Multiple Sclerosis Journal - Experimental, Translational and Clinical最新文献

Fatigue in multiple sclerosis: A scoping review of pharmacological and nonpharmacological interventions.

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-02-13 eCollection Date: 2025-01-01 DOI: 10.1177/20552173241312527

Mateo Diaz-Quiroz, Paula Catalina Chicue-Cuervo, Luna Garcia-Moreno, Mariana Gaviria-Carrillo, Claudia Talero-Gutierrez, Ximena Palacios-Espinosa

{"title":"Fatigue in multiple sclerosis: A scoping review of pharmacological and nonpharmacological interventions.","authors":"Mateo Diaz-Quiroz, Paula Catalina Chicue-Cuervo, Luna Garcia-Moreno, Mariana Gaviria-Carrillo, Claudia Talero-Gutierrez, Ximena Palacios-Espinosa","doi":"10.1177/20552173241312527","DOIUrl":"10.1177/20552173241312527","url":null,"abstract":"Introduction: Fatigue is a highly prevalent symptom in people with multiple sclerosis. It demands careful assessment and prompt intervention to improve their quality of life and overall burden of disease. This scoping review aims to provide a comprehensive synthesis and update of the existing evidence on the effectiveness of different pharmacological and nonpharmacological interventions for multiple sclerosis (MS)-related fatigue.Methods: To ensure the transparency and quality of the articles chosen for this scoping review, the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols extension for Scoping Reviews was used. Exclusively randomized controlled trials published between 2016 and 2023 were included.Results: Twenty-eight articles were analyzed. We found that pharmacological interventions are few and have included the use of Amantadine, Ondansetron, Methylphenidate, and Modafinil, with little effects on fatigue. Nonpharmacological interventions are diverse and include cognitive behavioral therapy, guided imagery, phototherapy, exercise, brain stimulation, and lavender administration with evidence of a statistically significant decrease in fatigue.Conclusions and discussion: Current evidence on the effectiveness of pharmacological and nonpharmacological interventions is inconclusive. Lack of knowledge of the pathophysiology of fatigue limits its prevention, control, and management recommendations. A comprehensive and interdisciplinary approach is required to manage this symptom in patients with MS.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173241312527"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early comorbidities and diagnostic challenges in people with multiple sclerosis with possible impact on disease management.

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI: 10.1177/20552173251315458

Christine Makarov, Ewan Donnachie, Alexander Hapfelmeier, Bernhard Hemmer, Christiane Gasperi

{"title":"Early comorbidities and diagnostic challenges in people with multiple sclerosis with possible impact on disease management.","authors":"Christine Makarov, Ewan Donnachie, Alexander Hapfelmeier, Bernhard Hemmer, Christiane Gasperi","doi":"10.1177/20552173251315458","DOIUrl":"10.1177/20552173251315458","url":null,"abstract":"Background: Comorbidities in people with multiple sclerosis (PwMS) can affect disease course and quality of life.Objectives: To investigate comorbidities in the five years after diagnosis, timing of comorbidity occurrence, age and sex effects, and differences between multiple sclerosis (MS) and other chronic autoimmune diseases (AIDs).Methods: In this retrospective cohort study, we systematically assessed differences in diagnosis frequencies in newly diagnosed PwMS (n = 9,880) compared to matched controls (noAID, n = 29,640) and individuals with other AIDs (psoriasis, n = 29,640; Crohn's disease, n = 9,880).Results: Some comorbidities of PwMS are similarly frequent in other AIDs, while others, such as depression, are more prevalent in PwMS (odds ratio (OR) vs noAID = 2.03(1.94-2.13)). We found that personality disorders are more frequently recorded in PwMS before (OR = 1.34(1.21-1.49)) and after MS diagnosis (OR = 1.32(1.16-1.5)), especially in women (OR = 1.39(1.2-1.6)). PwMS are more frequently diagnosed with Lyme disease (OR = 1.98(1.69-2.33)), which was predominantly recorded by general practitioners after presentation with neurological symptoms. We observed lower acute tonsillitis frequencies in PwMS (OR = 0.8(0.75-0.85)).Conclusions: Our results suggest that PwMS might have a generally increased risk for specific personality disorders. More frequent Lyme disease recordings for PwMS suggest misdiagnoses of MS symptoms. Lower tonsillitis frequencies suggest a link between MS and protection from specific infections.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251315458"},"PeriodicalIF":2.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of the Swedish Multiple Sclerosis registry for pediatric-onset multiple sclerosis.

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-02-09 eCollection Date: 2025-01-01 DOI: 10.1177/20552173251314118

Fredrik Sandesjö, Peter Alping, Katharina Fink, Ronny Wickström, Fredrik Piehl, Thomas Frisell, Kyla A McKay

引用次数: 0

Disproportional smaller fornix with altered microstructure in pediatric multiple sclerosis shown by high-resolution fluid-suppressed diffusion tractography.

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI: 10.1177/20552173251315161

Carly Weber, Colin Wilbur, Gregg Blevins, Christian Beaulieu

{"title":"Disproportional smaller fornix with altered microstructure in pediatric multiple sclerosis shown by high-resolution fluid-suppressed diffusion tractography.","authors":"Carly Weber, Colin Wilbur, Gregg Blevins, Christian Beaulieu","doi":"10.1177/20552173251315161","DOIUrl":"10.1177/20552173251315161","url":null,"abstract":"Background: Diffusion tensor imaging (DTI) in adults with multiple sclerosis (MS) has identified marked volume and diffusion abnormalities of the fornix, the main white matter (WM) output tract of the hippocampus.Objective: To determine if the fornix is affected in pediatric-onset MS (POMS) using the same DTI protocols used in adult-onset MS (AOMS), which would suggest its early involvement in the disease course.Methods: High-resolution, fluid-suppressed diffusion tractography was used to identify the fornix in 11 POMS patients (13-19 years old) and 26 controls. Fornix volume and diffusion metrics were compared between groups and with other total/regional brain volumes, and then correlated with cognitive/clinical scores.Results: POMS showed lower fornix volumes (-26%) compared to controls, which was greater than proportional losses in total and other regional brain volumes. Notably, the hippocampus volume was not lower in POMS. DTI yielded lower fractional anisotropy (-7%) and higher mean (+12%), axial (+7%), and radial (+16%) diffusivities in POMS. There were no significant correlations between fornix volume/diffusion metrics and cognitive/clinical scores.Conclusion: Diffusion tractography showed marked injury to the fornix in POMS that precedes injury to connected gray matter such as hippocampus, implicating the fornix as an early brain region affected in MS.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173251315161"},"PeriodicalIF":2.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic challenges in SLIPPERS syndrome: Case report.

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI: 10.1177/20552173241312534

İbrahim Acır, Ahmetcan Sezen, Murat Serhat Aygün, Ayşe Altıntaş

{"title":"Diagnostic challenges in SLIPPERS syndrome: Case report.","authors":"İbrahim Acır, Ahmetcan Sezen, Murat Serhat Aygün, Ayşe Altıntaş","doi":"10.1177/20552173241312534","DOIUrl":"10.1177/20552173241312534","url":null,"abstract":"Background: SLIPPERS (Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids) is a rare variant of a syndrome called CLIPPERS (Chronic Lymphocytic Inflammation with Ponsine Perivascular Enhancement Responsive to Steroids). SLIPPERS is characterized by distinct supratentorial lesions that share radiological and pathological characteristics with CLIPPERS. The ongoing issue is whether these syndromes should be considered as a distinct disease entity or simply a form for a variety of underlying conditions such as granulomatosis, vasculitis, and infectious diseases.Case: We present a unique case of SLIPPERS observed in a 26-year-old woman with no notable medical or familial background. Laboratory findings ruled out certain diseases from the list of differentials and cranial MRI showed T2 hyperintense areas with linear-patchy enhancements, a pattern consistent with SLIPPERS syndrome. Consequently, patient was diagnosed with SLIPPERS syndrome and received methylprednisolone therapy.Conclusion: Both SLIPPERS and CLIPPERS are complicated syndromes posing diagnostic challenges and requiring careful investigation to avoid misdiagnosis. Following a thorough differential diagnosis, appropriate treatment can be initiated, and follow-up is required.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173241312534"},"PeriodicalIF":2.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with self-reported work ability among people with multiple sclerosis in Sweden. 瑞典多发性硬化症患者自我报告工作能力的相关因素

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.1177/20552173241304324

Fitsum Sebsibe Teni, Alejandra Machado, Jessica Dervish, Katharina Fink, Hanna Gyllensten, Emilie Friberg

{"title":"Factors associated with self-reported work ability among people with multiple sclerosis in Sweden.","authors":"Fitsum Sebsibe Teni, Alejandra Machado, Jessica Dervish, Katharina Fink, Hanna Gyllensten, Emilie Friberg","doi":"10.1177/20552173241304324","DOIUrl":"https://doi.org/10.1177/20552173241304324","url":null,"abstract":"Background: Work ability index (WAI) is an instrument that measures work ability in workplace surveys and health examinations in occupational health and research. It has been used in different population groups. But research is limited among people with multiple sclerosis (PwMS).Objective: To determine the factors associated with work ability among PwMS in Sweden.Methods: A total of 4103 PwMS who answered a web-based survey were included in the analysis. Work ability was assessed using the work ability score (WAS) component of WAI. Univariable and multivariable linear regression analyses were performed to assess the association of sociodemographic, clinical, and self-reported health variables with WAS.Results: Just over half of the PwMS reported good (37.0%) or excellent (16.3%) WAS. The overall mean WAS was 6.9 (standard deviation = 2.8). Health-related quality of life (R-squared = 31.6%), fatigue (28.3%), occupation (22.6%), and expanded disability status scale (EDSS) score (18.1%), explained the highest proportions of variation in WAS, individually. In the adjusted model, occupation, EDSS score, and fatigue had the strongest associations with WAS with significantly lower scores in those with no occupation, higher EDSS score, and severe fatigue levels.Conclusion: Work ability among PwMS was lower than in the general population in Sweden. Occupation, EDSS score and fatigue were among the most important factors associated with work ability.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 1","pages":"20552173241304324"},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sick leave in the prodromal phase of multiple sclerosis and its association with diagnostic delay: A short report. 多发性硬化症前驱期的病假及其与诊断延误的关系：一个简短的报告。

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2024-12-18 eCollection Date: 2024-10-01 DOI: 10.1177/20552173241305982

Alejandra Machado, Emma Pettersson, Kristina Alexanderson, Jan Hillert, Emilie Friberg

引用次数: 0

Barriers to clinical follow-up visits in multiple sclerosis: A nationwide register-based study. 多发性硬化症临床随访的障碍：一项全国性的基于登记的研究。

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2024-12-18 eCollection Date: 2024-10-01 DOI: 10.1177/20552173241307619

Agata Beczek, Eskild Morten Landt, Lars Kristian Storr, Malene Beck, Luigi Pontieri, Melinda Magyari, Morten Dahl

{"title":"Barriers to clinical follow-up visits in multiple sclerosis: A nationwide register-based study.","authors":"Agata Beczek, Eskild Morten Landt, Lars Kristian Storr, Malene Beck, Luigi Pontieri, Melinda Magyari, Morten Dahl","doi":"10.1177/20552173241307619","DOIUrl":"10.1177/20552173241307619","url":null,"abstract":"Background: In Denmark, specialized multiple sclerosis (MS) clinics offer free-of-charge treatment to people with MS. However, not all people with MS attend regular clinical follow-up.Objective: To identify people with MS who do not attend Danish MS clinics and identify barriers to treatment.Methods: The Danish Multiple Sclerosis Registry was linked to other national Danish registries with follow-up from 2000-2020. We used a time-dependent Cox regression to rank factors associated with low attendance to clinical follow-up visits based on the magnitude of hazard ratios (HRs).Results: We included 10,175 adults with MS, of which 3862 (38%) had less than one visit annually. The five top-ranked factors that reduced the risk of visits occurring included never having received diseases modifying treatment (HR: 0.48; 95%CI: 0.46-0.49), been diagnosed with MS before 2009 (0.79; 0.78-0.81), association with MS center in an outer region of Denmark (0.82; 0.80-0.84), having progressive MS type (0.88; 0.86-0.91) and not having received symptomatic treatment at diagnosis (0.91; 0.89-0.93).Conclusion: Our results highlight disease-specific and geographic inequalities in the management of people with MS in Denmark. Strategies to prevent this inequality, especially for people with progressive phenotypes and those who need supportive and non-medical treatment and care, should be implemented.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"10 4","pages":"20552173241307619"},"PeriodicalIF":2.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping cognitive dysfunction in relapsing multiple sclerosis with mild disability: A cross-sectional study from South India. 绘制伴有轻度残疾的复发性多发性硬化症患者的认知功能障碍图：南印度横断面研究

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2024-12-12 eCollection Date: 2024-10-01 DOI: 10.1177/20552173241304302

Sruthi S Nair, Jissa Vinodha Thulaseedharan, Neenumol Kandagathparambil Rajan, Elshal Bava, Gowthami Nair, Soumya Sundaram, Muralidharan Nair, Chandrasekharan Kesavadas, Ramshekhar N Menon

{"title":"Mapping cognitive dysfunction in relapsing multiple sclerosis with mild disability: A cross-sectional study from South India.","authors":"Sruthi S Nair, Jissa Vinodha Thulaseedharan, Neenumol Kandagathparambil Rajan, Elshal Bava, Gowthami Nair, Soumya Sundaram, Muralidharan Nair, Chandrasekharan Kesavadas, Ramshekhar N Menon","doi":"10.1177/20552173241304302","DOIUrl":"10.1177/20552173241304302","url":null,"abstract":"Background: Cognitive dysfunction in multiple sclerosis (MS) occurs early. Locally adapted neuropsychological data from India in MS is scarce.Objectives: We aimed to identify the pattern of cognitive impairment in relapsing MS (RMS) with mild disability using a regionally-adapted MS-specific cognitive battery.Methodology: The study included 59 persons with MS (pwMS) with expanded disability status scale (EDSS)≤ 4 and 62 controls. The battery had 8 neuropsychological tests (Paced Auditory Serial Addition Test [PASAT], Symbol Digit Modalities Test [SDMT], Rey Auditory Verbal Learning Test [RAVLT], Brief Visuospatial Memory Test-Revised [BVMT-R], verbal fluency [VF], Judgement of Line Orientation Test [JOLOT], Wisconsin Card Sorting Test [WCST] and Trail Making Test-B [TMT-B]) with 11 measures. The scores were compared between the groups for pattern and associations of cognitive impairment.Results: The pwMS cohort had 39 (66.1%) females; mean age of 32.56 (±8.17) years. Scores were significantly worse for pwMS in 10 of 11 tests (except JOLOT). Cohen's-d test showed the largest effect sizes for PASAT, SDMT, VF and TMT-B. Cognitive impairment (defined as ≥2 abnormal tests) were noted in 41 (69.5%) pwMS. Male sex was associated with cognitive impairment (p = 0.002).Conclusions: In pwMS with mild disability, nearly two-thirds had cognitive abnormalities, predominantly involving processing speed, working memory, executive function, and VF.","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"10 4","pages":"20552173241304302"},"PeriodicalIF":2.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting alpha-4 integrin with natalizumab for intermediate uveitis associated with multiple sclerosis. 靶向α -4整合素与natalizumab治疗多发性硬化相关的中度葡萄膜炎。

IF 2.5

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2024-12-10 eCollection Date: 2024-10-01 DOI: 10.1177/20552173241301034

Aicee Dawn Calma, Stephanie Young, Jennifer Sandbach, Sean Riminton, Stephen W Reddel, Sudarshini Ramanathan

引用次数: 0