Minerva ginecologica最新文献_第5页

Efficacy and safety of a novel vaginal medical device in recurrent bacterial vaginosis: a multicenter clinical trial. 一种新型阴道医疗器械治疗复发性细菌性阴道病的疗效和安全性:一项多中心临床试验

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Minerva ginecologica Pub Date : 2020-10-01 DOI: 10.23736/S0026-4784.20.04661-4

Filippo Murina, Ciprian Crișan, Marius Biriș, Daniela Sîrbu, Dionisio F Barattini, Luca I Ardolino, Elena Casolati

{"title":"Efficacy and safety of a novel vaginal medical device in recurrent bacterial vaginosis: a multicenter clinical trial.","authors":"Filippo Murina, Ciprian Crișan, Marius Biriș, Daniela Sîrbu, Dionisio F Barattini, Luca I Ardolino, Elena Casolati","doi":"10.23736/S0026-4784.20.04661-4","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04661-4","url":null,"abstract":"Background: The effectiveness of a new vaginal medical device, which contains polycarbophil, 0.04% lauryl glucoside and glycerides (Polybactum®, Effik Italia Spa, Cinisello Balsamo, Milan, Italy), in reducing BV recurrence rate was investigated.Methods: This was a multicenter, open label, not comparative study. Women over 18 years old affected by recurrent BV were included. The latest episode was diagnosed by Amsel criteria 6-9 days before the start of the study and treated with vaginal metronidazole (gel 0.75% mg for 5 days or ovules 500 mg for 7 days). The recurrence was defined by at least 2 episodes in the previous 12 months. Polybactum® vaginal ovules, day 1-4-7, were started within the 12th and the 24th hour after the end of metronidazole therapy and repeated monthly for 3 cycles.Results: The first 41 patients enrolled were evaluated for an interim analysis 6 months after the study started; 2 patients interrupted the trial, leaving 39 evaluable subjects. The recurrence rate was significantly reduced compared to previous published data (10.26% vs. 40% P<0.001). In 35 patients without recurrence, the assessment of Lactobacillus vaginal flora performed by phase contrast microscopy evidenced a significant improvement form baseline (P=0.022) The investigator global assessment of tolerability was excellent in 38 out of 39 cases.Conclusions: Our research showed that 3 monthly cycles of Polybactum® ovules administered after one course of metronidazole vaginal therapy can reduce the rate of Bacterial vaginosis recurrence and improve the vaginal milieu, favoring the growth of vaginal lactobacillus species.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":"72 5","pages":"292-298"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10407652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of uterine dimensions and route of contained morcellation following laparoscopic hysterectomy. 腹腔镜子宫切除术后子宫尺寸与内含分裂路径的关系。

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-07-17 DOI: 10.23736/S0026-4784.20.04602-X

Aakriti R Carrubba, Alfredo J Jijon, Michael G Heckman, Danielle E Brushaber, Anita H Chen, Tri A Dinh, Christopher C Destephano

{"title":"Association of uterine dimensions and route of contained morcellation following laparoscopic hysterectomy.","authors":"Aakriti R Carrubba, Alfredo J Jijon, Michael G Heckman, Danielle E Brushaber, Anita H Chen, Tri A Dinh, Christopher C Destephano","doi":"10.23736/S0026-4784.20.04602-X","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04602-X","url":null,"abstract":"Background: The aim of this study was to determine if uterine dimensions on preoperative imaging are associated with route of contained morcellation during laparoscopic hysterectomy.Methods: This is a prospective cohort study of patients undergoing laparoscopic hysterectomy and requiring morcellation for specimen extraction from March 2017 through August 2019. A contained extraction system was inserted and manual morcellation was performed vaginally, abdominally, or via a combination of both methods in cases of failed vaginal extraction.Results: A total of 47 patients were treated. Median age was 47 (range 38-70). Morcellation was performed vaginally for 29 patients (61.7%), abdominally for 13 patients (27.7%), and via combined approach for 5 patients (10.6%). The combined group had the highest frequency of patients who were black (vaginal: 24%, abdominal: 31%, combined: 100%; P=0.005), the longest median total operating time (vaginal: 167 minutes, abdominal: 183 minutes, combined: 268 minutes; P=0.006) and the longest median time of uterine morcellation (vaginal: 14 minutes, abdominal: 37 minutes, combined: 85 minutes; P<0.001). There was strong evidence of a positive correlation with time of uterine morcellation for both largest uterine diameter (Spearman's r: 0.62, P<0.001) and uterine volume (Spearman's r: 0.70, P<0.001). These associations remained consistent after multivariable linear regression models that were adjusted for route of morcellation, hysterectomy type, and BMI (both P<0.001).Conclusions: Larger uterine dimensions are associated with increased total operating and morcellation times. Uterine size and volume on preoperative imaging were not associated with route of morcellation, but there was a trend towards failed vaginal extraction when uterine dimensions exceeded 16 centimeters.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":" ","pages":"316-324"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38165530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Behcet's disease and pregnancy: a systematic review. 白塞氏病与妊娠:系统综述。

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-05-13 DOI: 10.23736/S0026-4784.20.04564-5

Lucia Merlino, Federica Del Prete, Benedetta Lobozzo, Roberta Priori, Maria G Piccioni

{"title":"Behcet's disease and pregnancy: a systematic review.","authors":"Lucia Merlino, Federica Del Prete, Benedetta Lobozzo, Roberta Priori, Maria G Piccioni","doi":"10.23736/S0026-4784.20.04564-5","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04564-5","url":null,"abstract":"Introduction: Behcet's disease (BD) is a rare inflammatory, multisystemic, autoimmune disorder with unknown origin. BD is included in vasculitic disorders with a more frequent onset characterized by oral and genital ulcers associated with eye inflammation. However, BD has several clinical manifestations, and the most fearful complication is thrombotic involvement. BD occurs mainly in women of childbearing age, therefore it is important to identify the potential risks of pregnancy on the mother and fetus.Evidence acquisition: The aim of our review is to identify, through the study of existing literature, the possible consequences of pregnancy on the course of this disease, the potential risks for the mother and fetus in gestation period and in puerperium, in order to identify a correct pregnancy management in patient affected by BD.Evidence synthesis: Currently, there are few studies that have analyzed the consequences of the disease on the course of pregnancy and pregnancy on the activity of the pathology. Some authors believe that pregnancy may worsen the symptoms of the disease, while others may even improve the course. Many authors believe that thromboembolic events are the main problems for which focus attention on these patients, both in pregnancy and in puerperium. Different opinions exist about pregnancy complications and neonatal outcomes, although events such as abortion, intrauterine growth restriction and C-section appear to have a higher incidence in BD patients.Conclusions: There are no contraindications for the onset of pregnancy in BD patients. In most cases pregnancy can improve the course of the disease. However, in view of the potential adverse events, a thorough follow-up of the pregnancy is necessary in order to minimize any risks to the mother and fetus.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":" ","pages":"332-338"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37931284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

COVID-19 and mental health in the obstetric population: a lesson from a case of puerperal psychosis. 2019冠状病毒病与产科人群心理健康:一例产褥期精神病的经验教训

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-07-28 DOI: 10.23736/S0026-4784.20.04606-7

Massimo Franchi, Lidia Del Piccolo, Mariachiara Bosco, Carlotta Tosadori, Jvan Casarin, Antonio S Laganà, Simone Garzon

引用次数: 23

Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies. 槲皮素、姜黄和n -乙酰半胱氨酸在减少与子宫内膜异位症相关的炎症和疼痛中的整合效果。体外和体内研究。

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Minerva ginecologica Pub Date : 2020-10-01 DOI: 10.23736/S0026-4784.20.04615-8

Mario Fadin, Maria C Nicoletti, Marzia Pellizzato, Manuela Accardi, Maria G Baietti, Andrea Fratter

{"title":"Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In-vitro and in-vivo studies.","authors":"Mario Fadin, Maria C Nicoletti, Marzia Pellizzato, Manuela Accardi, Maria G Baietti, Andrea Fratter","doi":"10.23736/S0026-4784.20.04615-8","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04615-8","url":null,"abstract":"Background: to evaluate the efficacy of oral administration of a novel composition composed of quercetin, curcumin, acetylcysteine in reducing pain in women affected by endometriosis, through the reduction of the inflammatory-hyperproliferative component of the ectopic endometrial tissue.Methods: Thirty-three women with clinical diagnosis of endometriosis from at least 3 months have been enrolled. Patients have been treated daily with 200 mg of quercetin, 210 mg of dry extract of Curcuma longa (titrated at 95% in curcuminoids) and 150 mg of acetylcysteine (1 tablet of ALLIENDO®) for 2 months. The overall symptomatology with specific reference to dysmenorrhea, pelvic pain and dyspareunia, together with the frequency of nonsteroidal anti-inflammatory drugs (NSAID) drugs assumption have been evaluated at the beginning and at the end of the treatment.Results: Overall, the results collected at the end of the treatment according to the parameters evaluated and above mentioned on the 33 patients enrolled, show a significative improvement in the reduction of pain symptoms associated to endometriosis (P<0.001 for dysmenorrhea, pelvic pain and dyspareunia). The use of NSAIDs together with an overall reduction of their dosage and time of assumption has been reduced as well. No significative side effects have been observed.Conclusions: The aforementioned results suggest that administration of the composition described can represent a valuable adjuvant treatment in the reduction of pain symptomatology associated to endometriosis, triggered by inflammatory cascade and hyperproliferation of ectopic tissue.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":"72 5","pages":"285-291"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10407382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Vaginal Lactobacillus species and inflammatory biomarkers in pregnancy. 妊娠期阴道乳杆菌种类和炎症生物标志物。

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-05-13 DOI: 10.23736/S0026-4784.20.04566-9

Kushal Gandhi, Paula Gutierrez, John Garza, Taylor J Gray Wlazlo, Rebecca J Meiser, Samuel David, Maira Carrillo, Madhusudhanan Narasimhan, Michael Galloway, Gary Ventolini

{"title":"Vaginal Lactobacillus species and inflammatory biomarkers in pregnancy.","authors":"Kushal Gandhi, Paula Gutierrez, John Garza, Taylor J Gray Wlazlo, Rebecca J Meiser, Samuel David, Maira Carrillo, Madhusudhanan Narasimhan, Michael Galloway, Gary Ventolini","doi":"10.23736/S0026-4784.20.04566-9","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04566-9","url":null,"abstract":"Background: The aim of this study was to identify vaginal Lactobacillus spp. and quantify vaginal inflammatory cytokines in primigravida vs. multigravida women and pregnant vs. non-pregnant women.Methods: Vaginal swabs were obtained from four groups of patients. A real-time PCR was carried out to identify the Lactobacillus spp. Multiplex immunoassays were performed to quantify a total of 27 cytokines using the Bio-Plex MAGPIX multiplex reader and MesoQuick Plex SQ 120 (Meso Scale Diagnostics LLC, Rockville, MD, USA). Inferential statistics using hypothesis tests were applied to detect differences in cytokine levels.Results: Significant differences in cytokines and chemokines exist among the four populations of women studied. IP-10 is significantly higher in multigravida women as compared to primigravida women. IFN-γ, MCP-1, MIP-1β, IL-2 and IL-10 are significantly higher in non-pregnant women compared to pregnant women. L. iners was the most abundant species in multigravida, pregnant and non-pregnant patients, while L. crispatus was the most abundant species in primigravida patients. Significant differences in the levels of MIP-1β, TNF-α, PDGF-BB, VEGF-A, IL-12, and IL-10 exist between women identified with Lactobacillus species and women not identified with Lactobacillus species.Conclusions: There were significant differences regarding cytokines, chemokines, and Lactobacillus spp. among four groups of studied patients. With these results, we increase our understanding of the role that vaginal cytokines and Lactobacillus species have during pregnancy, with the goal that this novel research will be useful for examining vaginal biomarkers in obstetrical conditions.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":" ","pages":"299-309"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37931285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

SARS-CoV-2 infection in pregnant women: are there long-term effects in offspring's brain development? 孕妇感染SARS-CoV-2:对后代的大脑发育有长期影响吗?

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-06-05 DOI: 10.23736/S0026-4784.20.04598-0

Filippo Murina, Dario Sannino

引用次数: 0

Learning curve for gynecological oncologists in performing upper abdominal surgery. 妇科肿瘤学家进行上腹部手术的学习曲线。

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-07-17 DOI: 10.23736/S0026-4784.20.04605-5

Mariaclelia La Russa, Chrysoula G Liakou, Nikolaos Akrivos, Hilary L Turnbull, Timothy J Duncan, Jose J Nieto, Edward Cheong, Nikolaos Burbos

{"title":"Learning curve for gynecological oncologists in performing upper abdominal surgery.","authors":"Mariaclelia La Russa, Chrysoula G Liakou, Nikolaos Akrivos, Hilary L Turnbull, Timothy J Duncan, Jose J Nieto, Edward Cheong, Nikolaos Burbos","doi":"10.23736/S0026-4784.20.04605-5","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04605-5","url":null,"abstract":"Background: To assess the learning curve for gynecological oncologists in performing upper abdominal surgery for management of patients with advanced epithelial ovarian cancer (EOC).Methods: Patients undergoing cytoreductive surgery for stage IIIC and IV EOC that required at least one surgical procedure in the upper abdomen were divided in three numerically equal groups: group 1, 2 and 3 that underwent surgery between December 2012 and July 2014, August 2014 to March 2016 and April 2016 to March 2018 respectively.Results: One hundred and twenty-six patients were included. The percentage of patients undergoing primary surgery for group 1, 2 and 3 was 47.6%, 50.0% and 73.8%, respectively (P=0.02). There was significant increase in the percentage of patients undergoing cholecystectomy (P=0.02), resection of disease from porta hepatis (P=0.008), liver capsulectomy (P<0.001), lesser omentectomy (P<0.001) and celiac trunk lymphadenectomy (P<0.001) in the group 3. There was no difference in the percentage of patients undergoing splenectomy, diaphragmatic peritonectomy/resection and gastrectomy. Complete cytoreduction was achieved in 54.8%, 35.7% and 64.3% of patients in group 1, 2 and 3 respectively (P=0.028). There was no significant difference in the occurrence of grade 3-5 complications. Presence of a liver surgeon was required in 9.1%, 5.6% and 0% of cases in group 1, 2 and 3 respectively.Conclusions: The results reflect the evolution of surgical skills in the upper abdomen through the increase in the percentage of patients undergoing primary surgery, with the surgical team undertaking more complex procedures, less involvement of other specialties and simultaneously achieving higher rates of complete cytoreduction.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":" ","pages":"325-331"},"PeriodicalIF":1.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38165531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Predictor for unfavorable Johnsen scoring in non-obstructive azoospermia before intra cytoplasmic sperm insemination and its outcome. 胞浆内精子受精前非阻塞性无精子症不良约翰森评分的预测因素及其结果。

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Minerva ginecologica Pub Date : 2020-10-01 Epub Date: 2020-07-28 DOI: 10.23736/S0026-4784.20.04573-6

Muhammad A Abu, Siti A Tajuddin, Abdul K Abdul Karim, Mohd F Ahmad, Zainul R Mohd Razi, Mohd H Omar

引用次数: 0

Defining arrest in the 1st and 2nd stages of labor. 分娩第一和第二阶段骤停的定义。

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Minerva ginecologica Pub Date : 2020-09-03 DOI: 10.23736/S0026-4784.20.04644-4

A. Gimovsky

{"title":"Defining arrest in the 1st and 2nd stages of labor.","authors":"A. Gimovsky","doi":"10.23736/S0026-4784.20.04644-4","DOIUrl":"https://doi.org/10.23736/S0026-4784.20.04644-4","url":null,"abstract":"Normal labor is identified as regular uterine contractions in addition to dilation and effacement of the cervix. It is necessary to define normal labor in order to delineate when a woman's labor pattern diverges from that observed in most women. Labor irregularities are subdivided into protraction disorders and arrest disorders. Identifying abnormal labor patterns and initiating appropriate interventions are essential because prolonged labor is associated with an increase in perinatal morbidity. The objective of this review is to delineate both normal labor progress and also discuss the current evidence-based diagnosis and treatment of protraction and arrest disorders. Many subtleties go into defining the boundaries of the first and second stages of labor. Historically, the Friedman curve established normal limits, but currently, Zhang has advanced these definitions by accounting for current demographical characteristics and practice environments. The most significant variables for defining normal progress of labor are parity and regional anesthesia status. The most common causes of labor abnormalities are uterine inactivity, obesity, cephalopelvic disproportion and fetal malposition. Risks of extending the first and/or second stage of labor include postpartum hemorrhage, intraamniotic infection and potentially an increase in neonatal adverse outcomes. The management of labor disorders consists of oxytocin administration, amniotomy, intrauterine pressure catheter use and shared decisionmaking regarding proceeding with expectant management, operative vaginal delivery or cesarean delivery after weighing the risks and benefits of each option. The decision to extend the duration of labor is personalized for each mother-baby dyad and should be agreed upon depending on individual maternal and fetal circumstances.","PeriodicalId":18745,"journal":{"name":"Minerva ginecologica","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2020-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47306603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0