Neurochemical Journal最新文献

{"title":"Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis","authors":"V. S. Kudrin, V. G. Konkov, E.V. Shubenina, K. A. Kasabov, D. V. Sadovnik, A. H. Khairetdinova, A. E. Umriyukhin, L. G. Kolik","doi":"10.1134/s1819712424020053","DOIUrl":"https://doi.org/10.1134/s1819712424020053","url":null,"abstract":"<p><b>Abstract</b><i>—</i>The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (a dipeptide analogue of piracetam used in clinical practice as a nootropic agent) administration in intact and long-term ethanol (ETOH) exposed rats. Albino male rats were given 10% (vol/vol) ETOH solution as the only source of fluid 24 h/7 days per week (<i>n</i> = 5). Also we used intact rats of the same age which had no access to ethanol (<i>n</i> = 5). The excitatory and inhibitory amino acids in the extracellular space of the dorsal hippocampus in freely moving intact and ETOH-exposed rats during prolonged alcohol deprivation were measured using the intracerebral microdialysis method followed by HPLC/ED. There were no significant differences in the level of neurotransmitter amino acids between ETOH-exposed and intact animals. For the first time, in vivo experiments showed the effect of Noopept (1.5 mg/kg, i.p.) on the level of excitatory amino acids (an increase in aspartate by 2.38 times and glutamate by 2.28 times) along with an increase in the level of the inhibitory amino acid glycine by 3.13 times only in intact rats. Thus, in ETOH-exposed rats under the adaptive rearrangements in prolonged ethanol withdrawal, the neurochemical mechanisms of the hippocampus seem to be characterized by insensitivity to an acute Noopept administration. Animal neurochemical studies of long-term alcohol-induced changes in the mediator amino acids in the CNS may be of practical importance for the development of optimal strategies and pharmacotherapy.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"493 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia","authors":"Litao Shi, Rong Yang, Yaqian Wang","doi":"10.1134/s1819712424020132","DOIUrl":"https://doi.org/10.1134/s1819712424020132","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Intracranial hemorrhage (ICH) is the most critical secondary lesion of traumatic brain injury (TBI). Identifying novel biomarkers for the prediction of ICH occurrence and development in TBI patients would benefit the prognosis of TBI and provide targeted nursing strategies for ICH secondary to TBI. The study enrolled a total of 208 TBI patients, where 105 patients had ICH. Serum samples were collected and analyzed with PCR to evaluate the expression of miR-885-5p. The significance of miR-885-5p in predicting the risk and progression of ICH in TBI patients was assessed. Microglia was induced by lipopolysaccharide (LPS) and transfected with miR-885-5p mimic. The inflammation in microglia was estimated by the levels of TNF-α, IL-6, and IL-1β using ELISA. Significant downregulation of miR-885-5p was observed in ICH patients secondary to TBI, which was identified as a risk factor for ICH and discriminated TBI-ICH patients from TBI patients without secondary lesions. Reduced serum miR-885-5p was significantly associated with lower GCS score, lower NIHSS score, increasing intracranial hemorrhage, increasing edema volume of peripheral tissues, and dysregulated coagulation function of ICH patients. In microglia, LPS induced the downregulation of miR-885-5p and increasing levels of TNF-α, IL-6, and IL-1β. The overexpression of miR-885-5p could alleviate LPS-induced inflammation in microglia. Downregulated miR-885-5p predicted the occurrence and severity of ICH secondary to TBI and regulated neuroinflammation in microglia.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"62 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways","authors":"Roya Malekloo, Khashayar Bahramsari, Elham Sadat Afraz, Razieh Hassanzadeh, Asal Safarbalou, Ali Mohammad Falahati, Saeid Abbasi-Maleki, Ilia Asadi, Nasrollah Moradikor","doi":"10.1134/s1819712424020090","DOIUrl":"https://doi.org/10.1134/s1819712424020090","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Parkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly related with oxidant status and inflammatory responses. The administration of citral with antioxidant and anti-inflammatory properties may alleviate the negative effects of Parkinson. The present study aimed to assess the effects of citral nanoliposome on Parkinson’s treatment in a rat model. In this study, citral nanoliposome was successfully produced through employing a facile method. Additionally, 40 Wistar rats were divided into four groups (<i>n</i> = 10), one of which was considered as Sham and received no treatment. However, the other groups were administrated with rotenone, and/or treated with 5 and 10 mg/kg of citral for 21 days. Behavioral responses were evaluated based on the forced swimming test and hippocampal-dependent memory deficit. The rates were examined for tissue lipid peroxide (LPO), as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in brain. Further, they were investigated in terms of expression of brain-derived neurotrophic factor (BDNF), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and nuclear factor kappa B (NF-κB). The results suggested more immobility, higher LPO level, and a rise in the expression of TNF-α, IL-6, and NF-κB (<i>P</i> = 0.001) following rotenone administration. Furthermore, this treatment decreased climbing, retention latency, SOD and GPx activities, and BDNF expression (<i>P</i> = 0.001). The use of citral, especially in higher dose, reversed all the adverse effects of rotenone on behavioral responses, antioxidant status, BDNF, and inflammatory genes. Parkinson represents a closed relationship with movement deficiency, increased inflammation, and reduced oxidant status. Citral administration can be considered as a therapeutic option following future studies.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"62 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of PRR11 Induces Autophagy in Glioma Cells by Inhibiting Akt/mTOR Signaling Pathway","authors":"Zongxi Li, Lingxuan Ren, Lie Zhang","doi":"10.1134/s1819712424020077","DOIUrl":"https://doi.org/10.1134/s1819712424020077","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Glioma is the most common type of primary craniocerebral tumor. Understanding the molecular mechanisms of glioma occurrence and development will provide strategies for effectively treating glioma. Proline-rich protein 11 (PRR11) is a protein which is widely overexpressed in different tumors. TCGA data analysis showed that PRR11 expression was up-regulated in glioma tissues, but its role still needs to be further studied. Here, the role of PRR11 in glioma progression and the mechanism were investigated. We found PRR11 was overexpressed in glioma cells. Depletion of PRR11 suppressed the growth of glioma cells as well as induced cell cycle arrest. We further found PRR11 ablation induced the autophagy of glioma cells. Furthermore, knockdown of PRR11 restrained the activation of Akt/mTOR pathway, thereby suppressing the proliferation of glioma cells. We thought PRR11 could serve as a target for glioma therapy.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-Cadherin—a Potential Target for Psychopharmacology","authors":"Yu. Yu. Firstova, G. I. Kovalev","doi":"10.1134/s1819712424020041","DOIUrl":"https://doi.org/10.1134/s1819712424020041","url":null,"abstract":"<p><b>Abstract</b>—Glycoprotein N-cadherin (Neuronal cadherin) belongs to the family of calcium-dependent cell adhesion molecules, representing a key element that carries out intercellular contacts in brain neurons. However, it is involved not only in the mechanical connection of neurons but also influences the specifics of the further development and functional state of the neuron. This is due to the active interaction of N-cadherin with many proteins at the pre- and post-synapse, which initiates a cascade of reactions that provide processes such as long-term potentiation (underlying learning and memory), morphogenesis, neuronal recognition, activation of receptors (NMDA and AMPA types), and regulation of cytoskeleton formation. This polyfunctionality is necessary for specific neurons to connect to each other in a certain way, and such adhesion leads to the coordination of cell behavior through intercellular signaling and spatio-temporal control of differential gene expression. Mutations in the genes responsible for the expression of N-cadherin lead to various disorders of the functional activity of the synapse and the processes of spatial orientation and memory. Thus, involvement in important neuroplastic processes regulating cognitive functions and behavior determines interest in studying the effect of drugs on N-cadherin. In particular, N-cadherin deserves closer consideration by pharmacologists as a potential target in the mechanism of action of various psychoactive substances.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"23 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141166497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOX5 Attenuates Toxicity in Neural Stem Cells Induced by Sevoflurane Anesthesia via Regulating the PI3K/AKT Pathway","authors":"Feng Ju, Senbing Zhang, Xianjie Zhang, An Xie, Yuansheng Cao, Yukai Zhou","doi":"10.1134/s1819712424010070","DOIUrl":"https://doi.org/10.1134/s1819712424010070","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Differentiation and self-renewal capacity of neural stem cells are essential for the development and function of brain. Anesthesia exposure inhibits the differentiation and self-renewal capacity of neural stem cells, impairs neurological function during the development of brain. SOX5 exerted neuroprotective effect against ischemic stroke, and regulated chondrogenic differentiation of stem cells. However, the effect and mechanism of SOX5 on sevoflurane-induced neurotoxicity of neural stem cells have not been reported. Firstly, neural stem cells were isolated from hippocampus of neonatal rats. Results showed that the neural stem cells formed neurospheres, and expressed NESTIN. The isolated neural stem cells were then exposed to sevoflurane anesthesia. Sevoflurane exposure reduced expression of NESTIN, decreased cell viability and suppressed cell proliferation of neural stem cells, thus inhibiting the differentiation and self-renewal capacity of neural stem cells. Secondly, SOX5 was down-regulated in sevoflurane-induced neural stem cells. Over-expression of SOX5 enhanced cell viability of sevoflurane-induced neural stem cells, and promoted the cell proliferation. Moreover, sevoflurane induced cell cycle arrest at G0/G1 phase and promoted the cell apoptosis in neural stem cells. Over-expression of SOX5 attenuated sevoflurane-induced increase of G0/G1 ratio and apoptosis in neural stem cells. Thirdly, sevoflurane-induced decrease of phosphorylated PI3K (p-PI3K) and p-AKT expression in neural stem cells were reversed by SOX5 over-expression. In conclusion, SOX5 attenuated sevoflurane-induced toxicity in neural stem cells through inactivation of PI3K/AKT pathway.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"293 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141152499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Mechanisms of the Influence of Oxytocin and Vasopressin on Perception and Memory of Odors and on Social Behavior","authors":"I. G. Silkis","doi":"10.1134/s1819712424010215","DOIUrl":"https://doi.org/10.1134/s1819712424010215","url":null,"abstract":"<p><b>Abstract</b>—A possible mechanism is proposed for the influence of oxytocin and vasopressin on the functioning of the neural network in the CNS, in which olfactory information is processed and stored, and which plays an important role in social behavior. The effect of these neuropeptides on postsynaptic receptors associated with Gq/11 proteins contributes to the induction of long-term potentiation of excitatory synaptic inputs to the main projection cells and to inhibitory interneurons in the prefrontal cortex, hippocampus, piriform cortex, anterior olfactory nucleus, olfactory bulb and nucleus accumbens, including the olfactory tubercle. As a result of disynaptic inhibition in each of the structures, the signal-to-noise ratio is improved and the transmission of strong signals through projection neurons to their target cells is facilitated. Due to the fact that oxytocin promotes the release of dopamine by the neurons of the ventral tegmental area, the conditions for processing and memorizing olfactory information in the interconnected olfactory and hippocampal neural networks, including cortical and subcortical structures, are improved, and attention is also included in this processing. Long-term modification of the effectiveness of interneuronal connections in these networks under the influence of oxytocin and dopamine contributes to the formation and stabilization of contrasting neuronal representation of odors formed in cortical areas. Orientation of attention increases the significance of socially important olfactory stimuli and improves the conditions for the functioning of the reinforcement system necessary for adequate social behavior. Taking into account the known data on the correlation between social behavior and the density of oxytocin and vasopressin receptors on neurons of different structures, understanding the mechanisms of the influence of these neuropeptides on the functioning of the olfactory system can be useful for finding ways to correct behavior if necessary.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141152531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicles Secreted by the Activated THP-1 Cells Influence the Inflammation Gene Expression in Zebrafish","authors":"D. B. Sambur, O. V. Kalinina, A. D. Aquino, P. V. Tirikova, M. A. Migunova, E. E. Koroleva, A. S. Trulioff, A. A. Rubinshtein, I. V. Kudryavtsev, A. S. Golovkin","doi":"10.1134/s1819712424010197","DOIUrl":"https://doi.org/10.1134/s1819712424010197","url":null,"abstract":"<p><b>Abstract</b>—Extracellular vesicles secreted by immune cells may play a significant role in the initiation, maintenance, and progression of systemic inflammation. The aim of the study was to investigate the regulatory effect of extracellular vesicles (EVs) produced by activated monocyte-like THP-1 cells on expression levels of inflammatory genes in a zebrafish. Real-time PCR analysis was performed to investigate the relative expression levels of <i>il-1</i>β, <i>il-6</i>, <i>tnf-</i>α, <i>ifn-</i>γ, <i>mpeg-1.1</i>, <i>mpeg-1.2</i>, <i>mpx</i>, and <i>il-10</i> genes in the brain, liver, and heart of zebrafish followed by intracelomic injection of EVs produced by THP-1 cells activated with tumor necrosis factor (TNF) and phorbol-12-myristate-13-acetate (PMA) at different concentrations. EVs, secreted by THP-1 cells activated with TNF at a concentration of 10 ng/mL and PMA at concentrations of 16 and 50 ng/mL, reduced the expression levels of <i>il-1</i>β, <i>ifn-</i>γ, <i>tnf-</i>α, <i>mpx</i>, <i>mpeg-1.1</i>, <i>mpeg-1.2</i>, and <i>il-10</i> genes in the brain, heart and liver of <i>Danio rerio</i>. EVs secreted by THP-1 cells treated with TNF at doses of 10 and 20 ng/mL had opposite effects on the gene expression levels of <i>il-1</i>β in the brain<i>, il-1</i>β<i>, il-10</i>, and <i>il-6</i> in the heart; on <i>il-1</i>β, <i>il-10</i>, <i>mpx</i>, and <i>mpeg-1.2</i> in the liver. EVs secreted by THP-1 cells treated with PMA at doses of 16 and 50 ng/mL had opposite effects on the expression levels of <i>il-6</i> and <i>il-10</i> genes in the heart and <i>ifn-</i>γ gene in the liver. EVs produced by activated THP-1 cells have a systemic effect on <i>Danio rerio</i> manifested as changes in the expression of pro- and anti-inflammatory cytokine genes in the brain, liver, and heart. The qualitative composition of the EVs produced by activated THP-1 cells varies depending on the type and dose of the used stimulus, which reflects on strength and direction of the effects detected <i>in vivo</i>.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"19 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141152532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Paraoxonase, Arylesterase, Dipeptidyl Peptidase-IV, Oxidative Stress, and Oxidative DNA Damage in Patients with Obsessive-Compulsive Disorder","authors":"Eser Sağaltıcı, Hasan Belli, Aysegul Kirankaya, Hüseyin Köse, Cenk Ural, Mustafa Nuray Namlı, Onur Okan Demirci, Hasan Gökçay","doi":"10.1134/s1819712424010173","DOIUrl":"https://doi.org/10.1134/s1819712424010173","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Some findings have emerged from the field of oxidative stress in patients with psychiatric disorders. These date also state that oxidative balance and obsessive-compulsive disorder (OCD) are significantly related. Yet, researchers have not investigated oxidative stress, oxidative balance, and DNA damage together. We tested the levels of paraoxonase-1 (PON1), and arylesterase (ARE). We also tested the dipeptidyl peptidase-IV (DPP-IV), oxidative stress, and oxidative DNA damage. We enrolled 37 patients with OCD in the study. The diagnosis of OCD according to DSM-V criteria was established. Patients had not received treatment for at least 6 months. The controls were matched with the patients about sex, age, body mass index (BMI), and smoking. Clinicians used the sociodemographic information form. All subjects were evaluated with a semi-structured questionnaire. Serum PON1, ARE, DPP-IV, oxidative stress index (OSI), and 8‑hydroxideoxiguanosine (8-OHdG) calculations were conducted in the biochemical laboratory. PON1 and DPP-IV levels were not different between OCD patients and the control group (<i>P</i> &gt; 0.05). An oxidative DNA damage marker 8-OHdG—and OSI were higher in the patient’s group (<i>p</i> &lt; 0.05). But levels of ARE were significantly lower in OCD patients (<i>P</i> &lt; 0.05). We found evidence that oxidative stress-induced parameters such as OSI, ARE, and 8-OHdG might be related to a specific pathologic state in patients with OCD. The findings may provide a rationale for treating the pathological processes.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141152533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Expression of lncRNA XIST Assists in the Diagnosis of Parkinson’s Disease","authors":"Liang Zhang, Guoping Li, Dingci Lu, Qihe Dai","doi":"10.1134/s1819712424010276","DOIUrl":"https://doi.org/10.1134/s1819712424010276","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Long non-coding RNA (lncRNA) XIST has been implicated in the development of PD. Herein, we sought to investigate the diagnostic value of serum XIST expression in PD. We recorded clinical baseline data, including age, sex, body mass index (BMI), years of education, and PD family history, for PD patients and healthy controls, in addition to the disease course in PD patients. The disease severity of PD patients was assessed using the Hoehn-Yahr grading scale. We evaluated serum XIST expression levels in PD patients and healthy controls using RT-qPCR and assessed the correlation between serum XIST expression and the Unified Parkinson’s Disease Rating Scale (UPDRS) score. Additionally, we used receiver operating characteristic (ROC) curve to determine the diagnostic value of XIST expression for PD. Our results showed no significant differences in age, sex, BMI, and years of education between PD patients and healthy controls. However, more PD patients had a family history of PD. We found that serum XIST expression was significantly up-regulated in PD patients, and its levels were positively correlated with the UPDRS score. Higher PD stage was also associated with increased serum XIST expression. ROC analysis revealed that XIST expression had a diagnostic value for PD. In conclusion, our findings suggest that serum lncRNA XIST expression may serve as a potential diagnostic biomarker for PD.</p>","PeriodicalId":19119,"journal":{"name":"Neurochemical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141152510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}