Natural Polysaccharides in Drug Delivery and Biomedical Applications最新文献_第3页

Development and Characterization of Sustainable Antimicrobial Films Incorporated with Natamycin and Cellulose Nanocrystals for Cheese Preservation 纳他霉素和纤维素纳米晶复合抗菌膜的制备与表征

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2023-01-21 DOI: 10.3390/polysaccharides4010004

M. D. Sousa, Vânia Miria C. Clemente, Rosilene Maria de S. Santos, M. Oliveira, José Osvaldo Ramos Silva, Laís Fernanda Batista, C. Marques, A. Souza, E. Medeiros, N. Soares

{"title":"Development and Characterization of Sustainable Antimicrobial Films Incorporated with Natamycin and Cellulose Nanocrystals for Cheese Preservation","authors":"M. D. Sousa, Vânia Miria C. Clemente, Rosilene Maria de S. Santos, M. Oliveira, José Osvaldo Ramos Silva, Laís Fernanda Batista, C. Marques, A. Souza, E. Medeiros, N. Soares","doi":"10.3390/polysaccharides4010004","DOIUrl":"https://doi.org/10.3390/polysaccharides4010004","url":null,"abstract":"Environmental pollution and food safety are both issues of global concern. In this sense, sustainable and antimicrobial nanocomposites based on cellulose/poly (vinyl alcohol) blend incorporated with natamycin and cellulose nanocrystals (CNC) were manufactured and characterized. The developed films were evaluated according to their mechanical and optical properties, and their barrier to oxygen and water vapor permeation. The antimycotic activity was evaluated in vitro against fungi and yeasts. The film’s potential to act as an active packaging for Minas cheese preservation was also assessed. The incorporation of CNC increased the films’ tensile strength; however, it did not influence the barrier properties to water vapor (4.12 × 10−7 g·cm.m−1·h−1·Pa−1) and oxygen (3.64 × 10−13 g·cm·m−1·h−1·Pa−1). The incorporation of natamycin, on the other hand, resulted in films that were more opaque (around 24%) and of a yellowish color. The active nanocomposites developed showed antimicrobial effects against all analyzed fungi and yeasts (approximately 35 mm of inhibition zone) and were able to control the growth of S. cerevisiae in cheese, reducing a log cycle until the 12th day of storage. Since they performed well in vitro and on food, it was concluded that the films showed potential to be applied in Minas cheese preservation.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83791758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acknowledgment to the Reviewers of Polysaccharides in 2022 向2022年《多糖》审稿人致谢

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2023-01-17 DOI: 10.3390/polysaccharides4010003

引用次数: 0

Anthocyanin-Rich Jamun (Syzygium cumini L.) Pulp Transported on Protein-Coated Ionic Gelation Microparticles of Calcium Alginate: Production and Morphological Characteristics 花青素丰富的Jamun (Syzygium cumini L.)海藻酸钙蛋白包被离子凝胶微粒子的浆体运输:生产和形态特征

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2023-01-11 DOI: 10.3390/polysaccharides4010002

Vitor Renan da Silva, Gislaine Ferreira Nogueira, C. Soares, R. A. D. Oliveira

{"title":"Anthocyanin-Rich Jamun (Syzygium cumini L.) Pulp Transported on Protein-Coated Ionic Gelation Microparticles of Calcium Alginate: Production and Morphological Characteristics","authors":"Vitor Renan da Silva, Gislaine Ferreira Nogueira, C. Soares, R. A. D. Oliveira","doi":"10.3390/polysaccharides4010002","DOIUrl":"https://doi.org/10.3390/polysaccharides4010002","url":null,"abstract":"Jamun (Syzygium cumini L.) is a fruit rich in anthocyanins, an important group of natural pigments, with color ranging from red to blue, soluble in water, highly antioxidant. Despite its great potential for use as a natural dye, its application is a challenge, due to the instability of these compounds in the environmental conditions of processing and storage commonly used by the food industry. Therefore, this study evaluated the microencapsulation of anthocyanin-rich jamun pulp by ionic gelation (IG) and its protein-coating by electrostatic interaction (PC). The effect of the ratio of sodium alginate solids and jamun pulp (1:0.40 to 1:2, w/w) and the concentration of gelatin coating solution (0% to 10%, w/w) on the morphology, water and total protein content and anthocyanins content in the microparticles were evaluated. Visually, the IG particles showed color tones ranging from reddish to purplish, which became less intense and opaque after being submitted to the gelatin coating process. Microscopic images demonstrated that microparticles formed had an irregular and heterogeneous shape with disorganized gel network formation is due to the presence of solid structures of jamun pulp, observed within the microparticles. The greater the concentration of gelatin in the coating solution, the greater the protein adsorption for the formation of the protective layer, ranging from 21.82 ± 0.72% (T1) to 55.87 ± 4.23% (T6). Protein adsorption on the GI resulted in a decrease in moisture content (ranging from 87.04 ± 0.22 to 97.06 ± 0.12%) and anthocyanins contents (ranging from 5.84 ± 0.62 to 0.78 ± 0.14%) in the PC microparticles.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78947258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Potential Biomedical Applications of Modified Pectin as a Delivery System for Bioactive Substances 改性果胶作为生物活性物质递送系统的潜在生物医学应用

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2023-01-01 DOI: 10.3390/polysaccharides4010001

F. Odun-Ayo, L. Reddy

{"title":"Potential Biomedical Applications of Modified Pectin as a Delivery System for Bioactive Substances","authors":"F. Odun-Ayo, L. Reddy","doi":"10.3390/polysaccharides4010001","DOIUrl":"https://doi.org/10.3390/polysaccharides4010001","url":null,"abstract":"Pectin is a polysaccharide that has been recently gaining attention because it is renewable, inexpensive, biocompatible, degradable, non-toxic, non-polluting, and has mechanical integrity. The recent extraction techniques and modification to the structural property of pectin have led to the modified pectin whose chemical and surface functional groups yield galacturonic acid and galactose contents which are primarily responsible for its improved and better use in biomedical applications including drug delivery and thus producing high-value products. Major attention on modified pectin has been focused on the aspect of its bioactive functionalities that opposes cancer development. Nevertheless, modified pectin can be combined with a wide range of biopolymers with unique characteristics and activities which thus enhances its application in different areas. This has enabled the current applications of modified pectin through different approaches in addition to the prominent anti-cancer functional capabilities, which were reviewed. Furthermore, this paper highlights the potential of modified pectin as a delivery system of bioactive substances, its synergistic and prebiotic effects, gut microbiota effect and antiviral properties amongst other roles applicable in the biomedical and pharmaceutical industries.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87739339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Photo-Curing Chitosan-g-N-Methylolacrylamide Compositions: Synthesis and Characterization 光固化壳聚糖-g- n-甲基丙烯酰胺组合物:合成与表征

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-12-18 DOI: 10.3390/polysaccharides3040049

S. Uspenskii, V. Potseleev, E. Svidchenko, G. Goncharuk, A. Zelenetskii, T. Akopova

{"title":"Photo-Curing Chitosan-g-N-Methylolacrylamide Compositions: Synthesis and Characterization","authors":"S. Uspenskii, V. Potseleev, E. Svidchenko, G. Goncharuk, A. Zelenetskii, T. Akopova","doi":"10.3390/polysaccharides3040049","DOIUrl":"https://doi.org/10.3390/polysaccharides3040049","url":null,"abstract":"Chitosan is one of the promising compounds for use in various fields of medicine. However, for successful application, materials based on it must be insoluble in water and have specified physical and mechanical properties. In this work, we studied the interaction of N-methylolacrylamide (NMA) and chitosan upon concentration of the solutions, both under the action of UV radiation and without it, which results in curing of the polymer matrix. The main products, proposed mechanisms of the crosslinking reaction, and the influence of external conditions on these processes have been revealed using NMR, IR, and UV spectroscopy. It was found that the reaction proceeds along three pathways. The main reactions proceed with the amino groups of chitosan, and the hydroxymethyl and vinyl groups of NMA. Studies have shown that for the formation of insoluble materials based on chitosan, the best content in the initial cast solution is 2 wt% of chitosan at 0.25 wt% concentration of NMA. Films formed from such solutions possessed high strength and deformation characteristics, namely an elastic modulus of about 1500 GPa, a strength of about 30 MPa, and an elongation at break of about 100%.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74182428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin Health Promoting Effects of Natural Polysaccharides and Their Potential Application in the Cosmetic Industry 天然多糖对皮肤健康的促进作用及其在化妆品工业中的潜在应用

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-12-14 DOI: 10.3390/polysaccharides3040048

Yu-Xiu Yao, Baojun Xu

引用次数: 4

Reactive Extrusion-Assisted Process to Obtain Starch Hydrogels through Reaction with Organic Acids 反应挤出辅助工艺与有机酸反应制备淀粉水凝胶

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-12-05 DOI: 10.3390/polysaccharides3040046

B. M. Marim, J. Mantovan, Gina Alejandra Gil-Giraldo, Jéssica F Pereira, B. Simões, F. Yamashita, S. Mali

{"title":"Reactive Extrusion-Assisted Process to Obtain Starch Hydrogels through Reaction with Organic Acids","authors":"B. M. Marim, J. Mantovan, Gina Alejandra Gil-Giraldo, Jéssica F Pereira, B. Simões, F. Yamashita, S. Mali","doi":"10.3390/polysaccharides3040046","DOIUrl":"https://doi.org/10.3390/polysaccharides3040046","url":null,"abstract":"A totally green process based on reactive extrusion was used for the production of cassava starch hydrogels through reaction with two organic crosslinking agents, citric (CA) and tartaric (TA) acids. CA and TA were used at different concentrations (0, 2.5, 5.0, 10.0, 15.0, and 20.0%). Degree of substitution (DS) of hydrogels ranged from 0.023 to 0.365. Fourier transform infrared spectroscopy results showed a new band appearing at 1730 cm−1 associated with ester carbonyl groups. X-ray diffraction indicated that reactive extrusion resulted in the disappearance of diffraction peaks of native starch and samples with lower crystallinity indices ranging from 37% (native starch) to 8–11% in starch hydrogels. Morphology analysis showed that the original granular structure of starch was lost and replaced by a rougher and irregular structure. Water holding capacity values of starch hydrogels obtained by reactive extrusion were superior to those of native starch and the control sample (extruded without the crosslinking agents). Hydrogels obtained with the highest CA or TA concentration (20.0%) resulted in the higher DS and swelling capacities, resulting in samples with 870 and 810% of water retention, respectively. Reactive extrusion was effective in obtaining starch hydrogels by reaction with organic acids.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75258738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Role of Starch in Shaping the Rheo-Mechanical Properties of Fat-in-Water Emulsions 淀粉对水包脂肪乳剂流变力学性能的影响

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-12-05 DOI: 10.3390/polysaccharides3040047

R. Rezler

{"title":"The Role of Starch in Shaping the Rheo-Mechanical Properties of Fat-in-Water Emulsions","authors":"R. Rezler","doi":"10.3390/polysaccharides3040047","DOIUrl":"https://doi.org/10.3390/polysaccharides3040047","url":null,"abstract":"The DMA technique was used to conduct experiments on the rheo-mechanical properties of emulsified bovine fat meat products stabilised with potato starch. Starch gels with starch concentrations corresponding to the concentration of starch in water in the emulsions under analysis were used as control systems. The research showed that the rheo-mechanical properties of starch gels and starch–fat gels result from the conformational changes occurring within the structural elements of their spatial network. In starch gels, segments formed by complex associations of amylose chains are structural elements, whereas in starch–fat gels (emulsions) these are additionally amylose–fat complexes. Changes occurring during progressive retrogradation increase the degree of cross-linking in them. In starch gels, they are conditioned by the starch concentration, whereas in emulsions they are conditioned by the concentration of starch and the presence of fat. The parameters obtained by adjusting the Avrami equation to the data obtained with the DMA method enabled the determination of three forms of organisation of the dispersion structure of starch–fat systems. Each of these forms of structure organisation is conditioned by the concentration of starch in the emulsion system.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91347539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cellulose-Based Light-Management Films with Improved Properties Directly Fabricated from Green Tea 直接以绿茶为原料制备性能改善的纤维素基光管理薄膜

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-12-02 DOI: 10.3390/polysaccharides3040045

Jianfeng Peng, Xiaoqian Ji, Xinqun Xia, Cuiyue Li, Zhaoning Wei, Chen Chu, Zhen Xu, Jun Zhang, Guangmei Xia

{"title":"Cellulose-Based Light-Management Films with Improved Properties Directly Fabricated from Green Tea","authors":"Jianfeng Peng, Xiaoqian Ji, Xinqun Xia, Cuiyue Li, Zhaoning Wei, Chen Chu, Zhen Xu, Jun Zhang, Guangmei Xia","doi":"10.3390/polysaccharides3040045","DOIUrl":"https://doi.org/10.3390/polysaccharides3040045","url":null,"abstract":"Tea polyphenols are a phenolic bioactive compound extracted from tea leaves and have been widely used as additives to prepare functional materials used in packaging, adsorption and energy fields. Nevertheless, tea polyphenols should be extracted first from the leaves before use, leading to energy consumption and the waste of tea. Therefore, completely and directly utilizing the tea leaf to fabricate novel composite materials is more attractive and meaningful. Herein, semi-transparent green-tea-based all-biomass light-management films with improved strength, a tunable haze (60–80%) and UV-shielding properties (24.23% for UVA and 4.45% for UVB) were directly manufactured from green tea by adding high-degree polymerization wood pulps to form entanglement networks. Additionally, the green-tea-based composite films can be produced on a large scale by adding green tea solution units to the existing continuous production process of pure cellulose films. Thus, a facile and feasible approach was proposed to realize the valorization of green tea by preparing green-tea-based all-biomass light-management films that have great prospects in flexible devices and energy-efficient buildings.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86646392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Polysaccharide-Based Biodegradable Films: An Alternative in Food Packaging 以多糖为基础的可生物降解薄膜:食品包装的一种替代品

Natural Polysaccharides in Drug Delivery and Biomedical Applications Pub Date : 2022-11-25 DOI: 10.3390/polysaccharides3040044

E. Díaz-Montes

{"title":"Polysaccharide-Based Biodegradable Films: An Alternative in Food Packaging","authors":"E. Díaz-Montes","doi":"10.3390/polysaccharides3040044","DOIUrl":"https://doi.org/10.3390/polysaccharides3040044","url":null,"abstract":"Packaging can mitigate the physical, chemical, and microbiological phenomena that affects food products’ quality and acceptability. However, the use of conventional packaging from non-renewable fossil sources generates environmental damage caused by the accumulation of non-biodegradable waste. Biodegradable films emerge as alternative biomaterials which are ecologically sustainable and offer protection and increase food product shelf life. This review describes the role of biodegradable films as packaging material and their importance regarding food quality. The study emphasizes polysaccharide-based biodegradable films and their use in foods with different requirements and the advances and future challenges for developing intelligent biodegradable films. In addition, the study explores the importance of the selection of the type of polysaccharide and its combination with other polymers for the generation of biodegradable films with functional characteristics. It also discusses additives that cause interactions between components and improve the mechanical and barrier properties of biodegradable films. Finally, this compilation of scientific works shows that biodegradable films are an alternative to protecting perishable foods, and studying and understanding them helps bring them closer to replacing commercial synthetic packaging.","PeriodicalId":18775,"journal":{"name":"Natural Polysaccharides in Drug Delivery and Biomedical Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85562257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6