ACS Macro Letters最新文献_第7页

Autophagy-Activating Nanoautophagosome-Tethering Compounds for Targeted Protein Degradation Specifically in Tumor Cells

IF 5.8

ACS Macro Letters Pub Date : 2025-02-11 DOI: 10.1021/acsmacrolett.4c00789

Mengchen Xu, Jiajing Chen, Shuyu Wang, Linlin Xu, Xiaohui Wu, Jinpu Yu, Feihe Ma, Linqi Shi

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引用次数: 0

Autophagy-Activating Nanoautophagosome-Tethering Compounds for Targeted Protein Degradation Specifically in Tumor Cells

IF 5.1

ACS Macro Letters Pub Date : 2025-02-11 DOI: 10.1021/acsmacrolett.4c0078910.1021/acsmacrolett.4c00789

Mengchen Xu, Jiajing Chen, Shuyu Wang, Linlin Xu, Xiaohui Wu, Jinpu Yu*, Feihe Ma* and Linqi Shi*,

{"title":"Autophagy-Activating Nanoautophagosome-Tethering Compounds for Targeted Protein Degradation Specifically in Tumor Cells","authors":"Mengchen Xu, Jiajing Chen, Shuyu Wang, Linlin Xu, Xiaohui Wu, Jinpu Yu*, Feihe Ma* and Linqi Shi*, ","doi":"10.1021/acsmacrolett.4c0078910.1021/acsmacrolett.4c00789","DOIUrl":"https://doi.org/10.1021/acsmacrolett.4c00789https://doi.org/10.1021/acsmacrolett.4c00789","url":null,"abstract":"Autophagosome-tethering compounds (ATTECs) represent an emerging targeted protein degradation (TPD) technology that directly draws intracellular proteins of interest (POIs) into autolysosomes. Although ATTECs are currently dominated by small molecules, the poor cell-type specificity and pharmacokinetic profile limit their applications in certain diseases. Moreover, the suboptimal intrinsic autophagic activity of cells affects the ATTECs-mediated degradation capability. Here we develop a nano-ATTEC system using our unique mixed-shell polymeric micelle (MSPM)-based nanoplatform for tumor-specific degradation of POIs. We demonstrate that the MSPMs-based nano-ATTEC is efficiently taken up by tumor cells in the acidic tumor microenvironment and to degrade POIs, rather than by normal cells under physiological conditions. More importantly, we find that this nano-ATTEC can not only target autolysosomes but also robustly enhance the autophagy activity, thereby establishing a positive feedback mechanism based on the autophagy pathway for efficient degradation of POIs. We believe that this MSPMs-based nano-ATTEC will find broad applications in tumor therapy.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"14 3","pages":"250–257 250–257"},"PeriodicalIF":5.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Carbon Recovery in Photocatalytic Degradation of High-Density Polyethylene (HDPE): Blend with Stearic Acid as a Radical Source

IF 5.8

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.4c00726

Bin Lu, Kohei Takahashi, Kyoko Nozaki

引用次数: 0

Ultrafast Thermal RAFT Depolymerization at Higher Solid Contents

IF 5.8

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.5c00009

Dimitra Mantzara, Richard Whitfield, Hyun Suk Wang, Nghia P. Truong, Athina Anastasaki

引用次数: 0

High Carbon Recovery in Photocatalytic Degradation of High-Density Polyethylene (HDPE): Blend with Stearic Acid as a Radical Source

IF 5.1

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.4c0072610.1021/acsmacrolett.4c00726

Bin Lu, Kohei Takahashi* and Kyoko Nozaki*,

引用次数: 0

Correction to “Antibacterial Iodine-Releasing Coatings of Cross-Linked Poly(N-vinylpyrrolidone) Synthesized by Solvent-Free Initiated Chemical Vapor Deposition”

IF 5.1

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.5c0007110.1021/acsmacrolett.5c00071

Qing Song*, Zihan Xiao, Tong Liu, Haijun Gao, Ximan Chen, Qingyan Jia, Peng Li* and Dahai Wei*,

引用次数: 0

Mechanochromic Break Points Control the Toughness of Entangled Polyphenylenes

IF 5.8

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.4c00810

Annina Missikewitsch, Hartmut Komber, Till Biskup, Michael Sommer

引用次数: 0

Correction to “Antibacterial Iodine-Releasing Coatings of Cross-Linked Poly(N-vinylpyrrolidone) Synthesized by Solvent-Free Initiated Chemical Vapor Deposition”

IF 5.8

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.5c00071

Qing Song, Zihan Xiao, Tong Liu, Haijun Gao, Ximan Chen, Qingyan Jia, Peng Li, Dahai Wei

引用次数: 0

Cation Chemistry and Molecular Weight Effects on the Ion Conductivity in PEO-based Electrolytes

IF 5.1

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.4c0080210.1021/acsmacrolett.4c00802

Chrysostomos Papamichail, Olympia Techlemtzi, Georgia Nikolakakou and Emmanouil Glynos*,

{"title":"Cation Chemistry and Molecular Weight Effects on the Ion Conductivity in PEO-based Electrolytes","authors":"Chrysostomos Papamichail, Olympia Techlemtzi, Georgia Nikolakakou and Emmanouil Glynos*, ","doi":"10.1021/acsmacrolett.4c0080210.1021/acsmacrolett.4c00802","DOIUrl":"https://doi.org/10.1021/acsmacrolett.4c00802https://doi.org/10.1021/acsmacrolett.4c00802","url":null,"abstract":"This study investigates the fundamental influence of cation chemistry on the ionic conductivity of PEO-based electrolytes, with implications for advancing polymer electrolyte design. Two PEO systems─high molecular weight (Mw = 100 kg/mol) and low molecular weight (Mw = 0.35 kg/mol)─were blended with LiTFSI and NaTFSI salts to explore ion transport mechanisms. In the high-Mw PEO, where ion hopping dominates, smaller Li+ ions exhibit higher conductivity (σLiTFSI > σNaTFSI). In contrast, the low-Mw PEO, where ion diffusion is the primary mechanism, shows higher conductivity for larger Na+ ions (σNaTFSI > σLiTFSI). In the former, rheology measurements indicate that larger Na+ cations form more transient EO:Na+ contact, hindering cation hopping and reducing conductivity. In the latter, the stronger EO:Li+ interactions lead to a larger hydrodynamic radius and slower diffusion. Notably, PEO-0.35K:NaTFSI exhibits a room-temperature conductivity of σNaTFSI ≈ 4 × 10–4 S/cm, meeting the requirements for practical applications. These findings highlight the potential of low-Mw PEO and Na-based electrolytes for the development of efficient Na-ion batteries.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"14 2","pages":"225–230 225–230"},"PeriodicalIF":5.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmacrolett.4c00802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cation Chemistry and Molecular Weight Effects on the Ion Conductivity in PEO-based Electrolytes

IF 5.8

ACS Macro Letters Pub Date : 2025-02-10 DOI: 10.1021/acsmacrolett.4c00802

Chrysostomos Papamichail, Olympia Techlemtzi, Georgia Nikolakakou, Emmanouil Glynos

{"title":"Cation Chemistry and Molecular Weight Effects on the Ion Conductivity in PEO-based Electrolytes","authors":"Chrysostomos Papamichail, Olympia Techlemtzi, Georgia Nikolakakou, Emmanouil Glynos","doi":"10.1021/acsmacrolett.4c00802","DOIUrl":"https://doi.org/10.1021/acsmacrolett.4c00802","url":null,"abstract":"This study investigates the fundamental influence of cation chemistry on the ionic conductivity of PEO-based electrolytes, with implications for advancing polymer electrolyte design. Two PEO systems─high molecular weight (Mw = 100 kg/mol) and low molecular weight (Mw = 0.35 kg/mol)─were blended with LiTFSI and NaTFSI salts to explore ion transport mechanisms. In the high-Mw PEO, where ion hopping dominates, smaller Li+ ions exhibit higher conductivity (σLiTFSI > σNaTFSI). In contrast, the low-Mw PEO, where ion diffusion is the primary mechanism, shows higher conductivity for larger Na+ ions (σNaTFSI > σLiTFSI). In the former, rheology measurements indicate that larger Na+ cations form more transient EO:Na+ contact, hindering cation hopping and reducing conductivity. In the latter, the stronger EO:Li+ interactions lead to a larger hydrodynamic radius and slower diffusion. Notably, PEO-0.35K:NaTFSI exhibits a room-temperature conductivity of σNaTFSI ≈ 4 × 10–4 S/cm, meeting the requirements for practical applications. These findings highlight the potential of low-Mw PEO and Na-based electrolytes for the development of efficient Na-ion batteries.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"31 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0