Laura B Odom, Gary A Thomas, Jikku J Zachariah, Ian S Zagon, Patricia J McLaughlin
{"title":"Exploring the relationships of physical, mental, and emotional symptoms and serum biomarkers of angiogenesis in multiple sclerosis.","authors":"Laura B Odom, Gary A Thomas, Jikku J Zachariah, Ian S Zagon, Patricia J McLaughlin","doi":"10.1177/20552173251329904","DOIUrl":"10.1177/20552173251329904","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) involves symptoms that may be impacted by angiogenesis. Vascular endothelial growth factor (VEGF), a potent pro-angiogenic molecule, is elevated in early MS, but its activity in later disease is understudied. [Met<sup>5</sup>]-enkephalin (ENK) has anti-angiogenic activity and is decreased in persons with MS (PwMS).</p><p><strong>Objectives: </strong>To determine salient symptoms of MS and evaluate relationships between common MS symptoms and angiogenesis-associated biomarkers.</p><p><strong>Methods: </strong>PwMS and non-MS control participants were identified for this cross-sectional study. Walking times and self-reported fatigue, anxiety, depression, and pain were measured. Serum VEGF and [Met<sup>5</sup>] ENK levels were measured in a subset of PwMS.</p><p><strong>Results: </strong>PwMS (<i>n</i> = 66) had significantly greater fatigue than controls (<i>n</i> = 35). In PwMS, fatigue, anxiety, depression, and pain were positively intercorrelated; fatigue was positively correlated with slower walking. Serum ENK and VEGF had a trending negative relationship. Serum ENK, but not VEGF, had a trending negative relationship with the length of disease. Serum ENK and VEGF were not correlated to walking time or self-report measures.</p><p><strong>Conclusion: </strong>Fatigue is a salient MS symptom when compared to non-MS controls. Imbalanced pro- and anti-angiogenic signaling may influence fatigue in established MS, but further studies with larger sample sizes are needed to elucidate this potential relationship.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 2","pages":"20552173251329904"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camilla Juhl, Kasper Byskov, Lars G Hvid, Ulrik Dalgas, Uwe M Pommerich, Anders G Skjerbæk
{"title":"Cut-points of the 6-min walk test, the six spot step test, and the timed-25-foot walk test discriminating impaired from non-impaired walking capacity in persons with Multiple sclerosis.","authors":"Camilla Juhl, Kasper Byskov, Lars G Hvid, Ulrik Dalgas, Uwe M Pommerich, Anders G Skjerbæk","doi":"10.1177/20552173251324600","DOIUrl":"10.1177/20552173251324600","url":null,"abstract":"<p><strong>Background: </strong>Assessing and interpreting walking capacity in persons with Multiple sclerosis (PwMS) is essential in clinical practice and research - and thus for PwMS themselves - yet research evaluating cut-points is limited. The present study aims to establish cut-points for 6-min walk test (6MWT), six spot step test (SSST), and timed 25-foot walk test (T25FWT) in PwMS.</p><p><strong>Methods: </strong>Classification of PwMS having walking impairments and PwMS having limited or no walking impairments was based on distinct benchmarks for each walking test, as derived from the 12-item Multiple Sclerosis Walking Scale (MSWS-12) on a 5-point Likert scale. Cut-points, area under the curve (AUC), sensitivity (Se), and specificity (Sp) were established using receiver operating characteristic curve analyses.</p><p><strong>Results: </strong>A total of <i>n</i> = 211 ambulatory PwMS were enrolled (68% females, 54 ± 11 years, patient-determined disease step 2.9 ± 1.9 [range; 0-7], 65.1% relapse-remitting Multiple sclerosis). The following cut-points between the two groups were established: 6MWT (446 m; AUC = 0.82, Se = 0.87, Sp = 0.78), SSST (0.121 rounds/s (corresponding to 8.3 s); AUC = 0.80, Se = 0.84, Sp = 0.75), and T25FWT (1.39 m/s (corresponding to 5.5 s); AUC = 0.79, Se = 0.89, Sp = 0.69).</p><p><strong>Conclusion: </strong>Cut-points discriminating PwMS having walking impairments vs. PwMS having limited or no walking impairments were identified for 6MWT (446 m), SSST (8.3 s), and T25FWT (5.5 s).</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251324600"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valerie J Block, Kyra Henderson, Shane Poole, Gabby B Joseph, Jeffrey M Gelfand, Bruce Ac Cree, Riley Bove
{"title":"No evidence of fluctuations in daily step count between infusions in people with multiple sclerosis treated with anti-CD20 monoclonal antibodies.","authors":"Valerie J Block, Kyra Henderson, Shane Poole, Gabby B Joseph, Jeffrey M Gelfand, Bruce Ac Cree, Riley Bove","doi":"10.1177/20552173251329817","DOIUrl":"10.1177/20552173251329817","url":null,"abstract":"<p><strong>Background: </strong>Patients with multiple sclerosis (MS) on some disease-modifying therapies (i.e., natalizumab), report a \"wearing-off\" effect characterized by increased symptoms directly before infusions. Prior research suggests this may reflect natural MS fluctuations rather than true treatment waning; however, this has not been confirmed for anti-CD20 agents (e.g., ocrelizumab). Daily step count (STEPS) can reflect overall function. This study examined temporal associations between anti-CD20 therapy infusions and STEPS.</p><p><strong>Methods: </strong>Retrospective analysis evaluated data from two Fitbit-monitored cohorts (<i>N</i> = 145 total, 32 anti-CD20-treated participants) across 60 treatment cycles. Monthly STEPS were recorded directly pre- and three-month post-infusion over the six-month treatment intervals. Mixed-effects models evaluated the relationship between infusion timing, STEPS, and participant demographics, controlling for confounding variables.</p><p><strong>Results: </strong>No significant difference in STEPS was observed pre- versus post-infusion (<i>p</i> = 0.32). An average decrease of 3.3% was noted post-infusion but was not statistically significant. No associations between STEPS and participant characteristics (e.g., age, disability level) were identified. Individual variability existed, but no clear group-level trends emerged.</p><p><strong>Conclusions: </strong>This study found no evidence of an association between timing of anti-CD20 infusion and changes in STEPS. Findings highlight the need for integrating objective measures with patient-reported outcomes and biomarkers in future research to better understand potential treatment fluctuations.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251329817"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Martin, M S Aigrot, N Frère, R Lepaulmier, B Stankoff, U Boschert, C Lubetzki, B Zalc
{"title":"Positive effect of evobrutinib in CNS remyelination models and lack of synergy with clemastine-A dose response study.","authors":"E Martin, M S Aigrot, N Frère, R Lepaulmier, B Stankoff, U Boschert, C Lubetzki, B Zalc","doi":"10.1177/20552173251326913","DOIUrl":"10.1177/20552173251326913","url":null,"abstract":"<p><strong>Background: </strong>To recover normal functions, remyelination in multiple sclerosis is crucial. Although endogenous remyelination occurs, it is often insufficient, and finding molecules promoting repair of demyelinated lesions is needed.</p><p><strong>Objectives: </strong>To compare the remyelination potential of evobrutinib, an inhibitor of Bruton's tyrosine kinase and clemastine, an antagonist of M1 muscarinic acetylcholine receptor.</p><p><strong>Methods: </strong>Remyelination was investigated in lysolecithin demyelinated organotypic mouse cerebellar slices and a transgenic <i>Xenopus</i> model of inducible-demyelination.</p><p><strong>Results: </strong>Evobrutinib (100 nM) and clemastine (200 nM) potentiated remyelination of mouse cerebellar slices by a factor of 2.9 and 1.76, respectively. In conditionally demyelinated <i>Xenopus</i>, evobrutinib and clemastine increased remyelination by a factor of 1.61 and 1.92, respectively. Evobrutinib targets Bruton's tyrosine kinase expressed by microglia, and we showed that the increase in number of myeloid cells following demyelination is due to an extravasation from nearby vessels of macrophages migrating toward the optic nerve. In contrast, clemastine is expected to antagonize muscarinic receptor 1 expressing cells of the oligodendroglial lineage. We investigated a possible synergistic effect on remyelination by adding simultaneously both molecules. In both experimental models tested no significative improvement on remyelination of co-treatment with evobrutinib plus clemastine was observed.</p><p><strong>Discussion: </strong>While evobrutinib increased 1.59 fold the number of microglia/macrophages, in the presence of clemastine the number of innate immune cells was decreased by 0.39 fold, therefore counteracting the beneficial effect of microglia/macrophages on remyelination.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251326913"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laurits Taul-Madsen, Ulrik Dalgas, Hjalte Riis, Magnus K Broløs, Jesper Lundbye-Jensen, Lars G Hvid
{"title":"Implications of maximal muscle strength and aerobic capacity for lower extremity physical function in people with multiple sclerosis-a cross-sectional study.","authors":"Laurits Taul-Madsen, Ulrik Dalgas, Hjalte Riis, Magnus K Broløs, Jesper Lundbye-Jensen, Lars G Hvid","doi":"10.1177/20552173251326171","DOIUrl":"10.1177/20552173251326171","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is characterized by impairment of physical function that is often linked to neuromuscular and cardiovascular deficits. However, the specific contributions of muscle strength and aerobic capacity to physical function in MS are not fully understood.</p><p><strong>Objective: </strong>This study aimed to investigate the independent roles of maximal muscle strength (MVC) and aerobic capacity (VO<sub>2</sub>peak) on lower extremity physical function, as measured by the 6-minute walk test (6MWT) and five-time sit-to-stand test (5STS) in people with MS (pwMS).</p><p><strong>Methods: </strong>In a cross-sectional study, 150 pwMS underwent assessment of VO<sub>2</sub>peak, maximal voluntary contraction (MVC), and physical function (6MWT and 5STS). Regression analyses were conducted to explore the associations between physiological parameters and physical function.</p><p><strong>Results: </strong>MVC and VO<sub>2</sub>peak were moderately associated with (i.e., explained) 6MWT (R² = 0.40, p < 0.001), yet with VO<sub>2</sub>peak (β = 7.9, std. β = 0.45, p < 0.001) having a preferential influence compared to MVC (β = 48.2, std. β = 0.26, p < 0.001). MVC and VO<sub>2</sub>peak were weakly associated with (i.e., explained) 5STS (R² = 0.14, p < 0.001), yet with MVC (β = 0.06, std. β = 0.28, p = 0.004) having a preferential influence compared to VO<sub>2</sub>peak (β = 0.00, std. β = 0.16, p = 0.101).</p><p><strong>Conclusion: </strong>Both maximal muscle strength and aerobic capacity to physical function in pwMS. Maximal muscle strength was preferentially linked to performance in the 5STS test, whereas aerobic capacity was preferentially linked to performance in the 6MWT. These findings support the need for tailored exercise interventions to target specific physiological deficits during MS rehabilitation.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251326171"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Päivi Hämäläinen, Matias Viitala, Merja Soilu-Hänninen, Hanna Kuusisto, Marja Niiranen, Sari Avikainen, Juha Puustinen, Juhani Ruutiainen, Mervi Ryytty, Henrik Ahvenjärvi, Carl Björkholm, Annika Hulten
{"title":"Evaluation of patient-perceived fatigue in multiple sclerosis utilizing the Finnish MS registry.","authors":"Päivi Hämäläinen, Matias Viitala, Merja Soilu-Hänninen, Hanna Kuusisto, Marja Niiranen, Sari Avikainen, Juha Puustinen, Juhani Ruutiainen, Mervi Ryytty, Henrik Ahvenjärvi, Carl Björkholm, Annika Hulten","doi":"10.1177/20552173251325098","DOIUrl":"10.1177/20552173251325098","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize patient-perceived fatigue by using the Finnish Multiple Sclerosis (MS) registry data.</p><p><strong>Materials & methods: </strong>Fatigue was assessed with the Fatigue Severity Scale (FSS), the Fatigue Scale for Motor and Cognitive Functions (FSMC), and the Visual Analogue Scale-Fatigue. Disease severity was evaluated with the Expanded Disability Status Scale and symptoms with the Visual Analogue Scales. Patient reported outcomes (PROs) included the Multiple Sclerosis Neuropsychological Questionnaire, the Euro Quality of Life - 5 dimensions, the 15 D, and the Multiple Sclerosis Impact Scale. For the purposes of the study, patients were classified to those without (FSS ≤ 4) and those with (FSS ≥ 5) fatigue. The FSS scores were correlated with the results of other PROs.</p><p><strong>Results: </strong>Based on the 512 FSS scores, 47% of the patients reported fatigue (FSS ≥ 5). Fatigue was related to higher disability, lower education, and smoking. FSS correlated significantly with other measures of fatigue, cognitive, and mood symptoms, and was associated with lower Quality of Life.</p><p><strong>Conclusions: </strong>As an invisible and debilitating symptom fatigue should be evaluated systematically. In the screening, it is important to recognize the characteristics of the different scales. Whereas the FSS may serve as an overall screen, the FSMC may help to identify aspects of cognitive and motor fatigue separately.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251325098"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jérôme de Seze, Chiara Zecca, Giovanni Castelnovo, Xavier Ayrignac, Patrick Vermersch, Claudio Gobbi, Giulia Mallucci, Clarisse Carra-Dallière, Pierre Labauge, Kévin Bigaut, Laurent Kremer, Nicolas Collongues, Livia Lanotte, Eric Thouvenot, Christine Ernon, Dominique Dive
{"title":"European experience of cladribine tablets in elderly patients with multiple sclerosis: Could it be the last treatment?","authors":"Jérôme de Seze, Chiara Zecca, Giovanni Castelnovo, Xavier Ayrignac, Patrick Vermersch, Claudio Gobbi, Giulia Mallucci, Clarisse Carra-Dallière, Pierre Labauge, Kévin Bigaut, Laurent Kremer, Nicolas Collongues, Livia Lanotte, Eric Thouvenot, Christine Ernon, Dominique Dive","doi":"10.1177/20552173251321810","DOIUrl":"10.1177/20552173251321810","url":null,"abstract":"<p><strong>Background: </strong>Recent studies support the need for early and intensive disease-modifying treatment (DMT) for patients with multiple sclerosis (PWMS). Abrupt DMT withdrawal may risk disease reactivation. Recent studies showed that MS disease activity was not rare after DMT withdrawal for PWMS aged >45/55 y. Immune reconstitution therapy (IRT) with cladribine tablets (CladT), may be an option for older PWMS who wish to stop DMT.</p><p><strong>Objective: </strong>We retrospectively analysed PWMS aged >45 y who initiated CladT in 6 MS centers in Europe.</p><p><strong>Results: </strong>One hundred and twenty nine PWMS (95 women/34 men, mean age 55.0 +/-7.5y initiated CladT; 83 (64.3%) previously received platform DMT, 35 (27.2%) previously received high efficacy DMT and 11 (8.5%) received CladT as a 1<sup>st</sup> DMT due to a late onset of MS or to a delayed therapy decision. Mean follow-up was 2.4 y (1-5) on CladT. Only three patient experienced 4 relapses. The first one had 2 relapses after switching from fingolimod with a 2-month interval between treatments. The 2 remaining were naïve patients that had a relapse between the 2 courses of CladT.</p><p><strong>Conclusion: </strong>Last/exit therapy with CladT seems to avoid MS disease reactivation in older PWMS and may be an interesting alternative solution to continue immunosuppression/immunomodulation.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251321810"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruth Ann Marrie, Afolasade Fakolade, Janice Linton, Colleen J Maxwell, Dalia Rotstein, Brayden Schindell, Helen Tremlett, Ann Yeh, Marcia Finlayson
{"title":"Characterizing the diversity of the multiple sclerosis population in Canada: A scoping review.","authors":"Ruth Ann Marrie, Afolasade Fakolade, Janice Linton, Colleen J Maxwell, Dalia Rotstein, Brayden Schindell, Helen Tremlett, Ann Yeh, Marcia Finlayson","doi":"10.1177/20552173251321814","DOIUrl":"10.1177/20552173251321814","url":null,"abstract":"<p><strong>Background: </strong>This scoping review aimed to identify existing information and gaps in knowledge regarding the diversity characteristics of the multiple sclerosis (MS) population in Canada.</p><p><strong>Methods: </strong>We searched MEDLINE, EMBASE, Cumulated Index in Nursing and Allied Health Literature (CINAHL), SCOPUS and ProQuest's global dataset of theses and dissertations from 2010 to January 12, 2024. Data sources were case reports/series, cohort studies, case-control studies, analytical cross-sectional studies, randomized clinical trials, qualitative, mixed methods, participatory studies and systematic reviews conducted in Canada, published in English or French, that included participants with clinically isolated syndrome or MS. Sample characteristics were extracted applying Cochrane's PROGRESS-Plus framework.</p><p><strong>Results: </strong>We included 259 studies, most often studying disease-modifying therapy (24.3%) and access to care (20.9%). Among primary data collection studies 40% used one recruitment strategy, usually MS Clinics and MS Canada. Age (92.7%) and sex (86.9%) were reported most often, ≤10% of studies reported race or ethnicity; religion, sexual orientation and language were not reported.</p><p><strong>Conclusions: </strong>We lack an understanding of characteristics of people living with MS in Canada relevant to health equity. Existing research has been insufficiently inclusive. Better reporting of diversity characteristics is needed, along with specific efforts to recruit and retain more diverse samples.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251321814"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Maunula, Sini M Laakso, Matias Viitala, Merja Soilu-Hänninen, Marja-Liisa Sumelahti, Sari Atula
{"title":"Incidence and prevalence of multiple sclerosis during eras of evolving diagnostic criteria-a nationwide population-based registry study over five decades.","authors":"Anna Maunula, Sini M Laakso, Matias Viitala, Merja Soilu-Hänninen, Marja-Liisa Sumelahti, Sari Atula","doi":"10.1177/20552173251326173","DOIUrl":"10.1177/20552173251326173","url":null,"abstract":"<p><strong>Background: </strong>Impact of changing diagnostic criteria for the population-based incidence of multiple sclerosis (MS) has not been investigated.</p><p><strong>Objective: </strong>To assess the effect of changing diagnostic criteria on national MS incidence and prevalence in Finland from 1974 to 2021.</p><p><strong>Methods: </strong>We identified patients with MS (pwMS) through the National MS registry and the national Care Register for Healthcare and divided them into four groups based on the year of MS diagnosis: 1) Schumacher criteria (1974-1982), 2) Poser criteria (1983-2000), 3) Earlier McDonald criteria (2001-2016), and 4) Current McDonald criteria (2017-2021). Age-adjusted incidence and prevalence were calculated.</p><p><strong>Results: </strong>Age-adjusted incidence per 10<sup>5</sup> person years increased from 3.7 (95% CI 3.5-3.8) during the Schumacher criteria period to 9.2 (95% CI 9.0-9.4) during the earlier McDonald criteria. During the Current McDonald criteria incidence stabilized to 8.6 (95% CI 8.3-9.0). Prevalence increased from 24.3 (95% CI 22.8-25.8) to 241.5 (95% CI 237.3-245.6) per 10<sup>5</sup> person years.</p><p><strong>Conclusion: </strong>Both incidence and prevalence of MS increased significantly. Incidence showed a sharp increase when entering the twenty-first century, after which it stabilized. Increasing incidence was likely related to incorporation of MRI in the diagnostic criteria. Current diagnostic criteria did not further increase the incidence.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251326173"},"PeriodicalIF":2.5,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuvro Roy, Janel Haughton, Dhanajay Vaidya, Scott D Newsome
{"title":"Implementation of a safety program initiative for monitoring infusion disease modifying therapies for multiple sclerosis.","authors":"Shuvro Roy, Janel Haughton, Dhanajay Vaidya, Scott D Newsome","doi":"10.1177/20552173251320791","DOIUrl":"10.1177/20552173251320791","url":null,"abstract":"<p><strong>Objective: </strong>To determine the efficacy of a safety program designed for monitoring infusion disease-modifying therapies (DMTs) prescribed for multiple sclerosis (MS).</p><p><strong>Background: </strong>Infusion-based high-efficacy DMTs represent a major advance in the treatment of MS. However, safe administration requires close monitoring. Non-adherence to safety monitoring can lead to DMT-related complications.</p><p><strong>Methods: </strong>A safety nurse navigator reviewed charts for infusion DMT patients from November 2020 to December 2022, and contacted them to address incomplete safety monitoring. Patients were screened for the primary outcome of incomplete safe infusion, including outdated safety labs, imaging, and/or recent follow-up with their neurologist. Logistic regression was performed for predictors of incomplete safety monitoring and of successful safety intervention.</p><p><strong>Results: </strong>Three hundred and forty-three patients were on infusible DMTs over the study time period: 75 natalizumab, 31 rituximab, and 237 ocrelizumab. Two hundred and eighty-six (83%) patients did not meet the criteria for safe infusion; 64% lacked safety labs, 47% prescriber follow-up, and 26% an MRI. The nurse succeeded in 82% of interactions. B-cell depletion was linked to outdated lab monitoring, whereas natalizumab use was associated with outdated appointments and imaging.</p><p><strong>Conclusions: </strong>This safety initiative identified gaps for managing infusion-based MS DMTs. Our safety nurse navigator successfully identified incomplete safety monitoring and intervened to avoid drug-related complications.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251320791"},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}