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Nature Reviews Drug Discovery最新文献

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Towards a universal snake antivenom 走向一种通用的抗蛇毒血清
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00092-0
{"title":"Towards a universal snake antivenom","authors":"","doi":"10.1038/d41573-025-00092-0","DOIUrl":"https://doi.org/10.1038/d41573-025-00092-0","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolonging the antidepressant effects of ketamine 延长氯胺酮的抗抑郁作用
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00094-y
{"title":"Prolonging the antidepressant effects of ketamine","authors":"","doi":"10.1038/d41573-025-00094-y","DOIUrl":"https://doi.org/10.1038/d41573-025-00094-y","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blocking a cell surface protein beats AML 阻断细胞表面蛋白可以治疗AML
Nature Reviews Drug Discovery Pub Date : 2025-06-02 DOI: 10.1038/d41573-025-00095-x
{"title":"Blocking a cell surface protein beats AML","authors":"","doi":"10.1038/d41573-025-00095-x","DOIUrl":"https://doi.org/10.1038/d41573-025-00095-x","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new drug target for NRAS(Q61) mutant-expressing cancers 表达NRAS（Q61）突变的癌症的新药物靶点
Nature Reviews Drug Discovery Pub Date : 2025-05-29 DOI: 10.1038/d41573-025-00091-1
{"title":"A new drug target for NRAS(Q61) mutant-expressing cancers","authors":"","doi":"10.1038/d41573-025-00091-1","DOIUrl":"https://doi.org/10.1038/d41573-025-00091-1","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: GLP-1-based therapies for diabetes, obesity and beyond 作者更正：glp -1为基础的治疗糖尿病，肥胖和其他疾病
Nature Reviews Drug Discovery Pub Date : 2025-05-28 DOI: 10.1038/s41573-025-01231-3
Daniel J. Drucker
{"title":"Author Correction: GLP-1-based therapies for diabetes, obesity and beyond","authors":"Daniel J. Drucker","doi":"10.1038/s41573-025-01231-3","DOIUrl":"https://doi.org/10.1038/s41573-025-01231-3","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Drug Discovery</i> https://doi.org/10.1038/s41573-025-01183-8, published online 25 April 2025.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triggering ferroptosis in drug-tolerant cancer cells 引发耐药癌细胞铁下垂
Nature Reviews Drug Discovery Pub Date : 2025-05-27 DOI: 10.1038/d41573-025-00090-2
{"title":"Triggering ferroptosis in drug-tolerant cancer cells","authors":"","doi":"10.1038/d41573-025-00090-2","DOIUrl":"https://doi.org/10.1038/d41573-025-00090-2","url":null,"abstract":"Discover the world’s best science and medicine | Nature.com","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Medicines Initiative public–private partnerships to enhance translational safety 创新药物倡议公私伙伴关系，加强转化安全
Nature Reviews Drug Discovery Pub Date : 2025-05-22 DOI: 10.1038/d41573-025-00080-4
Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche, Jonathan Moggs, Shashi K. Ramaiah, Jacques Richard, Gunnar Schütz, Nathalie Seigneuret, Thomas Steger-Hartmann, Elisabetta Vaudano
{"title":"Innovative Medicines Initiative public–private partnerships to enhance translational safety","authors":"Salah-Dine Chibout, Dominique Brees, Magda Chlebus, Philippe Detilleux, Loic Laplanche, Jonathan Moggs, Shashi K. Ramaiah, Jacques Richard, Gunnar Schütz, Nathalie Seigneuret, Thomas Steger-Hartmann, Elisabetta Vaudano","doi":"10.1038/d41573-025-00080-4","DOIUrl":"https://doi.org/10.1038/d41573-025-00080-4","url":null,"abstract":"Innovative Medicines Initiative projects focused on translational safety have developed a range of tools to improve preclinical assessments of potential drug toxicities, and demonstrated the value of integrating data from multiple companies.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amylin takes another shot at the obesity prize Amylin再次向肥胖奖发起挑战
Nature Reviews Drug Discovery Pub Date : 2025-05-20 DOI: 10.1038/d41573-025-00088-w
{"title":"Amylin takes another shot at the obesity prize","authors":"","doi":"10.1038/d41573-025-00088-w","DOIUrl":"https://doi.org/10.1038/d41573-025-00088-w","url":null,"abstract":"Drug developers are re-advancing amylin analogues for obesity, two decades since the FDA approved the first of these hormone mimetics for diabetes.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is the FDA’s plan to phase out animal toxicity testing realistic? FDA淘汰动物毒性测试的计划现实吗？
Nature Reviews Drug Discovery Pub Date : 2025-05-15 DOI: 10.1038/d41573-025-00087-x
{"title":"Is the FDA’s plan to phase out animal toxicity testing realistic?","authors":"","doi":"10.1038/d41573-025-00087-x","DOIUrl":"https://doi.org/10.1038/d41573-025-00087-x","url":null,"abstract":"Lorna Ewart, Chief Scientific Officer at Emulate, discusses the new opportunities and remaining challenges facing organs on chips.","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting neutrophils for cancer therapy 靶向中性粒细胞用于癌症治疗
Nature Reviews Drug Discovery Pub Date : 2025-05-15 DOI: 10.1038/s41573-025-01210-8
Jeff W. Kwak, A. McGarry Houghton
{"title":"Targeting neutrophils for cancer therapy","authors":"Jeff W. Kwak, A. McGarry Houghton","doi":"10.1038/s41573-025-01210-8","DOIUrl":"https://doi.org/10.1038/s41573-025-01210-8","url":null,"abstract":"<p>Neutrophils are among the most abundant immune cell types in the tumour microenvironment and have been associated with poor outcomes across multiple cancer types. Yet despite mounting evidence of their role in tumour progression, therapeutic strategies targeting neutrophils have only recently gained attention and remain limited in scope. This is probably due to the increasing number of distinct neutrophil subtypes identified in cancer and the limited understanding of the mechanisms by which these subsets influence tumour progression and immune evasion. In this Review, we discuss the spectrum of neutrophil subtypes — including those with antitumour activity — and their potential to polarize towards tumour-suppressive phenotypes. We explore the molecular pathways and effector functions by which neutrophils modulate cancer progression, with an emphasis on identifying tractable therapeutic targets. Finally, we examine emerging clinical trials aimed at modulating neutrophil lineages and consider their implications for patient outcomes.</p>","PeriodicalId":18847,"journal":{"name":"Nature Reviews Drug Discovery","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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