi.org/10.1016/j.jss.2013.03.051","url":null,"abstract":"<p><strong>Background: </strong>Cell-specific gene transfer and sustained transgene expression are goals of cutaneous gene therapy. Pseudotyping strategy with adeno-associated viral (AAV) vectors has the potential to confer unique cellular tropism and transduction efficiency. We hypothesize that pseudotyped AAV vectors have differential tropism and transduction efficiency under normal and wound conditions in dermal fibroblasts.</p><p><strong>Materials and methods: </strong>We packaged AAV2 genome with green fluorescent protein reporter in capsids of other serotypes, AAV5, AAV7, and AAV8, producing pseudotyped vectors AAV2/5, AAV2/7, and AAV2/8, respectively. Murine and human dermal fibroblasts were transduced by the different pseudotypes for 24 h at multiplicities of infection 10(2), 10(3), 10(4), and 10(5). We assessed transduction efficiency at days 3 and 7. Experiments were repeated in a simulated wound environment by adding 10 ng/mL platelet-derived growth factor-B to culture media.</p><p><strong>Results: </strong>Transduction efficiency of the pseudotyped AAV vectors was dose dependent. Multiplicity of infection 10(5) resulted in significantly higher gene transfer. Under normal culture conditions, the pseudotyping strategy conferred differential transduction of dermal fibroblasts, with significantly enhanced transduction of murine cells by AAV2/5 and AAV2/8 compared with AAV2/2. Adeno-associated virus 2/8 was more efficacious in transducing human cells. Under wound conditions, transduction efficiency of AAV2/2, 2/5, and 2/8 was significantly lower in murine fibroblasts. At day 3 under wound conditions, all vectors demonstrated similar transduction efficiency, but by day 7, the three pseudotyped vectors transduced significantly more murine cells compared with AAV2/2. However, in human cells, there was no significant difference in the transduction efficiency of each pseudotype between normal and wound conditions at both 3 and 7 d.</p><p><strong>Conclusions: </strong>The AAV pseudotyping strategy represents a gene transfer technology that can result in differential transduction of dermal fibroblasts. The differences in transduction efficiency in murine and human dermal fibroblasts in both the normal and wound environment highlight issues with translatability of gene transfer techniques. These data provide a template for using pseudotyped AAV vectors in cutaneous applications.</p>","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":" ","pages":"691-8"},"PeriodicalIF":2.2,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jss.2013.03.051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31362466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient involvement in the decision-making process improves satisfaction and quality of life in postmastectomy breast reconstruction.","authors":"Azra A Ashraf,&nbsp;Salih Colakoglu,&nbsp;John T Nguyen,&nbsp;Alexandra J Anastasopulos,&nbsp;Ahmed M S Ibrahim,&nbsp;Janet H Yueh,&nbsp;Samuel J Lin,&nbsp;Adam M Tobias,&nbsp;Bernard T Lee","doi":"10.1016/j.jss.2013.04.057","DOIUrl":"https://doi.org/10.1016/j.jss.2013.04.057","url":null,"abstract":"<p><strong>Background: </strong>The patient-physician relationship has evolved from the paternalistic, physician-dominant model to the shared-decision-making and informed-consumerist model. The level of patient involvement in this decision-making process can potentially influence patient satisfaction and quality of life. In this study, patient-physician decision models are evaluated in patients undergoing postmastectomy breast reconstruction.</p><p><strong>Methods: </strong>All women who underwent breast reconstruction at an academic hospital from 1999-2007 were identified. Patients meeting inclusion criteria were mailed questionnaires at a minimum of 1 y postoperatively with questions about decision making, satisfaction, and quality of life.</p><p><strong>Results: </strong>There were 707 women eligible for our study and 465 completed surveys (68% response rate). Patients were divided into one of three groups: paternalistic (n = 18), informed-consumerist (n = 307), shared (n = 140). There were differences in overall general satisfaction (P = 0.034), specifically comparing the informed group to the paternalistic group (66.7% versus 38.9%, P = 0.020) and the shared to the paternalistic group (69.3% versus 38.9%, P = 0.016). There were no differences in aesthetic satisfaction. There were differences found in the SF-12 physical component summary score across all groups (P = 0.033), and a difference was found between the informed and paternalistic groups (P < 0.05). There were no differences in the mental component score (P = 0.42).</p><p><strong>Conclusions: </strong>Women undergoing breast reconstruction predominantly used the informed model of decision making. Patients who adopted a more active role, whether using an informed or shared approach, had higher general patient satisfaction and physical component summary scores compared with patients whose decision making was paternalistic.</p>","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":" ","pages":"665-70"},"PeriodicalIF":2.2,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jss.2013.04.057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31455492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and ethnic disparities in the treatment of unruptured thoracoabdominal aortic aneurysms in the United States.","authors":"Dean J Arnaoutakis,&nbsp;Brandon W Propper,&nbsp;James H Black,&nbsp;Eric B Schneider,&nbsp;Ying Wei Lum,&nbsp;Julie A Freischlag,&nbsp;Bruce A Perler,&nbsp;Christopher J Abularrage","doi":"10.1016/j.jss.2013.03.018","DOIUrl":"https://doi.org/10.1016/j.jss.2013.03.018","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies have found increased mortality in minority patients undergoing abdominal aortic aneurysm repair. The goal of this study was to identify racial and ethnic disparities in patients undergoing thoracoabdominal aortic aneurysm repair.</p><p><strong>Materials and methods: </strong>We queried the Nationwide Inpatient Sample (2005-2009) using International Classification of Diseases, Ninth Revision, Clinical Modification codes for repair of unruptured thoracoabdominal aneurysms. The primary outcome was death. Secondary outcomes included postoperative complications. We performed multivariate analysis adjusting for age, gender, race, comorbidities (Charlson index), insurance type, and surgeon and hospital operative volumes and characteristics.</p><p><strong>Results: </strong>Overall, 1541 white, 207 black, and 117 Hispanic patients underwent thoracoabdominal aortic aneurysm repair. White patients tended to be older (P = 0.003), whereas black patients had a higher incidence of diabetes mellitus (P = 0.04). Black and Hispanic patients were less likely to have an elective admission (P < 0.001) and more likely to have repair performed at a hospital with a lower average annual surgical volume (P = 0.04). Postoperative complications were similar among the groups (P = 0.31). On multivariate analysis, increased mortality was independently associated with Hispanic ethnicity (relative ratio [RR], 2.57; 95% confidence interval [CI], 1.25-5.25; P = 0.01), cerebrovascular disease (RR, 1.88; 95% CI, 1.10-3.23; P = 0.02), and age (RR, 1.04; 95% CI, 1.01-1.07; P = 0.004).</p><p><strong>Conclusions: </strong>Hispanic ethnicity is independently associated with increased mortality after repair of unruptured thoracoabdominal aneurysms. This finding was independent of preoperative comorbidities, postoperative complications, and surgeon and hospital operative volumes. Further studies are necessary to determine whether this mortality difference persists after the index hospitalization.</p>","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":" ","pages":"651-7"},"PeriodicalIF":2.2,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jss.2013.03.018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40239318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcineurin inhibitors and Clostridium difficile infection in adult lung transplant recipients: the effect of cyclosporine versus tacrolimus.","authors":"Janet T Lee,&nbsp;Bryan A Whitson,&nbsp;Rosemary F Kelly,&nbsp;Jonathan D'Cunha,&nbsp;Jordan M Dunitz,&nbsp;Marshall I Hertz,&nbsp;Sara J Shumway","doi":"10.1016/j.jss.2013.03.041","DOIUrl":"https://doi.org/10.1016/j.jss.2013.03.041","url":null,"abstract":"<p><strong>Background: </strong>Tacrolimus (FK506) has a superior immunosuppressive effect compared with cyclosporine (CSA) without a significant increase in generalized infectious complications. Differences in specific infections such as Clostridium difficile (CDI) have not been reported. We investigated the relationship between calcineurin inhibitors and CDI, hypothesizing that choice of calcineurin inhibitor (CSA or FK506) after lung transplantation would have no effect on the incidence of CDI.</p><p><strong>Methods: </strong>We performed a retrospective chart review of lung transplant recipients between June 1, 2000, and December 31, 2005, at a single institution. Positive CDI assays through December 11, 2011, were also recorded. We used Student's t- and chi-squared tests (α = 0.05) to compare CSA and FK506 groups. We calculated adjusted hazard ratios for CDI using Cox proportional hazard models.</p><p><strong>Results: </strong>We identified 217 lung transplant recipients: 106 patients in the CSA group and 111 patients in the FK506 group. A total of 31 patients (27.9%) in the FK506 group developed CDI postoperatively compared with 20 patients (18.9%) in the CSA group (P = 0.16). The adjusted hazard ratio for CDI in the FK506 group was not significantly higher (1.53; 95% confidence interval, 0.78-2.98). There was no significant difference in the intensive care unit or total length of stay, in-hospital incidence rate, time to first CDI episode, or recurrence rate between groups.</p><p><strong>Conclusions: </strong>The CDI rates were not significantly higher in the FK506 group than the CSA group in our study. These data are consistent with previous studies on FK506 that show no increase in infectious complications over CSA, and demonstrate its continued safety in lung transplantation.</p>","PeriodicalId":191568,"journal":{"name":"The Journal of surgical research","volume":" ","pages":"599-604"},"PeriodicalIF":2.2,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jss.2013.03.041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31433423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}