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Answer to Photoquiz A polyposis syndrome. 照片测试A息肉病综合征的答案。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-12-01
R J L F Loffeld, K van der Hem, I Ambrose
{"title":"Answer to Photoquiz A polyposis syndrome.","authors":"R J L F Loffeld, K van der Hem, I Ambrose","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to Photoquiz A fascinating liver abscess. 一个迷人的肝脓肿。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-12-01
C A J van Beers, A-J van Tienhoven, C Stijnis, J Veenstra
{"title":"Answer to Photoquiz A fascinating liver abscess.","authors":"C A J van Beers, A-J van Tienhoven, C Stijnis, J Veenstra","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipegfilgrastim for prophylaxis of chemotherapy-induced neutropenia in Dutch patients. 利非格昔汀预防荷兰患者化疗引起的中性粒细胞减少症。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
J N H Timmer-Bonte, J Ouwerkerk, L M Faber, L G M Kerkhofs, L Laterveer, D Ten Oever, B P van Rees, P W van der Linden
{"title":"Lipegfilgrastim for prophylaxis of chemotherapy-induced neutropenia in Dutch patients.","authors":"J N H Timmer-Bonte,&nbsp;J Ouwerkerk,&nbsp;L M Faber,&nbsp;L G M Kerkhofs,&nbsp;L Laterveer,&nbsp;D Ten Oever,&nbsp;B P van Rees,&nbsp;P W van der Linden","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy (CT)-induced neutropenia and febrile neutropenia (FN) can lead to changes in the treatment plan, potentially worsening the cancer outcome. This study evaluated the effect of the glycopegylated granulocyte-colony stimulating factor lipegfilgrastim, used as primary (PP) or secondary prophylaxis (SP), on treatment modifications in adult patients receiving cytotoxic CT with or without biological/targeted therapy (BT) for solid and haematological tumours.</p><p><strong>Methods: </strong>This phase 4, prospective, observational study was conducted in eight centres in the Netherlands, in 2015-2017. Other study objectives were to characterise the population of cancer patients receiving lipegfilgrastim, to evaluate the incidence of CT-induced neutropenic events, and to assess safety.</p><p><strong>Results: </strong>Of 142 patients, 73.94% had breast cancer and 55.63% received CT in the adjuvant setting. Most patients received lipegfilgrastim as PP (74.65%) and were at low (34.51%) or high risk (39.44%) of FN. CT dose delays were recorded for 22.64% and 36.11% of patients receiving lipegfilgrastim for PP and SP, respectively. CT dose reductions were recorded for 2.11% of patients; no CT dose omissions and one BT dose omission occurred. FN and grade III/IV neutropenia were reported for 5.63% and 9.86% of patients, respectively; associated hospitalisations were rare. The most frequently lipegfilgrastimrelated adverse events (AE) were myalgia, bone pain, and back pain. Serious AEs (55) were reported for 30 (21.13%) patients. There were two deaths, unrelated to lipegfilgrastim administration.</p><p><strong>Conclusion: </strong>Administration of lipegfilgrastim in routine clinical practice in the Netherlands results in limited CT/BT dose modifications and low incidence of neutropenic events, with no new safety concerns.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to Photo Quiz Septicaemia and liver abscesses after a skin ulcer in the tropics. 热带地区皮肤溃疡后的败血症和肝脓肿。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
D A R Castelijn, S G Vreden, C R C Doorenbos, J Kropff
{"title":"Answer to Photo Quiz Septicaemia and liver abscesses after a skin ulcer in the tropics.","authors":"D A R Castelijn,&nbsp;S G Vreden,&nbsp;C R C Doorenbos,&nbsp;J Kropff","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of strategic differences for internal medicine care in Dutch Emergency Departments. 荷兰急诊科的内科护理战略差异概述。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
S S Guillen
{"title":"An overview of strategic differences for internal medicine care in Dutch Emergency Departments.","authors":"S S Guillen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38519202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined antihypertensive treatment is better than mono-therapy in hypertensive patients. 高血压患者联合降压治疗优于单药治疗。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
O Kurtkulagi, G Aktas, S Bilgin, B Meryem Atak, T Taslamacioglu Duman, M Emin Demirkol
{"title":"Combined antihypertensive treatment is better than mono-therapy in hypertensive patients.","authors":"O Kurtkulagi,&nbsp;G Aktas,&nbsp;S Bilgin,&nbsp;B Meryem Atak,&nbsp;T Taslamacioglu Duman,&nbsp;M Emin Demirkol","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HT) is a chronic condition associated with serious complications. In the present cross-sectional study, we aimed to analyse factors that contribute to blood pressure control in subjects with HT.</p><p><strong>Methods: </strong>Subjects with HT admitted to outpatient internal medicine clinics of the institution were enrolled in the study. According to the Joint National Committee (JNC) VIII criteria, subjects with a mean blood pressure above target levels were defined as poorly-controlled hypertensive patients and others were grouped as well-controlled hypertensive patients. Clinical and laboratory parameters were compared between study groups.</p><p><strong>Results: </strong>Smokers were more prevalent in the poorly-controlled HT group compared to the well-controlled HT group (p = 0.001). The number of patients who adhered to dietary and exercise recommendations were greater in well-controlled HT group than poorly-controlled HT group (p < 0.001 for both). The rate of combined therapy was greater in well-controlled HT group compared to poorly-controlled HT group (p = 0.04).</p><p><strong>Conclusions: </strong>We suggest that, in addition to dietary and exercise recommendations and smoking cessation, treatment with combination therapy could be better in reaching blood pressure targets in patients with HT.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38519204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous remission of unidentified Cushing's disease revealed by hair cortisol analysis. 毛发皮质醇分析揭示不明库欣病的自发缓解。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
E van Boven, E T Massolt, E F C van Rossum, R M Kiewiet-Kemper
{"title":"Spontaneous remission of unidentified Cushing's disease revealed by hair cortisol analysis.","authors":"E van Boven,&nbsp;E T Massolt,&nbsp;E F C van Rossum,&nbsp;R M Kiewiet-Kemper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pituitary apoplexy is an infrequent but life-threatening complication of pituitary adenomas. When apoplexy occurs in a hormonally active adenoma, this may induce spontaneous remission of the clinical syndrome. In these cases, clinical suspicion of Cushing's disease or acromegaly may arise at presentation, but due to spontaneous remission of active hormone production, it is not possible to biochemically confirm this diagnosis in retrospect. Resolution of clinical symptoms during follow up retrospectively suggests the diagnosis. However, we describe a patient with Cushing's disease presenting with pituitary apoplexy, who was biochemically in remission at presentation. The diagnosis could be confirmed in retrospect using hair cortisol analysis, thereby enabling clinicians to adequately anticipate remission of Cushing's disease.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLH caused by an HSV-2 infection: a case report and review of the literature. 由HSV-2感染引起的HLH:一例报告和文献综述。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
E M Jongbloed, M A W Hermans, M Wabbijn, J J A van Kampen, J A M van Laar
{"title":"HLH caused by an HSV-2 infection: a case report and review of the literature.","authors":"E M Jongbloed,&nbsp;M A W Hermans,&nbsp;M Wabbijn,&nbsp;J J A van Kampen,&nbsp;J A M van Laar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Haemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory condition that can be triggered by infections, malignancies, or auto-immune diseases. Here, we present a patient with rapidly progressive HLH triggered by a herpes simplex virus type 2 (HSV-2) primary infection. The patient was successfully treated with intravenous high-dose acyclovir, immunoglobulins, and dexamethasone. This is the first report of HSV-2-associated HLH in an immunocompetent adult patient.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to Photo Quiz An unexpected infectious disease in wintertime. 冬季一种意想不到的传染病。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
V J Ruijters, H Visser, B P X Grady
{"title":"Answer to Photo Quiz An unexpected infectious disease in wintertime.","authors":"V J Ruijters,&nbsp;H Visser,&nbsp;B P X Grady","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients. 基质金属蛋白酶MMP-2、MMP-9及其抑制剂TIMP-1、TIMP-2在系统性红斑狼疮患者中的表达
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
H J Vira, V D Pradhan, V D Umare, A K Chaudhary, A G Rajadhyksha, M Y Nadkar, K Ghosh, A H Nadkarni
{"title":"Expression of the matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in systemic lupus erythematosus patients.","authors":"H J Vira,&nbsp;V D Pradhan,&nbsp;V D Umare,&nbsp;A K Chaudhary,&nbsp;A G Rajadhyksha,&nbsp;M Y Nadkar,&nbsp;K Ghosh,&nbsp;A H Nadkarni","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The study aimed to look at alterations in expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) and their potential use as biomarkers in the pathogensis of SLE.</p><p><strong>Methods: </strong>SLE patients (n = 41) and healthy controls (n = 50) were recruited. Quantitative RT-PCR/ELISA assays were performed for expression of MMP and TIMP mRNA in whole blood and PBMC; and corresponding serum protein levels. Intracellular levels of MMP-2 and MMP-9 proteins were analysed by flow cytometry.</p><p><strong>Results: </strong>Based on SLEDAI scores patients were grouped into active (SLEDAI ≥ 10) and inactive cases (SLEDAI < 10). In active cases, MMP-2 expression significantly increased and TIMP-2 expression was decreased (p < 0.0001) both at serum secretion (p = 0.0003) and mRNA (p < 0.0001) levels as compared to inactive cases. MMP-9 and TIMP-1 showed significantly reduced serum secretion and mRNA expression (p < 0.0001) in active cases as compared to inactive cases. Intracellular concentration of MMP-9 was reported to be higher in neutrophils, while MMP-2 was mainly found in lymphocytes of SLE patients as compared to controls. MMP/TIMP ratio profile was altered as SLE disease progresses.</p><p><strong>Interpretation & conclusions: </strong>Findings suggest disturbed MMP and TIMP levels have a role in the pathogenesis of SLE.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38519209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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