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Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics最新文献

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Automated light-based motor mapping of multiple limb movements in mice using deep neural networks 利用深度神经网络对小鼠多肢体运动进行基于光的自动运动映射
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics Pub Date : 2021-03-05 DOI: 10.1117/12.2578860
Nischal Khanal, K. Schulte, T. Voss, Jonah A. Padawer-Curry, Byungchan Kim, A. Bice, A. Bauer
{"title":"Automated light-based motor mapping of multiple limb movements in mice using deep neural networks","authors":"Nischal Khanal, K. Schulte, T. Voss, Jonah A. Padawer-Curry, Byungchan Kim, A. Bice, A. Bauer","doi":"10.1117/12.2578860","DOIUrl":"https://doi.org/10.1117/12.2578860","url":null,"abstract":"Recent developments in optogenetics allow for quick and minimally-invasive methods of studying functional brain organization in animal models. DeepLabCut (DLC), a toolbox for markerless pose estimation, offers the ability to track user-defined features in 3-dimensions with human level accuracy. We demonstrate a hybrid method utilizing DLC and optogenetic motor mapping to localize the movements of multiple modalities to the mouse cortex. We outline a pipeline to map and characterize multiple motor representations in anesthetized and awake mice. Furthermore, we identify behaviorally-relevant motor movements of multiple limbs reside in overlapping cortical representations of the respective limbs.","PeriodicalId":189801,"journal":{"name":"Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116023755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-gated diffuse correlation spectroscopy for functional imaging via 1064 nm pulse laser shaping and superconducting nanowire single photon sensing 时间门控漫射相关光谱在1064nm脉冲激光整形和超导纳米线单光子传感功能成像中的应用
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics Pub Date : 2021-03-05 DOI: 10.1117/12.2578909
N. Ozana, A. Peruch, Mitchell B. Robinson, Dibbyan Mazumder, M. Blackwell, N. Lue, S. Carp, M. Franceschini
{"title":"Time-gated diffuse correlation spectroscopy for functional imaging via 1064 nm pulse laser shaping and superconducting nanowire single photon sensing","authors":"N. Ozana, A. Peruch, Mitchell B. Robinson, Dibbyan Mazumder, M. Blackwell, N. Lue, S. Carp, M. Franceschini","doi":"10.1117/12.2578909","DOIUrl":"https://doi.org/10.1117/12.2578909","url":null,"abstract":"Recently, we developed a time-domain diffuse correlation spectroscopy (TD-DCS) method for neurovascular sensing with higher brain sensitivity. In this paper, laser pulse shaping was designed and demonstrated for TD-DCS at 1064 nm. A quantum superconducting nanowire single-photon detector (SNSPD) with high photon detection efficiency (PDE) and low jitter collects the back-scattered light from the brain. The presented approach is the first step towards scaling up a full fiber optic cap with 96 source channels and 192 custom-made single-photon detectors which will cover most of an adult head.","PeriodicalId":189801,"journal":{"name":"Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122042683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neuroprotection by optical delivery of therapeutic gene into retina 视网膜光学传递治疗基因的神经保护作用
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics Pub Date : 2021-03-05 DOI: 10.1117/12.2586104
Subrata Batabyal, Sanghoon Kim, Michaela Carlson, Houssam Al-Saad, J. Gallego, A. Dibas, S. Mohanty
{"title":"Neuroprotection by optical delivery of therapeutic gene into retina","authors":"Subrata Batabyal, Sanghoon Kim, Michaela Carlson, Houssam Al-Saad, J. Gallego, A. Dibas, S. Mohanty","doi":"10.1117/12.2586104","DOIUrl":"https://doi.org/10.1117/12.2586104","url":null,"abstract":"We hypothesized that PEDF gene transduction in retina can provide single-dose treatment to prevent ganglion cell damage. Here, we present OCT guided ultrafast laser based non-viral targeted delivery PEDF-encoding genes to retina for neuroprotection. The ultrafast laser gene delivery showed layer-specific reliable expression of PEDF gene in retina without any detectable damage. Monitoring of IOP and electroretinogram after ultrafast laser transfection showed no adverse changes. The ultrafast laser transfection of large PEDF genes in retina exhibited significant therapeutic benefit in an injury model. Absence of any immune response in retina subsequent to ultrafast-laser transfection provides unique opportunity for repeated dosing.","PeriodicalId":189801,"journal":{"name":"Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117020973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large scale mapping of the cortical microvascular velocities by the dynamic light scattering optical coherence tomography 动态光散射光学相干层析成像的大比尺皮质微血管速度制图
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics Pub Date : 2021-03-05 DOI: 10.1117/12.2583146
Mohammed Alfadhel, Qi Pian, Jianbo Tang, Grace V. Lee, Baoqiang Li, Buyin Fu, Yagmur Ayata, D. Boas, T. Secomb, S. Sakadžić
{"title":"Large scale mapping of the cortical microvascular velocities by the dynamic light scattering optical coherence tomography","authors":"Mohammed Alfadhel, Qi Pian, Jianbo Tang, Grace V. Lee, Baoqiang Li, Buyin Fu, Yagmur Ayata, D. Boas, T. Secomb, S. Sakadžić","doi":"10.1117/12.2583146","DOIUrl":"https://doi.org/10.1117/12.2583146","url":null,"abstract":"We present a framework to coregister a large set of blood flow measurements from the cortical microvascular segments obtained by DLS-OCT with the microvascular angiogram obtained using TPM. By using this framework, we estimated the distributions of the mean RBC velocities in arterioles, venules, and capillaries, and as a function of the branching order from over 1,000 microvascular segments. The developed tools will help with more quantitative analysis of the large data sets obtained by OCT and TPM in the studies involving normal brain functioning, progression of various diseases, and numerical modeling of the oxygen transport in the microvascular networks.","PeriodicalId":189801,"journal":{"name":"Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130325087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wide-field optical imaging along the neurovascular coupling pathway 沿神经血管耦合通路的宽视场光学成像
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics Pub Date : 2021-03-05 DOI: 10.1364/brain.2020.bw2c.5
Xiaodan Wang, A. Bice, A. Bauer
{"title":"Wide-field optical imaging along the neurovascular coupling pathway","authors":"Xiaodan Wang, A. Bice, A. Bauer","doi":"10.1364/brain.2020.bw2c.5","DOIUrl":"https://doi.org/10.1364/brain.2020.bw2c.5","url":null,"abstract":"Understanding how different diseases of the central nervous system affect neurovascular coupling will allow for linking changes in neural or metabolic dysfunction to changes in hemodynamic signaling upon which blood-based imaging methods rely. We developed a dual fluorophore imaging system for simultaneous, high-speed mapping of neural, metabolic, and hemodynamic activity. Proof-of-concept measurements of spontaneous and stimulus-evoked dynamics are presented in awake and anesthetized mice. This flexible hardware platform allows for integrating optogenetic stimulation for all optical neural circuit interrogation and readout, and for examining the interaction between multiple cell populations.","PeriodicalId":189801,"journal":{"name":"Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116376450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Matter: Volume 11629 前题:卷11629
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics Pub Date : 1900-01-01 DOI: 10.1117/12.2596819
{"title":"Front Matter: Volume 11629","authors":"","doi":"10.1117/12.2596819","DOIUrl":"https://doi.org/10.1117/12.2596819","url":null,"abstract":"","PeriodicalId":189801,"journal":{"name":"Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121139257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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