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Anti-inflammatory, Anti-glycation, Anti-tyrosinase and CDK4 Inhibitory Activities of Alaternin (=7-Hydroxyemodin) 7-羟基大黄素抗炎、抗糖化、抗酪氨酸酶及抑制CDK4活性
Natural product sciences Pub Date : 2021-03-31 DOI: 10.20307/nps.2021.27.1.28
Bhatarrai Grishma, Jeong‑Wook Choi, S. Seong, T. Nam, H. Jung, Jae Sue Choi
{"title":"Anti-inflammatory, Anti-glycation, Anti-tyrosinase and CDK4 Inhibitory Activities of Alaternin (=7-Hydroxyemodin)","authors":"Bhatarrai Grishma, Jeong‑Wook Choi, S. Seong, T. Nam, H. Jung, Jae Sue Choi","doi":"10.20307/nps.2021.27.1.28","DOIUrl":"https://doi.org/10.20307/nps.2021.27.1.28","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43876181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects 凉菜中酚类成分的抗炎和细胞毒作用
Natural product sciences Pub Date : 2021-03-31 DOI: 10.20307/NPS.2021.27.1.49
N. Anh, N. T. Duong, Pham Duc Vinh, Do Thi Thu Ha
{"title":"Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects","authors":"N. Anh, N. T. Duong, Pham Duc Vinh, Do Thi Thu Ha","doi":"10.20307/NPS.2021.27.1.49","DOIUrl":"https://doi.org/10.20307/NPS.2021.27.1.49","url":null,"abstract":"Balanophora laxiflora Hemsl. (Balanophoraceae) is a traditional medicinal plant with a diverse array of biological activities. In our exploration of new bioactive constituents from B. laxiflora, we isolated five compounds, including a new lignan, balanophorone (5), and four known phenolic compounds (1-4). The chemical structures of these compounds were determined by extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS, and CD. In addition, we evaluated the effects of each of the isolates (1-5) on the messenger RNA expression levels of tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and cytotoxicity against MCF-7 and MDA-MB- 231 breast cancer cells. Compound 2 showed significant inhibition of LPS-induced COX-2 and TNF-α expression in RAW 264.7 macrophages, while compound 4 showed moderate cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells, with IC50 values of 18.3 and 30.7 μM, respectively. No significant effects on the viability of normal mammary epithelial cells were observed.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68201665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A New Phenolic Compound from Lespedeza tomentosa 胡枝子中一个新的酚类化合物
Natural product sciences Pub Date : 2021-01-01 DOI: 10.20307/NPS.2021.27.3.169
Jang Hyeon Seok, Choi Seong Yeon, Yang Heejung, Kim Myong Jo, Chun Wanjoo, Kwon Yongsoo
{"title":"A New Phenolic Compound from Lespedeza tomentosa","authors":"Jang Hyeon Seok, Choi Seong Yeon, Yang Heejung, Kim Myong Jo, Chun Wanjoo, Kwon Yongsoo","doi":"10.20307/NPS.2021.27.3.169","DOIUrl":"https://doi.org/10.20307/NPS.2021.27.3.169","url":null,"abstract":"A new phenolic compound and three known flavonoids isolated from the MeOH extracts of Lespedeza tomentosa. Based on spectral data, the isolated compounds were identified as methyl 4,5-dihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)benzoate (1), 1-methoxylespeflorin G11 (2), farrerol (3) and 1-methoxylespeflorin I2 (4). Methyl 4,5-dihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)benzoate (1) is newly isolated from plant source.","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":"27 1","pages":"169-171"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68201776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Coumestan Glucoside from Eclipta prostrata 一种新的木犀中的Coumestan糖苷
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.289
Y. Seo, H. Kil, T. Rho, K. Yoon
{"title":"A New Coumestan Glucoside from Eclipta prostrata","authors":"Y. Seo, H. Kil, T. Rho, K. Yoon","doi":"10.20307/nps.2020.26.4.289","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.289","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44657730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp. Calyxapronols A-D，来自海洋海绵Calyx sp.的新Merohexaprenoid代谢产物。
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.303
Chang-Kwon Kim, K. Gustafson
{"title":"Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.","authors":"Chang-Kwon Kim, K. Gustafson","doi":"10.20307/nps.2020.26.4.303","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.303","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45953212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities 一种新的二苯乙烯二聚体及其他化学成分及其抗菌活性
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.317
Joseph Nguetse Dongmo Arnaud, Endeguele Ekom Steve, J. Tamokou, Ngoufack Tagousop Cyrille, D. Harakat, Voutquenne-Nazabadiok Laurence, Ngnokam David
{"title":"A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities","authors":"Joseph Nguetse Dongmo Arnaud, Endeguele Ekom Steve, J. Tamokou, Ngoufack Tagousop Cyrille, D. Harakat, Voutquenne-Nazabadiok Laurence, Ngnokam David","doi":"10.20307/nps.2020.26.4.317","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.317","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42749431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo 艾叶提取物(RW0117)的体内化学成分及对胃损伤的保护作用
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.268
Jin-Woo Lee, I. Lee, Se-Hoon Park, Min Jegal Chang, Keunwoo Choi, Hye-Young Jung, Jung-Ae Choi, Chan Lee, Ho Kyong Kim, Jung Suk Lee
{"title":"Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo","authors":"Jin-Woo Lee, I. Lee, Se-Hoon Park, Min Jegal Chang, Keunwoo Choi, Hye-Young Jung, Jung-Ae Choi, Chan Lee, Ho Kyong Kim, Jung Suk Lee","doi":"10.20307/nps.2020.26.4.268","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.268","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44434772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stereoselective Microbial Hydroxylation of Progestin, Norethisterone by Using Aspergillus niger and Penicillium citrinum 黑曲霉和青霉菌对孕激素、炔诺酮的立体选择性微生物羟基化
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.283
Azizud Din, Iqbal Muhammad, Ghulam Musharraf Syed, S. Saleem
{"title":"Stereoselective Microbial Hydroxylation of Progestin, Norethisterone by Using Aspergillus niger and Penicillium citrinum","authors":"Azizud Din, Iqbal Muhammad, Ghulam Musharraf Syed, S. Saleem","doi":"10.20307/nps.2020.26.4.283","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.283","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47727314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities 一种HPLC-PDA方法的建立和验证，该方法用于定量印楝中10种标记化合物，并评估其蛋白酪氨酸磷酸酶1B、α-葡萄糖苷酶和乙酰胆碱酯酶抑制活性
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/nps.2020.26.4.326
H. Duc, Dat Le Duc, E. Ma, B. Min, M. Woo
{"title":"Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities","authors":"H. Duc, Dat Le Duc, E. Ma, B. Min, M. Woo","doi":"10.20307/nps.2020.26.4.326","DOIUrl":"https://doi.org/10.20307/nps.2020.26.4.326","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43776506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp. 基于分子网络的去复制策略从Pleosporales sp.中分离出一种新的色酮。
Natural product sciences Pub Date : 2020-12-31 DOI: 10.20307/NPS.2020.26.4.340
Haeun Kwon, Kim Jun-Gu, Oh Jeong Joo, Jae Jin Kim, Gyu-Hyeok Kim, Hwang, Bang Yeon, J. Yim, Lee, Dongho
{"title":"Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp.","authors":"Haeun Kwon, Kim Jun-Gu, Oh Jeong Joo, Jae Jin Kim, Gyu-Hyeok Kim, Hwang, Bang Yeon, J. Yim, Lee, Dongho","doi":"10.20307/NPS.2020.26.4.340","DOIUrl":"https://doi.org/10.20307/NPS.2020.26.4.340","url":null,"abstract":"","PeriodicalId":19080,"journal":{"name":"Natural product sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48333742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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