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Metabolism: clinical and experimental最新文献

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A Phase 3, Multicenter, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Avexitide in Post-Bariatric Hypoglycemia (LUCIDITY) 一项3期、多中心、随机、双盲安慰剂对照研究评估阿维肽治疗减肥后低血糖的疗效和安全性
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156220
Ryan Miller , Marilyn Tan , Tracey McLaughlin , Mary Elizabeth Patti , Suzanne Bijl , Jennifer Hardy , Jorgji Kerthi , Jamie Timmons , Yuehui Wu , Zhengyu Yang , Lahar Mehta , Colleen Craig
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引用次数: 0
Prevalence of Hypercortisolism in Patients with Difficult-to-Control Type 2 Diabetes and High Blood Pressure: Results from CATALYST 高皮质醇血症在难以控制的2型糖尿病和高血压患者中的患病率：来自CATALYST的结果
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156214
Yehuda Handelsman , Vanita R. Aroda , Timothy Bailey , Robert S. Busch , John B. Buse , Elena Christofides , Ralph A. DeFronzo , Bradley Eilerman , Vivian Fonseca , Adline Ghazi , Steven E. Kahn , Mark Kipnes , Dan Lender , Jonathan G. Ownby , Jean Park , Julio Rosenstock , Michael Shanik , Lance Sloan , Ron Swerdloff , Guillermo Umpierrez , Daniel Einhorn
{"title":"Prevalence of Hypercortisolism in Patients with Difficult-to-Control Type 2 Diabetes and High Blood Pressure: Results from CATALYST","authors":"Yehuda Handelsman , Vanita R. Aroda , Timothy Bailey , Robert S. Busch , John B. Buse , Elena Christofides , Ralph A. DeFronzo , Bradley Eilerman , Vivian Fonseca , Adline Ghazi , Steven E. Kahn , Mark Kipnes , Dan Lender , Jonathan G. Ownby , Jean Park , Julio Rosenstock , Michael Shanik , Lance Sloan , Ron Swerdloff , Guillermo Umpierrez , Daniel Einhorn","doi":"10.1016/j.metabol.2025.156214","DOIUrl":"10.1016/j.metabol.2025.156214","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156214"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measures of Insulin Resistance (IR) Increase with Increasing BMI in a Population of Normoglycemic Working Adults 在正常血糖的工作成年人中，胰岛素抵抗（IR）随BMI的增加而增加
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156215
Judy Louie, Dov Shiffman, James B. Meigs, Lance Bare, Michael J. McPhaul
{"title":"Measures of Insulin Resistance (IR) Increase with Increasing BMI in a Population of Normoglycemic Working Adults","authors":"Judy Louie, Dov Shiffman, James B. Meigs, Lance Bare, Michael J. McPhaul","doi":"10.1016/j.metabol.2025.156215","DOIUrl":"10.1016/j.metabol.2025.156215","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156215"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Role of Hypoxia-Induced HIF-1α/SMAD2/VEGF Signaling in Promoting M2 Polarization of Renal Macrophages for Potential Renoprotective Effects 探讨缺氧诱导的HIF-1α/SMAD2/VEGF信号在促进肾巨噬细胞M2极化中的作用及其潜在的肾保护作用
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156230
Yaya Xu, Jiayue Xu, Jiru Li, Xiangmei Kong, Haoyun Mao, Zhiyi Du, Jiahui Zan, Lili Xu, Wen Qian, Zhushengying Ma, Yueniu Zhu, Xiaodong Zhu
{"title":"Exploring the Role of Hypoxia-Induced HIF-1α/SMAD2/VEGF Signaling in Promoting M2 Polarization of Renal Macrophages for Potential Renoprotective Effects","authors":"Yaya Xu, Jiayue Xu, Jiru Li, Xiangmei Kong, Haoyun Mao, Zhiyi Du, Jiahui Zan, Lili Xu, Wen Qian, Zhushengying Ma, Yueniu Zhu, Xiaodong Zhu","doi":"10.1016/j.metabol.2025.156230","DOIUrl":"10.1016/j.metabol.2025.156230","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156230"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Differences in Prevalence and Clinical Correlates of Dapagliflozin-Associated Diabetic Ketosis/Ketoacidosis in Patients with Type 2 Diabetes Mellitus 2型糖尿病患者达格列净相关糖尿病酮症/酮症酸中毒患病率及临床相关因素的性别差异
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156231
Maosheng Lee , Yanyan Tan , Siping Peng , Shimao Zhang , Hengxia Zhao , Huilin Li
{"title":"Gender Differences in Prevalence and Clinical Correlates of Dapagliflozin-Associated Diabetic Ketosis/Ketoacidosis in Patients with Type 2 Diabetes Mellitus","authors":"Maosheng Lee , Yanyan Tan , Siping Peng , Shimao Zhang , Hengxia Zhao , Huilin Li","doi":"10.1016/j.metabol.2025.156231","DOIUrl":"10.1016/j.metabol.2025.156231","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156231"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relacorilant Improved Blood Pressure and Maintained Other Cardiometabolic Improvements in Long-term Study in Patients With Endogenous Hypercortisolism (Cushing Syndrome) 内源性高皮质醇血症（库欣综合征）患者的长期研究中抗凝性改善血压和维持其他心脏代谢改善
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156213
Richard J. Auchus , Aleksandra Gilis-Januszewska , Corin Badiu , Aurelian-Emil Ranetti , Alexandra Kautzky-Willer , Rosario Pivonello , Georgiana Dobri , Harold J. Miller , Dan Niculescu , Amer Al-Karadsheh , Carmen Aresta , Iulia Cristina Tudor , Hristina Pashova , Katherine Araque , Andreas Moraitis
{"title":"Relacorilant Improved Blood Pressure and Maintained Other Cardiometabolic Improvements in Long-term Study in Patients With Endogenous Hypercortisolism (Cushing Syndrome)","authors":"Richard J. Auchus , Aleksandra Gilis-Januszewska , Corin Badiu , Aurelian-Emil Ranetti , Alexandra Kautzky-Willer , Rosario Pivonello , Georgiana Dobri , Harold J. Miller , Dan Niculescu , Amer Al-Karadsheh , Carmen Aresta , Iulia Cristina Tudor , Hristina Pashova , Katherine Araque , Andreas Moraitis","doi":"10.1016/j.metabol.2025.156213","DOIUrl":"10.1016/j.metabol.2025.156213","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156213"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects Of Late Onset Estradiol Treatment On Insulin Resistance And Lipid Metabolism In High-Fat-Fed Ovariectomized Female Mice 晚发性雌二醇治疗对高脂喂养去卵巢雌性小鼠胰岛素抵抗和脂质代谢的影响
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156205
A.G. Cruz, J.D.M. Santos, B.M.F. Trinca, A.R.M. Santos, J.P. Camporez
{"title":"Effects Of Late Onset Estradiol Treatment On Insulin Resistance And Lipid Metabolism In High-Fat-Fed Ovariectomized Female Mice","authors":"A.G. Cruz, J.D.M. Santos, B.M.F. Trinca, A.R.M. Santos, J.P. Camporez","doi":"10.1016/j.metabol.2025.156205","DOIUrl":"10.1016/j.metabol.2025.156205","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156205"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cumulative Effects of Vicadrostat (BI 690517) and Empagliflozin on Albuminuria in People with Chronic Kidney Disease Vicadrostat （BI 690517）和恩格列净对慢性肾病患者蛋白尿的累积效应
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156218
Peter Rossing , Sibylle J. Hauske , Lisa Cronin , Hiddo J.L. Heerspink , Juliane Meyerhoff , Shimoli V. Shah , Zhichao Sun , Dick de Zeeuw , Katherine R. Tuttle , on behalf of the ASi in CKD group
{"title":"Cumulative Effects of Vicadrostat (BI 690517) and Empagliflozin on Albuminuria in People with Chronic Kidney Disease","authors":"Peter Rossing , Sibylle J. Hauske , Lisa Cronin , Hiddo J.L. Heerspink , Juliane Meyerhoff , Shimoli V. Shah , Zhichao Sun , Dick de Zeeuw , Katherine R. Tuttle , on behalf of the ASi in CKD group","doi":"10.1016/j.metabol.2025.156218","DOIUrl":"10.1016/j.metabol.2025.156218","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156218"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian-timed Cycloset Therapy Reduces Cardiovascular Event Rate in Type 2 Diabetes (T2DM) Subjects with Clinical Features Suggestive of Elevated Sympathetic Nervous System Activity – Pilot Study Results 以昼夜节律为时间周期的周期疗法可降低伴有交感神经系统活动升高的2型糖尿病（T2DM）患者的心血管事件发生率——初步研究结果
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156224
Bindu Chamarthi, Michael Ezrokhi, Carl Stoelzel, Anthony H. Cincotta
{"title":"Circadian-timed Cycloset Therapy Reduces Cardiovascular Event Rate in Type 2 Diabetes (T2DM) Subjects with Clinical Features Suggestive of Elevated Sympathetic Nervous System Activity – Pilot Study Results","authors":"Bindu Chamarthi, Michael Ezrokhi, Carl Stoelzel, Anthony H. Cincotta","doi":"10.1016/j.metabol.2025.156224","DOIUrl":"10.1016/j.metabol.2025.156224","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156224"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pan-PPAR Agonist Lanifibranor Improves Liver Inflammation, Ballooning, and Fibrosis in a Diet-induced Obese MASH Hamster Model of Binge Drinking 泛ppar激动剂lanifbranor改善饮食诱导的狂饮肥胖仓鼠模型中的肝脏炎症、水肿和纤维化
IF 10.8 1区 医学
Metabolism: clinical and experimental Pub Date : 2025-06-01 DOI: 10.1016/j.metabol.2025.156202
François Briand, Estelle Grasset, Claire Bigot, Natalia Breyner, Thierry Sulpice
{"title":"The pan-PPAR Agonist Lanifibranor Improves Liver Inflammation, Ballooning, and Fibrosis in a Diet-induced Obese MASH Hamster Model of Binge Drinking","authors":"François Briand, Estelle Grasset, Claire Bigot, Natalia Breyner, Thierry Sulpice","doi":"10.1016/j.metabol.2025.156202","DOIUrl":"10.1016/j.metabol.2025.156202","url":null,"abstract":"","PeriodicalId":18694,"journal":{"name":"Metabolism: clinical and experimental","volume":"168 ","pages":"Article 156202"},"PeriodicalIF":10.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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