Neural Regeneration Research最新文献

{"title":"Dendritic spine research: Next frontier in the age of artificial intelligence.","authors":"Gonzalo Flores, Miguel A Zamora-Ursulo, Elías Manjarrez, Julio Cesar Morales-Medina, Hiram Tendilla-Beltrán","doi":"10.4103/NRR.NRR-D-25-01345","DOIUrl":"10.4103/NRR.NRR-D-25-01345","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5222-5223"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated multi-omics and machine learning identify Casp8 and Pycard as central regulators of pyroptosis and necroptosis in spinal cord injury.","authors":"Jiawei Du, Runquan Zheng, Feng Jing, Yigang Lv, Di Zhang, Hengxing Zhou, Shiqing Feng","doi":"10.4103/NRR.NRR-D-25-00969","DOIUrl":"10.4103/NRR.NRR-D-25-00969","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5333-5346"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics analysis of changes in the microbiota-gut-spinal cord axis in spinal cord injury.","authors":"Yingli Jing, Fan Bai, Zihan Li, Qiuying Wang, Yan Li, Weijin Liu, Shuangyue Zhang, Chen Gao, Yan Yu","doi":"10.4103/NRR.NRR-D-25-00739","DOIUrl":"10.4103/NRR.NRR-D-25-00739","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5541-5550"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell-derived small extracellular vesicles promote mitochondrial repair of dopaminergic neurons via Homer protein homolog 3 in Parkinson's disease.","authors":"Changlin Lian, Zhifeng Xu, Zi-Cong Wu, Xiao-Hui Deng, Dong-Xiao Lou, Zhong Pei, Qi Sun, Cheng-Lin Li, Lixin Pan, Yaoyuan Dong, Nan Ding, Guanghua Zhao, Yukai Wang, Qing-Ling Fu, Xin Li","doi":"10.4103/NRR.NRR-D-25-01839","DOIUrl":"10.4103/NRR.NRR-D-25-01839","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5632-5640"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomic atlas reveals temporal dynamics driving chronic peripheral nerve degeneration.","authors":"Lingxin Duan, Shiyan Liu, Lu Zhang, Bo Ma, Zhongyu Xu, Linyao Wang, Na Han, Wenya Hou, Yuhui Kou, Baoguo Jiang","doi":"10.4103/NRR.NRR-D-25-01347","DOIUrl":"10.4103/NRR.NRR-D-25-01347","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5380-5391"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146126052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clusterin: A clinical translation spearhead for extracellular chaperones that promotes neural regeneration.","authors":"Mark R Wilson, M Elizabeth Fini, Raffaella Soleti, Yves Delneste, Sandeep Satapathy","doi":"10.4103/NRR.NRR-D-25-01053","DOIUrl":"10.4103/NRR.NRR-D-25-01053","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5213-5214"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restarting synaptic remodeling and structural network: New treatment strategies for epilepsy.","authors":"Liuzhao Cao, Chengyu Pan, Xiujuan Wang, Baolin Zhang, Zhiyang Zhang, Changyin Yu, Zucai Xu","doi":"10.4103/NRR.NRR-D-25-00826","DOIUrl":"10.4103/NRR.NRR-D-25-00826","url":null,"abstract":"<p><p>Oxidative stress and lysosomal dysfunction are considered as critical contributors to epileptogenesis and its progression. These processes create a self-perpetuating cycle that worsens neuronal hyperexcitability, neuroinflammation, and synaptic pathology, while simultaneously impairing neural stem cell survival and neuroregeneration, which includes neurogenesis, synaptic remodeling, and circuit repair. Traditional treatments merely suppress discharges but overlook the synaptic damage, loss of inhibitory interneurons, and exhaustion of neural stem cells caused by oxidative stress and lysosomal dysfunction, making it difficult for the network structure to self-repair. The purpose of this review is to explore a new paradigm \"Restarting synaptic remodeling and structural network: A novel strategy for neuroregeneration in epilepsy.\" This review clearly outlines the mechanisms through which oxidative stress and lysosomal dysfunction damage synapses, neurons, and neural stem cells, as well as the reinforcing feedback loop that these two processes create within the epileptic network. In terms of nerve repair, a \"dual-target repair\" strategy can be implemented. On one hand, this involves using an activator of nuclear factor erythroid 2-related factor 2 combined with antioxidants to eliminate reactive oxygen species and protect existing synapses. On the other hand, it includes employing transcription factor EB agonists, mTOR inhibitors, or gene/enzyme replacement therapies to restore lysosomal degradation function, clear aggregates, and rebuild the inhibitory microenvironment. Taken together, the oxidative stress-lysosomal dysfunction-neuroregeneration axis provides a unifying framework that integrates molecular pathology with failed neural repair, offering a novel perspective for developing next-generation therapies aimed at both seizure reduction and circuit restoration. This paradigm shift emphasizes the potential of neuroregenerative strategies to restart synaptic remodeling and repair structural network in epilepsy and related neurodegenerative disorders.</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5085-5096"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of mechanobiology in neuroregeneration.","authors":"Yifeng Zheng, Radhika Puttagunta","doi":"10.4103/NRR.NRR-D-25-01590","DOIUrl":"10.4103/NRR.NRR-D-25-01590","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5232-5233"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms underlying neuroimmune networks as central regulators in combating neurodegenerative diseases.","authors":"Xiangqi Hu, Mengfan Yao, Fenglan Xu, Huajun Wang, Ming Lu, Chen Qiao","doi":"10.4103/NRR.NRR-D-25-01276","DOIUrl":"10.4103/NRR.NRR-D-25-01276","url":null,"abstract":"<p><p>Neuroimmune dysregulation is increasingly recognized as a key driver in the pathogenesis of neurodegenerative diseases. In addition to local glial responses within the central nervous system, neuroimmune dysregulation also involves peripheral immune activities and inter-organ communication networks. As previous studies have primarily concentrated on individual peripheral organs or specific immune cell types, the broader systemic immune network remains insufficiently investigated. To delay the onset and progression of neurodegenerative diseases, this review evaluates the latest therapeutic strategies and proposes feasible directions for the rational design of optimal immunomodulatory approaches. By focusing on central nervous system-intrinsic regulatory mechanisms, we delineate how microglia adopt context-dependent phenotypes and further elucidate the dynamic regulatory roles of astrocytes in maintaining blood-brain barrier integrity and synaptic homeostasis. Based on these insights, we propose a feasible direction for achieving a functional balance between neuroprotective phagocytosis and the regulation of chronic neuroinflammation. Furthermore, recent evidence indicates that peripheral immune populations, together with the central nervous system, also play a critical role in the therapeutic regulation of neurodegenerative diseases. As key components of peripheral immune populations, specific T-cell subsets can exert neuroprotective or neurotoxic effects, while B cells and macrophages also make notable contributions through antibody-independent mechanisms and metabolic reprogramming. This review outlines systemic pathways that connect peripheral organs to the brain, demonstrating how gut-derived metabolites, pulmonary immune responses, and renal-hepatic clearance collectively shape the immune regulation of the central nervous system. To achieve cell-specific modulation through neuroimmune pathways, this review further investigates glia-targeted therapeutic strategies, particularly in the areas of small molecules, biologics, and nanocarrier-based platforms. Meanwhile, this review also summarizes the current progress and limitations in neuroimmune-targeted drug development and offers valuable guidance for advancing future drug design. In summary, by integrating the analyses of single cells and multi-omics and utilizing organoid-based modeling, this review highlights the vital transition from broad immunosuppression to precision immunoregulation and proposes a novel regulatory framework spanning from the central to peripheral systems. It further offers targeted and feasible recommendations to advance neuroimmunology from theoretical exploration toward practical therapeutics. However, the implementation of these strategies still faces challenges from the temporal dynamics of immune activation, which could be potentially resolved by the enhancement of human glial cell-based biomimetic models and the improvement of stage-specific biomarkers.</p>","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5126-5136"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo imaging of central nervous system regeneration using Danionella cerebrum.","authors":"Mallika Misyuk, Joseph L Austin, Noelle R Walechka, Juliet A Peterka, Matthew B Veldman, Pui-Ying Lam","doi":"10.4103/NRR.NRR-D-25-00948","DOIUrl":"10.4103/NRR.NRR-D-25-00948","url":null,"abstract":"","PeriodicalId":19113,"journal":{"name":"Neural Regeneration Research","volume":" ","pages":"5506-5516"},"PeriodicalIF":8.5,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}