Bleeding, Thrombosis, and Vascular Biology最新文献_第3页

Blood platelets and Charles Darwin’s natural selection 血小板和达尔文的自然选择理论

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-03-30 DOI: 10.4081/btvb.2023.63

S. Momi, P. Gresele

引用次数: 0

Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA) 意大利血栓性疾病诊断和抗血栓治疗监测中心联合会(FCSA)下属卫生专业人员对临床研究的态度

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-03-21 DOI: 10.4081/btvb.2023.59

D. Poli, R. Tartaglia, D. Barcellona, P. Bucciarelli, A. Ciampa, E. Grandone, G. Malcangi, G. Rescigno, V. Toschi, S. Testa, A. Squizzato

{"title":"Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA)","authors":"D. Poli, R. Tartaglia, D. Barcellona, P. Bucciarelli, A. Ciampa, E. Grandone, G. Malcangi, G. Rescigno, V. Toschi, S. Testa, A. Squizzato","doi":"10.4081/btvb.2023.59","DOIUrl":"https://doi.org/10.4081/btvb.2023.59","url":null,"abstract":"Clinical research is vital in supporting evidence-based practice. However, several barriers make participation in research difficult. We performed a survey to evaluate the attitude to research of the members of the Italian Anticoagulation Clinics. The survey includes 19 closed questions on the perception of participating in research and exploring the benefit that health professionals wish to obtain. A total of 167 questionnaires were returned from 97/220 (44.1%) Centers, of which 89.7% were not academic. Participants (median age 56 years, range 29-75y; 56.3% females) were equally distributed all over the country; 151/167 (90.4%) of respondents believe that participating in research helps to reduce the routine of their work and allows a better quality of work, 72/167 (43.1%) complain heavy workload. More than 74% of respondents would like to participate in scientific meetings, without difference in relation to age. Instead, inclusion in the authorship of a scientific paper is of relevance for 75.6% of respondents ≤50 years and for 65.2% of respondents >50 years. A substantial positive attitude towards research was evident, suggesting that independent scientific societies could be of valuable support for the growth of research culture.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128465035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Science in Ukraine is “bleeding” 乌克兰的科学正在“流血”

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-03-14 DOI: 10.4081/btvb.2023.69

Giovanni De Gaetano

引用次数: 3

A case of acquired factor XIII deficiency secondary to plasmablastic lymphoma 原生质淋巴瘤继发获得性因子13缺乏1例

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-03-09 DOI: 10.4081/btvb.2023.53

Vincenzo Sammartano, Adele Santoni, E. Zappone, P. Calzoni, D. Fineschi, Eleonora Franceschini, Federico Caroni, A. Sicuranza, M. Bocchia, L. Puccetti

{"title":"A case of acquired factor XIII deficiency secondary to plasmablastic lymphoma","authors":"Vincenzo Sammartano, Adele Santoni, E. Zappone, P. Calzoni, D. Fineschi, Eleonora Franceschini, Federico Caroni, A. Sicuranza, M. Bocchia, L. Puccetti","doi":"10.4081/btvb.2023.53","DOIUrl":"https://doi.org/10.4081/btvb.2023.53","url":null,"abstract":"Acquired factor XIII (FXIII) deficiency is an extremely rare and potentially fatal bleeding disorder. Immune-mediated FXIII deficiency is due to the development of anti-FXIII autoantibodies which may develop with concomitant conditions that cause immune dysregulation such as malignancies or autoimmune disorders. Clinical presentation includes delayed post-operative bleeding or spontaneous soft tissue hematomas and/or cerebral bleeding. Since screening coagulation laboratory tests (prothrombin time, activated partial thromboplastin time, and fibrinogen) are typically normal, acquired FXIII deficiency is likely to be overlooked and underdiagnosed. The management of immune-mediated FXIII deficiency is based on hemostatic therapy, autoantibody removal and eradication of the underlying etiology; however, no treatment guidelines are still available. Here we report a case of acquired FXIII deficiency associated with plasmablastic lymphoma, in order to raise awareness of this rare bleeding disorder and consent prompt life-saving management.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126136733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinical usefulness of measuring thrombin generation 测定凝血酶生成的临床意义

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-03-06 DOI: 10.4081/btvb.2023.62

C. Hemker

引用次数: 0

Growing weapons to fight hemophilia 研发对抗血友病的武器

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-02-23 DOI: 10.4081/btvb.2023.64

P. Mannucci

引用次数: 0

Interaction between adenosine diphosphate receptors and protein-kinase C isoforms in platelet adhesion under flow condition 流动条件下血小板粘附中二磷酸腺苷受体与蛋白激酶C同工型的相互作用

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-02-16 DOI: 10.4081/btvb.2023.51

B. Shenkman, I. Budnik, Y. Einav

引用次数: 0

Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study 血浆纤维蛋白原水平与意大利成年人群的全因和病因特异性死亡率:Moli-sani研究结果

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2023-01-27 DOI: 10.4081/btvb.2023.46

R. Parisi, S. Costanzo, R. D. de Laat-Kremers, A. Di Castelnuovo, A. De Curtis, T. Panzera, M. Persichillo, C. Cerletti, G. de Gaetano, M. Donati, L. Iacoviello, B. de Laat, For the Moli-sani Study Investigators

{"title":"Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study","authors":"R. Parisi, S. Costanzo, R. D. de Laat-Kremers, A. Di Castelnuovo, A. De Curtis, T. Panzera, M. Persichillo, C. Cerletti, G. de Gaetano, M. Donati, L. Iacoviello, B. de Laat, For the Moli-sani Study Investigators","doi":"10.4081/btvb.2023.46","DOIUrl":"https://doi.org/10.4081/btvb.2023.46","url":null,"abstract":"Epidemiological data on the association between fibrinogen levels and mortality are scarse and controversial. Longitudinal analyses were performed, separately by sex, on 17,689 individuals from the Moli-sani study [53% women, ≥35 years, free from cardiovascular disease (CVD) or cancer at enrolment], to evaluate the association between plasma fibrinogen and all-cause and cause-specific mortality. Over a median follow-up of 11.2 years, 1,058 deaths (34.7% CVD, 36.3% cancer) were ascertained. Both in the lowest (1.12-2.64 g/L) and highest (≥3.62 g/L) fibrinogen quintiles, women had an increased all-cause mortality hazard, when compared with third quintile (2.97-3.23 g/L). Dose-response analyses showed a U-shaped relationship in women (P overall <0.0001; P non-linear association <0.0001), but a positive linear association for all-cause mortality in men (P overall 0.0038; P non-linear association 0.76). Similar trends for a U-shaped association were observed for CVD mortality, while no association was observed with cancer deaths. A U-shaped association of fibrinogen levels with other-cause mortality was also found in both sexes. This study shows that not only higher but also lower fibrinogen levels represent hazard for mortality when compared to normal levels; U-shaped curves being prevalently observed in women.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122748301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pleiotropic effects of anti-thrombotic therapies: have direct oral anticoagulants any anti-inflammatory effect? 抗血栓治疗的多效性:直接口服抗凝剂有抗炎作用吗?

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-12-14 DOI: 10.4081/btvb.2022.50

A. Gori, E. Camilleri, Alessia Bertelli, A. Rogolino, F. Cesari, E. Lotti, Tommaso Capobianco, Walther Iannotti, B. Giusti, R. Marcucci

{"title":"Pleiotropic effects of anti-thrombotic therapies: have direct oral anticoagulants any anti-inflammatory effect?","authors":"A. Gori, E. Camilleri, Alessia Bertelli, A. Rogolino, F. Cesari, E. Lotti, Tommaso Capobianco, Walther Iannotti, B. Giusti, R. Marcucci","doi":"10.4081/btvb.2022.50","DOIUrl":"https://doi.org/10.4081/btvb.2022.50","url":null,"abstract":"Direct oral anticoagulants (DOACs) are currently recommended by European guidelines as the first line therapy for both stroke prevention in patients with atrial fibrillation (AF) and the prevention and the treatment of venous thromboembolism (VTE). Recently, it has been speculated that DOACs have anti-inflammatory capabilities in reducing the abnormal release of pro-inflammatory factors in addition to inhibiting the activation of factor X or factor II of the coagulation cascade. However, this hypothesis is based on limited pathophysiological data with small sample size, often on in vitro studies. Real-world, in vivo, and large clinical data are scarce. The aim of the present study was the evaluation of the possible anti-inflammatory and anti-proliferative effects of DOACs treatment in a cohort of patients affected by AF or VTE, by analyzing an extensive panel of cytokines and molecules involved in the process of vascular and tissue remodeling. Our data evidenced that DOACs treatment is associated with variations in systemic inflammation markers and in metalloproteinases. Further studies with larger number of patients are required to confirm these data.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115764332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Well begun is half done 良好的开端是成功的一半

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-12-14 DOI: 10.4081/btvb.2022.61

G. de Gaetano

引用次数: 0