Neuromodulation最新文献

{"title":"ID# 2196828 CHARCOT SPINAL ARTHROPATHY IN PARKINSON’S DISEASE: A SYSTEMATIC REVIEW OF THE LITERATURE","authors":"Kiran K. Sankarappan BS","doi":"10.1016/j.neurom.2026.06.071","DOIUrl":"10.1016/j.neurom.2026.06.071","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e43"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2194842 SPINAL CORD STIMULATION FOR PAIN MANAGEMENT AFTER SPINAL CORD INJURY: A SYSTEMATIC REVIEW","authors":"Michael Suarez DO, David Gallacher MD","doi":"10.1016/j.neurom.2026.06.064","DOIUrl":"10.1016/j.neurom.2026.06.064","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e39"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2176876 CASE REPORT: PROGRESSIVE DISC HERNIATION AFTER INTRADISCAL PLATELET-RICH PLASMA INJECTION","authors":"Antonio Mondriguez-Gonzalez MD, Maneesh Tiwari MD","doi":"10.1016/j.neurom.2026.06.032","DOIUrl":"10.1016/j.neurom.2026.06.032","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e20"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2190876 HIPS DO NOT LIE: CURATIVE SUPERIOR GLUTEAL NEUROMODULATOR IMPLANTATION FOR REFRACTORY BILATERAL HIP PAIN","authors":"Nicole Haynes MD, Joseph Lang PA-C, MPAS, Yintin Chen DO, Dmitriy Treyster Pain Fellow","doi":"10.1016/j.neurom.2026.06.056","DOIUrl":"10.1016/j.neurom.2026.06.056","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e35"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation of Pancreatic Lymph Nodes as a Therapy for Type 1 Diabetes: An Anatomical Study on the Presence of a Neuro-Immune Link in Human Pancreatic Lymph Nodes and Potential Sites for Electrical Stimulation","authors":"Dyonne A.M. Koopmans-Lotgerink Bruinenberg MSc,&nbsp;Claire Mackaaij BSc,&nbsp;Eric Irwin PhD,&nbsp;Daniel J. Chew PhD,&nbsp;Isha Gupta PhD,&nbsp;Ronald L.A.W. Bleys PhD,&nbsp;Cindy G.J. Cleypool PhD","doi":"10.1016/j.neurom.2025.12.009","DOIUrl":"10.1016/j.neurom.2025.12.009","url":null,"abstract":"<div><h3>Objectives</h3><div>Experimental studies in nonobese diabetic mice show that electrical stimulation of sympathetic nerves innervating pancreatic lymph nodes (LNs) reduces T cell activation through β-2 adrenergic signaling and limits further β-cell destruction. Neuromodulation of pancreatic LNs may therefore represent a novel therapeutic approach for early-stage type 1 diabetes (T1D) in humans. This study aims to explore the presence of a sympathetic neuro-immune link in human pancreatic LNs and to identify surgically accessible neuromodulation sites.</div></div><div><h3>Materials and Methods</h3><div>Upstream pancreatic LNs 8a and 8p were selected as primary targets because they drain lymph from multiple downstream pancreatic LNs. The suitability of two potential stimulation sites to target the sympathetic innervation of these LNs, being the LN capsule and the nerve plexus surrounding the proximal common hepatic artery (CHA), was evaluated. Ten formaldehyde-fixed human cadavers were studied, and various techniques were used to collect macro- and microscopic data on pancreatic LNs and the proximal CHA with its surrounding nerve plexus.</div></div><div><h3>Results</h3><div>Human pancreatic LNs contain sympathetic nerves in both their capsule and parenchyma, the latter occasionally as discrete nerves located close to T cells. Of the two upstream LNs studied, LN 8a was consistently present, easily accessible, and showed clear sympathetic connections to the celiac and CHA nerve plexuses. However, its position varied, and it was located near the pancreas. The nerve plexus around the CHA was consistently observed and contained predominantly sympathetic nerves, with nerves to LN 8a originating from its anterior-caudal region.</div></div><div><h3>Conclusion</h3><div>Human pancreatic LNs contain a sympathetic neuro-immune link that could be targeted for T1D treatment. The proximal CHA’s nerve plexus appears the most promising neuromodulation site owing to its surgical accessibility, sympathetic predominance, and suitability for safe device implantation.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1200-1217"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral Nerve Stimulation Ameliorates Visceral Hypersensitivity Following 2,4,6-Trinitrobenzene Sulfonic Acid–Induced Colitis in Rats by Suppressing Inflammation and Reducing Colonic Epithelial Permeability","authors":"Shiying Li MBBS, MS,&nbsp;Jiande D.Z. Chen PhD","doi":"10.1016/j.neurom.2026.04.001","DOIUrl":"10.1016/j.neurom.2026.04.001","url":null,"abstract":"<div><h3>Objectives</h3><div>Visceral pain is a common and debilitating symptom of bowel disorders, such as irritable bowel syndrome and inflammatory bowel disease (IBD). Sacral nerve stimulation (SNS), widely used for fecal incontinence, has shown promise in treating inflammation and visceral hypersensitivity in rodent models, although its efficacy in IBD-associated visceral pain remains unclear. This study evaluated the effectiveness and underlying mechanisms of SNS on visceral hypersensitivity in a rodent IBD model.</div></div><div><h3>Materials and Methods</h3><div>Visceral hypersensitivity was induced through intracolonic administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS). Rats received SNS or sham treatment (one h/d for ten days) beginning five days post-TNBS. SNS was applied using a set of parameters previously shown effective in treating visceral pain in other methods of neuromodulation.</div></div><div><h3>Results</h3><div>Daily disease activity index scores increased significantly after TNBS but improved with SNS (<em>p</em> &lt; 0.05). Tumor necrosis factor α levels in the distal colon rose in TNBS rats (55.2 pg/mg vs 37.5 pg/mg in saline, <em>p</em> = 0.004) and decreased with SNS (43.2 pg/mg, <em>p</em> = 0.025 vs sham). Visceral motor reflex (VMR) responses to colorectal distension (40–80 mm Hg) were elevated three- to fourfold in TNBS rats, which was reduced by 34%–73% with SNS (<em>p</em> &lt; 0.001). Colitis reduced transepithelial electrical resistance (TEER, reflecting colonic epithelial permeability) by 48% (18.3 Ω·cm²), which improved by SNS (26.0 Ω·cm², <em>p</em> = 0.035). Plasma lipopolysaccharide levels were elevated in TNBS-sham rats (0.72 EU/mL vs 0.20 EU/mL saline, <em>p</em> &lt; 0.001) and reduced with SNS (0.45 EU/mL, <em>p</em> = 0.042). TEER negatively correlated with VMR responses.</div></div><div><h3>Conclusions</h3><div>SNS attenuates TNBS-induced visceral hypersensitivity by reducing inflammation and enhancing epithelial barrier integrity.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1166-1174"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Emptying in Response to Neural Gastric Electric Stimulation in an Acute Porcine Model","authors":"Jonathan Sivakumar MBBS, MS,&nbsp;John B. Furness PhD,&nbsp;James Fallon PhD,&nbsp;David B. Grayden PhD,&nbsp;Katherine Papastratos BSc,&nbsp;Jeremy Cottrell PhD,&nbsp;Jenny Zhou MEng,&nbsp;Phil G. Dinning PhD,&nbsp;Cuong Phu Duong PhD","doi":"10.1016/j.neurom.2026.07.005","DOIUrl":"10.1016/j.neurom.2026.07.005","url":null,"abstract":"<div><h3>Background</h3><div>Delayed gastric conduit emptying (DGCE) is a common complication following esophagectomy-associated gastric conduit surgery and is often resistant to conventional treatments. Neural gastric electrical stimulation (NGES) is a potential approach to managing DGCE by generating propulsive gastric contractions through timed bursts of high-frequency, multisite stimulation. This study evaluates the efficacy of NGES in increasing gastric emptying in an acute porcine vagally denervated postsurgical conduit.</div></div><div><h3>Materials and Methods</h3><div>Six anaesthetized pigs underwent a staged interventions to assess whether gastric emptying at baseline, after bilateral truncal vagotomy, and after creation of a gastric conduit was accelerated by anterior-plus-posterior (A-plus-P) NGES or anterior-only (A-only) NGES. NGES was delivered through sequential (proximal-to-distal) activation of multiple gastric serosal electrode pairs to induce coordinated peristalsis. Liquid gastric emptying was measured by direct effluent collection, and myoelectrical activity was recorded by the same electrodes. Percentage gastric emptying was compared across conditions using repeated-measures analysis.</div></div><div><h3>Results</h3><div>Vagotomy reduced 15-minute gastric emptying from 30.8 ± 26.0% to 7.9 ± 8.6% (<em>p</em> &lt; 0.01). NGES improved emptying after vagotomy to 48.8 ± 28.3% with A-plus-P electrode stimulation (<em>p</em> = 0.004) and 48.0 ± 27.4% with A-only electrode stimulation (<em>p</em> = 0.003). Gastric tubularization independently increased emptying to 70.0 ± 21.5% (<em>p</em> = 0.006 vs the vagotomized whole stomach), with a peak of 96.3 ± 6.5% when tubularization was combined with A-only NGES.</div></div><div><h3>Conclusions</h3><div>NGES, using gastric surface electrodes, effectively increases gastric emptying after acute vagotomy, with A-only electrode stimulation achieving comparable efficacy to A-plus-P stimulation. These findings position NGES as a promising therapy for DGCE and other refractory gastric motility disorders, supporting progression to chronic animal studies to assess long-term efficacy and safety.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1182-1190"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2184307 A NOVEL MINIATURE TRANSCRANIAL FOCUSED ULTRASOUND DEVICE FOR NEURAL MODULATION: FROM CELLULAR MECHANISMS TO PROOF-OF-CONCEPT APPLICATIONS","authors":"Veronika Házi PhD student,&nbsp;Édua Édes n/a,&nbsp;Barnabás Kovács n/a,&nbsp;Aletta Mészáros n/a,&nbsp;Zoltán Somogyvári PhD,&nbsp;Eszter Sipos PhD,&nbsp;Attila Szűcs PhD,&nbsp;Tamás Kiss PhD,&nbsp;Marcell Stippinger PhD","doi":"10.1016/j.neurom.2026.06.044","DOIUrl":"10.1016/j.neurom.2026.06.044","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e28"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149093728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2170743 THREE-YEAR OUTCOMES FROM A MULTICENTER, EUROPEAN REAL-WORLD STUDY ASSESSING PATIENTS USING FAST-ACTING SUBPERCEPTION THERAPY","authors":"Anthony Berg MD,&nbsp;M. Angeles Canos-Verdecho MD,&nbsp;Ashish Gulve MD,&nbsp;Jan Willem Kallewaard MD,&nbsp;Georgios Kyriakopoulos MD,&nbsp;Jose E. Llopis-Calatayud MD,&nbsp;Sarah Love-Jones MD,&nbsp;Georgios Matis MD,&nbsp;Jose Paz-Solis MD,&nbsp;Sylvie Raoul MD,&nbsp;Philippe Rigoard MD,&nbsp;Jan Vesper MD, PhD,&nbsp;Adam Williams MD,&nbsp;Simon Bayerl MD,&nbsp;Jan Willem Kallewaard MD","doi":"10.1016/j.neurom.2026.06.013","DOIUrl":"10.1016/j.neurom.2026.06.013","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages e8-e9"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2171343 TARGETED RADIOFREQUENCY ABLATION TECHNIQUES FOR SPECIFIC LOW BACK PAIN SYNDROMES: REAL-WORLD OBSERVATIONAL STUDY OUTCOMES","authors":"Georgios Kyriakopoulos MD,&nbsp;Fabrizio Cassini MD,&nbsp;Felice Occhigrossi MD","doi":"10.1016/j.neurom.2026.06.022","DOIUrl":"10.1016/j.neurom.2026.06.022","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e15"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}