Natural Sciences Engineering and Technology Journal最新文献_第4页

Enzyme Linked Immunosorbent Assay (ELISA) 酶联免疫吸附试验(ELISA)

Natural Sciences Engineering and Technology Journal Pub Date : 2021-08-19 DOI: 10.37275/NASETJOURNAL.V1I2.6

Maya Chandra Dita

引用次数: 1

Natural Sciences Engineering and Technology Journal Pub Date : 2021-08-13 DOI: 10.37275/nasetjournal.v1i1.4

Billy Peter Manawan

{"title":"Genetics in Colorectal Cancer","authors":"Billy Peter Manawan","doi":"10.37275/nasetjournal.v1i1.4","DOIUrl":"https://doi.org/10.37275/nasetjournal.v1i1.4","url":null,"abstract":"Colorectal cancer are the third most commonly diagnosed form of cancer globally, which about 11% of all cancer diagnoses. Obesity, together with kind of sedentary lifestyle, red meat consumption, tobacco, and alcohol consumption are considered as predisposing factors of progression of CRC. In the development of colorectal cancer, genetic factors having a role in its incidence. The hereditary type of colorectal cancer was divided into two types is polyposis and Lynch syndrome which have each and different mechanism and genetic pattern. Lynch syndrome contributes for 3–5% of CRC cases and is caused by a germline mutation in one of four genes associated with the DNA mismatch repair (MMR) system: MLH1, MSH2, MSH6, or PMS2. In polyposis, there are some types such as Familial Adenomatous Polyposis (FAP) which mostly caused by APC mutation, MYH-associated polyposis, and the rare hamartomatous polyposis syndromes. Genetic testing and better family history documentation can enable those with a hereditary predisposition for the neoplasm to take preventive measures. Some genetic testing can be used such as Microsatellite instability (MSI), immunohistochemistry (IHC), DNA sequencing and protein truncation that used for each type of hereditary colorectal cancer.","PeriodicalId":19046,"journal":{"name":"Natural Sciences Engineering and Technology Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82240367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-design of Biphenyl Chemical Factory from Benzene with Capacity of 10.000 Ton Per Year 年产1万吨苯联苯化工厂的前期设计

Natural Sciences Engineering and Technology Journal Pub Date : 2021-08-13 DOI: 10.37275/nasetjournal.v1i1.1

Roman Robiati

{"title":"Pre-design of Biphenyl Chemical Factory from Benzene with Capacity of 10.000 Ton Per Year","authors":"Roman Robiati","doi":"10.37275/nasetjournal.v1i1.1","DOIUrl":"https://doi.org/10.37275/nasetjournal.v1i1.1","url":null,"abstract":"The design of a biphenyl chemical plant from benzene with a capacity of 10,000 tons/year will be built in Tuban, East Java with a land area of 10,010 m2. The raw material in the form of Benzene is obtained from Trans-Pacific Petrochemical Indotama (TPPI), Tuban. The factory is designed to operate continuously for 330 days, 24 hours per day, and requires 214 employees. Biphenyl preparation begins with reacting benzene (2,807.74 kg/hour) in a Pipe Flow Reactor (R-01) at a reactor temperature of 377 oC and a pressure of 2 atm. This reaction takes place with a conversion of 90% and is endothermic so that a Hitech heater is used to maintain the operating temperature. The products that come out of the reactor are biphenyl and hydrogen. It is then cooled and condensed in a Partial Condenser (CD-01) to a temperature of 151 oC. Then enter into Separator-02 (SP-02) to separate hydrogen from a mixture of benzene, toluene and biphenyl. Hydrogen in the gas phase as a result of the separtor. The bottom product in the form of benzene, toluene and biphenyl in the liquid phase is pumped and put into a distillation tower (MD-01) to purify the product with the bottom product in the form of biphenyl with a purity of 99.3%. The result of the distillation tower is benzene and its impurities are recycled as feed into the reactor with a temperature of 83 oC and a pressure of 1 atm. This factory requires Fixed Capital (FC) Rp. 34,341,856,338,- + US$ 4,195,836, Working Capital (WC) (Rp. 127,536,505,173,- + US$ 170,019), Manufacturing Cost (MC) (Rp. 254,092,040,390,- + US$ 816,090), and General Expenses (GE) (Rp. 33,990,417,539,- + US$ 81,609). Economic analysis shows the value of ROI before tax is 50.38 % and the value of ROI after tax is 32.75%. POT before tax is 1.65 years and POT after tax is 2.34 years. The BEP value is 43.11% and the SDP value is 23.75%. The interest rate in DCF for 10 years is 19% on average. Thus, from a technical and economic point of view, a biphenyl plant from benzene with a capacity of 10,000 tons/year is worthy of consideration.","PeriodicalId":19046,"journal":{"name":"Natural Sciences Engineering and Technology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83010910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Redesign of the Patiayam Kudus Archaeological Museum with an Architectural Approach to Regionalism 用地域主义的建筑方法重新设计帕蒂亚姆·库德斯考古博物馆

Natural Sciences Engineering and Technology Journal Pub Date : 2021-08-13 DOI: 10.37275/nasetjournal.v1i1.2

M. Sulthon

引用次数: 0