ACS Macro Letters最新文献_第4页

Thermoresponsive Chiral Polymeric Microgels through In Situ Cross-Linking Polymerization of Thermally Aggregated Dendritic Phenylacetylenes 通过原位交联聚合热聚集枝状苯乙炔的热响应性手性聚合物微凝胶

IF 5.8

ACS Macro Letters Pub Date : 2026-10-20 DOI: 10.1021/acsmacrolett.6c00484

Ke Li,Xueting Lu,Afang Zhang,Wen Li

引用次数: 0

Construction and Photoresponsive Transformation of Multicompartment Vesicles Based on Cyanoethenylene-Bearing Amphiphilic Block Copolymers 含氰乙烯两亲嵌段共聚物多室囊泡的构建及光响应转化

IF 4.9

ACS Macro Letters Pub Date : 2026-10-20 Epub Date: 2026-09-12 DOI: 10.1021/acsmacrolett.6c00384

Congting Wei, Yuzhe Ma, Fengyi Cai, Hailong Che

{"title":"Construction and Photoresponsive Transformation of Multicompartment Vesicles Based on Cyanoethenylene-Bearing Amphiphilic Block Copolymers","authors":"Congting Wei, Yuzhe Ma, Fengyi Cai, Hailong Che","doi":"10.1021/acsmacrolett.6c00384","DOIUrl":"10.1021/acsmacrolett.6c00384","url":null,"abstract":"Polymer self-assembly represents a promising strategyto fabricatenanostructures with great potential for biomimetic applications. Nevertheless,the precise and controllable construction of cell-like multicompartmentarchitectures still remains a challenge. Herein, we propose a facile,high-efficiency strategy to construct multicompartment vesicles viaself-assembly of amphiphilic block copolymers bearing cyanoethenylenemoieties. The copolymers initially self-assemble into uniform sphericalvesicles, which were transformed into multicompartment nanostructuresdriven by modulation of osmotic pressure during solvent switchingprocess. Furthermore, ultraviolet (UV) irradiation induces intermolecular[2+2] cycloaddition of cyanoethenylene groups, which further promotespolymer chain rearrangement and intensified microphase separation.Consequently, the initial large compound vesicles evolve into monodispersespherical multicompartment nanospheres equipped with discrete internalcavities. The findings in this study offer a versatile platform forthe rational design and fabrication of biomimetic multicompartmentnanosystems.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"15 10","pages":"1475–1482"},"PeriodicalIF":4.9,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148973866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Targeting Nanoplatform Integrating Metabolic Glycan Labeling and Bioorthogonal Chemistry for Precise Delivery of Oxaliplatin to PSMA-Positive Prostate Cancer 整合代谢聚糖标记和生物正交化学的双靶向纳米平台用于精确递送奥沙利铂至psma阳性前列腺癌

IF 4.9

ACS Macro Letters Pub Date : 2026-10-20 Epub Date: 2026-09-14 DOI: 10.1021/acsmacrolett.6c00402

Guoliang Xu, Renhao Chang, Song Huang, Huijiao Ding, Wei Zhang, Songshen Chu, Feiyang Gao, Shankai Zhao, Lianqu Wang, Liqun Zhou, Jing Ma, Jiajia Wang

{"title":"Dual-Targeting Nanoplatform Integrating Metabolic Glycan Labeling and Bioorthogonal Chemistry for Precise Delivery of Oxaliplatin to PSMA-Positive Prostate Cancer","authors":"Guoliang Xu, Renhao Chang, Song Huang, Huijiao Ding, Wei Zhang, Songshen Chu, Feiyang Gao, Shankai Zhao, Lianqu Wang, Liqun Zhou, Jing Ma, Jiajia Wang","doi":"10.1021/acsmacrolett.6c00402","DOIUrl":"10.1021/acsmacrolett.6c00402","url":null,"abstract":"Platinum-basedchemotherapy drugs are widely used inthe treatmentof various cancers due to their broad antitumor spectrum, but theirclinical application is severely limited by significant systemic toxicityresulting from nonspecific cytotoxicity. Prostate-specific membraneantigen (PSMA), which is highly overexpressed in most prostate cancer(PCa) cells, presents a promising target for tumor-selective drugdelivery. In this study, we designed and synthesized a novel dual-targetingnanoplatform that combines metabolic glycan labeling and bioorthogonalchemistry for the precise delivery of oxaliplatin (OXP) to PSMA-positiveprostate cancer cells. The nanoplatform (DDM-NPs) is functionalizedwith DUPA, a high-affinity PSMA ligand, and encapsulates Ac4ManNAz for metabolic cell surface engineering. Subsequently, a bioorthogonalreaction between the azido-labeled cells and the bicyclo[6.1.0]non-4-yne(BCN)-conjugated prodrug (BCN-OXP) enhanced cellular uptake and cytotoxicityin PSMA-high-expressed cell lines (22Rv1) compared to PSMA-low-expressedcells (PC-3) in vitro and in vivo. Our work establishes a promising strategy to enhance the therapeuticindex of platinum drugs through active targeting and bioorthogonalreactions, offering a potential avenue for more effective and saferprostate cancer therapy.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"15 10","pages":"1506–1516"},"PeriodicalIF":4.9,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148973901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Functionalization of Polycarbonates and Polyurethanes via Organocatalyzed SNAr 有机催化SNAr快速功能化聚碳酸酯和聚氨酯

IF 4.9

ACS Macro Letters Pub Date : 2026-10-20 Epub Date: 2026-09-23 DOI: 10.1021/acsmacrolett.6c00412

Eddy W. P. Tan, Yi Yan Yang, James L. Hedrick, Nathaniel H. Park

引用次数: 0

Fabricationand Structure–Property Relationshipof High-Strength UHMWPE Films with Enhanced Thermal Conductivity 高强度超高分子量聚乙烯增强导热膜的制备及其结构性能关系

IF 5.8

ACS Macro Letters Pub Date : 2026-10-16 DOI: 10.1021/acsmacrolett.6c00455

Chenyu Yao,Yulong Li,Chaowei Xing,Panghui Ge,Zihao Gao,Zongbao Wang

{"title":"Fabrication\u0000and Structure–Property Relationship\u0000of High-Strength UHMWPE Films with Enhanced Thermal Conductivity","authors":"Chenyu Yao,Yulong Li,Chaowei Xing,Panghui Ge,Zihao Gao,Zongbao Wang","doi":"10.1021/acsmacrolett.6c00455","DOIUrl":"https://doi.org/10.1021/acsmacrolett.6c00455","url":null,"abstract":"Abstract Ultrahigh molecular weight polyethylene (UHMWPE) shows great application potential in flexible electronic thermal management and lightweight protection due to its low density, superior specific strength, and excellent electrical insulation. However, previous studies mainly focus on independently optimizing the mechanical or thermal conductivity (TC) of UHMWPE films, while the underlying mechanism of simultaneous regulation of both properties via crystalline structures remains unclear. In this work, shish crystals were retained during UHMWPE dissolution to enable sufficient chain disentanglement. Combined with multistage hot drawing, a strongly oriented crystalline structure was constructed to fabricate mechanically strong UHMWPE films with enhanced TC. The synergistic regulation mechanism of crystal evolution during ultradrawing on mechanical and thermal transport properties was systematically investigated. Increasing the draw ratio (DR) extends and orients molecular chains in densely entangled amorphous regions, promoting abundant short, small-diameter new shish crystals and improving the regularity of retained shish crystals. The concurrent rise in shish crystal orientation and total content optimizes both stress transfer efficiency and phonon transport pathways. At a DR of 48.5, the film achieves an in-plane TC of 42.1 W m–1 K–1 at 25 °C and a tensile strength of 1.49 GPa. This work provides new insights for the industrial preparation of advanced-performance flexible UHMWPE films.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"13 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cation-ConditionedOxidative Doping Enables DurableNear-Infrared Polymer Electrochromism 阳离子条件氧化掺杂实现持久的近红外聚合物电致变色

IF 5.8

ACS Macro Letters Pub Date : 2026-10-15 DOI: 10.1021/acsmacrolett.6c00354

Bingwei Bao,Yingying Hao,Xilu Wu,Qingchao Fan,Zaiyuan Zhang,Ru Xiao,Chengyi Hou,Qinghong Zhang,Yaogang Li,Kerui Li,Hongzhi Wang

{"title":"Cation-Conditioned\u0000Oxidative Doping Enables Durable\u0000Near-Infrared Polymer Electrochromism","authors":"Bingwei Bao,Yingying Hao,Xilu Wu,Qingchao Fan,Zaiyuan Zhang,Ru Xiao,Chengyi Hou,Qinghong Zhang,Yaogang Li,Kerui Li,Hongzhi Wang","doi":"10.1021/acsmacrolett.6c00354","DOIUrl":"https://doi.org/10.1021/acsmacrolett.6c00354","url":null,"abstract":"Abstract Oxidation of p-type conjugated polymers is compensated by anions, but their electrochromic response can also depend on electrolyte cations. Here, electropolymerized P(TAA-OC-TAA) is used to distinguish its intrinsic neutral–polaron–bipolaron evolution from cation-dependent state accessibility and reversibility. In situ UV–vis–NIR and Raman spectroscopy, impedance measurements, and density functional theory calculations show that cation composition alters interfacial kinetics and the local doping environment without changing the fundamental redox pathway. A mixed Li+/Zn2+ (Li–Zn) electrolyte affords 71.2% near-infrared modulation, with only a 3.7% decrease in the transmittance window after 1300 cycles. Controls using P3HT and PTTPA polymers and a Na+/Zn2+ (Na–Zn) electrolyte show that performance depends on cation–polymer matching rather than ion mixing alone. A complementary P(TAA-OC-TAA)/PBFDO device retains 88.75% of its initial optical modulation after 9000 switching cycles, demonstrating that electrolyte cation control can translate charge-state regulation into durable device-level electrochromism.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"13 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisitingthe Intrinsic Nonlinearity Dilution inModel Polystyrene Combs under Medium-Amplitude Oscillatory Shear 模型聚苯乙烯梳子在中振幅振荡剪切作用下的本征非线性稀释

IF 5.8

ACS Macro Letters Pub Date : 2026-10-15 DOI: 10.1021/acsmacrolett.6c00372

Hyeong Yong Song,Max G. Schußmann,Manfred Wilhelm,Kyu Hyun

引用次数: 0

Stereodefect Strategy Enables Thermally Resilient, Rapidly Crystallizable, High-Performance Aliphatic Polyester Thermoplastic Elastomers 立体缺陷策略使热弹性，快速结晶，高性能脂肪族聚酯热塑性弹性体

IF 5.8

ACS Macro Letters Pub Date : 2026-10-13 DOI: 10.1021/acsmacrolett.6c00423

Margaret S. Kumler,Marc A. Hillmyer

{"title":"Stereodefect Strategy Enables Thermally Resilient, Rapidly Crystallizable, High-Performance Aliphatic Polyester Thermoplastic Elastomers","authors":"Margaret S. Kumler,Marc A. Hillmyer","doi":"10.1021/acsmacrolett.6c00423","DOIUrl":"https://doi.org/10.1021/acsmacrolett.6c00423","url":null,"abstract":"Stereoblock star aliphatic polyester thermoplastic elastomers (APTPEs) comprised of poly(d-lactide)-b-poly(l-lactide)-b-poly(γ-methyl-ε-caprolactone) ((DLM)4) rapidly crystallize to give strong, tough, and resilient APTPEs. However, the high melting temperature of the stereocomplex formed in these materials (Tm ≈ 220 °C) is close to the onset temperature for thermally induced mass loss (Td,1% ≈ 230 °C). This decomposition of the polyester is likely due to depolymerization from the ends of the polymer chain. Here, we report the synthesis of APTPE stars containing stereodefective poly(lactide) end diblocks, that is poly(l-lactide) covalently bonded to a poly(d-lactide) segment that is intentionally doped with a small percentage of l-lactide defects. Incorporating a low level of stereodefects leads to a modest reduction in Tm, while maintaining high levels of crystallinity and rapid stereoblock crystallization rates. The resultant materials have physical properties that are nearly identical to stereoblock star polymers without defects but allow melt processing below the temperature at which significant mass loss begins to occur. To prepare these star block polymers, we also conducted the synthesis in a one-pot, one-catalyst system, aligning the process with the principles of green chemistry.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"83 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Mechanoresponsive Polyolefins via ADMET Polymerization: Enhancing Mechanophore Activation through Backbone Hydrogenation ADMET聚合合成机械反应性聚烯烃：通过主链加氢增强机械团活化

IF 5.8

ACS Macro Letters Pub Date : 2026-10-12 DOI: 10.1021/acsmacrolett.6c00468

Runhui Xu,Yizhuo Zhao,Hang Shen,Zhengbiao Zhang

{"title":"Synthesis of Mechanoresponsive Polyolefins via ADMET Polymerization: Enhancing Mechanophore Activation through Backbone Hydrogenation","authors":"Runhui Xu,Yizhuo Zhao,Hang Shen,Zhengbiao Zhang","doi":"10.1021/acsmacrolett.6c00468","DOIUrl":"https://doi.org/10.1021/acsmacrolett.6c00468","url":null,"abstract":"Polyolefins represent an important class of synthetic polymers, yet their functionalization remains challenging due to their nonpolar backbones. While mechanophores offer a promising strategy for introducing mechanoresponsive functionality, current approaches predominantly rely on complex multicyclic monomers and are largely limited to force-induced degradation. Herein, we report a facile strategy to synthesize mechanofluorescent polyolefins via acyclic diene metathesis (ADMET) using an anthracene–maleimide adduct as a readily accessible mechanophore. Copolymerization with 1,10-undecadiene afforded polyolefins that exhibited mechanofluorescent behavior upon ultrasonication, ball milling, and compression. Notably, hydrogenation of the unsaturated backbone yielded a semicrystalline polyethylene with significantly enhanced mechanophore activation efficiency under compression. DSC and WAXS analysis revealed that this enhancement originates from increased crystallinity and restricted segmental motion, which suppress energy dissipation and channel mechanical force more efficiently toward mechanophore activation. This work establishes ADMET as a promising strategy for constructing mechanoresponsive polyolefins and reveals a lever effect in which physical ordering governs mechanochemical activation in bulk.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"297 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acid-Triggered Crystallization Constructs Efficient Nontraditional Room-Temperature Phosphorescence Polymers 酸触发结晶构建高效的非传统室温磷光聚合物

IF 4.9

ACS Macro Letters Pub Date : 2026-09-15 Epub Date: 2026-08-27 DOI: 10.1021/acsmacrolett.6c00348

Tao Song, Taiyu Li, Hui Zhang, Yaping Zhang, Xiaoting Zhang, Rongmin Wang, Pengfei Song

{"title":"Acid-Triggered Crystallization Constructs Efficient Nontraditional Room-Temperature Phosphorescence Polymers","authors":"Tao Song, Taiyu Li, Hui Zhang, Yaping Zhang, Xiaoting Zhang, Rongmin Wang, Pengfei Song","doi":"10.1021/acsmacrolett.6c00348","DOIUrl":"10.1021/acsmacrolett.6c00348","url":null,"abstract":"Traditional room-temperature phosphorescence (RTP) materialsrelyon complex aromatic structures. However, achieving efficient and long-livedemission from simple polymers remains an appealing but difficult challenge.Herein, we propose an acid-triggered crystallization strategy foracrylamide (AM) and hydroxyethyl methacrylate (HEMA) copolymers. Theintroduction of HCl drives the conversion of AM into 3-chloropropionamide(3-CPA) crystals and generates protonated nitrogen species, with thehydroxyl and ester groups from HEMA working synergistically to reinforcethe hydrogen-bonding network. This structural evolution significantlyboosts the overall crystallinity of the polymer network, reinforcingconformational rigidification and effectively restricting molecularmotion. The strategy extends the emission lifetime from an initial4.3 ns to 366 ms, accompanied by all overall photoluminescence quantumyield (PLQY) of 15.4%. The resulting poly(acrylamide-hydroxyethylmethacrylate) (PAMHE) derivative exhibits a green afterglow. Thiswork offers a straightforward, metal-free paradigm for the designof high performance nontraditional RTP materials, holding immensepromise for advanced anticounterfeiting applications.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"15 9","pages":"1311–1319"},"PeriodicalIF":4.9,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148821775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0