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Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects 凉菜中酚类成分的抗炎和细胞毒作用
Natural product sciences Pub Date : 2021-03-31 DOI: 10.20307/NPS.2021.27.1.49
N. Anh, N. T. Duong, Pham Duc Vinh, Do Thi Thu Ha
{"title":"Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects","authors":"N. Anh, N. T. Duong, Pham Duc Vinh, Do Thi Thu Ha","doi":"10.20307/NPS.2021.27.1.49","DOIUrl":"https://doi.org/10.20307/NPS.2021.27.1.49","url":null,"abstract":"Balanophora laxiflora Hemsl. (Balanophoraceae) is a traditional medicinal plant with a diverse array of biological activities. In our exploration of new bioactive constituents from B. laxiflora, we isolated five compounds, including a new lignan, balanophorone (5), and four known phenolic compounds (1-4). The chemical structures of these compounds were determined by extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS, and CD. In addition, we evaluated the effects of each of the isolates (1-5) on the messenger RNA expression levels of tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and cytotoxicity against MCF-7 and MDA-MB- 231 breast cancer cells. Compound 2 showed significant inhibition of LPS-induced COX-2 and TNF-α expression in RAW 264.7 macrophages, while compound 4 showed moderate cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells, with IC50 values of 18.3 and 30.7 μM, respectively. No significant effects on the viability of normal mammary epithelial cells were observed.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68201665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A New Phenolic Compound from Lespedeza tomentosa 胡枝子中一个新的酚类化合物
Natural product sciences Pub Date : 2021-01-01 DOI: 10.20307/NPS.2021.27.3.169
Jang Hyeon Seok, Choi Seong Yeon, Yang Heejung, Kim Myong Jo, Chun Wanjoo, Kwon Yongsoo
{"title":"A New Phenolic Compound from Lespedeza tomentosa","authors":"Jang Hyeon Seok, Choi Seong Yeon, Yang Heejung, Kim Myong Jo, Chun Wanjoo, Kwon Yongsoo","doi":"10.20307/NPS.2021.27.3.169","DOIUrl":"https://doi.org/10.20307/NPS.2021.27.3.169","url":null,"abstract":"A new phenolic compound and three known flavonoids isolated from the MeOH extracts of Lespedeza tomentosa. Based on spectral data, the isolated compounds were identified as methyl 4,5-dihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)benzoate (1), 1-methoxylespeflorin G11 (2), farrerol (3) and 1-methoxylespeflorin I2 (4). Methyl 4,5-dihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)benzoate (1) is newly isolated from plant source.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"27 1","pages":"169-171"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68201776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Coumestan Glucoside from Eclipta prostrata 一种新的木犀中的Coumestan糖苷
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.289
Y. Seo, H. Kil, T. Rho, K. Yoon
{"title":"A New Coumestan Glucoside from Eclipta prostrata","authors":"Y. Seo, H. Kil, T. Rho, K. Yoon","doi":"10.20307/nps.2020.26.4.289","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.289","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44657730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities 一种新的二苯乙烯二聚体及其他化学成分及其抗菌活性
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.317
Joseph Nguetse Dongmo Arnaud, Endeguele Ekom Steve, J. Tamokou, Ngoufack Tagousop Cyrille, D. Harakat, Voutquenne-Nazabadiok Laurence, Ngnokam David
{"title":"A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities","authors":"Joseph Nguetse Dongmo Arnaud, Endeguele Ekom Steve, J. Tamokou, Ngoufack Tagousop Cyrille, D. Harakat, Voutquenne-Nazabadiok Laurence, Ngnokam David","doi":"10.20307/nps.2020.26.4.317","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.317","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42749431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp. Calyxapronols A-D，来自海洋海绵Calyx sp.的新Merohexaprenoid代谢产物。
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.303
Chang-Kwon Kim, K. Gustafson
{"title":"Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.","authors":"Chang-Kwon Kim, K. Gustafson","doi":"10.20307/nps.2020.26.4.303","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.303","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45953212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereoselective Microbial Hydroxylation of Progestin, Norethisterone by Using Aspergillus niger and Penicillium citrinum 黑曲霉和青霉菌对孕激素、炔诺酮的立体选择性微生物羟基化
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.283
Azizud Din, Iqbal Muhammad, Ghulam Musharraf Syed, S. Saleem
{"title":"Stereoselective Microbial Hydroxylation of Progestin, Norethisterone by Using Aspergillus niger and Penicillium citrinum","authors":"Azizud Din, Iqbal Muhammad, Ghulam Musharraf Syed, S. Saleem","doi":"10.20307/nps.2020.26.4.283","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.283","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47727314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo 艾叶提取物(RW0117)的体内化学成分及对胃损伤的保护作用
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.268
Jin-Woo Lee, I. Lee, Se-Hoon Park, Min Jegal Chang, Keunwoo Choi, Hye-Young Jung, Jung-Ae Choi, Chan Lee, Ho Kyong Kim, Jung Suk Lee
{"title":"Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo","authors":"Jin-Woo Lee, I. Lee, Se-Hoon Park, Min Jegal Chang, Keunwoo Choi, Hye-Young Jung, Jung-Ae Choi, Chan Lee, Ho Kyong Kim, Jung Suk Lee","doi":"10.20307/nps.2020.26.4.268","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.268","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44434772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities 一种HPLC-PDA方法的建立和验证，该方法用于定量印楝中10种标记化合物，并评估其蛋白酪氨酸磷酸酶1B、α-葡萄糖苷酶和乙酰胆碱酯酶抑制活性
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.326
H. Duc, Dat Le Duc, E. Ma, B. Min, M. Woo
{"title":"Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities","authors":"H. Duc, Dat Le Duc, E. Ma, B. Min, M. Woo","doi":"10.20307/nps.2020.26.4.326","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.326","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43776506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Four Dammarane Triterpenes and Their Inhibitory Properties Against Eight Receptor Tyrosine Kinases 四种达玛烷三萜及其对八种受体酪氨酸激酶的抑制作用
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.345
L. Heliawati, Khatimah Husnul, Hermawati Elvira, M. Yana
{"title":"Four Dammarane Triterpenes and Their Inhibitory Properties Against Eight Receptor Tyrosine Kinases","authors":"L. Heliawati, Khatimah Husnul, Hermawati Elvira, M. Yana","doi":"10.20307/nps.2020.26.4.345","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.345","url":null,"abstract":" In recent years, tyrosine kinases (TKs) have been the target to combat cancers, and most of the developed inhibitors are of synthetic origin. Natural compounds that have the properties as the TK’s inhibitors are very limited. This paper described the isolation of a new dammarane triterpene from the tree bark of Sandoricum koetjape, along with three known related dammaranes from the damar resin of Shorea javanica, as well as their inhibitory properties against eight receptor TKs (RTKs: EGFR, HER2, HER4, IGF1R, InsR, KDR, PDGFR, and PDGFR). Based on the NMR and mass spectral data the new compound was identified as (12,20S)-12,20dihydroxy-3,4-seco-dammaran-4,24-dien-3-oic acid (12-hydroxydammarenolic acid) (1), while the three known compounds were identified as (20S)-20-hydroxy-3,4-seco-dammaran-4,24-dien-3-oic acid (dammarenolic acid) (2), (3,20S)-3,20-dihydroxydammaran-24-ene (3), and (20S)-3-oxo-20-hydroxydammaran-24-ene (4). The tyrosine kinase assay of the four compounds resulted only 1 and 2 at concentration of 10 M that had weak activity against EGFR and InsR, with their % inhibitory were 30%, 27% (1), 45%, and 32% (2), respectively. The results suggested that the presence of a linear carboxylic acid group in both compounds could be of significance to the inhibitory properties against the two RTKs.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46972901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp. 基于分子网络的去复制策略从Pleosporales sp.中分离出一种新的色酮。
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/NPS.2020.26.4.340
Haeun Kwon, Kim Jun-Gu, Oh Jeong Joo, Jae Jin Kim, Gyu-Hyeok Kim, Hwang, Bang Yeon, J. Yim, Lee, Dongho
{"title":"Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp.","authors":"Haeun Kwon, Kim Jun-Gu, Oh Jeong Joo, Jae Jin Kim, Gyu-Hyeok Kim, Hwang, Bang Yeon, J. Yim, Lee, Dongho","doi":"10.20307/NPS.2020.26.4.340","DOIUrl":"https://doi.org/10.20307/NPS.2020.26.4.340","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48333742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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