New Innovations in Chemistry and Biochemistry Vol. 2最新文献

Study on Nanocomposites between PdNPs and Layered Double Hydroxides for Challenging Organometallic Catalysis PdNPs与层状双氢氧化物纳米复合材料的有机金属催化研究

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/3237f

Raquel V. Santos, A. C. Silva, Luiz Phelipe Tomasso, Douglas G. de Lima, A. B. C. Simas, L. F. B. Malta, J. D. Senra

引用次数: 0

Study on Synthesis, Spectral Characterization and in vitro Antibacterial Evaluation of Triaza and Dioxa Aza Spiro Derivatives Triaza和Dioxa Aza类螺旋衍生物的合成、光谱表征及体外抗菌评价研究

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/4167f

M. Natarajan, Elanchezhian Balachandravinayagam, S. Ganesan, M. Selvaraju

引用次数: 0

Determination of Thiolated Chitosan as Nanocarriers for Ocular Drug Delivery 巯基壳聚糖作为眼部给药纳米载体的测定

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/12726d

D. Shastri

{"title":"Determination of Thiolated Chitosan as Nanocarriers for Ocular Drug Delivery","authors":"D. Shastri","doi":"10.9734/bpi/nicb/v2/12726d","DOIUrl":"https://doi.org/10.9734/bpi/nicb/v2/12726d","url":null,"abstract":"Drug delivery through the ocular route now-a-days became more interesting and challenging due to its complex anatomical structure. Despite of numerous efforts by the formulating scientists all over the world there are many challenges need to be overcome in making the drug delivery through the corneal route. The main issue with conventional dosage forms is poor ocular bioavailability due to short ocular residence times caused by anatomical and pathophysiological barriers in the eye. As a result, substantial work has gone into creating nanotechnology-based drug delivery methods that increase precorneal residence time to improve ocular bioavailability of medicines. Polymers containing thiol groups have much higher adhesive properties than polymers that are generally thought to be mucoadhesive. Chitosan and its derivatives are excellent polymeric biomaterials that have a variety of uses in drug delivery, particularly through the ocular route. Thiolated derivatives (thiomers) of chitosan produced via immobilization of thiol groups on the primary amino groups of chitosan backbone has improved its mucoadhesive properties by establishment of electrostatic interactions with mucin and enhanced permeability and anti-protease activity. Moreover, it is also biocompatible, biodegradable, and non-toxic. Many drugs and therapeutics can be administered via nanoparticulate form also or as an in-situ gel forming systems through the ocular route using Thiolated chitosan. The main objective of this chapter is to provide an insight into the various approaches using Thiolated chitosan as nanocarrier for ocular drug delivery by summarizing recent findings and its applications in the field of ocular drug delivery.","PeriodicalId":19155,"journal":{"name":"New Innovations in Chemistry and Biochemistry Vol. 2","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76023641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents 1,3,4 -恶二唑类抗菌抗真菌药物的研究

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/13095d

B. Revanasiddappa, E. Subrahmanyam

引用次数: 1

Determination of Chemical Reactivities of Oxytocin and Vasopressin Peptide Hormones Studied through Conceptual Density Functional Theory (CDFT) and Molecular Electron Density Theory (MEDT) 概念密度泛函理论(CDFT)和分子电子密度理论(MEDT)研究催产素和抗利尿激素肽的化学反应性

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/4072f

N. Flores-Holguín, J. Frau, D. Glossman-Mitnik

{"title":"Determination of Chemical Reactivities of Oxytocin and Vasopressin Peptide Hormones Studied through Conceptual Density Functional Theory (CDFT) and Molecular Electron Density Theory (MEDT)","authors":"N. Flores-Holguín, J. Frau, D. Glossman-Mitnik","doi":"10.9734/bpi/nicb/v2/4072f","DOIUrl":"https://doi.org/10.9734/bpi/nicb/v2/4072f","url":null,"abstract":"This research reports the results of a study of the global and local chemical reactivity of the peptide hormones Oxytocin and Vasopressin based on the calculation of descriptors coming from Conceptual DFT as well as from Molecular Electron Density Theory for their consideration as a tool to explain the molecular interactions, and as a useful complement to those approximations based on Molecular Docking. The knowledge of the values of the global and local descriptors of the molecular reactivity of the Oxytocin and Vasopressin peptide hormones that have been studied through our proposed methodology could be useful in the development of new drugs based on these compound or some analogs relying in the chemical interaction between these peptides and their biological receptors of protein kind. It can be concluded that both approximations to the local chemical reactivity based on the descriptors are equally valid and complement each other, while the choosing of the Population Analysis used in their calculation is not a crucial point to be considered.","PeriodicalId":19155,"journal":{"name":"New Innovations in Chemistry and Biochemistry Vol. 2","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83813150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Assay of Betamethasone Pharmaceutical Dosage Forms by Visible Spectrophotometry 倍他米松制剂剂型的可见分光光度法分析

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/8205d

D. R. Kumar, C. Rambabu

引用次数: 0

A Study on Green Synthesis of Nano Cu Compounds (Malachite and Rouaite), Using Moringa oleifera Leaf Extract and their Photocatalytic, Antifungal, Anti-Inflammatory, and Antioxidant Properties 辣木叶提取物绿色合成纳米铜化合物(孔雀石和柔石)及其光催化、抗真菌、抗炎和抗氧化性能的研究

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/3768f

S. Darani, N. N. Devi, R. Rajakumari

{"title":"A Study on Green Synthesis of Nano Cu Compounds (Malachite and Rouaite), Using Moringa oleifera Leaf Extract and their Photocatalytic, Antifungal, Anti-Inflammatory, and Antioxidant Properties","authors":"S. Darani, N. N. Devi, R. Rajakumari","doi":"10.9734/bpi/nicb/v2/3768f","DOIUrl":"https://doi.org/10.9734/bpi/nicb/v2/3768f","url":null,"abstract":"Nano copper compounds (Malachite and Rouaite) were synthesized using Moringa oleifera leaf extract as the reducing agents and characterized by X-ray diffraction and Scanning electron microscopic analysis, respectively, for structure and morphology. The UV-vis absorption analysis of Malachite exhibits multiple peaks, and the energy bandgap obtained from the Taue plot was 5.32 eV for malachite and 3.7 eV for Rouaite. The photoluminescence spectra of Malachite and Rouaite show broadband emission in the green region of the visible spectrum. The photocatalytic activity of Malachite and Rouaite was examined with the natural dye of beetroot (Beta vulgaris) extract and observed that the absorption peak intensity of the dye decreases as the time of exposure to sunlight increases, indicating the degrading effect of the synthesized samples. The antifungal activity of Malachite and Rouaite with Candida albicans by agar disc diffusion method showed that Rouaite has more enhanced antifungal activity than Malachite. Thus, it is suggested that the green synthesized Rouaite and Malachite may be used in medicine for their antifungal and anti-inflammatory activities.","PeriodicalId":19155,"journal":{"name":"New Innovations in Chemistry and Biochemistry Vol. 2","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76255856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Success of Good Old and Highly Specific Separation Method in the Isolation of Bioactive Proteins: From Bench to Bedside Good Old高特异性分离方法在生物活性蛋白分离中的成功:从实验室到床边

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/11825d

D. Novick

引用次数: 0

KATP Channels Functioning is Critical for Mitochondrial Bioenergetics under Physical Stress KATP通道功能对物理应激下线粒体生物能量学至关重要

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/11158d

O. Akopova, I. Mankovska, V. Nosar, L. Kolchinskaya, V. Sagach

{"title":"KATP Channels Functioning is Critical for Mitochondrial Bioenergetics under Physical Stress","authors":"O. Akopova, I. Mankovska, V. Nosar, L. Kolchinskaya, V. Sagach","doi":"10.9734/bpi/nicb/v2/11158d","DOIUrl":"https://doi.org/10.9734/bpi/nicb/v2/11158d","url":null,"abstract":"The modulation of mKATP channel activity is known to have a great impact on energy metabolism in a living organism. The aim of this work was to study the impact of mKATP channels opening on the physical endurance in the rats subject to compulsory swimming with a load. Our purpose was to find a mechanistic basis to explain the modulation of the energy metabolism under exercise training by studying the direct effect of mKATP channel opening on mitochondrial functions. Male Wistar rats exhibiting high and low resistance to physical stress were separated in two groups, and subjected to compulsory swimming with a load. Swimming time (ST) was monitored from the start till the fatigue was reached, and the rats began to drawn. ST was reliably higher in high resistance group, which coincided with higher endogenous mKATP channels activity. Unlike this, mKATP channels blockers, glibenclamide and 5-hydroxydecanoate completely blocked mKATP channel in vivo and dramatically reduced ST in both groups, which indicated its dependence on mKATP channel activity. To find a mechanistic basis for the observed dependence, we studied the effect of mKATP channels opening on mitochondrial functions in vitro. mKATP channels opener diazoxide stimulated state 4 respiration and decreased RCR, but increased phosphorylation efficiency (P/O). On the contrary, mKATP channels blockers, dramatically reduced P/O. Based on the experiments, we came to the conclusion of the correlation between the physical endurance and P/O ratio, both dependent on mKATP channels activity. Thus, mKATP channels opening inhibited phosphorylation, but increased its efficiency, which reduced energy expense for ATP synthesis. In vivo this resulted in the improvement of the endurance in the animals with elevated mKATP channel activity. Possible mechanisms and physiological relevance of the observed phenomena are discussed.","PeriodicalId":19155,"journal":{"name":"New Innovations in Chemistry and Biochemistry Vol. 2","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86934323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greener Buchwald-Hartwig Reaction on Various Heterocycles Using Eucalyptol as Solvent 以桉木醇为溶剂的各种杂环更绿的Buchwald-Hartwig反应

New Innovations in Chemistry and Biochemistry Vol. 2 Pub Date : 2021-08-26 DOI: 10.9734/bpi/nicb/v2/11775d

J. F. Campos, Sabine Berteina‐Raboin

引用次数: 0