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Benefits of Using the CRISPR/Cas9 System for the Correction of Genetic Mutations 使用 CRISPR/Cas9 系统纠正基因突变的好处
IF 0.5 4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-09-01 DOI: 10.3103/s0891416823030084
{"title":"Benefits of Using the CRISPR/Cas9 System for the Correction of Genetic Mutations","authors":"","doi":"10.3103/s0891416823030084","DOIUrl":"https://doi.org/10.3103/s0891416823030084","url":null,"abstract":"<h3>Abstract</h3> <p>The discovery of the CRISPR/Cas9 gene scissors technology was a breakthrough in the development of gene therapy methods and attracted the attention of the entire scientific community. This technology provides prospects for the treatment of many neurodegenerative diseases and cancers that were previously considered almost incurable. To date, the mechanisms of the development and progression of these groups of nosologies are becoming increasingly studied due to discoveries in the field of molecular biology and genetics. However, the application of the CRISPR/Cas9 technology has some limitations and difficulties that should be considered. The development of works on the creation and selection of specific gene carriers, a thorough safety assessment of modern genetic manipulations, and the integrated participation of specialists from different fields of science will be important to solve the problems associated with the use of the CRISPR/Cas9 technology and achieve the desired therapeutic effect.</p>","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"30 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hantaviruses in Populations of Voles in Siberia 西伯利亚田鼠种群中的汉坦病毒
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020106
L. N. Yashina, S. A. Abramov, N. A. Smetannikova, B. S. Malyshev, T. A. Dupal, A. V. Krivopalov
{"title":"Hantaviruses in Populations of Voles in Siberia","authors":"L. N. Yashina, S. A. Abramov, N. A. Smetannikova, B. S. Malyshev, T. A. Dupal, A. V. Krivopalov","doi":"10.3103/s0891416823020106","DOIUrl":"https://doi.org/10.3103/s0891416823020106","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactobacillus crispatus and Human Herpes Simplex Virus-2, an In Vitro Study crispr乳杆菌与人类单纯疱疹病毒2的体外研究
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020040
Mehdi Moazzami Goudarzi, Mohammad Reza Fazeli, Abbas Akhavan Sepahi, Akram Eidi
{"title":"Lactobacillus crispatus and Human Herpes Simplex Virus-2, an In Vitro Study","authors":"Mehdi Moazzami Goudarzi, Mohammad Reza Fazeli, Abbas Akhavan Sepahi, Akram Eidi","doi":"10.3103/s0891416823020040","DOIUrl":"https://doi.org/10.3103/s0891416823020040","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"193 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant RBD of the SARS-CoV-2 Spike Protein: Production in Escherichia coli Cells, Binding to Antibodies, and Antiviral Activity SARS-CoV-2刺突蛋白的重组RBD:在大肠杆菌细胞中的产生、与抗体的结合和抗病毒活性
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020052
M. S. Gromova, A. V. Gromov, T. M. Grunina, A. M. Lyashchuk, Z. M. Galushkina, M. E. Subbotina, I. B. Esmagambetov, E. I. Ryabova, V. V. Prokofiev, A. V. Kovyrshina, A. A. Ilyukhina, A. Y. Shelkov, A. S. Karyagina, V. G. Lunin
{"title":"Recombinant RBD of the SARS-CoV-2 Spike Protein: Production in Escherichia coli Cells, Binding to Antibodies, and Antiviral Activity","authors":"M. S. Gromova, A. V. Gromov, T. M. Grunina, A. M. Lyashchuk, Z. M. Galushkina, M. E. Subbotina, I. B. Esmagambetov, E. I. Ryabova, V. V. Prokofiev, A. V. Kovyrshina, A. A. Ilyukhina, A. Y. Shelkov, A. S. Karyagina, V. G. Lunin","doi":"10.3103/s0891416823020052","DOIUrl":"https://doi.org/10.3103/s0891416823020052","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composition of Populations and Durations of Persistence of Bordetella pertussis Bacteria in Patients with Whooping Cough and Contact Persons 百日咳患者及接触者百日咳杆菌的种群组成及持续时间
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020064
A. Yu. Medkova, E. G. Semin, S. V. Kulikov, Yu. V. Nesterova, I. V. Babachenko, L. N. Sinyashina, G. I. Karataev
{"title":"Composition of Populations and Durations of Persistence of Bordetella pertussis Bacteria in Patients with Whooping Cough and Contact Persons","authors":"A. Yu. Medkova, E. G. Semin, S. V. Kulikov, Yu. V. Nesterova, I. V. Babachenko, L. N. Sinyashina, G. I. Karataev","doi":"10.3103/s0891416823020064","DOIUrl":"https://doi.org/10.3103/s0891416823020064","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135142733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal Antibody Panel for Hepatitis B Virus Genotype and HBsAg Subtype Identification: Results Obtained for Blood-Serum Samples from Three Regions of Russia 乙型肝炎病毒基因型和乙型肝炎表面抗原亚型鉴定的单克隆抗体小组:从俄罗斯三个地区获得的血清样本的结果
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020039
L. V. Bezuglova, E. I. Sergeeva, L. Yu. Voevodskaya, E. E. Lysykh, N. V. Polovitsa, I. V. Deliy, M. K. Ivanov, I. G. Netesova, S. V. Netesov
{"title":"Monoclonal Antibody Panel for Hepatitis B Virus Genotype and HBsAg Subtype Identification: Results Obtained for Blood-Serum Samples from Three Regions of Russia","authors":"L. V. Bezuglova, E. I. Sergeeva, L. Yu. Voevodskaya, E. E. Lysykh, N. V. Polovitsa, I. V. Deliy, M. K. Ivanov, I. G. Netesova, S. V. Netesov","doi":"10.3103/s0891416823020039","DOIUrl":"https://doi.org/10.3103/s0891416823020039","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA N6-Methyladenosine Pathway Writer Genes Expression Levels and Clinical Severity of Infection in Covid-19 Patients RNA n6 -甲基腺苷途径Writer基因表达水平与新冠肺炎患者感染的临床严重程度
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020118
Badel Arslan, Sevgi Baltacı, Burcu Bayyurt, Nil Özbilum Sahin, Murat Eser Akyurek, Mehmet Bakır, Serdal Arslan
{"title":"RNA N6-Methyladenosine Pathway Writer Genes Expression Levels and Clinical Severity of Infection in Covid-19 Patients","authors":"Badel Arslan, Sevgi Baltacı, Burcu Bayyurt, Nil Özbilum Sahin, Murat Eser Akyurek, Mehmet Bakır, Serdal Arslan","doi":"10.3103/s0891416823020118","DOIUrl":"https://doi.org/10.3103/s0891416823020118","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Mutations in gyrA Gene with Resistance to Fluoroquinolones in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis 耐多药结核分枝杆菌临床分离株gyrA基因突变与氟喹诺酮类药物耐药性的关系
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020027
Hanieh Bagherifard, Mitra Salehi, Mona Ghazi
{"title":"Association of Mutations in gyrA Gene with Resistance to Fluoroquinolones in Clinical Isolates of Multidrug-Resistant Mycobacterium tuberculosis","authors":"Hanieh Bagherifard, Mitra Salehi, Mona Ghazi","doi":"10.3103/s0891416823020027","DOIUrl":"https://doi.org/10.3103/s0891416823020027","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LZTFL1 rs17713054 Polymorphism as an Indicator Allele for COVID-19 Severity LZTFL1 rs17713054多态性作为COVID-19严重程度的指示等位基因
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s0891416823020088
Mona Roozbehani, Hossein Keyvani, MohammadHossein Razizadeh, Parastoo Yousefi, Ali Gholami, Alireza Tabibzadeh, Leila Mousavizadeh
{"title":"LZTFL1 rs17713054 Polymorphism as an Indicator Allele for COVID-19 Severity","authors":"Mona Roozbehani, Hossein Keyvani, MohammadHossein Razizadeh, Parastoo Yousefi, Ali Gholami, Alireza Tabibzadeh, Leila Mousavizadeh","doi":"10.3103/s0891416823020088","DOIUrl":"https://doi.org/10.3103/s0891416823020088","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135142735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pogo DNA Transposons in the Genomes of the Aurelia Genus Jellyfish 水母属基因组中的Pogo DNA转座子
4区 生物学
Molecular Genetics, Microbiology and Virology Pub Date : 2023-06-01 DOI: 10.3103/s089141682302009x
Y. N. Ulupova, M. V. Puzakov, L. V. Puzakova
{"title":"Pogo DNA Transposons in the Genomes of the Aurelia Genus Jellyfish","authors":"Y. N. Ulupova, M. V. Puzakov, L. V. Puzakova","doi":"10.3103/s089141682302009x","DOIUrl":"https://doi.org/10.3103/s089141682302009x","url":null,"abstract":"","PeriodicalId":19005,"journal":{"name":"Molecular Genetics, Microbiology and Virology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135142734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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