NATIONAL JOURNAL OF NEUROLOGY最新文献

{"title":"HUNTINGTON'S DISEASE. CLINICAL CASE","authors":"R. Shiraliyeva, A. K. Mammadbayli, U. A. Asadova","doi":"10.61788/njn.v1i23.11","DOIUrl":"https://doi.org/10.61788/njn.v1i23.11","url":null,"abstract":"Huntington's disease is a neurodegenerative disease that affects basal ganglia in the white matter of the nervous system, tailed nucleus, thalamus, black substance, limbic system, cerebral cortex, cerebellum, manifested by autosome-dominant drive. In patients with early debut, the clinical course is more severe than in the classical form. In the absence of proper symptomatic treatment, neurological signs become more severe and sharply expressive.","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE RELATIONSHIP OF TIME PERCEPTION WITH WORKING MEMORY IN PATIENTS WITH MULTIPLE SCLEROSIS","authors":"E.E. Deveci, O. Saraydar, S. Aksu, G. Kutlu","doi":"10.61788/njn.v1i23.15","DOIUrl":"https://doi.org/10.61788/njn.v1i23.15","url":null,"abstract":"Objectives. Multiple Sclerosis (MS) is a chronic disease characterized by neuroinflammation of the central nervous system leading to progressive demyelination, loss of axons, and neurodegeneration. Meta-analyses have shown a cognitive impairment with a moderate effect size between healthy volunteers and MS patients, most apparently in working memory (WM), attention, and processing speed. It has recently been found that the perception of time has also been impaired in MS patients. This study aims to examine the relationship between WM and time perception in individuals with MS. Methods. Letter Number Sequencing Test (LNST), Time Interval Estimation Test, and Time Interval Production Test (TIPT) were administered to 50 MS patients. Individuals were allocated into low and high WM groups according to the median value of the LNST total score to compare time perception performance. Results. The mean age of the sample was 39.2. In the sample consisting of 14 male and 36 female participants, the mean number of educated years was 10.7 years, the age of disease onset was 31.9 years, and the duration of the disease was 7.2 years. A correlation was found between TIPT Ratio for 4 seconds and WM as well as disease severity. 29 people were in the low WM group and 21 people were in the high WM group. Age, age of disease onset, and the number of educated years were found to be higher in the high WM group. The TIPT Ratio for 4 seconds was lower in the high WM group. Conclusion. Consistent with the literature, a relationship was found between WM and time perception in individuals with MS in the 4 seconds, in which WM is considered to have a crucial role. The production of a 4- second interval was considered to be used as a marker reflecting both disease severity and WM capacity.","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METHODOLOGICAL BASIS FOR STUDYING THE MEDICOSOCIAL CONSEQUENCES OF THE FEMALE REPRODUCTIVE SYSTEM ON THE BACKGROUND OF MULTIPLE SCLEROSIS","authors":"N.A. Hamidova","doi":"10.61788/njn.v1i23.24","DOIUrl":"https://doi.org/10.61788/njn.v1i23.24","url":null,"abstract":"","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REGIONAL FEATURES OF THE MORBIDITY RATE OF CEREBRAL PALSY DEPENDING ON AGE AND GENDER","authors":"I.E. Hajiyeva, A. K. Mammadbayli","doi":"10.61788/njn.v1i23.04","DOIUrl":"https://doi.org/10.61788/njn.v1i23.04","url":null,"abstract":"The aim of the study: to assess age-gender characteristics of morbidity rate of cerebral palsy among children in regions of the Republic of Azerbaijan. Materials and methods. Materials of Cerebral Palsy Register created by us. The prevalence (per 100 children) of pathology at different ages (up to 5 years, 5 years and older) among girls and boys in all regions and cities of Azerbaijan was determined. Statistical processing was conducted by the method of qualitative signs. Results. The prevalence of cerebral palsy was 0.27±0.005% among boys, 0.17±0.004 among girls (р<0.001). The index was higher among children aged 0-5 years (0.68±0.01%) than among children aged 5-18 years (0.06±0.001%). These indicators were different in cities and regions of the republic. Conclusions. A relatively high morbidity rate of cerebral palsy is typical for the cities Baku, Sumgayit, Mingachevir and Shirvan, also for regions Absheron, Barda, etc. Cerebral palsy is seen among boys 1.5 times more often. This feature is more pronounced especially in separate districts (1.7 times).","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROMYELITIS OPTICA. CASE REPORT","authors":"A. K. Mammadbayli, Sh.N. Mehtiyeva, S.C. Ismayilova","doi":"10.61788/njn.v1i23.22","DOIUrl":"https://doi.org/10.61788/njn.v1i23.22","url":null,"abstract":"Introduction. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease that causes severe demyelination, especially in the optic nerve and spinal cord with typical clinical manifestations of acute optic neuritis and transverse myelitis. The frequency of occurrence worldwide is estimated at 1-2 people out of every 100,000 people. Case report. Our patient was a 37-year-old woman. She felt a sudden vision loss since May 2022. She related this condition to another case of unknown etiology that she encountered in January of that year - numerous vesicular-type rashes appeared on the abdomen and back and lasted for 3 days, but the traces of those rashes remained for some time in the form of hypopigmentation. In November 2022, she has a sudden vision loss again. \"Vitiligo-type\" white spots were visible around the eyes and on the hands. In neurological examination: eyeball movements are complete in all directions, photoreaction is preserved (D=S), nose-lip folds are symmetrical (D=S), tongue is on the midline, swallowing is not disturbed. Muscle tone and muscle strength in upper and lower limbs are normal, reflexes have increased (D=S). No changes in gait and sensory disturbances have been observed. The functions of the pelvic organs have not been disturbed. Intellect appears appropriate for age, speech has not changed. Ophthalmologist's examination, both eyes have high degree of myopia, myopic astigmatism. Contrasted Cranial MRI- Angiography revealed increased signal in the intracranial segments of the bilateral optic nerve, chiasm, and bilateral optic tract level. The MRI image was initially evaluated in favor of bilateral optic neuritis. USG of the thyroid gland showed sonographic changes in favor of Hashimoto's thyroiditis, and autoimmune thyroiditis was detected. In chest MRI, a demyelinating lesion of 3 mm at C4 level, a 2 mm broad-based protrusion at C4-5 disc that minimally compresses the spinal cord, an annular swelling at C5-6 disc that compresses the anterior subarachnoid area, Th1 – 6 mm, Th5 – 12 mm, Th9 – 10-38 mm long demyelinating lesions were seen. Discussion. According to the available literature, the detection of AQP-4 protein antibodies in serum, which has a role in the pathogenesis of the disease, can play a decisive role in differential diagnosis. In clinical practice, despite the phenotypic and serological characteristics of this disease, the diagnosis is often difficult. Because there are various autoimmune, infectious and neoplastic etiologies phenotypic, manifestations of diseases can mimic neuromyelitis optica. However, based on the clinical symptoms and the results of instrumental examinations, our patient was diagnosed with neuromyelitis optica. She was treated with hormonal therapy and plasmapheresis, and a significant positive change in neurological symptoms was observed. Conclusion. Despite the difficulties in the differential diagnosis of neuromyelitis optica with other demyelinating diseases, especially wit","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LATERAL AMYOTROPHIC SCLEROSIS IN THE PRACTICE OF A CARDIOLOGIST","authors":"E. V. Khorolets, S.V. Shlyk","doi":"10.61788/njn.v1i23.10","DOIUrl":"https://doi.org/10.61788/njn.v1i23.10","url":null,"abstract":"Comorbid pathology affects the course and outcome of the disease. The observation of a patient after acute myocardial infarction with the development of amyotrophic lateral sclerosis is a special case. The progression of neurological symptoms in amyotrophic lateral sclerosis leads to decompensation of respiratory and heart failure and an unfavorable outcome of the disease.","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SPINAL SURGERY: HISTORICAL ASPECTS AND CONTEMPORARY APPROACHES IN THE TREATMENT OF DEGENERATIVE DISORDERS","authors":"A.M. Furman, O.M. Komarov, M.V. Khyzhnyak, I.J. Garayev","doi":"10.61788/njn.v1i23.03","DOIUrl":"https://doi.org/10.61788/njn.v1i23.03","url":null,"abstract":"The issue of treating discogenic neurocompression syndromes remains highly relevant in modern medicine due to the variability in clinical manifestations and the lack of a unified approach to its treatment. Lumbar microdiscectomy remains the standard treatment for intervertebral disc herniations in the lumbar spine. The primary goal of surgical treatment for degenerative disorders is to achieve complete decompression of neural structures with minimal surgical trauma. The widespread adoption of advanced minimally invasive endoscopic techniques for intervertebral disc herniations has significantly reduced the number of disabled individuals worldwide, thus addressing the societal challenges associated with this condition. This literature review is dedicated to the development and evolution of endoscopic technologies, transitioning from open surgical interventions to percutaneous endoscopic procedures.","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYELOPROLIFERATIVE DISEASES AS A CAUSE OF ACUTE CEREBROVASCULAR ACCIDENT","authors":"Y. Shatokhin, I. Snezhko, E. V. Ryabikina, E. V. Degtereva","doi":"10.61788/njn.v1i23.13","DOIUrl":"https://doi.org/10.61788/njn.v1i23.13","url":null,"abstract":"Among the hemorheological forms of thrombophilia, chronic myeloproliferative diseases (CMPD) play an important role: polycythemia vera, essential thrombocythemia, primary myelofibrosis, the complications of which are arterial and venous thrombosis, including acute cerebrovascular accident (ACV). Identification of changes in the hemogram in such patients requires a thorough examination to exclude CMPD: monitoring of hemogram parameters in dynamics, hemostasiological examination, and determination of the level of erythropoietin, spleen size, and molecular-genetic study. Patients with chronic MPD and stroke need to start cytoreductive therapy (α-interferons, hydroxyurea) in a timely manner, conduct active long-term antithrombotic treatment (anticoagulants, antiplatelet agents) in order to prevent thromboembolism and improve the prognosis of the disease.","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"367 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROFIBROMATOSIS TYPE 1. CLINICAL CASE","authors":"R. Shiraliyeva, A. K. Mammadbayli, U. A. Asadova","doi":"10.61788/njn.v1i23.08","DOIUrl":"https://doi.org/10.61788/njn.v1i23.08","url":null,"abstract":"The relevance of the topic covered in the article is related to the fact that doctors have little knowledge about this nosology. For this reason, a timely and incorrect diagnosis can result in wrong treatment, reduce the patient's quality of life and even lead to death. The diagnosis of the patient we investigated was determined according to the clinical criteria developed by the National Institute of Health of the United States. If genetic examination is not performed, the established diagnosis can be considered justified. It is imperative that several medical professionals (neurologist, traumatologist, ophthalmologist, surgeon, pediatrician, gynecologist, etc.) are aware of a disease like neurofibromatosis (NF). Basing on the clinical criteria developed by the US National Institutes of Health provides favorable conditions for diagnosing patients.","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DYNAMIC MONITORING OF MULTIMODAL EVOKED POTENTIALS IN PATIENTS WITH MULTIPLE SCLEROSIS AND OPTIC NEURITIS AT ONSET","authors":"R. Shiraliyeva, N.A. Nasrullayeva","doi":"10.61788/njn.v1i23.26","DOIUrl":"https://doi.org/10.61788/njn.v1i23.26","url":null,"abstract":"","PeriodicalId":18831,"journal":{"name":"NATIONAL JOURNAL OF NEUROLOGY","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139353754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}