Molekul Pub Date : 2023-07-10 DOI: 10.20884/1.jm.2023.18.2.5402

Thaifah Muthohharoh, Linda Johana Latumahina, S. Suyanta, S. Suherman

{"title":"Analysis of Petroleum Products Spill Potential Impact (Gasoline and Diesel Fuels) on Soil Fertility Quality Around Pertamina Rewulu-Cilacap Pipeline Bantul-Yogyakarta","authors":"Thaifah Muthohharoh, Linda Johana Latumahina, S. Suyanta, S. Suherman","doi":"10.20884/1.jm.2023.18.2.5402","DOIUrl":"https://doi.org/10.20884/1.jm.2023.18.2.5402","url":null,"abstract":"This research focused on analyzing the potential impact of petroleum products spill (gasoline and diesel fuels) on soil fertility quality around PERTAMINA Rewulu-Cilacap Pipeline Bantul, Yogyakarta. The objectives of this study were to analyze the change of soil fertility parameters that are contaminated by gasoline and diesel fuel oils, compared to uncontaminated soil as control. Soil samples were collected from Pertamina Rewulu-Cilacap around the pipeline. Some physico-chemical properties that reflect soil fertility were determined using standard physico-chemical methods and Total Petroleum Hydrocarbon (TPH) using Gas Chromatography. Soil samples were divided into three points (I, II, and III) based on taken places. The study started with analysis of physical and chemical properties of the soil, then petroleum products (gasoline and diesel) were added to the soil samples. The contaminated soil and control then analyzed for identify the fertility quality and TPH content. The results showed that petroleum product contamination increases N, P, and reduces K concentrations in the soil. The sample in point III had the highest values of TPH concentration without any additional petroleum products. After addition of a dose of 13% gasoline, the concentration of TPH in point I, II, and III increased by 0.036%, 0.08% and 0.008%. With the addition of 15% diesel in the sample, the TPH concentration of point I, II, and III increased by 0.892 %, 1.198%, and 0.91%.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48389840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholestan Steroids from The Stem Bark of Aglaia angustifolia Miq and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines 沙枣茎皮胆固醇甾类化合物及其对MCF-7乳腺癌症细胞系的细胞毒性作用

Molekul Pub Date : 2023-07-10 DOI: 10.20884/1.jm.2023.18.2.6205

R. P. Hutagaol, T. Mozef, S. Fajriah, Gian Primahana, U. Supratman, D. Harneti, A. Hidayat, K. Awang, Y. Shiono

{"title":"Cholestan Steroids from The Stem Bark of Aglaia angustifolia Miq and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines","authors":"R. P. Hutagaol, T. Mozef, S. Fajriah, Gian Primahana, U. Supratman, D. Harneti, A. Hidayat, K. Awang, Y. Shiono","doi":"10.20884/1.jm.2023.18.2.6205","DOIUrl":"https://doi.org/10.20884/1.jm.2023.18.2.6205","url":null,"abstract":"With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research objective was to find secondary metabolites that have activity as anti-breast cancer compounds from endemic Indonesian Aglaia, such as Aglaia angustifolia Miq. Two cholestan type steroids, stigmast-5en-3α-acetat (1), as a new steroid with α-sterochemistry of acetyl moiety at C-3 and 23a-homostigmast-5en-3β-ol (2), with unusual side chain were isolated for the first time from the stem bark of Aglaia angustifolia Miq or known as segara tree in Kalimantan. The chemical structures of two steroids were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, NOESY, 1H-1H COSY) and HRTOF-MS, as well as by comparing with previously reported spectral data. These two steroids were isolated for the first time from this genus. Steroids 1 and 2 were evaluated for cytotoxic activity against MCF-7 breast cancer cells and showed weak activity with IC50 values of 829.0 and 903.0 µg/mL, respectively.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44189316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Identification of Cellulolytic Bacteria from Gut of Horn Beetle Larvae (Oryctes rhinoceros L.) 角甲虫幼虫肠道纤维素分解菌的分离与鉴定

Molekul Pub Date : 2023-07-10 DOI: 10.20884/1.jm.2023.18.2.6848

R. Riskawati, H. Natsir, S. Dali, M. Baharuddin

{"title":"Isolation and Identification of Cellulolytic Bacteria from Gut of Horn Beetle Larvae (Oryctes rhinoceros L.)","authors":"R. Riskawati, H. Natsir, S. Dali, M. Baharuddin","doi":"10.20884/1.jm.2023.18.2.6848","DOIUrl":"https://doi.org/10.20884/1.jm.2023.18.2.6848","url":null,"abstract":"The horn beetle larvae (Oryctes rhinoceros L.) contain symbiotic bacteria that are used to digest and degrade cellulose as food so that it has the potential to produce cellulase enzymes. This study aims to isolate, characterize and identify microbial symbionts from horn beetle larvae that have the potential to produce cellulase enzymes.The methods in this study include morphology and physiology identification of bacteria, qualitative and quantitative activity tests and species determination using 16S rRNA sequencing technique. Based on the results of morphological observations, five bacterial isolates were taken which has the potential as a cellulase producer is indicated by the presence of a clear zone that is produced when a qualitative test is carried out using congo red staining with different cellulolytic indices. Based on the quantitative bacterial activity test using UV-Vis, the highest activity was found in PES3 isolates at 1.62 x 10-2 and PES5 at 1.61 x 10-2. Species determination results found that PES3 isolates belonged to the genus Acinetobacter and PES5 belonged to Pseudomonas. In addition to the isolates obtained for the environment and the industrial sector, cellulolytic bacteria can provide added value such as hydrolyze cellulose waste into alternative fuels.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49132050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Evaluation of Some Sulfonamide-Substituted of 1,3,5-Triphenyl Pyrazoline Derivatives as Tyrosinase Enzyme Inhibitors 一些磺胺取代1,3,5-三苯基吡唑啉衍生物酪氨酸酶抑制剂的合成与评价

Molekul Pub Date : 2023-07-10 DOI: 10.20884/1.jm.2023.18.2.6936

Nofal Herfindo, N. Frimayanti, Ihsan Ikhtiarudin, Yum Eryanti, A. Zamri

引用次数: 0

Adsorption of Congo Red onto Humic Acid Isolated from Peat Soil Gambut Regency, South Kalimantan 刚果红在南加里曼丹泥炭土甘布县腐殖酸上的吸附

Molekul Pub Date : 2023-07-10 DOI: 10.20884/1.jm.2023.18.2.8685

Dewi Umaningrum, Radna Nurmasari, U. Santoso, M. Astuti, Hapsari Tyas Pradita

{"title":"Adsorption of Congo Red onto Humic Acid Isolated from Peat Soil Gambut Regency, South Kalimantan","authors":"Dewi Umaningrum, Radna Nurmasari, U. Santoso, M. Astuti, Hapsari Tyas Pradita","doi":"10.20884/1.jm.2023.18.2.8685","DOIUrl":"https://doi.org/10.20884/1.jm.2023.18.2.8685","url":null,"abstract":"Humic acid is one of the green materials for wastewater treatment including for removal dyes as an adsorbent. Humic acid was isolated from peat soil, Gambut Regency, South Kalimantan following International Humic Substances Society method, and used to adsorb Congo red. The adsorption process was carried out in a batch system and the effect of pH, contact time, and adsorption capacity of Congo red on humic acid were studied. The adsorbent characterization by using FTIR. The results showed that the adsorption of Congo red on humic acid occurred at the optimum pH of pH 6, the optimum contact time was 120 minutes. The adsorption capacity of Congo red onto humic acid of 33.33 mg/g and follows the Langmuir model with R2 = 0.9926. The characterization of humic acid functional groups before and after adsorption of Congo red showed that the signal at 1,712.79 cm-1 were shifted to 1,705.07 cm-1 and 1,273.02 cm-1 were shifted to 1,265.30 cm-1. These suggested that the mechanism interaction was the electrostatic interaction between -NH3+ functional group of Congo red group and -COO- functional group of humic acid. It means that humic acid isolated from peat soil could be used as an adsorbent for the removal Congo red.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44985963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Ionophore from p-t-Butyl-(carboxymethoxy)calix[4]arene Substituted Amide 对叔丁基-(羧基甲氧基)杯芳烃取代酰胺合成离子载体

Molekul Pub Date : 2023-03-21 DOI: 10.20884/1.jm.2023.18.1.5927

Nasriadi Dali, S. Dali, Armadi Chairunnas, H. Amalia, Srie Puspitasari

引用次数: 0

Essential Oils of Alpinia monopleura and Their Antibacterial and Antioxidant Activity 黄姜精油及其抗菌抗氧化活性

Molekul Pub Date : 2023-03-21 DOI: 10.20884/1.jm.2023.18.1.6265

A. W. Yodha, E. Badia, Musdalipah Musdalipah, Muhammad Azdar Setiawan, Nurafifah Daud, Angriani Fusvita, A. Fristiohady, Sahidin Sahidin

{"title":"Essential Oils of Alpinia monopleura and Their Antibacterial and Antioxidant Activity","authors":"A. W. Yodha, E. Badia, Musdalipah Musdalipah, Muhammad Azdar Setiawan, Nurafifah Daud, Angriani Fusvita, A. Fristiohady, Sahidin Sahidin","doi":"10.20884/1.jm.2023.18.1.6265","DOIUrl":"https://doi.org/10.20884/1.jm.2023.18.1.6265","url":null,"abstract":"Alpinia monopleura is an endemic plant which widespread and abundant in Sulawesi. Nevertheless, previous studies have not studied the chemical compound and biological activity. This study describes the chemical compounds and antibacterial and antioxidant properties of the essential oils isolated from A. monopleura. The essential oil was obtained by the hydro distillation method and interpreted by GCMS. Antibacterial properties were determined by the agar diffusion method, while DPPH and ABTS determined antioxidant activity. The most important components are α-caryophyllene, β-pinene, limonene, α-pinene, β-caryophyllene and caryophyllene oxide. Essential oils of leaves and fruit showed excellent antibacterial properties with a MIC strength of 31.3 μg/mL against Staphylococcus aureus ATCC 25023 and Escherichia coli ATCC 35218. The highest antioxidant effect was also shown by inhibiting ABTS and DPPH radicals, with IC50 strength of essential oil obtained from the leaf being 15.60 and 19.42 μg/mL, respectively, while from the fruit were 10.44 and 11.93 μg/mL. These antibacterial and antioxidant properties indicate that essential oils have advantages in their use in the food and pharmaceutical industries.","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48984087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adsorption of Rhodamine B on Spherical Activated Carbon synthesized from Waste Bagasse Liquid using Hydrothermal Process 水热法从蔗渣废液合成球形活性炭吸附罗丹明B

Molekul Pub Date : 2023-03-20 DOI: 10.20884/1.jm.2023.18.1.5510

U. Sulaeman, Baynuri Ikhya Ulumuddin, R. Andreas, Irmanto Irmanto, P. Iswanto

引用次数: 0

Does Divacancy Defect Combine with N,S-Codoping Enhance the Electronic Properties of Graphene to Its Interaction with K+ Ion? N、s共掺杂是否能提高石墨烯与K+离子相互作用的电子性能?

Molekul Pub Date : 2023-03-20 DOI: 10.20884/1.jm.2023.18.1.7077

Y. Hidayat, F. Rahmawati, K. Nugrahaningtyas, Abduro’uf Althof Abiyyi

引用次数: 0

An Insight of Cryptocarya Secondary Metabolites as Anticancer P388: Study of Molecular Docking and ADMET Properties 隐卡子次生代谢产物作为抗癌药物P388的研究——分子对接和ADMET性质的研究

Molekul Pub Date : 2023-03-20 DOI: 10.20884/1.jm.2023.18.1.6364

Herlina Rasyid, Riska Mardiyanti, Ihsanul Arief, W. D. Saputri

{"title":"An Insight of Cryptocarya Secondary Metabolites as Anticancer P388: Study of Molecular Docking and ADMET Properties","authors":"Herlina Rasyid, Riska Mardiyanti, Ihsanul Arief, W. D. Saputri","doi":"10.20884/1.jm.2023.18.1.6364","DOIUrl":"https://doi.org/10.20884/1.jm.2023.18.1.6364","url":null,"abstract":"Secondary metabolites isolated from Cryptocarya was known to have various activity especially their cytotoxicity in P388 cell. There were two species of Cryptocarya studied in this research that were Cryptocarya konishii and Cryptocarya lucida. In both species, 8 isolate compounds had bioactivity as anticancer in P388 cells. This study aimed to know the binding affinity and ADMET properties of each isolated compound through P-glycoprotein substrate since this protein was reported to be responsible for the inhibition of P388 cells. Molecular docking was performed using AutoDock4 and AutoDockTools software to know the binding energy and interaction of isolate compounds against the P-glycoprotein substrate. ADMET properties calculation was done using the pkCSM web server for all compounds. Molecular docking results showed that Kurzichalcolactone B (7) isolated from C. lucida had the lowest binding energy. It resulted in the highest total intermolecular energy from the contribution of van der Waals and hydrogen bond energy. The lowest binding energy is indicating the stable interaction of ligand and substrate. Calculation of ADMET properties resulted that some of the isolate compounds fulfilling the minimum standard parameters in ADMET properties. ","PeriodicalId":18773,"journal":{"name":"Molekul","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43019841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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