Molecular Neuropsychiatry最新文献_第10页

Front & Back Matter 正面和背面

Molecular Neuropsychiatry Pub Date : 2016-10-01 DOI: 10.1159/000452644

Q. Nguyen, E. Rodrigues, M. Farah, W. Mieler, D. Do, O. Michielin, G. Coukos, G. Coscas, J. Cunha-Vaz, A. Loewenstein, G. Soubrane, K. Priftis, M. Anthracopoulos, D. Mathalon, T. Petryshen, M. Picciotto

引用次数: 0

Familial Influences on Mismatch Negativity and Its Association with Plasma Glutamate Level: A Magnetoencephalographic Study in Twins 错配阴性的家族影响及其与血浆谷氨酸水平的关系:双胞胎脑磁图研究

Molecular Neuropsychiatry Pub Date : 2016-09-20 DOI: 10.1159/000449426

Y. Nishimura, Y. Kawakubo, M. Suga, K. Hashimoto, Y. Takei, K. Takei, H. Inoue, M. Yumoto, R. Takizawa, K. Kasai

{"title":"Familial Influences on Mismatch Negativity and Its Association with Plasma Glutamate Level: A Magnetoencephalographic Study in Twins","authors":"Y. Nishimura, Y. Kawakubo, M. Suga, K. Hashimoto, Y. Takei, K. Takei, H. Inoue, M. Yumoto, R. Takizawa, K. Kasai","doi":"10.1159/000449426","DOIUrl":"https://doi.org/10.1159/000449426","url":null,"abstract":"Mismatch negativity (MMN) or its magnetic counterpart (magnetic mismatch negativity; MMNm) is regarded as a promising biomarker for schizophrenia. Previous electroencephalographic studies of MMN have demonstrated a moderate-to-high heritability for MMN amplitudes. N-methyl-D-aspartate receptor-dependent glutamatergic neurotransmission is implicated in MMN generation. We hypothesized that the differences between identical twins in MMNm variables might be associated with differences in plasma levels of amino acids involved in glutamatergic neurotransmission. Thirty-three pairs of monozygotic (MZ) and 10 pairs of dizygotic (DZ) twins underwent MMNm recording. The MMNm in response to tone duration changes, tone frequency changes, and phonemic changes was recorded using 204-channel magnetoencephalography. Of these, 26 MZ and 7 DZ twin pairs underwent blood sampling for determination of plasma amino acid levels. MMNm peak strength showed relatively high correlations in both MZ and DZ twin pairs. The differences in MMNm latencies tended to correlate with the differences in plasma amino acid levels within MZ pairs, while no significant correlation was observed after the Bonferroni correction. We observed a familial trait in MMNm strength. The differences in MMN latency in MZ twins might be influenced by changes in glutamate levels and glutamate-glutamine cycling; however, the results need to be replicated.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"19 1","pages":"161 - 172"},"PeriodicalIF":0.0,"publicationDate":"2016-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89981890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic Disorders 精神障碍中催产素受体(OXTR)甲基化与认知

Molecular Neuropsychiatry Pub Date : 2016-08-13 DOI: 10.1159/000448173

Tyler B. Grove, K. Burghardt, A. Kraal, Ryan J. Dougherty, S. Taylor, V. Ellingrod

引用次数: 14

A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree 一种罕见的CACNA1D变异与7例双相I型障碍的大谱系分离

Molecular Neuropsychiatry Pub Date : 2016-08-02 DOI: 10.1159/000448041

Jessica Ross, Erika Gedvilaite, J. Badner, C. Erdman, L. Baird, N. Matsunami, M. Leppert, Jinchuan Xing, W. Byerley

{"title":"A Rare Variant in CACNA1D Segregates with 7 Bipolar I Disorder Cases in a Large Pedigree","authors":"Jessica Ross, Erika Gedvilaite, J. Badner, C. Erdman, L. Baird, N. Matsunami, M. Leppert, Jinchuan Xing, W. Byerley","doi":"10.1159/000448041","DOIUrl":"https://doi.org/10.1159/000448041","url":null,"abstract":"Whole-genome sequencing was performed on 3 bipolar I disorder (BPI) cases from a multiplex pedigree of European ancestry with 7 BPI cases. Within CACNA1D, a gene implicated by genome-wide association studies, a G to C nucleotide transversion at 53,835,340 base pairs (bps) was found predicting the substitution of proline for alanine at amino acid position 1751 (A1751P). Using Sanger sequencing, the DNA variant was shown to co-segregate with the remaining 4 BPI cases within the pedigree. A high-resolution DNA denaturing curve method was then used to screen for the presence of the A1751P change in 4,150 BPI cases from the NIMH Genetics Initiative. The A1751P variant was found in 4 BPI cases. A second variant within exon 43, a C to T nucleotide transition, was found in 1 case at 53,835,355 bps, predicting the substitution of tryptophan for arginine at amino acid position 1771 (R1771W). In the NHLBI Exome Sequencing Project database, the heterozygous A1751P variant was present in 3 of 4,300 subjects of European ancestry, and the R1771W change was not present in any subject. Given the rarity of these variants, large-scale case/control rare variant sequencing studies will be required for definitive conclusions.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"23 1","pages":"145 - 150"},"PeriodicalIF":0.0,"publicationDate":"2016-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80039414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation 在一个小家族中，NPAS3突变与精神分裂症分离导致蛋白质聚集

Molecular Neuropsychiatry Pub Date : 2016-07-27 DOI: 10.1159/000447358

L. Nucifora, Yee‐Wen Candace Wu, Brian J. Lee, L. Sha, R. Margolis, C. Ross, A. Sawa, F. C. Nucifora Jr

{"title":"A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation","authors":"L. Nucifora, Yee‐Wen Candace Wu, Brian J. Lee, L. Sha, R. Margolis, C. Ross, A. Sawa, F. C. Nucifora Jr","doi":"10.1159/000447358","DOIUrl":"https://doi.org/10.1159/000447358","url":null,"abstract":"Schizophrenia and other major mental illnesses result from a complex interplay of genetic and environmental factors. We previously identified a mutation in NPAS3 that results in a valine to isoleucine (V304I) amino acid substitution segregating with schizophrenia in a small family. The amino acid change occurs in a potentially critical region for protein function. Furthermore, the same amino acid substitution in proteins related to familial Alzheimer's disease and transthyretin amyloidosis has been associated with protein aggregation. In this study, we demonstrate that NPAS3 is prone to aggregation, and that the V304I mutation in NPAS3 increases this propensity in both bacterial and mammalian expression systems. We also show that NPAS3-V304I reduces soluble endogenous NPAS3, and increases insoluble endogenous NPAS3 and leads to alteration of transcriptional activity. These results suggest that protein aggregation, potentially leading to cell dysfunction via a loss of protein function through sequestration, may contribute to the pathogenesis of schizophrenia and other forms of mental illness. Further exploration of the mechanisms leading to abnormal protein quality control could lead to new therapeutic targets.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"23 1","pages":"133 - 144"},"PeriodicalIF":0.0,"publicationDate":"2016-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82173890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Dopamine D2L Receptor Is Required for Visual Discrimination and Reversal Learning 多巴胺D2L受体是视觉辨别和逆向学习所必需的

Molecular Neuropsychiatry Pub Date : 2016-07-21 DOI: 10.1159/000447970

M. Morita, Yanyan Wang, T. Sasaoka, Kinya Okada, M. Niwa, A. Sawa, T. Hikida

引用次数: 12

Genetics of Common Antipsychotic-Induced Adverse Effects. 常见抗精神病药物引起的不良反应的遗传学。

Molecular Neuropsychiatry Pub Date : 2016-07-01 Epub Date: 2016-05-20 DOI: 10.1159/000445802

Raymond R MacNeil, Daniel J Müller

{"title":"Genetics of Common Antipsychotic-Induced Adverse Effects.","authors":"Raymond R MacNeil, Daniel J Müller","doi":"10.1159/000445802","DOIUrl":"https://doi.org/10.1159/000445802","url":null,"abstract":"The effectiveness of antipsychotic drugs is limited due to accompanying adverse effects which can pose considerable health risks and lead to patient noncompliance. Pharmacogenetics (PGx) offers a means to identify genetic biomarkers that can predict individual susceptibility to antipsychotic-induced adverse effects (AAEs), thereby improving clinical outcomes. We reviewed the literature on the PGx of common AAEs from 2010 to 2015, placing emphasis on findings that have been independently replicated and which have additionally been listed to be of interest by PGx expert panels. Gene-drug associations meeting these criteria primarily pertain to metabolic dysregulation, extrapyramidal symptoms (EPS), and tardive dyskinesia (TD). Regarding metabolic dysregulation, results have reaffirmed HTR2C as a strong candidate with potential clinical utility, while MC4R and OGFR1 gene loci have emerged as new and promising biomarkers for the prediction of weight gain. As for EPS and TD, additional evidence has accumulated in support of an association with CYP2D6 metabolizer status. Furthermore, HSPG2 and DPP6 have been identified as candidate genes with the potential to predict differential susceptibility to TD. Overall, considerable progress has been made within the field of psychiatric PGx, with inroads toward the development of clinical tools that can mitigate AAEs. Going forward, studies placing a greater emphasis on multilocus effects will need to be conducted. ","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"2 2","pages":"61-78"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000445802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34371975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Front & Back Matter 正面和背面

Molecular Neuropsychiatry Pub Date : 2016-07-01 DOI: 10.1159/000448202

引用次数: 0

Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report. 白细胞端粒长度预测重度抑郁症的SSRI反应:初步报告。

Molecular Neuropsychiatry Pub Date : 2016-07-01 Epub Date: 2016-06-22 DOI: 10.1159/000446500

Christina M Hough, F Saverio Bersani, Synthia H Mellon, Elissa S Epel, Victor I Reus, Daniel Lindqvist, Jue Lin, Laura Mahan, Rebecca Rosser, Heather Burke, John Coetzee, J Craig Nelson, Elizabeth H Blackburn, Owen M Wolkowitz

{"title":"Leukocyte telomere length predicts SSRI response in major depressive disorder: A preliminary report.","authors":"Christina M Hough, F Saverio Bersani, Synthia H Mellon, Elissa S Epel, Victor I Reus, Daniel Lindqvist, Jue Lin, Laura Mahan, Rebecca Rosser, Heather Burke, John Coetzee, J Craig Nelson, Elizabeth H Blackburn, Owen M Wolkowitz","doi":"10.1159/000446500","DOIUrl":"https://doi.org/10.1159/000446500","url":null,"abstract":"Short leukocyte telomere length (LTL) may be associated with several psychiatric disorders, including major depressive disorder (MDD). Short LTL has previously been associated with poor response to psychiatric medications in bipolar disorder and schizophrenia, but no studies have prospectively assessed the relationship of LTL to SSRI response in MDD. We assessed pre-treatment LTL, depression severity (using the Hamilton Depression Rating Scale [HDRS]), and self-reported positive and negative affect in 27 healthy, unmedicated adults with MDD. Subjects then underwent open-label treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant for eight weeks, after which clinical ratings were repeated. Analyses were corrected for age, sex and BMI. \"Non-responders\" to treatment (HDRS improvement <50%) had significantly shorter pre-treatment LTL, compared to \"Responders\" (p=0.037). Further, shorter pre-treatment LTL was associated with less improvement in negative affect (p<0.010) but not with changes in positive affect (p=0.356). This preliminary study is the first to assess the relationship between LTL and SSRI response in MDD and among the first to prospectively assess its relationship to treatment outcome in any psychiatric illness. Our data suggest that short LTL may serve as a vulnerability index of poorer response to SSRI treatment, but this needs examination in larger samples.","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"2 2","pages":"88-96"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446500","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34581646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder. 患者成纤维细胞代谢物的扰动谱暗示α-氨基己二酸是双相情感障碍的潜在生物标志物。

Molecular Neuropsychiatry Pub Date : 2016-07-01 Epub Date: 2016-06-24 DOI: 10.1159/000446654

Joanne H Huang, Shaunna S Berkovitch, Jonathan Iaconelli, Bradley Watmuff, Hyoungjun Park, Shrikanta Chattopadhyay, Donna McPhie, Dost Öngür, Bruce M Cohen, Clary B Clish, Rakesh Karmacharya

{"title":"Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.","authors":"Joanne H Huang, Shaunna S Berkovitch, Jonathan Iaconelli, Bradley Watmuff, Hyoungjun Park, Shrikanta Chattopadhyay, Donna McPhie, Dost Öngür, Bruce M Cohen, Clary B Clish, Rakesh Karmacharya","doi":"10.1159/000446654","DOIUrl":"https://doi.org/10.1159/000446654","url":null,"abstract":"Many studies suggest the presence of aberrations in cellular metabolism in bipolar disorder. We studied the metabolome in bipolar disorder to gain insight into cellular pathways that may be dysregulated in bipolar disorder and to discover evidence of novel biomarkers. We measured polar and nonpolar metabolites in fibroblasts from subjects with bipolar I disorder and matched healthy control subjects, under normal conditions and with two physiologic perturbations: low-glucose media and exposure to the stress-mediating hormone dexamethasone. Metabolites that were significantly different between bipolar and control subjects showed distinct separation by principal components analysis methods. The most statistically significant findings were observed in the perturbation experiments. The metabolite with the lowest p value in both the low-glucose and dexamethasone experiments was α-aminoadipate, whose intracellular level was consistently lower in bipolar subjects. Our study implicates α-aminoadipate as a possible biomarker in bipolar disorder that manifests under cellular stress. This is an intriguing finding given the known role of α-aminoadipate in the modulation of kynurenic acid in the brain, especially as abnormal kynurenic acid levels have been implicated in bipolar disorder. ","PeriodicalId":18957,"journal":{"name":"Molecular Neuropsychiatry","volume":"2 2","pages":"97-106"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446654","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34371977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10