{"title":"Hardware and software","authors":"S. Murata, H. Kurokawa","doi":"10.1007/978-4-431-54055-7_9","DOIUrl":"https://doi.org/10.1007/978-4-431-54055-7_9","url":null,"abstract":"","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"13 1","pages":"250-251"},"PeriodicalIF":0.0,"publicationDate":"2020-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90945407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural aspects of protein synthesis","authors":"A. Liljas, S. Al-Karadaghi","doi":"10.1107/S0907444906023766","DOIUrl":"https://doi.org/10.1107/S0907444906023766","url":null,"abstract":"This comprehensive and highly illustrated book provides a basic and up-to-date summary of translation on bacterial ribosomes, with emphasis on the structural insights. It is an attempt to present the ribosome and its functional activities in a coherent manner. Two types of illustrations are used to describe the translation field: simplified black-and-white illustrations to depict aspects of translation and color plates to give correct structural representations. The book presents essentially all aspects of the translation system, focusing on the relation between structure and function. Upper level undergraduates and graduate students with an interest in protein synthesis will find this lecture notes volume invaluable. The book is also an essential source of information for researchers who want to get an overview of translation.","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"6 1","pages":"767-771"},"PeriodicalIF":0.0,"publicationDate":"2004-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84828749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Starting off right","authors":"Elizabeth Lightfoot, V. Pappas, Jeffrey L. Chait","doi":"10.1177/10442073030140010201","DOIUrl":"https://doi.org/10.1177/10442073030140010201","url":null,"abstract":"This article presents a case study of how a state disability agency, committed to consumer participation in policy making, adapted a meeting strategy called Open Space Technology (OST) for use in policy making. The authors first describe how OST was adapted and used to allow for front-end citizen participation at town meetings. They then present the results of a document analysis to show the effectiveness of the technique: There was a great range of citizen input; the input was reflected in the state plan, and nearly 90% of the plan reflected the issues generated at the town meetings. The authors argue that OST is a promising technique for more effective involvement of citizens in the public policy process.","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"33 1","pages":"847-847"},"PeriodicalIF":0.0,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81969378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Valle, A. Zavialov, Wen Li, S. Stagg, J. Sengupta, R. C. Nielsen, P. Nissen, S. Harvey, M. Ehrenberg, J. Frank
{"title":"Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy","authors":"M. Valle, A. Zavialov, Wen Li, S. Stagg, J. Sengupta, R. C. Nielsen, P. Nissen, S. Harvey, M. Ehrenberg, J. Frank","doi":"10.1142/9789813234864_0033","DOIUrl":"https://doi.org/10.1142/9789813234864_0033","url":null,"abstract":"","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"10 1","pages":"1074-1074"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90697159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural genomics of RNA.","authors":"J A Doudna","doi":"10.1038/80729","DOIUrl":"https://doi.org/10.1038/80729","url":null,"abstract":"<p><p>A detailed understanding of the functions and interactions of biological macromolecules requires knowledge of their molecular structures. Structural genomics, the systematic determination of all macromolecular structures represented in a genome, is focused at present exclusively on proteins. It is clear, however, that RNA molecules play a variety of significant roles in cells, including protein synthesis and targeting, many forms of RNA processing and splicing, RNA editing and modification, and chromosome end maintenance. To comprehensively understand the biology of a cell, it will ultimately be necessary to know the identity of all encoded RNAs, the molecules with which they interact and the molecular structures of these complexes. This report focuses on the feasibility of structural genomics of RNA, approaches to determining RNA structures and the potential usefulness of an RNA structural database for both predicting folds and deciphering biological functions of RNA molecules.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"954-6"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrative database analysis in structural genomics.","authors":"M Gerstein","doi":"10.1038/80739","DOIUrl":"https://doi.org/10.1038/80739","url":null,"abstract":"<p><p>An important aspect of structural genomics is connecting coordinate data with whole-genome information related to phylogenetic occurrence, protein function, gene expression, and protein-protein interactions. Integrative database analysis allows one to survey the 'finite parts list' of protein folds from many perspectives, highlighting certain folds and structural features that stand out in particular ways.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"960-3"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Automation of X-ray crystallography.","authors":"E Abola, P Kuhn, T Earnest, R C Stevens","doi":"10.1038/80754","DOIUrl":"https://doi.org/10.1038/80754","url":null,"abstract":"<p><p>Structure-based biological discovery is entering a new era with the development of industrialized macromolecular structure determination pipelines. Intense, highly focused X-rays from integrated synchrotron radiation beam lines combined with significant advances in protein expression, purification, and micro-crystallization automation allow for the full streamlining of the traditionally tedious and time consuming process of determining the three dimensional structures of macromolecules.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"973-7"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural genomics in the biotechnology sector.","authors":"S Dry, S McCarthy, T Harris","doi":"10.1038/80718","DOIUrl":"https://doi.org/10.1038/80718","url":null,"abstract":"<p><p>Commercial efforts in structural genomics focus on providing to pharmaceutical customers information that relates to the suitability of specific proteins as drug targets and the informed selection and refinement of lead compounds generated by high-throughput screening and rational approaches. These efforts follow a variety of business models and are impacted by activities in the public domain, recent technological advances, and the changing intellectual property landscape.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"946-9"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Creating a structural genomics consortium.","authors":"A R Williamson","doi":"10.1038/80726","DOIUrl":"https://doi.org/10.1038/80726","url":null,"abstract":"<p><p>A group of multinational companies, together with the Wellcome Trust, is attempting to form a charitable organization, the Structural Genomics Consortium. The goal will be to obtain X-ray structures for a broad representation across families of human proteins and to place the structural coordinates in the public database.</p>","PeriodicalId":18848,"journal":{"name":"Nature Structural Biology","volume":"7 Suppl ","pages":"953"},"PeriodicalIF":0.0,"publicationDate":"2000-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/80726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21928162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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