Neirofiziologiia = Neurophysiology最新文献

Dynamic Clamp Analysis of Synaptic Integration in Sympathetic Ganglia. 交感神经节突触整合的动态钳形分析。

Neirofiziologiia = Neurophysiology Pub Date : 2007-11-01 DOI: 10.1007/s11062-008-9002-y

J P Horn, P H M Kullmann

{"title":"Dynamic Clamp Analysis of Synaptic Integration in Sympathetic Ganglia.","authors":"J P Horn, P H M Kullmann","doi":"10.1007/s11062-008-9002-y","DOIUrl":"https://doi.org/10.1007/s11062-008-9002-y","url":null,"abstract":"Advances in modern neuroscience require the identification of principles that connect different levels of experimental analysis, from molecular mechanisms to explanations of cellular functions, then to circuits, and, ultimately, to systems and behavior. Here, we examine how synaptic organization of the sympathetic ganglia may enable them to function as use-dependent amplifiers of preganglionic activity and how the gain of this amplification may be modulated by metabotropic signaling mechanisms. The approach combines a general computational model of ganglionic integration together with experimental tests of the model using the dynamic clamp method. In these experiments, we recorded intracellularly from dissociated bullfrog sympathetic neurons and then mimicked physiological synapses with virtual computer-generated synapses. It thus became possible to analyze the synaptic gain by recording cellular responses to complex patterns of synaptic activity that normally arise in vivo from convergent nicotinic and muscarinic synapses. The results of these studies are significant because they illustrate how gain generated through ganglionic integration may contribute to the feedback control of important autonomic behaviors, in particular to the control of the blood pressure. We dedicate this paper to the memory of Professor Vladimir Skok, whose rich legacy in synaptic physiology helped establish the modern paradigm for connecting multiple levels of analysis in studies of the nervous system.","PeriodicalId":19121,"journal":{"name":"Neirofiziologiia = Neurophysiology","volume":"39 6","pages":"423-429"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11062-008-9002-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28404023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

[Relationship between the crystal lattice structure and the biological action of some agonists of amino acid receptors]. [某些氨基酸受体激动剂的晶格结构与生物作用的关系]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

L S Kertser, K V Baev

引用次数: 0

[Influence of phosphorylation on the functional properties of the sodium channel reconstructed in an artificial membrane]. [磷酸化对人工膜重构钠通道功能特性的影响]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

M K Malysheva, V A Zhukareva, T F Kastrikina

引用次数: 0

[Electron-cytochemical study of carbohydrate components in the surface membrane of cultured Helix pomatia neurons]. [培养海马螺旋神经元表面膜碳水化合物组分的电子细胞化学研究]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

L M Koval', N I Kononenko, M D Lutsik, E N Iavorskaia

引用次数: 0

[The mechanism of the effect of the sympathetic nervous system on skin receptors]. [交感神经系统对皮肤感受器的作用机制]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01 DOI: 10.1007/BF01052853

E D Efes

引用次数: 2

[GTP-dependent dopamine reception in central nervous system tissues in the pond snail]. [田螺中枢神经系统组织中gtp依赖性多巴胺接收]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

I M Prudnikov, V N Tsyvkin, T F Kastrikina

引用次数: 0

[Effect of stimulation of the thalamic reticular nucleus on spino-bulbo-spinal reflex activity]. 刺激丘脑网状核对脊髓-球-脊髓反射活动的影响。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

Z I Nanobashvili, N A Khizanishvili

引用次数: 0

[Effect of alpha-latrotoxin on synaptic transmission between identified neurons in Helix central nervous system]. [α -latrotoxin对Helix中枢神经系统神经元间突触传递的影响]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

O N Osipenko, A V Romanenko, E A Petrushenko, Ia T Terletskaia

引用次数: 0

[The excitation of the fibers of the funiculus dorsalis medullae spinalis during the stimulation of different groups of cutaneous and muscle nerve fibers in the cat]. [猫不同组皮神经纤维和肌神经纤维刺激时脊髓背髓索纤维的兴奋]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

V L Shaposhnikov

{"title":"[The excitation of the fibers of the funiculus dorsalis medullae spinalis during the stimulation of different groups of cutaneous and muscle nerve fibers in the cat].","authors":"V L Shaposhnikov","doi":"","DOIUrl":"","url":null,"abstract":"Electric stimulation of various groups of fibres of cutaneous and muscle nerve of cat has been studied for its effect on action potentials in the gray dorsal column fibres, Registration was performed at the level L2--L3 from ipsi- and contralateral dorsal columns, using needle electrodes. Action potentials of dorsal columns, arisen by stimulation of cutaneous nerves, had a more complex form than those of stimulated muscle nerves. Nonmyelinated fibres of a cutaneous nerve are shown to relate to those of dorsal columns. Excitation of high-threshold A- and C-fibres activates the most fast-conducting fibres of dorsal columns. When a stimulus was applied to all fibres of the cutaneous nerve, the action potentials with conduction velocities of 146-0.24 m/s were recorded in dorsal columns. It was shown that such conduction velocities remained in dorsal columns to level C7. Stimulation of muscle nerves excited only myelinic fibres of dorsal columns, the conduction velocities ranging from 90 to 2.3 m/s. By alternating stimulation of either nerve with a 30-300 ms interval we decreased the action potential amplitude of the nerve that was the second to be stimulated. It is likely be related to convergence of the cutaneous and muscle nerve inputs in the spinal cord on the same neurons. A suggestion is made that faster transfer of high-threshold cutaneous signals in dorsal column are associated with the necessity of rapid information about damaging stimulation.","PeriodicalId":19121,"journal":{"name":"Neirofiziologiia = Neurophysiology","volume":"24 5","pages":"625-32; discussion 633-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12504856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effect of vitamins B2 and B6 on the functional properties of cholinoreceptors in molluscan neurons]. [维生素B2和B6对软体动物神经元胆碱受体功能的影响]。

Neirofiziologiia = Neurophysiology Pub Date : 1992-01-01

V A Diatlov, A V Platoshin

引用次数: 0