Neuroimmunology and Neuroinflammation最新文献_第9页

Azygos anterior cerebral artery aneurysm with subarachnoid hemorrhage 奇型脑前动脉瘤伴蛛网膜下腔出血

Neuroimmunology and Neuroinflammation Pub Date : 2018-09-28 DOI: 10.20517/2347-8659.2018.37

D. Chowdhury, N. Ahmed, B. Chaurasia, K. Barua

引用次数: 3

Predictors of severity and outcome and roles of intravenous thrombolysis and biomarkers in first ischemic stroke 首次缺血性脑卒中严重程度、结果的预测因素以及静脉溶栓和生物标志物的作用

Neuroimmunology and Neuroinflammation Pub Date : 2018-09-27 DOI: 10.20517/2347-8659.2018.28

K. Ghosh, Ramesh Bhattacharya, Saikat Ghosh, M. Mahata, Sarbajit Das, Suman Das, G. Mondal

{"title":"Predictors of severity and outcome and roles of intravenous thrombolysis and biomarkers in first ischemic stroke","authors":"K. Ghosh, Ramesh Bhattacharya, Saikat Ghosh, M. Mahata, Sarbajit Das, Suman Das, G. Mondal","doi":"10.20517/2347-8659.2018.28","DOIUrl":"https://doi.org/10.20517/2347-8659.2018.28","url":null,"abstract":"Aim: Stroke is one of the leading causes of death and disability. The proportion of patients receiving recombinant tissue plasminogen activator is low in our country. Biomarkers to identify patients at risk of severe disease, and guide treatment and prognosis would be valuable. This article aims to identify the factors that can independently prognosticate the acute phase of ischemic stroke. Methods: All patients with the first episode of ischemic stroke admitted to the Neurology Department between 1st December 2017 to 31st March 2018 were included in this pilot study. Stroke severity was evaluated using the National Institute of Health Stroke Scale (NIHSS). Patients being admitted within 4.5 h of onset of symptoms were thrombolysed with injection alteplase. For each patient, 4 serum biomarkers (D-dimer, fibrinogen, C-reactive protein and neuron specific enolase) were evaluated at admission and 24 h later. Discharged patients were assessed on an outpatient basis using the modified Rankin scale. The study primarily aimed to identify the factors predicting the severity and outcome of stroke, and to evaluate the effect of thrombolysis on the outcome. The secondary aim was to evaluate the role of biomarkers to predict the unfavorable outcome and the chance of post thrombolysis hemor-","PeriodicalId":19129,"journal":{"name":"Neuroimmunology and Neuroinflammation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44542541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

2018 Mental Health and Neurology Conference 2018心理健康与神经病学会议

Neuroimmunology and Neuroinflammation Pub Date : 2018-09-25 DOI: 10.20517/2347-8659.2018.45

M. H. Machfoed

引用次数: 0

Glioma associated microglia/macrophages, a potential pharmacological target to promote antitumor inflammatory immune response in the treatment of glioblastoma 胶质瘤相关的小胶质细胞/巨噬细胞，在胶质母细胞瘤治疗中促进抗肿瘤炎症免疫反应的潜在药理学靶点

Neuroimmunology and Neuroinflammation Pub Date : 2018-09-20 DOI: 10.20517/2347-8659.2018.42

C. D. Russo, N. Cappoli

引用次数: 16

Erratum: Characteristics and predictive biomarkers of drug resistant epilepsy -- study in Georgia 勘误表：耐药癫痫的特征和预测性生物标志物——在格鲁吉亚的研究

Neuroimmunology and Neuroinflammation Pub Date : 2018-09-06 DOI: 10.20517/2347-8659.2018.54

Neuroimmunology and Neuroinflammation Editorial Office

引用次数: 1

The novel-molecule T11TS facilitated arousal of glioma-mediated dormancy of bone-marrow hematopoietic stem-cells 新型分子T11TS促进胶质瘤介导的骨髓造血干细胞休眠的唤醒

Neuroimmunology and Neuroinflammation Pub Date : 2018-08-30 DOI: 10.20517/2347-8659.2018.13

Somnath Mondal, A. Datta, I. Hazra, Sk Md Omar Faruk, S. Moitra, S. Chaudhuri, Lakshyajeet Nath, P. Das, A. Basu, S. Tripathi, S. Chaudhuri

引用次数: 2

In silico design of novel gold-phosphate containing compounds as selective inhibitors of cathepsin B in neuroinflammation 新型含磷酸金化合物作为组织蛋白酶B在神经炎症中的选择性抑制剂的计算机设计

Neuroimmunology and Neuroinflammation Pub Date : 2018-08-27 DOI: 10.20517/2347-8659.2018.34

Alexsey V. Raevsky, M. Sharifi, V. Pinchuk, A. Klegeris

引用次数: 0

Systemic therapy in patients with NSCLC with brain metastasis: the emerging role of immunotherapy 非小细胞肺癌脑转移患者的系统治疗：免疫疗法的新作用

Neuroimmunology and Neuroinflammation Pub Date : 2018-08-23 DOI: 10.20517/2347-8659.2018.39

J. Niu, Junle Zhou, S. Lindebak, Fade Mahmoud

引用次数: 2

Cerebral fat embolism syndrome after long bone fracture due to traffic accident: a case report 交通事故致长骨骨折并发脑脂肪栓塞综合征1例

Neuroimmunology and Neuroinflammation Pub Date : 2018-08-01 DOI: 10.20517/2347-8659.2018.23

Xingwu Chen, Jianfeng Fang, M. Deng, Ting Jiang, Feng Luo

{"title":"Cerebral fat embolism syndrome after long bone fracture due to traffic accident: a case report","authors":"Xingwu Chen, Jianfeng Fang, M. Deng, Ting Jiang, Feng Luo","doi":"10.20517/2347-8659.2018.23","DOIUrl":"https://doi.org/10.20517/2347-8659.2018.23","url":null,"abstract":"Cerebral fat embolism syndrome (CFES) is an uncommon but serious complication of long bone fracture. We reported a 19-year-old male patient who sustained CFES due to multiple limbs long bone fractures after a traffic accident injury. He gradually developed into coma within 24 h after his injury. The arterial blood gas analyses were normal. There was a small amount of gas in the right pleural cavity on the thoracic computed tomography (CT). Although there were no remarkable intracranial abnormalities on the initial brain CT findings, the typical brain magnetic resonance imaging (MRI) findings of the starfield pattern and scattered foci were observed. Both T2-weighted imaging and diffusion weighted imaging of MRI indicated multiple scattered lesions in the bilateral cerebrum hemisphere white matter, grey matter, basal ganglia, corpus callosum and thalamus indicative of acute infarcts without microbleeding on the susceptibilityweighted imaging sequences. With the above findings, the diagnosis of the case was cerebral fat embolism syndrome. Although the patient was treated with comprehensive support in the intensive care unit, he remained unconscious and was discharged after 7 days of hospitalization.","PeriodicalId":19129,"journal":{"name":"Neuroimmunology and Neuroinflammation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48594915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Therapeutic approach targeting apolipoprotein E binding region and low-density lipoprotein receptor for Alzheimer��s disease 针对载脂蛋白E结合区和低密度脂蛋白受体治疗阿尔茨海默病的方法

Neuroimmunology and Neuroinflammation Pub Date : 2018-07-31 DOI: 10.20517/2347-8659.2018.26

Michael Leon, D. Sawmiller, B. Giunta, Jun Tan

{"title":"Therapeutic approach targeting apolipoprotein E binding region and low-density lipoprotein receptor for Alzheimer��s disease","authors":"Michael Leon, D. Sawmiller, B. Giunta, Jun Tan","doi":"10.20517/2347-8659.2018.26","DOIUrl":"https://doi.org/10.20517/2347-8659.2018.26","url":null,"abstract":"Approximately 13% of the population over the age of 65 years is estimated to have AD. The total number of cases is expected to increase over the coming decades. The apolipoprotein E (ApoE) genotype is the greatest genetic determinant for Alzheimer’s disease (AD) development. The ApoE4 allele increases the risk of AD by 4 to 14 fold while the ApoE2 allele has an opposing effect; decreasing risk. Indeed many studies have demonstrated that carriers of the ApoE2 allele are associated with greater likelihood of survival to advanced age, superior verbal learning ability in advanced age, and reduced accumulation of amyloid pathology in the aged brain. In addition, it is known that ApoE proteins have different affinities for the low-density lipoprotein receptor (LDLR), with ApoE2 having the weakest binding to the LDL receptor at < 2% relative to ApoE3 and E4. Because ApoE2 has shown protective effects in regard to AD, a novel approach for ApoE4 carriers may be to create a peptide antagonist that blocks the ApoE interactions with LDLR at its 135-150 N-terminal binding domain. This peptide may create a more ApoE2-like structure by decreasing the affinity of ApoE4 for LDLR thereby reducing AD onset, memory impairment, and amyloid plaque formation. In this review, we will discuss the different detrimental effects that ApoE4 can cause. Most importantly, we will review how ApoE4 binding to LDLR promotes AD pathogenesis and how blocking ApoE4 binding may be a promising novel therapeutic approach for AD.","PeriodicalId":19129,"journal":{"name":"Neuroimmunology and Neuroinflammation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41911081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5