National Journal of Physiology, Pharmacy and Pharmacology最新文献

{"title":"Sural nerve conduction: Amplitude and distal latency of sensory nerve action potential","authors":"Ahammed H, Benny D, Jija M, A. A, Divya Unnikrishnan, S. Nath","doi":"10.5455/njppp.2023.13.11529202214112022","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.11529202214112022","url":null,"abstract":"Background: The sensory nerve action potential (SNAP) is an important factor in the electro diagnostic evaluation of a patient with suspected peripheral neuropathy. Sural nerve is the most frequently studied nerve in the electrophysiology. For proper diagnosis sural sensory conduction abnormalities, a reference data are required for each electrophysiology laboratory. Aims and Objectives: The aim of the study was to find out normative reference data of amplitude and distal latency (DL) of sural SNAP for Northern Kerala population. Materials and Methods: The study was designed as cross-sectional and observational study and analysis of values was done using SPSS version 16. A total of 250 healthy subjects of age 15–50 from Northern Kerala participated in the study which included equal number of males and females. Results: Normative reference data for sensory amplitude and DL were derived in the present study. Sensory amplitude was more and DL was found to be less in female population, indicating faster nerve conduction in female. Conclusion: The reference data derived here can be utilized to detect any abnormality sural nerve sensory conduction. The gender effect on sural nerve sensory conduction parameters can be attributed to the height difference, as nerve conduction velocity is inversely proportional to height.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84394288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of body fat percentage with phase angle in young adults using bioelectric impedance analyzer - A cross-sectional study","authors":"Taniya Tyagi, K. K. K. Singh, Ruchi Tyagi","doi":"10.5455/njppp.2023.13.01053202318042023","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.01053202318042023","url":null,"abstract":"<jats:p />","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88417410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of short-term breathing meditation on serum lipid profile and fasting blood glucose level among young healthy adults","authors":"Shikha Singh, J. Saxena, Dolly Rastogi, Atosh Kumar, Anupama Gupta, Jayvardhan Singh, Preeti Kanawjia, Saurabh Saha","doi":"10.5455/njppp.2023.13.05259202308062023","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.05259202308062023","url":null,"abstract":"<jats:p />","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85383704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omeprazole-induced cardiac arrhythmia – A case report","authors":"V. Bhandari, Narinder P. Singh, Sheveta Dureja","doi":"10.5455/njppp.2023.13.10482202209112022","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.10482202209112022","url":null,"abstract":"Omeprazole, a Proton pump inhibitor, is widely prescribed in patients with chronic gastroesophageal reflux. Patients continue to use omeprazole for long period of time even without the supervision of the doctor. The authors report a 50-year-old male patient with a 5-year history of omeprazole use, who complained of chest discomfort. ECG on admission showed atrial fibrillation. Laboratory findings showed hypomagnesaemia, hypocalcaemia, and hypokalemia. The case report emphasizes the importance of patient education regarding the use and adverse drug reactions of the prescribed medications.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85402408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study to evaluate the efficacy of clobetasol and curcumin in patients with oral submucous fibrosis","authors":"P. Upadhyay, Bhavna Barthunia, Poulomi Bhakta, Amit A Upadhyah","doi":"10.5455/njppp.2023.13.01012202310012023","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.01012202310012023","url":null,"abstract":"Background: Oral submucous fibrosis (OSMF) was considered primarily as a disease prevalent in Southern Asia and southern Asian immigrants. However, it has been associated with an increased risk of malignant transformation and beginning to garner considerable attention world-wide. The main aim in management of OSMF is to relieve burning sensation and improve mouth opening. Aim and Objective: This study aimed to compare efficacy of curcumin (2 g) and topical clobetasol propionate (0.05%) cream in management of OSMF. Materials and Methods: This prospective and randomized study was conducted among sixty clinically diagnosed patients between age group of 18 and 50 years of age. They were randomly divided into two groups. Group A patients were instructed to apply topical clobetasol propionate cream (0.05%) thrice daily for 6 weeks. Group B patients were prescribed oral curcumin lozenges for 6 weeks. Recalls were done every week for up to 6 weeks for both groups for which burning sensation and mouth opening parameters were recorded. Results: The prevalence of OSMF was more in the younger age group which was due to increase in the chewing habit. Reduction in burning sensation was seen among patients in both groups but a significant reduction of 6.67 was seen with clobetasol group when compared with curcumin group with mean reduction of 2.53. Marked improvement in mouth opening was seen with Clobetasol ointment group when compared to curcumin group with a mean increase in mouth opening of 3.57 mm in the former and only 0.47 mm improvement in the latter. Conclusion: In the present study, both treatments were beneficial in reducing burning sensation significantly with clobetasol group showing better improvement as compared to curcumin group. There was a significant improvement in mouth opening with clobetasol group and nonsignificant results were obtained with curcumin group. Therefore, clobetasol can be opted as a drug of choice in improving mouth opening in OSMF patients.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"255 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73069578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional evaluation of behavior and attitude of pharmacists toward dispensing non-OTC drugs without prescription in a city of Southern Rajasthan","authors":"Meena Atray, R Patil Vijay, V. Chhipa","doi":"10.5455/njppp.2023.13.105032022023102022","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.105032022023102022","url":null,"abstract":"Background: Over the counter (OTC), drugs are found to be safe and appropriate for use without supervision of a healthcare professional such as physician and they can be purchased by consumers without prescription. The study gains its importance because of the spreading of misuse of antibiotics and various drugs adverse drug reactions in the society. Aims and Objectives: The main aim of the study is to observe as to how many pharmacists/chemists/drug store sellers follow or violate the drug cosmetic act. Materials and Methods: It is an observational and cross-sectional study conducted among pharmacies of Udaipur city, urban areas of Southern Rajasthan. The study includes a sample size of 200 pharmacies selected through convenient random sampling. A detailed semi-structured questionnaire is administered to the pharmacists. The set of questions include types of drugs, reason for dispensing, knowledge, and attitude of pharmacist toward dispensing non-OTC drugs. All the private pharmacies willing to participate were included in the study. Data are entered in Microsoft Excel and statistically analyzed. Results: The results throw light on the behavior and pattern of dispensing habits of the drug store sellers of the city of Udaipur, Southern Rajasthan. It was observed that many pharmacists are in fact in the habit of dispensing non-OTC drugs in almost all the areas. Conclusions: Results give insights about the groups of drugs, logic, behavior, and knowledge level of pharmacists involved in dispensing practices in the city of Udaipur. There should be structured educational campaigns (or use of media, internet, newspaper, radio, television, advertisements, mobiles, etc.) for both pharmacists and public.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81555844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized and parallel-group study of cost-effectiveness analysis of escitalopram and desvenlafaxine in moderate-to-severe depression","authors":"G. K, Moulya Nagaraj, P. S, J. R, Lakshmi Pandith","doi":"10.5455/njppp.2023.13.12618202209012022","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.12618202209012022","url":null,"abstract":"Background: Cost-effectiveness analysis (CEA) measures costs and outcomes in monetary terms, it can be used to compare net benefits of all types of interventions. CEA is most important for chronic conditions such as depression requiring long-term/lifelong medications. Depression is a mood disorder affecting all age groups with a considerable impact on the quality of life. It imposes an economic burden on the individual, family, and society. Among antidepressants, selective serotonin reuptake inhibitors and serotonin-noradrenaline reuptake inhibitors are commonly preferred since they are well-tolerated and efficacious. As there are only few studies done in Indian population to compare the efficacy and tolerability of Escitalopram and Desvenlafaxine, and no CEA have been done to compare the cost-effectiveness of Escitalopram and Desvenlafaxine, the present study was taken up. Therefore, the present study was undertaken. Aims and Objectives: The aim of the study was to evaluate the cost-effectiveness of Escitalopram and Desvenlafaxine in the treatment of moderate-to-severe depression. Materials and Methods: A randomized, open-label, standard controlled, parallel-group, and 8-week study of CEA of Escitalopram and Desvenlafaxine was performed in 60 subjects with newly diagnosed moderate-to-severe depression. Clinical improvement was assessed using the montgomery and asberg depression rating scale (MADRS). CEA was analyzed using average cost-effectiveness ratio (ACER) and increment cost-effectiveness ratio (ICER). Results: Escitalopram and Desvenlafaxine showed a significant reduction in the total MADRS scores. Escitalopram showed a faster onset of action and was more efficacious than Desvenlafaxine in reducing depressive symptoms. ACER shows a lesser cost required for Escitalopram over Desvenlafaxine. Negative ICER and increment net benefit analysis demonstrate that Escitalopram is cost-effective versus Desvenlafaxine. Study drugs were well tolerated, with mild nausea in the Desvenlafaxine group. Conclusion: Escitalopram was more cost-effective in comparison to Desvenlafaxine in moderate to severe depression.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83912535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sjogren’s syndrome presenting as hypokalemic periodic paralysis, a rare manifestation: A case series","authors":"Namita Mohanty, M. Nageswar, Sangeeta Rout, Soumyaranjan Mishra","doi":"10.5455/njppp.2023.13.0312502321032023","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.0312502321032023","url":null,"abstract":"Sjogren’s syndrome is a chronic and slowly progressing autoimmune disease characterized by lyphocytic infiltration of exocrine glands resulting in Sicca syndrome (xerostomia and keratocunjuntivitis sicca). The disease can present alone or along with other autoimmune diseases leading to significant organ specific and systemic disease. Middle aged women (Female: Male: 9:1) are primarily affected. Extraglandular (systemic) manifestations are seen in one third of patients with Sjogren’s syndrome. Among the extraglandular manifestations, renal involvement is commonly seen. Renal involvement in the form of tubulointerstitial nephritis (TIN) is more common compared to glomerular involvement. Distal renal tubular acidosis (RTA) is more common manifestation of TIN presenting as mild hypokalemia, metabolic acidosis, and rarely with hypokalemic periodic paralysis. We report three cases of hypokalemic periodic paralysis with metabolic acidosis, two in respiratory paralysis, diagnosed as distal RTA. On further evaluation of distal RTA, the patient diagnosed to have Sjogren’s syndrome and managed accordingly. Our report shows that Sjogren’s syndrome is a rare but important cause of hypokaemic periodic paralysis due to RTA.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82934511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of assessing knowledge, attitude, and practice of materiovigilance among staff nurses in Medical College and Hospital, Kolkata","authors":"Nirmalya Manna, Sayantan Mazumdar, Pratiti Panchanan, Sudipta Das","doi":"10.5455/njppp.2023.13.05239202318052023","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.05239202318052023","url":null,"abstract":"Background: Medical devices play a vital role in health-care delivery. However, the usage of medical devices is not devoid of potential risks. It is critical to evaluate the risks of medical devices during their use with implementing a strong monitoring system to detect medical device-associated adverse events (MDAEs). Drugs Controller General India launched Materiovigilance Programme of India (MvPI) with the primary aim to monitor MDAEs. Spontaneous reporting of MDAEs by health-care professionals is the fundamental element for successful functioning of medical device surveillance system. Although the program was launched 7 years ago, no such study regarding knowledge, attitude, and practice among Nurses was found in Eastern India. Aim and Objectives: This aimed to assess knowledge, attitude, and practice regarding MvPI and reporting of MDAEs among staff nurses posted in different departments of Medical College, Kolkata. Materials and Methods: A cross-sectional, descriptive study among nurses was done. A self-administered, pre-tested, structured, pre-validated questionnaire was distributed to 230 nurses. A software called SPSS, version 21.0, was used to analyze the data. Results: A total of 227 responses were received. About 44.9% (102) of the staff nurses had adequate knowledge about various aspects of materiovigilance and MvPI. 91.2% (202) of the participating nurses had a positive attitude toward reporting a MDAE. However, only 8.3% (19) have reported an event. Conclusion: Among the study participants, there was a lack of transition from knowledge and a supportive attitude to practice of MDAE reporting. To improve spontaneous reporting of MDAEs, conducting various training programs such as workshops and CMEs may be beneficial.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89972126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of depression, anxiety, and stress in COVID-19-positive patients with chronic illness – A comparative study","authors":"S. Sukumaran, Shibulal Achambattu","doi":"10.5455/njppp.2023.13.04220202302052023","DOIUrl":"https://doi.org/10.5455/njppp.2023.13.04220202302052023","url":null,"abstract":"Background: The physical, social, and emotional difficulties posed by chronic illnesses can result in depression, anxiety, and stress, which are common mental health conditions. The severe acute respiratory syndrome-CoV-2 virus, which causes the novel respiratory illness COVID-19, has had a significant impact on the global population, especially those who already have underlying chronic illnesses. In this study, we tried to evaluate the psychological stress, depression, and anxiety experienced by COVID-positive patients with and without chronic health conditions, while they are quarantined as a result of the COVID-19 pandemic. Aim and Objectives: The objectives of this study were to assess the prevalence of depression, anxiety, and stress among COVID-positive patients and to compare the prevalence of depression, anxiety, and stress among COVID-positive patients with and without chronic illness in a district in North Kerala. Materials and Methods: This observational and cross-sectional study was carried out in a district in the northern state of Kerala, India. A study population of 251 individuals who had positive COVID tests participated in the study. Out of this group, 117 people had chronic health problems such as high blood pressure, diabetes, and heart disease, while the remaining 134 people were without any chronic illness. An online questionnaire including sociodemographics and depression, anxiety, and stress scale -21 was used to evaluate depression, anxiety, and stress among the participants. Results: COVID patients with chronic illnesses experienced severe depression at a rate of 77.8% compared to 20.1% in those without any chronic illness. Patients with chronic illnesses who tested positive for COVID-19 also experienced severe anxiety in 77.8% of cases, compared to the 23.8% of really severe cases of anxiety among COVID patients who do not have any chronic illnesses. Moderate stress levels were observed in 76.06% of COVID patients with chronic illness when compared to 22.4% in those with no comorbidities. Conclusion: According to the study’s findings, people with chronic illnesses experience higher levels of stress, anxiety, and depression than those who do not have those conditions. The existence of such a high prevalence and severity of psychological issues among quarantined patients with COVID-19 underscores the need for serious attention to the mental health status of these patients.","PeriodicalId":18969,"journal":{"name":"National Journal of Physiology, Pharmacy and Pharmacology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90691978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}