Nephrology Dialysis Transplantation最新文献

{"title":"Recurrence of CKD-associated pruritus after discontinuation of Difelikefalin.","authors":"Rémi Brasme, Alexandre Candellier, Morgane Wetzstein, Maxime Schleef, Pablo Urena-Torres, Léa Moret, Céline Estournet, Vladimir Coliche, Amandine Darres, Angelo Testa, Nathalie Maisonneuve, Marie-Flore Hennino","doi":"10.1093/ndt/gfaf081","DOIUrl":"https://doi.org/10.1093/ndt/gfaf081","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of different heparin-free dialysis methods.","authors":"Marie Quennepoix, Laetitia Koppe, Alban Bevier, Christophe Barba, Maxime Espi, Cécile Barnel, Denis Fouque, Etienne Novel-Catin","doi":"10.1093/ndt/gfaf082","DOIUrl":"https://doi.org/10.1093/ndt/gfaf082","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic lung diseases and kidney disease: pathophysiology and management.","authors":"Silvia De Rosa, Sergio Lassola, Fabio Silvio Taccone, Denise Battaglini","doi":"10.1093/ndt/gfaf077","DOIUrl":"https://doi.org/10.1093/ndt/gfaf077","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a critical complication in patients with chronic lung diseases (CLD), particularly during acute exacerbations. This review focuses on the pathophysiological mechanisms linking CLD to AKI and highlights key clinical strategies to mitigate its impact. CLD patients with pre-existing kidney dysfunction face an increased risk of AKI due to impaired gas exchange, systemic inflammation, and neurohormonal activation. Hypoxemia and hypercapnia contribute to kidney hypoperfusion, endothelial dysfunction, and sodium-water imbalances, exacerbating renal injury. Current management strategies prioritize minimizing mechanical ventilation-related damage, optimizing hemodynamics, and preventing AKI progression. A multidisciplinary approach is essential to improving outcomes, emphasizing early identification and targeted interventions for CLD-associated AKI.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High measured GFR as a predictor of all-cause mortality and cardiovascular disease in a prospective non-diabetic population cohort.","authors":"Bjørn O Eriksen, Matteo Fasiolo, Ulla D Mathisen, Trond G Jenssen, Jon V Norvik, Jørgen Schei, Vidar T N Stefansson, Toralf Melsom","doi":"10.1093/ndt/gfaf079","DOIUrl":"https://doi.org/10.1093/ndt/gfaf079","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>High glomerular filtration rate (GFR) is generally regarded as beneficial but has been associated with cardiovascular disease (CVD) and all-cause mortality in epidemiological studies. However, these investigations may have been biased by the non-GFR determinants of estimated GFR (eGFR). We compared the risk of high baseline iohexol clearance (mGFR) and eGFR based on creatinine or cystatin C in a prospective longitudinal population-based study of the Renal Iohexol Clearance Survey (RENIS) cohort.</p><p><strong>Methods: </strong>The cohort consists of a representative sample of the general population of persons between 50 and 64 years of age without baseline CVD, diabetes or kidney disease in the municipality of Tromsø in Norway. We investigated nonlinear associations in general additive Cox regression models adjusted for CVD risk factors.</p><p><strong>Results: </strong>During a median follow-up of 14.1 years, 232 CVD outcomes and 117 deaths occurred in a study population of 1552 persons. For all-cause mortality, no association was found for mGFR but the previously reported association between high eGFRcrea and increased risk was confirmed. For the CVD outcome, the best fitting model included interactions between mGFR or eGFR and the urinary albumin-creatinine ratio (ACR). An mGFR or eGFRcys greater than 85 mL/min/1.73 m2 was associated with an elevated HR for CVD in participants with high-normal ACR (>10 mg/g) only.</p><p><strong>Conclusions: </strong>A high mGFR or eGFRcys is not associated with an increased risk of CVD or all-cause mortality in the general non-diabetic population with normal ACR. Previous findings of an association with high eGFRcrea were most likely caused by non-GFR confounders. In persons with high-normal ACR, high mGFR or eGFRcys is associated with an increased risk of CVD.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dent disease: clinical practice recommendations.","authors":"Arend Bökenkamp, Gema Ariceta, Detlef Böckenhauer, Olivier Devuyst, Francesco Emma, David van Bennekom, Elena Levtchenko, John Sayer, Aude Servais, Rosa Vargas, Marcin Zaniew, Larisa Prikhodina","doi":"10.1093/ndt/gfaf003","DOIUrl":"10.1093/ndt/gfaf003","url":null,"abstract":"<p><p>Dent disease is a rare X-linked tubulopathy that is characterized by low-molecular-weight proteinuria associated with hypercalciuria, which may lead to nephrolithiasis, nephrocalcinosis, and kidney failure between the third and fifth decades of life in 30%-80% of affected males. The disease is most often associated with various manifestations of proximal tubular dysfunction. Affected individuals may present nephrotic-range proteinuria which may be misinterpreted and cause diagnostic delay. Due to its rarity, there is limited evidence to guide diagnosis and management. These clinical practice recommendations summarize the current knowledge on Dent disease and provide guidance for diagnosis and management. The recommendations are based on a systematic search of the literature and were endorsed by a Delphi procedure among stakeholders in the field as well as the respective ERA and ESPN working groups.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"852-864"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored management strategies for IgA nephropathy based on clinical presentations.","authors":"Manuel Praga, Fernando Caravaca-Fontán, Iara Da Silva, Gema Fernández-Juárez, Eduardo Gutiérrez, Angel M Sevillano, Hernan Trimarchi","doi":"10.1093/ndt/gfae289","DOIUrl":"10.1093/ndt/gfae289","url":null,"abstract":"<p><p>The treatment landscape for immunoglobulin A nephropathy is rapidly evolving with the introduction of novel therapies targeting diverse disease pathways. Some have already been approved in different countries, while others are under investigation in randomized controlled trials (RCTs) with encouraging results. However, almost all performed RCTs have included only patients with refractory non-nephrotic proteinuria and preserved renal function. Other clinical presentations (rapidly progressive forms, malignant hypertension, thrombotic microangiopathy, nephrotic syndrome) have received less attention and are systematically excluded from RCTs. In contrast, certain aspects, such as the impact of haematuria or management in special populations (e.g. pregnant patients or transplant recipients), remain underexplored. This review proposes therapeutic algorithms to guide treatment decisions in different clinical scenarios while highlighting gaps in current research.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"874-883"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac magnetic resonance assessment of cardiac function across chronic kidney disease stages.","authors":"Shutian An, Hao Qian, Jinxiu Yang, Caiyun Han, Yanzimeng Ye, Yan Liu, Wei Deng, Xiuzheng Yue, Yongqiang Yu, Ren Zhao, Xiaohu Li","doi":"10.1093/ndt/gfae222","DOIUrl":"10.1093/ndt/gfae222","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease prevalence remains high among chronic kidney disease (CKD) patients. Mechanisms and treatments to improve prognosis remain of paramount importance, and imaging biomarkers of left ventricular myocardial structure and function have better defined the phenotype of renal cardiomyopathy. The left atrial function and right heart remain are less well reported in CKD. This study used cardiac magnetic resonance imaging (CMR) to assess the interplay of left atrial and right ventricular function.</p><p><strong>Methods: </strong>In a cross-sectional study, we examined 58 CKD patients (Group I: stages 2-3, n = 25; Group II: stages 4-5, n = 33). Additionally, 26 age-matched healthy controls were included. Comprehensive CMR protocols (1.5T) were employed, encompassing cine imaging, native T1 and T2 mapping, and tissue tracking strain analysis. Left ventricular (LV), right ventricular (RV) and left atrial (LA) structure, function and strain parameters were assessed.</p><p><strong>Results: </strong>Compared with healthy controls, both Groups I and II exhibited impaired RV and LA function. right ventricular end-diastolic volume index and right ventricular end-systolic volume index showed significant increases in both Groups I and II (P < .001). All LV, RV and LA strain parameters were reduced in the patient groups (all P < .001). In the univariate binary logistic regression, several parameters, including age, blood pressure, RV volumes and LV/RV strain, were found to have a statistically significant association with CKD. In a multivariable model adjusted for other confounders, RV GLS and left atrial strain remained as independent significant predictors.</p><p><strong>Conclusions: </strong>RV size, LA strain and volume assessed by CMR serve as markers of RV and LA cardiac dysfunction in CKD patients with preserved LVEF. Greater attention should be given to RV and LA dysfunction for early identification of cardiac dysfunction in CKD patients.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"908-916"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing collaboration between academia and industry in kidney disease research.","authors":"Robert J Unwin, Benjamin Challis, Iain MacPhee, Pernille B L Hansen, Rachel Jones, Alan Salama, Jonathan Barratt","doi":"10.1093/ndt/gfae272","DOIUrl":"10.1093/ndt/gfae272","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"836-838"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond ChatGPT: next generation artificial intelligence tools for nephrologists.","authors":"José Enrique Ruiz-Cabello, Andrea Cifuentes-Talavera, Orsolya Cseprekál, Fernando Caravaca-Fontán","doi":"10.1093/ndt/gfae223","DOIUrl":"10.1093/ndt/gfae223","url":null,"abstract":"","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"833-835"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference values for handgrip strength, five times sit-to-stand and gait speed in patients on hemodialysis.","authors":"Marvery P Duarte, Otávio T Nóbrega, Barbara P Vogt, Marina S Pereira, Maryanne Z C Silva, Dario R Mondini, Henrique S Disessa, Angélica N Adamoli, Daiana C Bündchen, Bruna R M Sant'Helena, Rodrigo R Krug, Maristela Bohlke, Antônio J Inda-Filho, Ricardo M Lima, Carla M Avesani, Luiz R Nakamura, Maycon M Reboredo, Heitor S Ribeiro","doi":"10.1093/ndt/gfae232","DOIUrl":"10.1093/ndt/gfae232","url":null,"abstract":"<p><strong>Background: </strong>Low levels of muscle strength and physical performance predict adverse clinical outcomes in patients on hemodialysis; however, reference values remain lacking. We described reference values for handgrip strength, five times sit-to-stand (STS-5) and 4-m gait speed in a large-scale sample of patients on hemodialysis.</p><p><strong>Methods: </strong>Baseline data from the SARCopenia trajectories and associations with adverse clinical outcomes in patients on HemoDialysis (SARC-HD) study were analyzed. Muscle strength was evaluated using handgrip strength and the STS-5, whereas physical performance was evaluated using usual 4-m gait speed before a midweek dialysis session. Sex- and age-specific smoothed reference curves for each test at the 3rd, 15th, 50th, 85th and 97th percentiles were constructed using generalized additive models for location shape and scale. Comparisons between sex and age were also performed.</p><p><strong>Results: </strong>Data from 1004 patients (39% female; 19-96 years; 49% ≥60 years) were analyzed. Declines in muscle strength and physical performance were observed with advancing age in both sexes. However, among males, muscle strength and performance were similar between 18 and 49 years of age. Males exhibited substantially greater performance in handgrip strength [10.3 kg, 95% confidence interval (CI) 9.1 to 11.4] and 4-m gait speed (0.10 s, 95% CI 0.05 to 0.14) compared with females. Older patients, independent of sex, exhibited poorer performance on most tests. Lower handgrip strength in the arm with arteriovenous fistula was observed in both sexes (males -2.3 kg, 95% CI -2.8 to -1.7; and females -2.1 kg, 95% CI -2.6 to -1.6).</p><p><strong>Conclusion: </strong>Reference values obtained in this study may be used in clinical and research settings to identify patients on hemodialysis with low physical function according to sex and age. Future studies should test these reference values as potential predictors of adverse clinical outcomes.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"987-996"},"PeriodicalIF":4.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}