氯倍他索与姜黄素治疗口腔黏膜下纤维化疗效的比较研究

P. Upadhyay, Bhavna Barthunia, Poulomi Bhakta, Amit A Upadhyah
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摘要

背景:口腔黏膜下纤维化(OSMF)被认为主要是南亚和南亚移民的一种疾病。然而,它与恶性转化的风险增加有关,并开始在世界范围内引起相当大的关注。治疗OSMF的主要目的是减轻烧灼感,改善口腔张开。目的与目的:比较姜黄素(2 g)与丙酸氯倍他索(0.05%)乳膏治疗OSMF的疗效。材料与方法:本前瞻性随机研究纳入60例临床诊断的患者,年龄在18 - 50岁之间。他们被随机分成两组。A组患者使用0.05%丙酸氯倍他索乳膏,每日3次,连用6周。B组患者口服姜黄素含片,疗程6周。两组每周进行一次回顾,持续6周,记录烧灼感和张嘴参数。结果:低龄组OSMF患病率较高,与咀嚼习惯增加有关。两组患者的烧灼感均有所减轻,但与姜黄素组相比,氯倍他索组的烧灼感明显减少6.67,姜黄素组的烧灼感平均减少2.53。与姜黄素组相比,氯倍他索软膏组口腔开口明显改善,前者平均增加3.57 mm,后者仅改善0.47 mm。结论:两种治疗均能显著减轻烧灼感,氯倍他索组明显优于姜黄素组。氯倍他索组对患者的开口有显著改善,姜黄素组对患者的开口无显著改善。因此,氯倍他索可以作为改善OSMF患者开口的首选药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comparative study to evaluate the efficacy of clobetasol and curcumin in patients with oral submucous fibrosis
Background: Oral submucous fibrosis (OSMF) was considered primarily as a disease prevalent in Southern Asia and southern Asian immigrants. However, it has been associated with an increased risk of malignant transformation and beginning to garner considerable attention world-wide. The main aim in management of OSMF is to relieve burning sensation and improve mouth opening. Aim and Objective: This study aimed to compare efficacy of curcumin (2 g) and topical clobetasol propionate (0.05%) cream in management of OSMF. Materials and Methods: This prospective and randomized study was conducted among sixty clinically diagnosed patients between age group of 18 and 50 years of age. They were randomly divided into two groups. Group A patients were instructed to apply topical clobetasol propionate cream (0.05%) thrice daily for 6 weeks. Group B patients were prescribed oral curcumin lozenges for 6 weeks. Recalls were done every week for up to 6 weeks for both groups for which burning sensation and mouth opening parameters were recorded. Results: The prevalence of OSMF was more in the younger age group which was due to increase in the chewing habit. Reduction in burning sensation was seen among patients in both groups but a significant reduction of 6.67 was seen with clobetasol group when compared with curcumin group with mean reduction of 2.53. Marked improvement in mouth opening was seen with Clobetasol ointment group when compared to curcumin group with a mean increase in mouth opening of 3.57 mm in the former and only 0.47 mm improvement in the latter. Conclusion: In the present study, both treatments were beneficial in reducing burning sensation significantly with clobetasol group showing better improvement as compared to curcumin group. There was a significant improvement in mouth opening with clobetasol group and nonsignificant results were obtained with curcumin group. Therefore, clobetasol can be opted as a drug of choice in improving mouth opening in OSMF patients.
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