Study on 1, 3, 4-Oxadiazole Derivatives as an Antibacterial and Antifungal Agents

In the present investigation a new series of 1, 3, 4-oxadiazoles (3a-j) were synthesized by reacting INH (1) and substituted aromatic acids (2) in presence of POCl3. The new compounds were established on the basis of IR, 1H NMR and Mass spectral data. The compounds were subjected for In-vitro antibacterial and antifungal activities and compared with the standard drugs Some of the tested compounds showed good activity against all the organisms. The presence of electron donating and withdrawing groups at the fourth position is mainly responsible for showing the good activity.