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New antibiotic for urinary tract infections nabs FDA approval 治疗尿路感染的新抗生素获FDA批准
Nature Reviews Drug Discovery Pub Date : 2025-03-31 DOI: 10.1038/d41573-025-00064-4
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引用次数: 0
Publisher Correction: Fibrosis: cross-organ biology and pathways to development of innovative drugs 出版商更正：纤维化：跨器官生物学和创新药物开发途径
Nature Reviews Drug Discovery Pub Date : 2025-03-31 DOI: 10.1038/s41573-025-01190-9
Florian Rieder, Laura E. Nagy, Toby M. Maher, Jörg H. W. Distler, Rafael Kramann, Boris Hinz, Marco Prunotto
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引用次数: 0
Non-incretin peptide curbs appetite 非肠促胰岛素肽抑制食欲
Nature Reviews Drug Discovery Pub Date : 2025-03-28 DOI: 10.1038/d41573-025-00062-6
{"title":"Non-incretin peptide curbs appetite","authors":"","doi":"10.1038/d41573-025-00062-6","DOIUrl":"https://doi.org/10.1038/d41573-025-00062-6","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two routes to tamp down microglia in traumatic brain injury 两种途径抑制创伤性脑损伤中的小胶质细胞
Nature Reviews Drug Discovery Pub Date : 2025-03-26 DOI: 10.1038/d41573-025-00060-8
{"title":"Two routes to tamp down microglia in traumatic brain injury","authors":"","doi":"10.1038/d41573-025-00060-8","DOIUrl":"https://doi.org/10.1038/d41573-025-00060-8","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards an oral norovirus vaccine 研制口服诺如病毒疫苗
Nature Reviews Drug Discovery Pub Date : 2025-03-25 DOI: 10.1038/d41573-025-00058-2
{"title":"Towards an oral norovirus vaccine","authors":"","doi":"10.1038/d41573-025-00058-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00058-2","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blocking ceramide signalling alleviates atherosclerosis 阻断神经酰胺信号可缓解动脉粥样硬化
Nature Reviews Drug Discovery Pub Date : 2025-03-25 DOI: 10.1038/d41573-025-00057-3
{"title":"Blocking ceramide signalling alleviates atherosclerosis","authors":"","doi":"10.1038/d41573-025-00057-3","DOIUrl":"https://doi.org/10.1038/d41573-025-00057-3","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying novel antibiotic targets 鉴定新的抗生素靶点
Nature Reviews Drug Discovery Pub Date : 2025-03-25 DOI: 10.1038/d41573-025-00059-1
{"title":"Identifying novel antibiotic targets","authors":"","doi":"10.1038/d41573-025-00059-1","DOIUrl":"https://doi.org/10.1038/d41573-025-00059-1","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small-molecule hypoxia therapy 小分子缺氧疗法
Nature Reviews Drug Discovery Pub Date : 2025-03-25 DOI: 10.1038/d41573-025-00056-4
{"title":"Small-molecule hypoxia therapy","authors":"","doi":"10.1038/d41573-025-00056-4","DOIUrl":"https://doi.org/10.1038/d41573-025-00056-4","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New approach methodologies: EU regulatory horizons 新方法方法论：欧盟监管视野
Nature Reviews Drug Discovery Pub Date : 2025-03-24 DOI: 10.1038/d41573-025-00053-7
Mariana Edwards, Oriane Blanquie, Orla Moriarty, Sonja Beken, Falk Ehmann
{"title":"New approach methodologies: EU regulatory horizons","authors":"Mariana Edwards, Oriane Blanquie, Orla Moriarty, Sonja Beken, Falk Ehmann","doi":"10.1038/d41573-025-00053-7","DOIUrl":"https://doi.org/10.1038/d41573-025-00053-7","url":null,"abstract":"New approach methodologies (NAMs) have the potential to progressively transform medicines development by reducing reliance on animal testing while increasing the relevance of nonclinical data to patients. However, achieving regulatory acceptance of NAMs demands enhanced collaboration, clear guidance and continuous, science-based adaptation of the regulatory environment to accommodate emerging innovation.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabinoid targets hidden pocket for safer pain relief 大麻素目标隐藏口袋更安全的疼痛缓解
Nature Reviews Drug Discovery Pub Date : 2025-03-24 DOI: 10.1038/d41573-025-00055-5
{"title":"Cannabinoid targets hidden pocket for safer pain relief","authors":"","doi":"10.1038/d41573-025-00055-5","DOIUrl":"https://doi.org/10.1038/d41573-025-00055-5","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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