A M Soto, B H Duvilanski, A R De Guglielmone, C J Gómez
{"title":"Precursors for RNA synthesis and their metabolism in developing rat brain.","authors":"A M Soto, B H Duvilanski, A R De Guglielmone, C J Gómez","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"4 5","pages":"277-85"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15527021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kinetic properties of beta-galactosidase of human brain tissue.","authors":"J J Lisman, G J Hooghwinkel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"4 3","pages":"167-79"},"PeriodicalIF":0.0,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15939264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enzymatic degradation of myelin basic protein in central nervous system lesions of monkeys with experimental allergic encephalomyelitis.","authors":"H C Rauch, E R Einstein, J Csejtey","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 3","pages":"195-205"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15234721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A developmental study of the relationship between the protein components of rat CNS myelin.","authors":"D H Adams, J Osborne","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship between the major and minor protein components of the myelin sheath, and between fractions soluble and insoluble in chloroform methanol has been studied in rat brain between 5 and 60 days of age. The results suggest a continuous sequential buildup of the myelin sheath, in which while the minor protein components form the major proportion of early myelin their contribution is progressively reduced by the addition of myelin specific proteins. Chloroform methanol insoluble myelin is recognisable before the CMS fraction appears. The minor proteins are present in the brain several days before myelination and then appear to migrate into myelin. However, the myelin specific proteins can only be detected shortly before myelination. The results underline previous suggestions that the myelin sheath has a unique protein composition, and suggest that the specific components arise de novo just before they are required. They are not consistent with the supposition that myelin consists of glial cell membrane and are discussed in relation to current views on the myelination process.</p>","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 2","pages":"91-112"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Age-dependent utilization of phenylalanine for the synthesis of neuronal and glial proteins.","authors":"D E Johnson, O Z Sellinger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. Groups of 5-, 10-, 18- and 43-day old rats were injected intracerebrally with a single dose of [U14C] phenylalanine and its conversion to acid-soluble metabolites was determined in the cerebral cortex over a period of 24 h. Although the most rapid utilization of [14C] phenylalanine occurred initially in the oldest group, by 45 min the 18-day old cortex had the lowest levels of unchanged [14C] phenylalanine; by 24 h [14C] phenylalanine was, in turn, lowest in the 10-day old cortex. 2. The specific radioactivity of [14C] phenylalanine decreased rapidly at all ages for the first 2 h; it then continued to decrease in the two younger age groups while it remained virtually constant in the two older ones. 3. We also determined the incorporation of [14C] phenylalanine into, and the loss of radioactivity from, cortical, glial and neuronal proteins, isolated from animals injected on their 10th, 18th and 43rd day of life and followed over a period of two weeks. a. The proteins of the 10-day old cortex attained the highest specific radioactivity and were labeled at the highest rate. b. The glial proteins and particularly those of the 10-day old cortex were consistently more highly radioactive than the neuronal proteins; the rates of radioactivity decay from neuronal and glial proteins were parallel, however. c. The decay of the radioactivity followed a similar time course at all ages and for all proteins examined, exhibiting two phases, a rapid one extending from day 1 (day 3 in the 18-day old cortex) to day 7 and a slower phase extending through the entire second week.</p>","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 2","pages":"113-23"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25248980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histochemistry of postnatally developing feline spinal roots. II. Occurrence of acid phosphatase activity as studied by light and electron microscopical methods.","authors":"C H Berthold","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 5","pages":"291-310"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15244290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The alkaline ribonuclease system in the sciatic nerve of the chick during development.","authors":"C Mezei, Y W Hu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 1","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15816806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Apamin from bee venom: effects of the neurotoxin on cultures of the embryonic mouse cortex.","authors":"P E Spoerri, J Jentsch, P Glees","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 4","pages":"207-14"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15846666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fixation and numerical estimation of myelinated nerve fibres during initial myelination in the cat.","authors":"C H Berthold, T Carlstedt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19126,"journal":{"name":"Neurobiology","volume":"3 1","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15680471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}