Neurodegenerative disease management最新文献_第2页

Analyzing multiple-sclerosis progression: stage-specific biomarker insights via explainable machine learning. 分析多发性硬化症的进展：通过可解释的机器学习了解特定阶段的生物标志物。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-02 DOI: 10.1080/17582024.2026.2654373

Selahaddin Batuhan Akben, Ayşenur Bilirim, Cantürk Akben, Şule Aydın Türkoğlu

{"title":"Analyzing multiple-sclerosis progression: stage-specific biomarker insights via explainable machine learning.","authors":"Selahaddin Batuhan Akben, Ayşenur Bilirim, Cantürk Akben, Şule Aydın Türkoğlu","doi":"10.1080/17582024.2026.2654373","DOIUrl":"https://doi.org/10.1080/17582024.2026.2654373","url":null,"abstract":"Background: Multiple Sclerosis (MS) is a chronic autoimmune disease where early diagnosis from Clinically Isolated Syndrome (CIS) remains challenging.Methods: This study investigates stage-specific biomarkers for CIS-to-MS conversion using explainable machine learning on a 10-year prospective dataset of 273 CIS patients, stratified by EDSS scores (1, 2, 3).Results: Following data preprocessing and 10-fold cross-validation, Shapley analysis identified clinical, MRI, demographic, and environmental variables. Models achieved high accuracy (EDSS = 1: 89.5% via KNN; EDSS = 2/3: 100% via SVM/Ensemble). Periventricular MRI lesions and oligoclonal bands were primary predictors across all stages. Spinal cord lesions became decisive at EDSS = 3, while motor symptoms were critical for early diagnosis. Lower education and lack of breastfeeding increased MS risk; varicella history showed positive correlation.Conclusion: These AI models effectively identify stage-specific biomarkers, revealing the dynamic importance of MRI findings. The influence of psychosocial and environmental factors underscores a multidisciplinary approach for MS management and early diagnosis.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"1-12"},"PeriodicalIF":3.4,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paratonia in dementia: diagnosis and management strategies. 痴呆中的共济失调：诊断和管理策略。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-11-18 DOI: 10.1080/17582024.2025.2591413

Shubha Joshi, Porimita Chutia, Shailendra Mohan Tripathi

引用次数: 0

Brexpiprazole for treating agitation in different groups of people with Alzheimer's dementia: a plain language summary. 布雷吡拉唑治疗不同人群阿尔茨海默氏痴呆症患者的躁动：简单的语言总结。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2026-02-14 DOI: 10.1080/17582024.2026.2623968

Jared Stroud, Jeffrey L Cummings, Sanjeda R Chumki, Pedro Such, David Wang, Anton M Palma, Zhen Zhang, George T Grossberg

引用次数: 0

Exploring prodrug approaches for Alzheimer's treatment: an overview. 探索阿尔茨海默病治疗的前药方法：综述。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-06-26 DOI: 10.1080/17582024.2025.2514990

Priya Kumari, Dileep Kumar, Shakuntala Chopade, Dipanjan Karati

引用次数: 0

Knowledge mapping of biomarkers in amyotrophic lateral sclerosis: a comprehensive bibliometric and visual analysis. 肌萎缩性侧索硬化症生物标志物的知识图谱：一个全面的文献计量学和视觉分析。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-09-04 DOI: 10.1080/17582024.2025.2554525

Yan Huang, Yantong Wan, Jie Chen, Mengchen Qin, Jieyan Wang, Hui Liang

{"title":"Knowledge mapping of biomarkers in amyotrophic lateral sclerosis: a comprehensive bibliometric and visual analysis.","authors":"Yan Huang, Yantong Wan, Jie Chen, Mengchen Qin, Jieyan Wang, Hui Liang","doi":"10.1080/17582024.2025.2554525","DOIUrl":"10.1080/17582024.2025.2554525","url":null,"abstract":"Background: Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease, and there is currently an urgent need to identify valuable biomarkers to accelerate diagnosis, optimize treatment and prognosis.Methods: To conduct a bibliometric analysis of publications related to \"ALS biomarker\" over the past 20 years, utilizing the subject search feature of the Web of Science Core Collection along with CiteSpace, VOSviewer, and Bibliometrix.Results: This review presents a 20-year bibliometric analysis of ALS biomarker research (2004-2024), analyzing 2535 publications showing rising trends. The United States led contributions, with Turner, Martin R as the most productive/cited author. Key research hotspots included cerebrospinal fluid, tdp-43, clinical trial, and neuroinflammation. Topics such as neurofilament light chain, machine learning, and exosomes could potentially represent the cutting edge of future research.Conclusion: In summary, this study uses bibliometric analysis of ALS biomarker research to provide a forward-looking perspective on its future limitations and potential.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"191-207"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential diagnostic markers in Alzheimer's disease: current perspectives and future directions. 阿尔茨海默病的潜在诊断标志物：目前的观点和未来的方向。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-09-05 DOI: 10.1080/17582024.2025.2554515

Menghan Zheng, Simiao Wang, Jianping Jia

{"title":"Potential diagnostic markers in Alzheimer's disease: current perspectives and future directions.","authors":"Menghan Zheng, Simiao Wang, Jianping Jia","doi":"10.1080/17582024.2025.2554515","DOIUrl":"10.1080/17582024.2025.2554515","url":null,"abstract":"Alzheimer's disease (AD), the most common form of dementia, remains a leading neurodegenerative disorder that necessitates the development of diagnostic markers. While current cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers facilitate diagnostic accuracy, their invasive and pricey nature limits widespread application. Blood-based biomarkers, such as plasma Aβ42/40 and phosphorylated tau isoforms, are emerging as accessible alternatives. Biomarkers reflecting neurodegeneration (e.g. neurofilament light chain, brain-derived tau) and neuroinflammation (e.g. glial fibrillary acidic protein, TSPO-PET) provide additional insights into disease progression. Novel approaches - including exosomal and Aβ seeds biomarkers, omics techniques, and retinal imaging - further broaden the diagnostic landscape. Despite the promising perspectives, challenges remain in validity and utility. This review highlights recent advances of AD diagnostic markers, evaluates their clinical potential and limitations, and outlines future directions guided by the Geneva five-phase roadmap. The ultimate aim is to facilitate earlier detection and timely intervention of this burdensome disorder.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"225-237"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of triptolide herb on the progression of Alzheimer's disease preclinical models: a systematic review. 雷公藤甲素对阿尔茨海默病临床前模型进展的影响：系统综述。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-09-24 DOI: 10.1080/17582024.2025.2562776

Rabab Shami, Rania El Majzoub, Ali Ismail, Jana Kotaich, Mariam Kassem, Ghida Safadieh, Mohammad Fayyad-Kazan, Bahia Chahine

{"title":"Effects of triptolide herb on the progression of Alzheimer's disease preclinical models: a systematic review.","authors":"Rabab Shami, Rania El Majzoub, Ali Ismail, Jana Kotaich, Mariam Kassem, Ghida Safadieh, Mohammad Fayyad-Kazan, Bahia Chahine","doi":"10.1080/17582024.2025.2562776","DOIUrl":"10.1080/17582024.2025.2562776","url":null,"abstract":"Aim: This study aims to systematically evaluate and synthesize preclinical evidence on the neuroprotective effects of Triptolide (Tri) in Alzheimer's disease (AD) models, focusing on its impact on amyloid-beta accumulation, synaptic dysfunction, neuroinflammation, oxidative stress, autophagy, and apoptosis.Introduction: AD is the most common cause of dementia, yet current treatments largely target symptoms rather than underlying pathology. Tri, a bioactive compound from Tripterygium wilfordii, has shown promise due to its anti-inflammatory, antioxidant, and neuroprotective properties.Methods: A systematic search of PubMed, Embase, and Web of Science was conducted up to 16 March 2024. English-language in vivo and in vitro studies on Tri's effects in AD models were included. Methodological quality was assessed using SYRCLE and SciRAP tools. The review is registered in PROSPERO (CRD42024521822).Results: Out of 403 studies, 15 met the inclusion criteria (6 in vivo, 8 in vitro, 1 both). Tri reduced Aβ burden, enhanced memory and synaptic integrity, suppressed neuroinflammation and oxidative stress, and modulated autophagy and apoptosis.Conclusion: Tri demonstrates significant multi-target neuroprotective effects in AD preclinical models. Further high-quality studies are warranted to optimize dosing, delivery, and safety for clinical translation.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"239-251"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The difference between cystatin C- and creatinine-based estimated glomerular filtration rate and survival in amyotrophic lateral sclerosis: a population-based cohort study. 肌萎缩性侧索硬化症中基于胱抑素C和肌酐的肾小球滤过率和存活率的差异：一项基于人群的队列研究。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-09-02 DOI: 10.1080/17582024.2025.2554224

Yahui Zhu, Jiongming Bai, Hongfen Wang, Mao Li, Fei Yang, Xinyuan Pang, Rongrong Du, Jiarui Zhao, Xusheng Huang, Fang Cui

{"title":"The difference between cystatin C- and creatinine-based estimated glomerular filtration rate and survival in amyotrophic lateral sclerosis: a population-based cohort study.","authors":"Yahui Zhu, Jiongming Bai, Hongfen Wang, Mao Li, Fei Yang, Xinyuan Pang, Rongrong Du, Jiarui Zhao, Xusheng Huang, Fang Cui","doi":"10.1080/17582024.2025.2554224","DOIUrl":"10.1080/17582024.2025.2554224","url":null,"abstract":"Objectives: We investigated the relationship between cystatin C- and creatinine-based estimated glomerular filtration rate (eGFRdiff) and amyotrophic lateral sclerosis (ALS) outcomes.Methods: We enrolled ALS patients diagnosed between January 2014 and December 2019. Experienced neurologists followed up the participants until January 2022. Absolute difference between eGFR (eGFRabdiff) and relative difference between eGFR (eGFRrediff) were obtained. Cox proportional hazard models were used to evaluate the relationship between eGFRdiff and ALS survival.Results: Negative eGFRabdiff were common in the patients (74.7%). For each SD increase of eGFRabdiff, the risk of poor prognosis for ALS patients decreased by 1.9% (HR, 0.981; 95% CI, 0.973-0.989). For each 10% increment in eGFRrediff, the risk of poor prognosis for ALS patients decreased by 17.7% (HR, 0.823; 95% CI, 754-0.898).Conclusions: We found that large eGFRdiff was associated with poor prognosis in ALS. Monitoring eGFRdiff in ALS population facilitates prognostic stratification assessment and precise management.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"153-161"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of isokinetic exercises on balance, proprioception, quality of life, and kinesiophobia in multiple sclerosis. 等速运动对多发性硬化症患者平衡、本体感觉、生活质量和运动恐惧症的影响。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-09-02 DOI: 10.1080/17582024.2025.2552599

Melek A Selcuk, Burcu D Cakit, Ufuk Ergun

{"title":"Effects of isokinetic exercises on balance, proprioception, quality of life, and kinesiophobia in multiple sclerosis.","authors":"Melek A Selcuk, Burcu D Cakit, Ufuk Ergun","doi":"10.1080/17582024.2025.2552599","DOIUrl":"10.1080/17582024.2025.2552599","url":null,"abstract":"Aim: To evaluate the effects of isokinetic hamstring and quadriceps muscle (IHGM)-strengthening and home exercises on balance, proprioception, fear of falling (FoF), kinesiophobia, and quality of life in persons with multiple sclerosis (PwMS).Methods: The peak torque/body mass of the IHGMs, the absolute angular error (AAE) and mean AAE of the less and more affected legs, and the scores of the Dynamic Gait Index, 10-meter walk test, Berg Balance Scale (BBS), Modified Falls Efficacy Scale, Multiple Sclerosis Quality of Life-54 (MSQoL-54), Visual Analog Scale, and Tampa Scale of Kinesiophobia-17 (TSK-17) were evaluated before and after the training programs.Results: Isokinetic exercises resulted in significantly higher improvements in the BBS (p = 0.008) and MSQoL-54 physical (p = 0.006) scores and the quadriceps muscle strength at 180°/s angular velocity in the less affected leg (p = 0.001) compared to home exercises.Conclusions: Isokinetic exercises can improve muscle strength, QoL, and balance in PwMS without complications or exacerbations.","PeriodicalId":19114,"journal":{"name":"Neurodegenerative disease management","volume":" ","pages":"163-172"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13011628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention Gated-VGG with deep learning-based features for Alzheimer's disease classification. 基于深度学习特征的注意力门控vgg用于阿尔茨海默病分类。

IF 3.4

Neurodegenerative disease management Pub Date : 2026-04-01 Epub Date: 2025-09-10 DOI: 10.1080/17582024.2025.2554495

Deepthi K Moorthy, P Nagaraj

引用次数: 0