Molecular Neuropsychiatry最新文献_第3页

Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. 具有各种抗焦虑、抗抑郁或促进认知特征的新型苯二氮卓类配体。

Molecular Neuropsychiatry Pub Date : 2019-04-01 DOI: 10.1159/000496086

Thomas D Prevot, Guanguan Li, Aleksandra Vidojevic, Keith A Misquitta, Corey Fee, Anja Santrac, Daniel E Knutson, Michael Rajesh Stephen, Revathi Kodali, Nicolas M Zahn, Leggy A Arnold, Petra Scholze, Janet L Fisher, Bojan D Marković, Mounira Banasr, James M Cook, Miroslav Savic, Etienne Sibille

{"title":"Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles.","authors":"Thomas D Prevot, Guanguan Li, Aleksandra Vidojevic, Keith A Misquitta, Corey Fee, Anja Santrac, Daniel E Knutson, Michael Rajesh Stephen, Revathi Kodali, Nicolas M Zahn, Leggy A Arnold, Petra Scholze, Janet L Fisher, Bojan D Marković, Mounira Banasr, James M Cook, Miroslav Savic, Etienne Sibille","doi":"10.1159/000496086","DOIUrl":"https://doi.org/10.1159/000496086","url":null,"abstract":"Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced function of GABA interneurons is associated with both mood and cognitive symptoms. Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting. Varying the profile of activity of BZs at GABAA-Rs is predicted to uncover additional therapeutic potential. We synthesized four novel imidazobenzodiazepine (IBZD) amide ligands and tested them for positive allosteric modulation at multiple α-GABAA-R (α-positive allosteric modulators), pharmacokinetic properties, as well as anxiolytic and antidepressant activities in adult mice. Efficacy at reversing stress-induced or age-related working memory deficits was assessed using a spontaneous alternation task. Diazepam (DZP) was used as a control. Three ligands (GL-II-73, GL-II-74, and GL-II-75) demonstrated adequate brain penetration and showed predictive anxiolytic and antidepressant efficacies. GL-II-73 and GL-II-75 significantly reversed stress-induced and age-related working memory deficits. In contrast, DZP displayed anxiolytic but no antidepressant effects or effects on working memory. We demonstrate distinct profiles of anxiolytic, antidepressant, and/or pro-cognitive activities of newly designed IBZD amide ligands, suggesting novel therapeutic potential for IBZD derivatives in depression and aging.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"5 2","pages":"84-97"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000496086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder. 精神分裂症风险基因SETD1A细胞敲低后的转录变化富集于与该疾病相关的常见变异。

Molecular Neuropsychiatry Pub Date : 2019-04-01 Epub Date: 2019-03-25 DOI: 10.1159/000497181

Darren Cameron, Derek J Blake, Nicholas J Bray, Matthew J Hill

{"title":"Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder.","authors":"Darren Cameron, Derek J Blake, Nicholas J Bray, Matthew J Hill","doi":"10.1159/000497181","DOIUrl":"https://doi.org/10.1159/000497181","url":null,"abstract":"Loss of function mutations in SETD1A are the first experiment-wide significant findings to emerge from exome sequencing studies of schizophrenia. Although SETD1A is known to encode a histone methyltransferase, the consequences of reduced S ETD1A activity on gene expression in neural cells have, to date, been unknown. To explore transcriptional changes through which genetic perturbation of SETD1A could confer risk for schizophrenia, we have performed genome-wide gene expression profiling of a commonly used human neuroblastoma cell line in which SETD1A expression has been experimentally reduced using RNA interference (RNAi). We identified 1,031 gene expression changes that were significant in two separate RNAi conditions compared with control, including effects on genes of known neurodevelopmental importance such as DCX and DLX5. Genes that were differentially expressed following SETD1A knockdown were enriched for annotation to metabolic pathways, peptidase regulator activity and integrin-mediated regulation of cell adhesion. Moreover, differentially expressed genes were enriched for common variant association with schizophrenia, suggesting a degree of molecular convergence between this rare schizophrenia risk factor and susceptibility variants for the disorder operating more generally.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":" ","pages":"109-114"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000497181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37329508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder. 精神分裂症和双相情感障碍中线粒体和核 DNA 之间的新型复杂相互作用。

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2019-02-05 DOI: 10.1159/000495658

Anton Schulmann, Euijung Ryu, Vanessa Goncalves, Brandi Rollins, Michael Christiansen, Mark A Frye, Joanna Biernacka, Marquis P Vawter

{"title":"Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder.","authors":"Anton Schulmann, Euijung Ryu, Vanessa Goncalves, Brandi Rollins, Michael Christiansen, Mark A Frye, Joanna Biernacka, Marquis P Vawter","doi":"10.1159/000495658","DOIUrl":"10.1159/000495658","url":null,"abstract":"Mitochondrial dysfunction has been associated with schizophrenia (SZ) and bipolar disorder (BD). This review examines recent publications and novel associations between mitochondrial genes and SZ and BD. Associations of nuclear-encoded mitochondrial variants with SZ were found using gene- and pathway-based approaches. Two control region mitochondrial DNA (mtDNA) SNPs, T16519C and T195C, both showed an association with SZ and BD. A review of 4 studies of A15218G located in the cytochrome B oxidase gene (CYTB, SZ = 11,311, control = 35,735) shows a moderate association with SZ (p = 2.15E-03). Another mtDNA allele A12308G was nominally associated with psychosis in BD type I subjects and SZ. The first published study testing the epistatic interaction between nuclear-encoded and mitochondria-encoded genes demonstrated evidence for potential interactions between mtDNA and the nuclear genome for BD. A similar analysis for the risk of SZ revealed significant joint effects (34 nuclear-mitochondria SNP pairs with joint effect p ≤ 5E-07) and significant enrichment of projection neurons. The mitochondria-encoded gene CYTB was found in both the epistatic interactions for SZ and BD and the single SNP association of SZ. Future efforts considering population stratification and polygenic risk scores will test the role of mitochondrial variants in psychiatric disorders.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"5 1","pages":"13-27"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465701/pdf/mnp-0005-0013.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress in Schizophrenia. 雄激素受体 CAG 三核苷酸重复长度和雷洛昔芬治疗与精神分裂症患者睾酮水平和感知压力的性别特异性关系

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2018-11-20 DOI: 10.1159/000495062

Samantha J Owens, Thomas W Weickert, Tertia D Purves-Tyson, Ellen Ji, Christopher White, Cherrie Galletly, Dennis Liu, Maryanne O'Donnell, Cynthia Shannon Weickert

{"title":"Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress in Schizophrenia.","authors":"Samantha J Owens, Thomas W Weickert, Tertia D Purves-Tyson, Ellen Ji, Christopher White, Cherrie Galletly, Dennis Liu, Maryanne O'Donnell, Cynthia Shannon Weickert","doi":"10.1159/000495062","DOIUrl":"10.1159/000495062","url":null,"abstract":"Lower testosterone levels are associated with greater negative symptoms in men with schizophrenia. Testosterone signals via androgen receptor (AR). A functional variant in the AR gene (CAG trinucleotide repeat polymorphism) is associated with circulating testosterone and mood-related symptoms in healthy people. Raloxifene increases testosterone in healthy males and reduces symptom severity and improves cognition in schizophrenia; however, whether raloxifene increases testosterone in men with schizophrenia is unknown. We assessed the interaction of a functional AR gene variant and adjunctive raloxifene on peripheral testosterone and symptom severity in schizophrenia. Patients with schizophrenia (59 males and 38 females) participated in a randomized, double-blind, placebo-controlled, crossover trial of adjunctive raloxifene (120 mg/day). Healthy adults (46 males and 41 females) were used for baseline comparison. Baseline circulating testosterone was decreased in male patients compared to male controls and positively correlated with CAG repeat length in male controls and female patients. Male patients with short, compared to long, CAG repeat length had higher stress scores. Raloxifene treatment increased testosterone in male patients, but was unrelated to AR CAG repeat length, suggesting that raloxifene's effects may not depend on AR activity. Sex-specific alterations of the relationship between AR CAG repeat length and testosterone suggest that altered AR activity may impact perceived stress in men with schizophrenia.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"5 1","pages":"28-41"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465742/pdf/mnp-0005-0028.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches. 精神分裂症的表观遗传因素:机制和实验方法。

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2019-02-15 DOI: 10.1159/000495063

Melanie Föcking, Benjamin Doyle, Nayla Munawar, Eugene T Dillon, David Cotter, Gerard Cagney

引用次数: 17

Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder. 自杀未遂及共病性物质使用障碍患者的脑基因表达模式

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2018-11-12 DOI: 10.1159/000493940

Brenda Cabrera, Nancy Monroy-Jaramillo, Gabriel Rodrigo Fries, Roberto Cuauhtemoc Mendoza-Morales, Fernando García-Dolores, Alejandra Mendoza-Larios, Carlos Diaz-Otañez, Consuelo Walss-Bass, David Colin Glahn, Patricia Ostrosky-Wegman, Cristobal Fresno, Humberto Nicolini

{"title":"Brain Gene Expression Pattern of Subjects with Completed Suicide and Comorbid Substance Use Disorder.","authors":"Brenda Cabrera, Nancy Monroy-Jaramillo, Gabriel Rodrigo Fries, Roberto Cuauhtemoc Mendoza-Morales, Fernando García-Dolores, Alejandra Mendoza-Larios, Carlos Diaz-Otañez, Consuelo Walss-Bass, David Colin Glahn, Patricia Ostrosky-Wegman, Cristobal Fresno, Humberto Nicolini","doi":"10.1159/000493940","DOIUrl":"https://doi.org/10.1159/000493940","url":null,"abstract":"Background/aim: Although individuals with substance use disorder (SUD) are at high risk of committing suicide, most studies of postmortem gene expression exclude subjects with SUD due to the potential confounding effect of drugs in the transcriptome. Thus, little is known about the gene expression profile in suicides with SUD. The identification of altered biological processes in suicides with SUD is crucial in the comprehension of the interaction between both pathologies.Methods: We evaluated the gene expression profile in the dorsolateral prefrontal area of suicides and nonsuicides with and without SUD by microarrays.Results: We identified 222 differentially expressed genes, predominately enriched in cell proliferation in the comparison between suicides with and without SUD. When comparing the transcriptome of suicides with SUD to nonsuicides with SUD, we identified 550 differentially expressed genes, mainly enriched in oxidative phosphorylation. Differentially expressed genes (1,417) between suicides and nonsuicides without SUD were detected. Most of them were related to mitochondrial function.Conclusion: Interaction between suicide and SUD seems to influence the expression of genes involved in glial proliferation and glutamatergic neurotransmission. These results highlight, for the first time, that suicides with SUD have a gene expression profile distinct from that of subjects with only one of these disorders.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"5 1","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000493940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

OMICS Approaches to Unravel the Complexity of Psychiatric Disorders: Impact on Biomarker Discovery. 揭示精神疾病复杂性的组学方法:对生物标志物发现的影响。

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2018-11-19 DOI: 10.1159/000495247

Daniel Martins-de-Souza

引用次数: 1

X-Aptamer Technology Identifies C4A and ApoB in Blood as Potential Markers for Schizophrenia. x -适体技术鉴定血液中的C4A和ApoB是精神分裂症的潜在标志物。

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2018-10-10 DOI: 10.1159/000492331

Consuelo Walss-Bass, Ganesh L R Lokesh, Elena Dyukova, David G Gorenstein, David L Roberts, Dawn Velligan, David E Volk

{"title":"X-Aptamer Technology Identifies C4A and ApoB in Blood as Potential Markers for Schizophrenia.","authors":"Consuelo Walss-Bass, Ganesh L R Lokesh, Elena Dyukova, David G Gorenstein, David L Roberts, Dawn Velligan, David E Volk","doi":"10.1159/000492331","DOIUrl":"https://doi.org/10.1159/000492331","url":null,"abstract":"The field of proteomics is rapidly gaining territory as a promising alternative to genomic approaches in the efforts to unravel the complex molecular mechanisms underlying schizophrenia and other psychiatric disorders. X-aptamer tech-nology has emerged as a novel proteomic approach for high-sensitivity analyses, and we hypothesized that this technology would identify unique molecular signatures in plasma samples from schizophrenia patients (n = 60) compared to controls (n = 20). Using a combinatorial library of X-aptamer beads, we developed a two-color flow cytometer-based approach to identify specific X-aptamers that bound with high specificity to each target group. Based on this, we synthesized two unique X-aptamer sequences, and specific proteins pulled down from the patient and control groups by these X-aptamers were identified by mass spectrometry. We identified two protein biomarkers, complement component C4A and ApoB, upregulated in plasma samples from schizophrenia patients. ELISA validation suggested that the observed differences in C4 levels in patients are likely due to the presence of the illness itself, while ApoB may be a marker of antipsychotic-induced alterations. These studies highlight the utility of the X-aptamer technology in the identification of biomarkers for schizophrenia that will advance our understanding of the pathophysiological mechanisms of this disorder.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"5 1","pages":"52-59"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000492331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice. 氯胺酮对小鼠谷氨酸能和gaba能系统的影响:蛋白质组学和代谢组学研究。

Molecular Neuropsychiatry Pub Date : 2019-03-01 Epub Date: 2018-11-15 DOI: 10.1159/000493425

Katja Weckmann, Michael J Deery, Julie A Howard, Renata Feret, John M Asara, Frederik Dethloff, Michaela D Filiou, Christiana Labermaier, Giuseppina Maccarrone, Kathryn S Lilley, Marianne Mueller, Christoph W Turck

{"title":"Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice.","authors":"Katja Weckmann, Michael J Deery, Julie A Howard, Renata Feret, John M Asara, Frederik Dethloff, Michaela D Filiou, Christiana Labermaier, Giuseppina Maccarrone, Kathryn S Lilley, Marianne Mueller, Christoph W Turck","doi":"10.1159/000493425","DOIUrl":"https://doi.org/10.1159/000493425","url":null,"abstract":"Ketamine, a noncompetitive, voltage-dependent N-Methyl-D-aspartate receptor (NMDAR) antagonist, has been shown to have a rapid antidepressant effect and is used for patients experiencing treatment-resistant depression. We carried out a time-dependent targeted mass spectrometry-based metabolomics profiling analysis combined with a quantitative based on in vivo 15N metabolic labeling proteome comparison of ketamine- and vehicle-treated mice. The metabolomics and proteomics datasets were used to further elucidate ketamine's mode of action on the gamma-aminobutyric acid (GABA)ergic and glutamatergic systems. In addition, myelin basic protein levels were analyzed by Western Blot. We found altered GABA, glutamate and glutamine metabolite levels and ratios as well as increased levels of putrescine and serine - 2 positive modulators of the NMDAR. In addition, GABA receptor (GABAR) protein levels were reduced, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) subunit Gria2 protein levels were increased upon ketamine treatment. The significantly altered metabolite and protein levels further significantly correlated with the antidepressant-like behavior, which was assessed using the forced swim test. In conclusion and in line with previous research, our data indicate that ketamine impacts the AMPAR subunit Gria2 and results in decreased GABAergic inhibitory neurotransmission leading to increased excitatory neuronal activity.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"5 1","pages":"42-51"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000493425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Exercise Reduces Salivary Morning Cortisol Levels in Patients with Depression. 运动可降低抑郁症患者早晨唾液皮质醇水平。

Molecular Neuropsychiatry Pub Date : 2019-02-01 Epub Date: 2018-12-19 DOI: 10.1159/000494699

Md Shafiqur Rahman, Xuan Zhao, Jia Jia Liu, Enid Quintana Torres, Babylonia Tibert, Parvin Kumar, Viktor Kaldo, Nils Lindefors, Yvonne Forsell, Catharina Lavebratt

{"title":"Exercise Reduces Salivary Morning Cortisol Levels in Patients with Depression.","authors":"Md Shafiqur Rahman, Xuan Zhao, Jia Jia Liu, Enid Quintana Torres, Babylonia Tibert, Parvin Kumar, Viktor Kaldo, Nils Lindefors, Yvonne Forsell, Catharina Lavebratt","doi":"10.1159/000494699","DOIUrl":"https://doi.org/10.1159/000494699","url":null,"abstract":"Purpose of the study: Cortisol hypersecretion plays a role in depression pathophysiology. Internet-based cognitive behavioural therapy (ICBT) and physical exercise (PE) are new treatment alternatives for depression, and their long-lasting effect on cortisol is unknown. We investigated cortisol level changes after 12 weeks of ICBT, PE or treatment as usual (TAU).Procedures: The present pre-post repeated measure study analysed data derived from a randomised controlled trial evaluating the effects of 12 weeks' interventions of ICBT, PE and TAU in depressed primary care patients (Sweden 2011-2013) and aimed at prospectively evaluating the within-group effects of ICBT, PE and TAU on diurnal salivary cortisol levels in a small representative subsample (n = 56, 38 and 27, respectively).Results: We found a marked flattening of the diurnal cortisol slope (p = 0.004) and a reduced cortisol level at awakening (p = 0.017) after 12 weeks of PE treatment. No apparent effects of ICBT or TAU interventions were seen on diurnal cortisol levels.Conclusions and message: PE reduced the rate of cortisol level decline across the day in depressed adults. ICBT and TAU treatments had no detectable effects on diurnal cortisol levels. Larger samples are required for the detection and comparison of smaller effects of PE, ICBT and TAU on diurnal cortisol levels.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":" ","pages":"196-203"},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000494699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37008444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5