National Journal of Maxillofacial Surgery最新文献

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An innovative technique for nasotracheal fiberoptic intubation using SNPA and its comparison with conventional technique: RCT. 使用SNPA进行鼻气管纤维插管的创新技术及其与传统技术的比较:RCT。
National Journal of Maxillofacial Surgery Pub Date : 2023-01-01 Epub Date: 2023-04-14 DOI: 10.4103/njms.njms_120_22
Kavita Meena, Rajesh Kumar Meena, Deepak Palanisamy, Deepesh, Aditya Prakash Nayak
{"title":"An innovative technique for nasotracheal fiberoptic intubation using SNPA and its comparison with conventional technique: RCT.","authors":"Kavita Meena,&nbsp;Rajesh Kumar Meena,&nbsp;Deepak Palanisamy,&nbsp;Deepesh,&nbsp;Aditya Prakash Nayak","doi":"10.4103/njms.njms_120_22","DOIUrl":"10.4103/njms.njms_120_22","url":null,"abstract":"ABSTRACT Background: Awake nasotracheal fiberoptic intubation by conventional technique is time consuming and requires expertise. Complications encountered in the conventional technique sometime leads to procedure failure. Objective: The primary aim of this study was to compare the innovative technique using split nasopharyngeal airway (SNPA) with the conventional technique for nasotracheal fiberoptic intubation in terms of time taken for intubation. Method: This was a prospective, randomized, and single blind study conducted with 80 patients who were scheduled for maxillofacial surgery. Patients were randomized into two groups, group CFBI (conventional fiberoptic intubation) and group SNPA (split nasopharyngeal airway). In both the groups patients were prepared for awake fiberoptic naso-tracheal intubation. In Group CFBI (N = 41) awake naso-tracheal intubation was achieved by conventional technique of bronchoscope first approach. In Group SNPA (N = 39) spirally split nasopharyngeal airway was used first as a conduit for the passage of fiberoptic bronchoscope. The primary objective was to assess the time taken for intubation. The secondary objectives were to assess the rate of complications in the form of bleeding, cough, desaturation during the procedure, laryngospasm, and nasal bleeding. Result: The time taken for intubation was 6.15 ± 3.0 minutes in CFBI group and 3.10 ± 1.35 minutes in SNPA group and this this difference was statically significant with P value <0.001. Desaturation during the procedure was more in CFBI (99.46 ± 0.75) compared to SNPA (99 ± 0) group with significant difference P value <0.001. Conclusion: Split nasopharyngeal airway was used as conduit for the passage for the flexible fibreoptic bronchoscope and it considerably reduced the time required for fiberoptic nasotracheal intubation compared to the conventional technique of endotracheal tube first approach. Split nasopharyngeal airway provided better intubating conditions with lesser complications and superior patient comfort.","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"14 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ac/51/NJMS-14-41.PMC10235747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9950364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tapia syndrome following TMJ gap arthroplasty: A case report and review of literature 颞下颌关节间隙置换术后Tapia综合征1例报告及文献复习
National Journal of Maxillofacial Surgery Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_24_22
Sonal Jawa, Neeraj Singh, Suresh S. Naruka
{"title":"Tapia syndrome following TMJ gap arthroplasty: A case report and review of literature","authors":"Sonal Jawa, Neeraj Singh, Suresh S. Naruka","doi":"10.4103/njms.njms_24_22","DOIUrl":"https://doi.org/10.4103/njms.njms_24_22","url":null,"abstract":"Tapia syndrome is an extremely rare condition involving simultaneous paralysis of cranial nerves X (recurrent laryngeal branch) and XII. It is mostly believed to occur as a neuropraxic complication of intraoperative airway management. We present a unique case of a 17-year-old female with dysphonia, dysphagia, and deviation of tongue to the right side following temporomandibular joint gap arthroplasty for release of left TMJ ankylosis. A clinical diagnosis of Tapia's syndrome was made on exclusion of surgical or intracranial etiology and conservative management was performed. The aim of this study is to discuss the possible etiology, symptoms, and treatment of this disease along with a review of seven cases of Tapia syndrome associated with maxillofacial surgeries.","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levels of nitric oxide in smokers and nonsmokers with chronic periodontitis before and after nonsurgical periodontal treatment 慢性牙周炎吸烟者和非吸烟者非手术牙周治疗前后一氧化氮水平的变化
National Journal of Maxillofacial Surgery Pub Date : 2023-01-01 DOI: 10.4103/njms.njms_405_21
Deepti Wadhwa, Virendra Kumar, Mukesh Kumar Hasija, Afshan Bey
{"title":"Levels of nitric oxide in smokers and nonsmokers with chronic periodontitis before and after nonsurgical periodontal treatment","authors":"Deepti Wadhwa, Virendra Kumar, Mukesh Kumar Hasija, Afshan Bey","doi":"10.4103/njms.njms_405_21","DOIUrl":"https://doi.org/10.4103/njms.njms_405_21","url":null,"abstract":"Introduction: The purpose of this study was to determine the level of nitric oxide (NO) in both serum and saliva of smokers and nonsmokers with chronic periodontitis before and after scaling and root planing, as well as to compare the same (NO levels) with the severity of periodontitis. Materials and Methods: Sixty people took part in the study and were divided into three groups. The control group (Group I) involved 20 patients who were nonsmokers with healthy periodontium. The other two groups included 20 patients each, where Group II was nonsmokers with chronic periodontitis and Group III was smokers with chronic periodontitis. In addition, NO generation was quantified indirectly in this study using the Griess reaction to determine the nitrite level in serum and saliva. Results: The mean value of salivary and serum NO was higher in Group III than in Group II, and NO decreased considerably ( P < 0.01) in both Groups II and III after treatment compared to before treatment. Conclusion: Serum and salivary NO levels can be used as a good predictor of the inflammatory condition of the periodontium in smokers.","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135612017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Antero-medially displaced condylar head leading to pseudoankylosis: A case report. 勘误表:髁突前内侧移位导致假性强直:一例报告。
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 DOI: 10.4103/njms.njms_195_22
{"title":"Erratum: Antero-medially displaced condylar head leading to pseudoankylosis: A case report.","authors":"","doi":"10.4103/njms.njms_195_22","DOIUrl":"10.4103/njms.njms_195_22","url":null,"abstract":"<p><p>[This corrects the article on p. S162 in vol. 13, PMID: 36393950.].</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"498"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/67/0e/NJMS-13-498.PMC9851359.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10585395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of efficacy 3Dimensional 4-hole trapezoid condyle plate for treatment of base of condyle fracture. 三维四孔梯形髁突钢板治疗髁突基底部骨折的疗效评价。
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 Epub Date: 2022-12-10 DOI: 10.4103/njms.njms_506_21
Roger Paul, Bharathi Suvvada, Prasanna Polomarasetty, Sai Kumar Thumu, P V Santosh
{"title":"Evaluation of efficacy 3Dimensional 4-hole trapezoid condyle plate for treatment of base of condyle fracture.","authors":"Roger Paul,&nbsp;Bharathi Suvvada,&nbsp;Prasanna Polomarasetty,&nbsp;Sai Kumar Thumu,&nbsp;P V Santosh","doi":"10.4103/njms.njms_506_21","DOIUrl":"10.4103/njms.njms_506_21","url":null,"abstract":"<p><strong>Aim: </strong>The aim of our study was to evaluate the effectiveness of open reduction and internal fixation of the base of condyle using a 3D 4-hole trapezoid condyle plate (4-HTCP).</p><p><strong>Materials and methods: </strong>A group of 25 subjects of an age range of 21-52 years (mean 32.7 ± 8.7 years) were treated of which, 7(28%) were female and 18 (72%), were male. All the patients were examined according to standard protocol. A retromandibular approach was used in all the patients.</p><p><strong>Results: </strong>The time taken for operating on the condyle alone was recorded it was between 30 minutes to one hour in 5 (20%) patients, between one-two hours in 19 (76%) patients and greater than two hours in 1 (4%) patient. Time taken from reduction of fracture to placement of the last screw was recorded. In 15 (60%) patients the time taken was less than ten minutes, in 10 (40%) patients the time taken ranged from 10-15 minutes. 6 (24%) patients needed additional exposure to facilitate the procedure. Postoperatively all the patients were followed up for a minimum of 9 months and a maximum of 30 months (mean 19.5 ± 5.87 months). The range of mandibular movements was satisfactory. The maximum incisal opening was in the range of 25-37 mm (mean- 31.4 ± 3.38 mm)on the first post-operative day. 31.4 ± 3.4 mm 6 weeks postoperatively, 43.8 ± 4.3 mm 3 months postoperatively, 46.7 ± 2.9 mm 6 months postoperatively and 49.7 ± 4.5 mm 9 months postoperatively. Taking into consideration the transient hypofunction of the facial nerve (8%) and TMJ disorder (8%) the aggregate complication rate in our study was 16%.</p><p><strong>Conclusion: </strong>Our study concludes that 4HTCP is a reliable and rigid choice of osteosynthesis for the base of condyle fractures.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"405-410"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/6b/NJMS-13-405.PMC9851361.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10585400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Are olfactory and gustatory symptoms useful at predicting disease severity markers in COVID-19 infection? 嗅觉和味觉症状在预测新冠肺炎感染的疾病严重程度标志物方面有用吗?
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 Epub Date: 2022-12-10 DOI: 10.4103/njms.njms_38_22
Mojgan Falaki, Saeed Abdi, Shervin Shafiei, Mohammadreza Moslemi, Behrad Rahbani Nobar, Reza Tabrizi, Meysam Mohammadikhah, Hamidreza Moslemi
{"title":"Are olfactory and gustatory symptoms useful at predicting disease severity markers in COVID-19 infection?","authors":"Mojgan Falaki,&nbsp;Saeed Abdi,&nbsp;Shervin Shafiei,&nbsp;Mohammadreza Moslemi,&nbsp;Behrad Rahbani Nobar,&nbsp;Reza Tabrizi,&nbsp;Meysam Mohammadikhah,&nbsp;Hamidreza Moslemi","doi":"10.4103/njms.njms_38_22","DOIUrl":"10.4103/njms.njms_38_22","url":null,"abstract":"<p><strong>Context: </strong>The relationship between olfactory and gustatory dysfunction (OGD) and COVID-19 infection severity is still unclear.</p><p><strong>Aim: </strong>To investigate the correlation between OGD in COVID-19-infected individuals and RT-PCR results, chest CT scan abnormality, lymphocyte counts, hospital admission units, age, body temperature, and blood oxygen saturation.</p><p><strong>Setting and design: </strong>Case-control study.</p><p><strong>Materials and methods: </strong>The sample was composed of laboratory and chest X-ray confirmed COVID-19-infected patients from four hospitals. The patients were divided into case and control groups based on the presence of OGD symptoms. The predictor variable was OGD. The outcome variable was gender, hospital admission unit, chest CT scan abnormality, PCR, lymphocyte counts, age, body temperature, and blood oxygen saturation.</p><p><strong>Statistical analysis used: </strong>Bivariate statistics were computed and the <i>P</i> value was set at 0.05.</p><p><strong>Results: </strong>The sample consisted of 189 patients. Smell and taste disorders were found in 31.7% and 24.3% of patients, respectively. OGD was significantly correlated with positive PCR results (<i>P</i> < 0.001) and general unit admission (<i>P</i> < 0.05) during hospitalization. Additionally, patients with OGD had significantly lower mean age (<i>P</i> < 0.001), higher body temperature (<i>P</i> < 0.01), and blood oxygen saturation (<i>P</i> < 0.01). However, OGD was not correlated with gender, chest CT scan abnormality, or lymphocyte counts (<i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>OGD symptoms can be used to detect COVID-19-infected patients. OGD can be used to predict less severe disease mainly by its correlation with the less amount of hospital care, more negative PCR results, higher body temperature, and higher blood oxygen saturation.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"357-361"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/00/NJMS-13-357.PMC9851345.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10585402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Biomechanical evaluation of different fixation techniques following modified sagittal split ramus osteotomy using buccal step: An in vitro study. 改良矢状劈开支颊阶截骨后不同固定技术的生物力学评价:一项体外研究。
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 Epub Date: 2022-12-10 DOI: 10.4103/njms.njms_321_21
Pratik Dhananjay Warade, Rajesh Kshirsagar, Prasamita Mishra, Pranave Prasad, Amruta Sardeshmukh
{"title":"Biomechanical evaluation of different fixation techniques following modified sagittal split ramus osteotomy using buccal step: An <i>in vitro</i> study.","authors":"Pratik Dhananjay Warade,&nbsp;Rajesh Kshirsagar,&nbsp;Prasamita Mishra,&nbsp;Pranave Prasad,&nbsp;Amruta Sardeshmukh","doi":"10.4103/njms.njms_321_21","DOIUrl":"10.4103/njms.njms_321_21","url":null,"abstract":"<p><strong>Objective: </strong>This study was to evaluate the efficacy of three different designs of rigid fixation using polyurethane hemimandible replicas following modified sagittal split ramus osteotomy with buccal step.</p><p><strong>Materials and methods: </strong>Forty-eight polyurethane hemimandible replicas have been used. Following the osteotomy and fixation, each specimen has been mounted on a Universal Testing unit using a prefabricated customized jig and has been tested to a range of vertical forces starting from 0 <i>N</i> on the incisal edge of lateral incisor and lateral forces of on lateral surface of mandibular first molar. Progressive load has been applied until a deflection of 10 mm was observed. SPSS version 20 has been used for analyzing the data. The biomechanical stability of different osteosynthesis has been compared using a one-way ANOVA with post hoc Bonferroni test. <i>P</i> ≤ 0.05 will be considered statistically significant.</p><p><strong>Results: </strong>After advancement of 7 mm, comparison of vertical load and lateral load among different miniplate systems showed that load was maximum in bicortical screws in inverted L pattern followed by T-shaped miniplate system and was least in single six-hole straight plate (0.001) at <i>P</i> ≤ 0.05.</p><p><strong>Conclusion: </strong>Our study concludes that bicortical screws in inverted \"L\" pattern are more resistant to lateral load as well as on the application of vertical load when compared to other fixation techniques and statistical difference was evident.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"443-448"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/6d/NJMS-13-443.PMC9851348.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10635067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the correlation between interleukin 1β levels in peri-implant crevicular fluid as an adjunctive diagnostic marker with clinical and radiographic parameters for assessing the peri-implant health status. 评估作为辅助诊断标志物的种植体周围沟液中白细胞介素1β水平与评估种植体周围健康状况的临床和放射学参数之间的相关性。
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 Epub Date: 2022-12-10 DOI: 10.4103/njms.njms_337_21
Manish Khatri, Mansi Bansal, Komal Puri, Sourabh Mehrotra, Ashish Kumar, Mohd Rehan
{"title":"Evaluation of the correlation between interleukin 1β levels in peri-implant crevicular fluid as an adjunctive diagnostic marker with clinical and radiographic parameters for assessing the peri-implant health status.","authors":"Manish Khatri,&nbsp;Mansi Bansal,&nbsp;Komal Puri,&nbsp;Sourabh Mehrotra,&nbsp;Ashish Kumar,&nbsp;Mohd Rehan","doi":"10.4103/njms.njms_337_21","DOIUrl":"10.4103/njms.njms_337_21","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-1β (IL-1β) is one of the most important cytokines that seems to have an important role in the inflammatory process in gingival and peri-implant tissues. As peri-implant crevicular fluid (PICF) provides with a more swift and objective measure of the disease activity, the present study was conducted to evaluate IL-1β level in PICF as a biochemical marker and to investigate its correlation with clinical parameters and radiological parameters.</p><p><strong>Materials and methods: </strong>After evaluating all the patients following inclusion and exclusion criteria, 60 patients were selected for the study. After 3-4 months of implants placement, the implants were exposed following standard surgical procedure. PICF sample from implant site was taken 3 days after suture removal with gingival former still in place followed by measurement of clinical and radiological parameters.</p><p><strong>Results: </strong>There was significant increase in IL-1β levels in both the follow-ups from baseline with variable and minimal change in the clinical parameters and radiological parameters as well, which shows that IL-1β levels change significantly even when there is a minimal gingival inflammation.</p><p><strong>Conclusion: </strong>Therefore, IL-1β level in PICF can be used as an adjunctive diagnostic marker to clinical and radiographic parameters for assessing the peri-implant health status.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"421-429"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/08/NJMS-13-421.PMC9851343.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10577968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment outcomes in poor metabolizers of cytochrome P450 2A6 with concurrent chemoradiotherapy in locally advanced head- and neck-squamous cell carcinoma. 局部晚期头颈部鳞状细胞癌细胞色素P450 2A6代谢不良者同时放化疗的治疗结果。
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 Epub Date: 2022-12-10 DOI: 10.4103/njms.NJMS_312_21
Deepa Aggarwal, Sudhir Singh, Mohammad Ali, Abhay Singh, Kirti Srivastava, Rajeev Gupta, Madan Lal Brahma Bhatt, Seema Devi
{"title":"Treatment outcomes in poor metabolizers of cytochrome P450 2A6 with concurrent chemoradiotherapy in locally advanced head- and neck-squamous cell carcinoma.","authors":"Deepa Aggarwal,&nbsp;Sudhir Singh,&nbsp;Mohammad Ali,&nbsp;Abhay Singh,&nbsp;Kirti Srivastava,&nbsp;Rajeev Gupta,&nbsp;Madan Lal Brahma Bhatt,&nbsp;Seema Devi","doi":"10.4103/njms.NJMS_312_21","DOIUrl":"10.4103/njms.NJMS_312_21","url":null,"abstract":"<p><strong>Introduction: </strong>Human Cytochrome 2A6 (CYP2A6) is involved in the oxidative metabolism of the nicotine to the inactive cotinine. CYP2A6 is a primary enzyme in nicotine metabolism, the enzyme has been proposed as a novel target for smoking cessation.</p><p><strong>Materials and methods: </strong>A total of 70 male patients of locally advanced head- and neck-squamous cell carcinoma confirmed by histopathological examination were enrolled in this study. All patients received concurrent chemoradiotherapy (total dose of 70 Gray in 35 fractions in 7 weeks with concurrent tablet capecitabine 1250 mg/m<sup>2</sup>/day). Response assessment was based on response evaluation criteria in solid tumor criteria. Total ribonucleic acid (RNA) was isolated from the whole blood of all patients by TRI REAGENT BD (SIGMA USA) followed by real-time polymerase chain reaction assay which was done in studying messenger RNA (mRNA) expression of Excision Repair Cross Complementation Group 1 in blood lymphocytes of patient.</p><p><strong>Results: </strong>The most common stage prevalent was Stage IV A in 28 (56%) patients followed by Stage III in 16 (32%) patients. Out of 70, 20 (28.6%) patients defaulted for treatment, so the analysis was done in 56 patients. A total of 19 (34%) patients had a complete response (CR) and 17 (30%) patients had no response. In all the patients who had CR, posttreatment relative quantification (RQ) expression levels were high. Among nonresponders only three had higher RQ folds and the rest 14 had lower RQ folds.</p><p><strong>Conclusion: </strong>Posttreatment expression levels of CYP2A6 were found to be a better predictor for tumor response to the treatment than the pretreatment expression levels. Almost all the patients having higher RQ folds had CR and those having lower RQ folds had either no response or progressive disease on follow-up visits.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"362-366"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/16/NJMS-13-362.PMC9851368.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10580229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is extracorporeal plating ideal for condylar fracture? A case report with a two-year follow-up study. 体外钢板治疗髁突骨折理想吗?一份带有两年随访研究的病例报告。
National Journal of Maxillofacial Surgery Pub Date : 2022-09-01 Epub Date: 2022-12-10 DOI: 10.4103/njms.njms_499_21
Nathiya Balasubramaniyan, Ganesan Suresh Kumar, M James Antony Bhagat, Veeramuthu Muthulingam
{"title":"Is extracorporeal plating ideal for condylar fracture? A case report with a two-year follow-up study.","authors":"Nathiya Balasubramaniyan,&nbsp;Ganesan Suresh Kumar,&nbsp;M James Antony Bhagat,&nbsp;Veeramuthu Muthulingam","doi":"10.4103/njms.njms_499_21","DOIUrl":"10.4103/njms.njms_499_21","url":null,"abstract":"<p><p>Management of condylar fractures includes the closed and open methods. The closed method, although is conservative, has disadvantages such as inadequate reduction, disturbances in occlusion, and a decrease in ramal height. To overcome these disadvantages, surgeons prefer open reduction and internal fixation. One of the methods used is extracorpeal fixation of condyle fractures. This method has a limiting factor of excessive condylar resorption and avascular necrosis. We report a two-year follow-up of a patient with condylar head resorption and fractured implant.</p>","PeriodicalId":18827,"journal":{"name":"National Journal of Maxillofacial Surgery","volume":"13 3","pages":"491-494"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/3b/NJMS-13-491.PMC9851363.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10585397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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