{"title":"An overview of structural genomics.","authors":"S K Burley","doi":"10.1038/80697","DOIUrl":"https://doi.org/10.1038/80697","url":null,"abstract":"<p><p>With access to sequences of entire human genomes plus those of various model organisms and many important microbial pathogens, structural biology is on the verge of a dramatic transformation. Our newfound wealth of sequence information will serve as the foundation for an important initiative in structural genomics. We are poised to embark on a systematic program of high-throughput X-ray crystallography and NMR spectroscopy aimed at developing a comprehensive view of the protein structure universe. Structural genomics will yield a large number of experimental protein structures (tens of thousands) and an even larger number of calculated comparative protein structure models (millions). This enormous body of structural data will be freely available, and promises to accelerate scientific discovery in all areas of biological science, including biodiversity and evolution in natural ecosystems, agricultural plant genetics, breeding of farm and domestic animals, and human health and disease.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"932-4"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Sánchez, U Pieper, F Melo, N Eswar, M A Martí-Renom, M S Madhusudhan, N Mirković, A Sali
{"title":"Protein structure modeling for structural genomics.","authors":"R Sánchez, U Pieper, F Melo, N Eswar, M A Martí-Renom, M S Madhusudhan, N Mirković, A Sali","doi":"10.1038/80776","DOIUrl":"https://doi.org/10.1038/80776","url":null,"abstract":"<p><p>The shapes of most protein sequences will be modeled based on their similarity to experimentally determined protein structures. The current role, limitations, challenges and prospects for protein structure modeling (using information about genes and genomes) are discussed in the context of structural genomics.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"986-90"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80776","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21927418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural genomics in North America.","authors":"T C Terwilliger","doi":"10.1038/80700","DOIUrl":"https://doi.org/10.1038/80700","url":null,"abstract":"<p><p>Structural genomics in North America has moved remarkably quickly from ideas to pilot projects. Just three years ago, the field was only a concept, independently being discussed by its many inventors. Now it is already a well-organized, increasingly-funded, consortium-based effort to determine protein structures on a large scale.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"935-9"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural genomics in Europe: slow start, strong finish?","authors":"U Heinemann","doi":"10.1038/80707","DOIUrl":"https://doi.org/10.1038/80707","url":null,"abstract":"<p><p>Structural genomics in Europe is slowly coming off the ground. So far, European Commission funding is restricted to methods development projects, whereas structural genomics programs are funded from national sources. The research outlook is more toward techniques for high-throughput structure analysis than toward a systematic coverage of protein fold space. At present, there is little European coordination of the structural genomics effort.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"940-2"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80707","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H M Berman, T N Bhat, P E Bourne, Z Feng, G Gilliland, H Weissig, J Westbrook
{"title":"The Protein Data Bank and the challenge of structural genomics.","authors":"H M Berman, T N Bhat, P E Bourne, Z Feng, G Gilliland, H Weissig, J Westbrook","doi":"10.1038/80734","DOIUrl":"https://doi.org/10.1038/80734","url":null,"abstract":"<p><p>The PDB has created systems for the processing, exchange, query, and distribution of data that will enable many aspects of high throughput structural genomics.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"957-9"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80734","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J M Thornton, A E Todd, D Milburn, N Borkakoti, C A Orengo
{"title":"From structure to function: approaches and limitations.","authors":"J M Thornton, A E Todd, D Milburn, N Borkakoti, C A Orengo","doi":"10.1038/80784","DOIUrl":"https://doi.org/10.1038/80784","url":null,"abstract":"<p><p>This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"991-4"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80784","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21927419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural genomics for science and society.","authors":"W G Hol","doi":"10.1038/80744","DOIUrl":"https://doi.org/10.1038/80744","url":null,"abstract":"<p><p>The field of robotics is affecting structural biology, enabling the era of structural genomics. The potential impact on protein fold prediction, biology, protein engineering and medicine is immense. Unraveling mysteries in the protein structure universe will require a dedicated effort for decades to come with computational toxicology as possibly a century long challenge.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"964-6"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G T Montelione, D Zheng, Y J Huang, K C Gunsalus, T Szyperski
{"title":"Protein NMR spectroscopy in structural genomics.","authors":"G T Montelione, D Zheng, Y J Huang, K C Gunsalus, T Szyperski","doi":"10.1038/80768","DOIUrl":"https://doi.org/10.1038/80768","url":null,"abstract":"<p><p>Protein NMR spectroscopy provides an important complement to X-ray crystallography for structural genomics, both for determining three-dimensional protein structures and in characterizing their biochemical and biophysical functions.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"982-5"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80768","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New roles for structure in biology and drug discovery.","authors":"R B Russell, D S Eggleston","doi":"10.1038/80691","DOIUrl":"https://doi.org/10.1038/80691","url":null,"abstract":"","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"928-30"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural genomics programs at the US National Institute of General Medical Sciences.","authors":"J C Norvell, A Z Machalek","doi":"10.1038/80694","DOIUrl":"https://doi.org/10.1038/80694","url":null,"abstract":"","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"931"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80694","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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