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S17 Therapeutic Drug Monitoring of the Biosimilar (AMJEVITA™, Adalimumab-atto) Using Labcorp Adalimumab Assay for Drug Level and Anti-Drug Antibodies S17 使用 Labcorp 阿达木单抗检测试剂盒检测生物仿制药（AMJEVITA™，阿达木单抗-atto）的药物浓度和抗药抗体，对其进行治疗药物监测
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995804.85093.96
Kelly Y. Chun, Monique Bastidas, Lythou Yeo, Susie Magpantay, Judah Scott, M. Zikry, Wayne Galdamez
{"title":"S17 Therapeutic Drug Monitoring of the Biosimilar (AMJEVITA™, Adalimumab-atto) Using Labcorp Adalimumab Assay for Drug Level and Anti-Drug Antibodies","authors":"Kelly Y. Chun, Monique Bastidas, Lythou Yeo, Susie Magpantay, Judah Scott, M. Zikry, Wayne Galdamez","doi":"10.14309/01.ajg.0000995804.85093.96","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995804.85093.96","url":null,"abstract":"Background: There are limited studies assessing the impact of pediatric-onset in fl ammatory bowel disease (IBD) on infant and pregnancy outcomes. Low birth weight and preterm birth are known pregnancy complications in IBD patients with active disease. Therefore, this study sought to evaluate pregnancy outcomes in patients with pediatric-onset versus adult-onset Crohn ’ s disease (CD), particularly with regard to intrauterine growth and prematurity delivery. Methods: In this single center, retrospective comparative cohort study, patients with pediatric-onset (diagnosed , 18 years old) and adult-onset CD (diagnosed $ 18 years old) who had documented prenatal care between 2012-2023 were identi fi ed. Patients were excluded for following at outside institutions for primary IBD care. We compared co-primary outcomes (gestational age and size), and secondary outcomes (assisted reproduction usage, mode of delivery, and neonatal intensive care unit (NICU) stay), between the two groups. Data was obtained from an electronic medical record via natural language processing and con fi rmed with manual veri fi cation. Categorical variables were analyzed using chi-squared test or Fisher exact test when appropriate; continuous variables were assessed with t-test if normally distributed. Statistical signi fi cance was determined by p value , 0.05. Results: A total of 208 infants were delivered, 119 to pediatric-onset CD and eighty-nine to adult-onset CD mothers. There was no signi fi cant di ff erence with regard to race between the groups. The mother ’ s age at delivery was signi fi cantly lower in pediatric-onset CD patients (median [IQR]: 30.2 [26.3, 34.5] vs 32.5 [29.8, 35.3] years, p 5 0.0006). There was a numerically","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"61 ","pages":"S5 - S6"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S82 New Blood-Based Test, 7-Alpha-Hydroxy-4-Cholesten-3-One (7AlphaC4), for Bile Acid Malabsorption in Patients With Inflammatory Bowel Disease or Unspecified Diarrhea S82 新型血基检验--7-α-羟基-4-胆甾烯-3-酮（7AlphaC4），用于检测炎症性肠病或不明原因腹泻患者的胆汁酸吸收不良情况
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996072.09336.ae
Jane M. Yang, Andrew Lehrhoff, Kelly Y. Chun
{"title":"S82 New Blood-Based Test, 7-Alpha-Hydroxy-4-Cholesten-3-One (7AlphaC4), for Bile Acid Malabsorption in Patients With Inflammatory Bowel Disease or Unspecified Diarrhea","authors":"Jane M. Yang, Andrew Lehrhoff, Kelly Y. Chun","doi":"10.14309/01.ajg.0000996072.09336.ae","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996072.09336.ae","url":null,"abstract":"Background: There is a paucity of data looking speci fi cally on the e ff ects of NSTEMI on patients with ulcerative colitis (UC). We sought to analyze this relationship further by examining the national inpatient sample database to describe in-hospital trends and","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"29 2","pages":"S22 - S23"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139018122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S74 Which Endoscopic Severity Assessment Tool Correlates Best With Non-Invasive Crohn’s Disease Activity Parameters? S74 哪种内窥镜严重程度评估工具与非侵袭性克罗恩病活动参数相关性最佳？
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996040.18783.b7
T. Capela, T. Gonçalves, C. Arieira, J. Cotter
{"title":"S74 Which Endoscopic Severity Assessment Tool Correlates Best With Non-Invasive Crohn’s Disease Activity Parameters?","authors":"T. Capela, T. Gonçalves, C. Arieira, J. Cotter","doi":"10.14309/01.ajg.0000996040.18783.b7","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996040.18783.b7","url":null,"abstract":"Background: There are few data on the quality-of-care for in fl ammatory bowel disease (IBD) in public, private or mixed hospitals. Aim: To evaluated clinic and quality parameters and their association with need for ICU and death in Brazilian hospitals. Methods: Multicentre study carried out in 26 hospitals including 488 admissions of patients with IBD were analyzed between June 2021 and October 2022. Results","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"231 9","pages":"S20 - S21"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139019928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S57 Clinical Profile of Patients With Inflammatory Bowel Disease in Brazil: Analysis of the National Registry (GEDIIB) S57 巴西炎症性肠病患者的临床概况：对国家登记处（GEDIIB）的分析
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995972.98243.9c
Adriana Ribas Andrade, L. Sassaki, Mikael Farias, J. Parente, G. Zabot, Pedro Pertence, Gabriela Bezerra, Roberto Junior, Camila Chiqueti, João Feldman, A. Quaresma, R. Parra, O. Féres, Carlos Henrique Santos, N. Almeida, F. Fortes, Jaciane Fontes, G. Santana, M. C. Lopes, V. Salgado, Bernardo Carvalho, M. Bafutto, Silvia Araújo, R. Luporini, Heitor Souza, Fabio Maximiano, G. Herrerias, R. Saad-Hossne, R. Fróes, C. Flores
{"title":"S57 Clinical Profile of Patients With Inflammatory Bowel Disease in Brazil: Analysis of the National Registry (GEDIIB)","authors":"Adriana Ribas Andrade, L. Sassaki, Mikael Farias, J. Parente, G. Zabot, Pedro Pertence, Gabriela Bezerra, Roberto Junior, Camila Chiqueti, João Feldman, A. Quaresma, R. Parra, O. Féres, Carlos Henrique Santos, N. Almeida, F. Fortes, Jaciane Fontes, G. Santana, M. C. Lopes, V. Salgado, Bernardo Carvalho, M. Bafutto, Silvia Araújo, R. Luporini, Heitor Souza, Fabio Maximiano, G. Herrerias, R. Saad-Hossne, R. Fróes, C. Flores","doi":"10.14309/01.ajg.0000995972.98243.9c","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995972.98243.9c","url":null,"abstract":"Background: In response to the rising prevalence of in fl ammatory bowel disease (IBD) in Brazil, which now exceeds 100 cases per 100,000 inhabitants, the Brazilian Crohn ’ s Disease and Colitis Organization (GEDIIB) established a National Registry of Patients with IBD to gather information about these conditions. This study presents a comprehensive analysis, encompassing all fi ve geographic regions of the country (North, Northeast, Center-West, Southeast, and South), based on data collected over a span of three years. Methods: A cohort study was conducted from August 2020 to August 2023. The data were sourced from medical records and patient consultationsusing theREDCap platform, withapprovals obtained from the ethics boards of participating institutions. Results: The study comprised 2,831 patients, with 47% diagnosed with ulcerative colitis (UC) and 51.1% with Crohn ’ s disease (CD). Sixty-two percent were followed in public centers, and 38% in the private system. The average age at diagnosis was 38 6 15.5 years for UC and 33.7 6 14.9 years for CD. Females predominated, constituting 64.5% of UC cases and 53.4% of CD cases. The majority of patientswereofCaucasiandescent(58.4%forUC,63.7%forCD),followedbymixed-raceindividuals (32.3%forUC,29.1%forCD)andBlackindividuals(8.8%forUC,6.6%","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"204 2","pages":"S16 - S16"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139020041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S119 Outcomes of Ulcerative Colitis in Octogenarians, Nonagenarians, and Centenarians: A Population-Based Study S119 八旬老人、非耄耋老人和百岁老人的溃疡性结肠炎预后：一项基于人群的研究
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996220.54802.aa
T. Elias, R. Beshai, Charles Yang, Mark Tawfik, Ramneet Wadehra, Howard M. Weinberg, Joshua Soliman, Jonathen Foster, Lucy Joo
{"title":"S119 Outcomes of Ulcerative Colitis in Octogenarians, Nonagenarians, and Centenarians: A Population-Based Study","authors":"T. Elias, R. Beshai, Charles Yang, Mark Tawfik, Ramneet Wadehra, Howard M. Weinberg, Joshua Soliman, Jonathen Foster, Lucy Joo","doi":"10.14309/01.ajg.0000996220.54802.aa","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996220.54802.aa","url":null,"abstract":"continental dimensions like Brazil, we observed the importance of distance approach as a tool to evaluate patients with IBD, and based on the patients report outcome (PRO) we directed them to face-to-face care or not, in order to control the spread of virus S119 Outcomes of Ulcerative Colitis in Octogenarians, Nonagenarians, and Centenarians: A Population-Based Study","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"160 ","pages":"S32 - S32"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139021579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S146 Evaluating Treatment Perception and Productivity Impairment in Inflammatory Bowel Diseases Patients on Anti-TNF Therapy S146 评估接受抗肿瘤坏死因子治疗的炎症性肠病患者的治疗感知和生产力受损情况
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996328.94305.53
H. Nieves-Jiménez, Yue-Sai Jao, S. Ortiz-Domenech, F. Marrero-Concepción, Jesús G. Rivera-Román, Manuel A. Colón-Terrón, Fabiola T. Matos-Jiménez, Sergio A. Burgos-Rosado, Jon C. Vélez-Morell, Esther A. Torres
{"title":"S146 Evaluating Treatment Perception and Productivity Impairment in Inflammatory Bowel Diseases Patients on Anti-TNF Therapy","authors":"H. Nieves-Jiménez, Yue-Sai Jao, S. Ortiz-Domenech, F. Marrero-Concepción, Jesús G. Rivera-Román, Manuel A. Colón-Terrón, Fabiola T. Matos-Jiménez, Sergio A. Burgos-Rosado, Jon C. Vélez-Morell, Esther A. Torres","doi":"10.14309/01.ajg.0000996328.94305.53","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996328.94305.53","url":null,"abstract":"","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"634 ","pages":"S39 - S39"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139026423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S42 Tailoring Crohn’s Disease Surveillance After Ileocolic Resection: The Importance of Inflammatory Biomarkers S42 回结肠切除术后克罗恩病监测的定制：炎症生物标志物的重要性
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995908.19720.68
Ana Isabel Ferreira, C. Arieira, S. Xavier, J. Cotter
{"title":"S42 Tailoring Crohn’s Disease Surveillance After Ileocolic Resection: The Importance of Inflammatory Biomarkers","authors":"Ana Isabel Ferreira, C. Arieira, S. Xavier, J. Cotter","doi":"10.14309/01.ajg.0000995908.19720.68","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995908.19720.68","url":null,"abstract":", immunohistochemical staining for IgG4 was performed on the patient ’ s colon biopsies, which revealed a high percentage of the IgG cells in the lamina propria with . 50% positivity for IgG4. This con fi rmed the patient ’ s IgG4 mediated colitis, and he has now started rituximab therapy. Conclusions: We demonstrate a case of IgG4-RD misclassi fi ed as CD and GPA and emphasize the importance of consideration of this rare disorder in appropriate patients. Clinical follow-up and response to rituximab will be described at the time of this case presentation.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"102 ","pages":"S12 - S12"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138986403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S98 Relationship Between Depression and Severity in Inflammatory Bowel Disease S98 抑郁症与炎症性肠病严重程度之间的关系
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996136.09094.dc
G. Veitía, Gabriela Abreu, Rafael Montero, B. Pernalete
{"title":"S98 Relationship Between Depression and Severity in Inflammatory Bowel Disease","authors":"G. Veitía, Gabriela Abreu, Rafael Montero, B. Pernalete","doi":"10.14309/01.ajg.0000996136.09094.dc","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996136.09094.dc","url":null,"abstract":"Discussion: Colonoscopy is an important","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"38 8","pages":"S27 - S27"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138987222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S23 Real-World Effectiveness of Advanced Therapies on Bowel Urgency in Patients With Crohn’s Disease in the United States S23 先进疗法对美国克罗恩病患者肠道紧迫性的实际效果
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995828.37128.5f
James Lewis, Wai Man Maria Chan, R. Moses, Xian Zhou, Yitong Wang, Payal Jha, T. Gibble
{"title":"S23 Real-World Effectiveness of Advanced Therapies on Bowel Urgency in Patients With Crohn’s Disease in the United States","authors":"James Lewis, Wai Man Maria Chan, R. Moses, Xian Zhou, Yitong Wang, Payal Jha, T. Gibble","doi":"10.14309/01.ajg.0000995828.37128.5f","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995828.37128.5f","url":null,"abstract":"Background","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"696 ","pages":"S7 - S7"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S76 Aseptic Splenic Abscesses: Evaluating for Infectious versus Inflammatory Causes S76 无菌性脾脓肿：评估感染性和炎症性原因
The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996048.29168.53
K. Dunleavy, Konstantinos Papadakis
{"title":"S76 Aseptic Splenic Abscesses: Evaluating for Infectious versus Inflammatory Causes","authors":"K. Dunleavy, Konstantinos Papadakis","doi":"10.14309/01.ajg.0000996048.29168.53","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996048.29168.53","url":null,"abstract":"of drug-induced","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"100 1","pages":"S21 - S21"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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