Molecular medicine reports最新文献_第5页

Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review). 复发性妊娠丢失中的肠道微生物群-免疫串扰：机制和治疗观点（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-08-07 DOI: 10.3892/mmr.2026.13979

Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu

{"title":"Gut microbiota‑immune crosstalk in recurrent pregnancy loss: Mechanisms and therapeutic perspectives (Review).","authors":"Nanjian Luo, Han Hu, Xiaoting Zeng, Yi Huan Zhang, Qi Deng, En Ni Tang, Yu Hu","doi":"10.3892/mmr.2026.13979","DOIUrl":"10.3892/mmr.2026.13979","url":null,"abstract":"Recent studies have indicated the relationships between the human reproductive system, gut microbiota and immune crosstalk. These interactions can influence pregnancy outcomes, which occasionally result in adverse consequences for the mother and fetus. However, key questions remain unresolved, such as identifying the microbiota capable of modulating immune cells during pregnancy. The present review aimed to investigate the relationship between microbiota and T cell types and to clarify the mechanism through which these interactions occur. In pregnancy‑related disease models, it is still unclear whether T helper cell (Th17)/regulatory T cells (Treg cells) are generated in situ or migrate into inflamed tissues. The present review explored the association of gastrointestinal dysbiosis with the female reproductive system and the role of the maternal‑fetal interface. In particular, the effect of gut microbiota‑derived short‑chain fatty acids, bile acids, indoles and their derivatives on immune signaling networks is discussed. Furthermore, the effects of these networks on infectious, metabolic and female pregnancy periods are summarized. Finally, the translational potential of modulating gut microbiota through probiotics and dietary interventions to restore immune homeostasis and improve pregnancy outcomes in Recurrent pregnancy loss (RPL) is also evaluated. The present review aimed to assist patients in developing a more profound comprehension of the underlying causes of unexplained RPL and broaden the spectrum of potential therapeutic strategies for infertility.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review). 环状rna与剪接因子在宫颈癌中的相互作用：调节、相互作用和治疗。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-09-04 DOI: 10.3892/mmr.2026.14006

Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima

{"title":"Interaction of circular RNAs with splicing factors in cervical cancer: Modulation, interplay and theranostics (Review).","authors":"Amahle Nyalambisa, Afra Basera, Ntombikayise Xelwa, Olalekan Fadebi, Zodwa Dlamini, Rahaba Marima","doi":"10.3892/mmr.2026.14006","DOIUrl":"10.3892/mmr.2026.14006","url":null,"abstract":"Cervical cancer (CCa) is a worldwide health concern, particularly in low‑ and middle‑income countries. Human papillomavirus infection is a key risk factor in the development of CCa. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs) and long ncRNAs (lncRNAs), are important regulators of cancer progression, including CCa, offering potential therapeutic targets. Compared with lncRNAs and miRNAs, circRNAs are the least studied ncRNAs. circRNAs, distinguished by a closed‑loop structure and resistance to exonucleases, serve diverse roles in cancer, functioning as miRNA sponges and regulating gene expression. circRNAs are produced primarily by back‑splicing and comprise both intronic and exonic sequences. Notably, circRNAs are key regulators of alternative splicing, as they are able to enhance the expression of splicing factors (SFs) by sequestering miRNAs. Despite their importance, the interactions between circRNAs and SFs in CCa remain to be elucidated. The present review highlights the interplay between circRNAs and SFs in CCa pathogenesis; it describes the influence of SFs on circRNA production, the regulatory feedback between circRNAs and SFs, and the potential implications of this interaction in CCa diagnostics and therapeutics. To conduct the present review a targeted literature search was conducted across PubMed, Scopus and Google Scholar using defined search terms to identify peer‑reviewed studies published between 2006 and 2024. The findings were synthesized to explore the mechanistic insights and translational implications of circRNA‑SF interactions in CCa.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho. 组蛋白去乙酰化酶3介导的组蛋白去乙酰化联合活化转录因子3通过抑制Klotho促进肾纤维化。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-08-07 DOI: 10.3892/mmr.2026.13985

Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu

{"title":"Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho.","authors":"Zhiying Yang, Xueling Wang, Wenhong Li, Hao Chen, Gang Liu","doi":"10.3892/mmr.2026.13985","DOIUrl":"10.3892/mmr.2026.13985","url":null,"abstract":"Renal fibrosis is a representative pathological trait of renal aging and chronic kidney disease. However, the regulatory mechanisms of histone deacetylation in renal fibrosis remain unclear. A mouse renal fibrosis model was constructed using the unilateral ureteric obstruction method, and HK2 cells treated with TGF‑β were used to create a renal fibrosis cell model. Low expression of Klotho in renal fibrosis is associated with histone deacetylase 3 (HDAC3)‑mediated histone deacetylation. After TGF‑β treatment, H3K9ac and Klotho binding was markedly decreased, while H3K9ac was enriched in the Klotho group after the addition of the HDAC3 inhibitor. Further experiments demonstrated that HDAC3 binding activates transcription factor 3, inhibits Klotho transcription and promotes cellular renal fibrosis. The absence of Klotho may activate the Wnt/β‑catenin and NF‑κB pathways to promote oxidative stress and inflammation, thereby exacerbating the fibrotic process. HDAC3 binds to ATF3 to transcriptionally repress Klotho, leading to activation of the Wnt/β‑catenin and NF‑κB pathways and exacerbation of renal fibrosis.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13488142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review). 脑缺血再灌注损伤中线粒体功能障碍驱动的铁下垂：机制和治疗策略（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-08-21 DOI: 10.3892/mmr.2026.13997

Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li

{"title":"Mitochondrial dysfunction‑driven ferroptosis in cerebral ischemia‑reperfusion injury: Mechanisms and therapeutic strategies (Review).","authors":"Jianhui Li, Annan Liu, Wei Gao, Liping Xing, Peihan Duan, Honglin Li","doi":"10.3892/mmr.2026.13997","DOIUrl":"10.3892/mmr.2026.13997","url":null,"abstract":"Ischemic stroke remains a leading cause of mortality and disability worldwide. Although vascular recanalization is essential for salvaging the ischemic penumbra, subsequent reperfusion may initiate a cascade of secondary brain injury, a pathological process referred to as cerebral ischemia‑reperfusion injury (CIRI). Ferroptosis, an iron‑dependent form of programmed cell death characterized by the excessive accumulation of lipid peroxides and membrane damage, has emerged as a critical driver of neuronal death in CIRI. Growing evidence supports mitochondrial dysfunction as not only a downstream outcome of bioenergetic failure, but also a central regulatory node within the ferroptotic cascade. The present review systematically summarizes how mitochondrial dysfunction increases neuronal susceptibility to ferroptosis across the pathophysiological progression of CIRI, with a particular focus on the underlying mechanisms. Specifically, a multidimensional pathological network composed of multiple mitochondrial abnormalities, including mitochondrial reactive oxygen species bursts, Ca2+ overload and disruption of the mitochondrial quality control system, encompassing mitochondrial biogenesis, mitochondrial dynamics and mitophagy, synergistically amplifies lipid peroxidation and drives neuronal ferroptosis. Finally, advances and future perspectives regarding mitochondria‑centered therapeutic strategies are highlighted, offering novel insights into the development of targeted neuroprotective interventions against CIRI‑induced ferroptosis.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review). 解锁microRNA作为免疫检查点抑制剂治疗疗效和不良事件的预测性生物标志物的潜力（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-08-21 DOI: 10.3892/mmr.2026.13998

Xi Wang, Baojun Duan, Jun Bai, Huitong Liu

{"title":"Unlocking the potential of microRNA as predictive biomarkers for efficacy and adverse events in immune checkpoint inhibitor therapy (Review).","authors":"Xi Wang, Baojun Duan, Jun Bai, Huitong Liu","doi":"10.3892/mmr.2026.13998","DOIUrl":"10.3892/mmr.2026.13998","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have shown promise in cancer therapy by enhancing antitumor immune responses, but patient responses are variable, with some experiencing limited efficacy and others suffering from severe immune‑related adverse events (irAEs). Identifying predictive biomarkers for ICI efficacy and toxicity is required for optimizing patient selection and treatment outcomes. MicroRNAs (miRNAs), small non‑coding RNA molecules that regulate gene expression, have emerged as potential biomarkers due to their role in immune regulation and tumor biology. Studies have shown that miRNA profiles in tumor tissues and blood can predict ICI responses. Specific miRNAs, such as miR‑155, miR‑21 and miR‑146a, are associated with enhanced antitumor responses, whereas others, such as miR‑34a and miR‑200c, are linked to resistance by modulating immune evasion. Additionally, altered miRNA expression reflects immune activation or dysregulation, playing a role in irAEs. The present review discussed the potential of miRNAs as predictive biomarkers for ICI therapy, their challenges in clinical integration and their promise for improving ICI treatment precision and safety, although further research is required for clinical application.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review). 自噬：肠化生的机制和治疗前景（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-08-21 DOI: 10.3892/mmr.2026.13999

Laifeng Wu, Lingchen Liao, Ziwei Xia, Qiao Zeng, An Huang, Zhiyong Cao

引用次数: 0

Advances in miR‑200c regulation of apoptosis, pyroptosis and autophagy in disease (Review). miR - 200c调控疾病中细胞凋亡、焦亡和自噬的研究进展（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-07-31 DOI: 10.3892/mmr.2026.13975

Xiaona Wang, Hua Du, Yingxu Shi

引用次数: 0

Association between periodontitis and heart failure: Mechanisms and clinical implications (Review). 牙周炎和心力衰竭的关系：机制和临床意义（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-07-31 DOI: 10.3892/mmr.2026.13974

Xinyue Zhang, Xiaoli An

{"title":"Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).","authors":"Xinyue Zhang, Xiaoli An","doi":"10.3892/mmr.2026.13974","DOIUrl":"10.3892/mmr.2026.13974","url":null,"abstract":"Periodontitis, a common oral disease, is increasingly recognized for its potential impact on systemic health, particularly its association with heart failure (HF). HF is a complex clinical syndrome with a multifactorial pathogenesis. Emerging evidence suggests that periodontitis may influence the cardiovascular system and contribute to the onset and progression of HF through mechanisms such as systemic inflammation, microbial shifts, and immune dysregulation. However, current research still faces limitations in establishing causality and elucidating the precise underlying mechanisms. Furthermore, clinical intervention strategies require further investigation. Relevant literature was identified from PubMed, Web of Science, and Scopus using keywords related to periodontitis and heart failure, and screened for relevance to epidemiological evidence, mechanistic insights, and clinical implications. The present review aimed to summarize the mechanisms linking periodontitis and HF, analyze their shared pathophysiological basis, and discuss the potential role of periodontal treatment in improving outcomes for patients with HF. Clinically, periodontal assessment may be considered in patients with heart failure as part of multidisciplinary care, but current evidence remains insufficient to support definitive recommendations that such evaluation or treatment improves HF outcomes.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review). 芦丁对肝损伤的保护作用及氧化应激机制研究进展（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-08-07 DOI: 10.3892/mmr.2026.13982

Teng Sun, Lei Ye

{"title":"Research progress on the protective effect and oxidative stress mechanism of rutin against liver injury (Review).","authors":"Teng Sun, Lei Ye","doi":"10.3892/mmr.2026.13982","DOIUrl":"10.3892/mmr.2026.13982","url":null,"abstract":"Addressing the global health burden of liver injury necessitates the exploration of novel prevention and treatment strategies. The therapeutic use of the natural flavonoid rutin, which is renowned for its notable antioxidant properties, has emerged as a promising area of research. The present review systematically examines the protective mechanisms of rutin and research progress on its use across various liver‑injury models. Primarily, the present review assesses the current knowledge and therapeutic challenges of liver injury, emphasizing the requirement for in‑depth studies on its pathogenesis and the development of innovative treatment approaches. Given the widespread recognition of oxidative stress as a key contributor to liver injury, the present review specifically details the effects of oxidative stress on biological macromolecules, as well as the central roles of the nuclear factor erythroid 2‑related factor 2 and nuclear factor‑κB pathways in modulating antioxidant, anti‑inflammatory and apoptotic responses. Building on this foundation, the present review critically evaluates the antioxidant properties of rutin and its hepatoprotective effects, which are mediated through regulation of the aforementioned pathways. Furthermore, the potential of nanotechnology to enhance the bioavailability and delivery efficiency of rutin is explored. By synthesizing mechanistic evidence and evaluating nano‑strategies, the present review establishes a coherent framework for the hepatoprotective activities of rutin, thereby advancing the field towards mechanism‑guided therapeutic development and targeted delivery solutions for liver injury.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resurrection biology: Melatonin as a modulator of anastasis (Review). 复活生物学：褪黑素作为恢复的调节剂（综述）。

IF 5 3区医学

Molecular medicine reports Pub Date : 2026-10-01 Epub Date: 2026-09-04 DOI: 10.3892/mmr.2026.14004

Alexandros Georgiou, Russel J Reiter, Vassilis Zoumpourlis, Demetrios A Spandidos

{"title":"Resurrection biology: Melatonin as a modulator of anastasis (Review).","authors":"Alexandros Georgiou, Russel J Reiter, Vassilis Zoumpourlis, Demetrios A Spandidos","doi":"10.3892/mmr.2026.14004","DOIUrl":"10.3892/mmr.2026.14004","url":null,"abstract":"Although apoptosis is regarded as an irreversible and terminal process, recent research has identified anastasis as a cellular mechanism that enables cell recovery even after the activation of executioner caspases. While important in supporting tissue homeostasis following mild or transient injury, anastasis presents significant challenges in oncology, as cancer cells may exploit this phenomenon to evade chemotherapy, subsequently acquiring aggressive traits such as genomic instability, stem‑like properties, and increased metastatic capacity. N‑acetyl‑5‑methoxytryptamine (melatonin), recognized for its antioxidant activity and role as a mitochondrial regulator, has been associated with several biological processes that overlap with pathways involved in anastasis, including mitochondrial bioenergetics, redox homeostasis, and DNA repair mechanisms. However, direct evidence supporting a role for melatonin in regulating anastasis remains limited. The present review consolidated current insights into the molecular regulation of anastasis, examining its biphasic transcriptional profile and oncogenic consequences, while exploring the mechanistic links between melatonin biology and pathways relevant to apoptotic recovery and evaluating the therapeutic prospects of melatonin in targeting anastasis as a strategy to mitigate tumor recurrence and improve clinical outcomes.","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"34 4","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0