Minerva cardiology and angiology最新文献

{"title":"Role of jianxin granules in heart failure: evidence from network pharmacology, molecular docking and experimental verification.","authors":"Qiufang Ouyang, Luting Zhang, Yongzhong Chen, Leilei Liu, Meihua Chen, Jinxian Yan, Tao You, Jinjian Guo","doi":"10.23736/S2724-5683.24.06511-6","DOIUrl":"10.23736/S2724-5683.24.06511-6","url":null,"abstract":"<p><strong>Background: </strong>Jianxin (JX) granules is a traditional Chinese medicine widely used in the treatment of heart failure (HF), but the mechanism is unclear. This study aimed to investigate the mechanism of JX granules in the treatment of HF based on network pharmacology analysis and in-vivo experiments.</p><p><strong>Methods: </strong>A series of network pharmacology methods was employed to ascertain potential targets and critical pathways implicated in the therapeutic action of JX granules against HF. Subsequently, molecular docking was utilized to investigate the binding affinity of key active constituents within JX granules to these targets. In-vivo experiments, echocardiography, hematoxylin and eosin, Masson's trichrome assay, and western blot analysis were conducted to validate the efficacy and mechanism of JX granules in treating rats with HF.</p><p><strong>Results: </strong>A total of 122 active components, 896 drug targets, 1216 HF-related targets, and 136 targets pertinent to drug-disease interactions were identified. 151 key targets and 725 core clusters were detected through protein-protein interaction network analysis. Among these, interleukin 6 (IL-6), vascular endothelial growth factor a (VEGFA), and serine/threonine kinase 1 (AKT1) were core hub genes. Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis revealed the critical pathways, including epidermal growth factor receptor (EGFR), advanced glycation end products (AGEs) and their receptors (RAGE) pathway, along with hypoxia-inducible factor 1 (HIF-1) signaling pathway. Molecular docking studies demonstrated high binding affinities between key targets and the pivotal active ingredients of Danshenol A, salvianolic acid B, and arachidonic acid. Furthermore, animal studies corroborated that JX granules improve cardiac function and reduce myocardial fibrosis, potentially by modulating the expression of IL-6, VEGFA, and p-AKT1.</p><p><strong>Conclusions: </strong>The bioactive components within JX granules, such as Danshenol A, salvianolic acid B, and arachidonic acid may exert therapeutic effects on HF through modulation of IL-6, VEGFA, and AKT1 gene expression. This study provides a scientific basis for subsequent clinical application of JX granules and an in-depth investigation of their mechanisms of action.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"285-295"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minerva Cardiology and Angiology's take on disrupting cardiovascular boundaries.","authors":"Giuseppe Biondi-Zoccai, Isotta Chimenti, Elena De Falco, Elena Tremoli","doi":"10.23736/S2724-5683.25.06952-2","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06952-2","url":null,"abstract":"","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":"73 3","pages":"255-257"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New risk classification adapting SCAI shock stages to patients with pulmonary embolism (RISA-PE).","authors":"Rocío Párraga, Carlos Real, Jesús Jiménez-Mazuecos, María-Eugenia Vázquez-Álvarez, Ernesto Valero, Maite Velázquez, Daniel Tébar, Neus Salvatella, Eva Rumiz, Valeriano Ruiz Quevedo, Fernando Sabatel-Pérez, Ignacio Amat-Santos, Iñigo Lozano, Irene Elizondo, Abel Andrés-Morist, Iván Núñez-Gil, Juan J Portero, Nieves Gonzalo, Miriam Juárez Fernández, Ana Viana-Tejedor, Carlos Ferrera, Pablo Salinas","doi":"10.23736/S2724-5683.24.06609-2","DOIUrl":"10.23736/S2724-5683.24.06609-2","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary embolism (PE) treatment is based on risk stratification according to European Society of Cardiology (ESC) guidelines. However, emerging therapies in acute PE may require a more granular risk classification. Therefore, the objective of the present study was to propose a new RIsk claSsification Adapting the SCAI shock stages to right ventricular failure due to acute PE (RISA-PE).</p><p><strong>Methods: </strong>This registry included consecutive intermediate-high risk (IHR) or high-risk (HR)-PE patients selected for catheter-directed interventions (CDI) from 2018 to 2023 in 15 Spanish centers (NCT06348459). Patients were grouped according to RISA-PE classification as A (right ventricular dysfunction and troponin elevation); B (A + serum lactate >2 mmol/L OR shock index ≥1); C (persistent hypotension); D (obstructive shock); and E (cardiac arrest). In-hospital adverse events were assessed to evaluate RISA-PE performance.</p><p><strong>Results: </strong>A total of 334 patients were included (age 62.1±15.2 years, 55.7% males). The incidence of in-hospital all-cause death was progressively higher with increasing RISA-PE stage (1.2%, 6.4%, 19.0%, 25.6%, and 57.7% for stages A, B, C, D, and E, respectively, P value for linear trend<0.001). However, using the ESC classification, there was an abrupt difference between IHR- and HR-PE patients regarding mortality (4.3% vs. 29.3%, P<0.001). The incidence of in-hospital major bleeding and acute kidney injury followed a similar pattern.</p><p><strong>Conclusions: </strong>The user-friendly RISA-PE classification may improve the granularity in stratifying PE patients' risk and warrants evaluation in larger studies with different therapeutic approaches in order to detect its utility as a decision-making scale.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":"304-314"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in vascular dementia-related mortality in the United States from 2005 to 2020.","authors":"Ali Salman, Dua Batool Zaide, Rayaan Imran, Hoor Ul Ain, Muhammad O Bhatti, Laiba Batool, Beena Muntaha Nasir, Laiqa Tariq, Shaaf Ahmad, Mohammad S Khan Khakwani, Muhammad Qasim, Syed A Hassan, Namra S Raja, Minahil Aamir, Muhammad W Nasir, Shayan Marsia","doi":"10.23736/S2724-5683.25.06719-5","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06719-5","url":null,"abstract":"<p><strong>Background: </strong>The aging population in the USA has led to a concomitant rise in the prevalence of vascular dementia (VaD), yet there remains a paucity of investigation into mortality trends associated with VaD among adults.</p><p><strong>Methods: </strong>This cross-sectional analysis utilized death certificate data from the Centers for Disease Control and Prevention's WONDER database. VaD-associated mortality was identified using the International Statistical Classification of Diseases and Related Health Problems-10th revision (ICD-10) code F01. Crude, and age-adjusted VaD-associated mortality rates per 100,000 and their corresponding 95% confidence intervals (CI) were computed. Age-adjusted mortality rates (AAMRs) were standardized to the 2000 US census population.</p><p><strong>Results: </strong>From 2005 to 2020, there were 375,575 deaths attributed to VaD among older adults. We observed a gradual increase in AAMR (APC: 3.70, 95% CI [-4.14, 5.21]) from 2005 to 2015, succeeded by a pronounced escalation (APC: 9.07, 95% CI [6.09, 17.62]) until 2020. The highest AAMR was noted in the West (17.65, 95% CI [17.55, 17.76]), followed by the Midwest (AAMR: 12.66, 95% CI [12.58, 12.75]), the South (AAMR: 12.60, 95% CI [12.54, 12.67]), and the Northeast (AAMR: 8.60, 95% CI [8.53, 8.68]). Metropolitan areas exhibited higher AAMRs (10.9, 95% CI [10.8, 11.0]) compared to non-metropolitan areas (8.1, 95% CI [8.00, 8.3]). Among age groups, individuals aged 75-85 and older showed the highest overall AAMR (99.80, 95% CI [99.47, 100.14]). In addition, non-Hispanic Black or African-American subset of the population showed the highest overall AAMR (8.12, [95% CI: 8.03, 8.20]).</p><p><strong>Conclusions: </strong>Our findings underscore the imperative for targeted public health interventions aimed at addressing regional disparities and age-specific vulnerabilities to mitigate the mounting burden of VaD-related mortality.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right heart failure: lights and shadows.","authors":"Francesca Giordana, Sebastian Cinconze, Lucia Coppini, Chiara Bernelli","doi":"10.23736/S2724-5683.25.06644-X","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06644-X","url":null,"abstract":"<p><p>Right heart function is essential for overall heart health and plays a crucial role in the prognosis of patients with heart failure. A comprehensive assessment of the right ventricle (RV) that includes various clinical and hemodynamic parameters, as well as imaging techniques, provides important insights into the structure and function of the right heart. Advanced imaging methods, such as cardiac MRI, offer further clarity regarding the morphology and performance of the right heart. Interventional therapies have transformed treatment options and the prognosis for patients with advanced RV failure, and these therapies should be integrated into a comprehensive care plan. Ongoing research into the molecular and genetic factors contributing to right heart dysfunction is expected to reveal new therapeutic targets. Continued advancements in imaging and treatment options are vital for enhancing patient outcomes. In this review, we provide a detailed analysis of RV function, diagnosis, and therapy for RV failure.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing cardiovascular screening in master athletes: the role of exercise stress echocardiography.","authors":"Valentina Pescatore, Mattia Grassi, Stefano Palermi, Marco Vecchiato, Erica Brugin, Silvia Compagno, Carlo Zanella, Salvatore Saccà, Antonello D'Andrea, Giulia Quinto, Andrea Ermolao, Franco Giada","doi":"10.23736/S2724-5683.25.06747-X","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06747-X","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular (CV) disease is a significant risk even among seemingly healthier populations like master athletes, who face unique CV challenges due to their advanced age and high-intensity physical activities. Exercise stress echocardiography (ESE) has emerged as a valuable diagnostic tool to detect exercise-induced coronary artery disease (CAD), offering advantages over traditional exercise stress testing (EST) by integrating echocardiographic imaging. This article aimed to assess the diagnostic value and efficacy of ESE for detecting CAD in master athletes who exhibit exercise-induced alterations during pre-participation screening (PPS) EST.</p><p><strong>Methods: </strong>This retrospective study analyzed 521 master athletes (aged 35 years and older) who underwent annual CV assessments including EST as part of their PPS at Noale Hospital, Venice, Italy, from September 2020 to August 2023. Participants who showed exercise-induced alterations suspicious for CAD on EST were further evaluated using ESE.</p><p><strong>Results: </strong>Of the 521 athletes screened, 58 (11.1%) exhibited suspicious alterations for CAD during EST. ESE further identified 13 athletes with wall motion abnormalities (WMA), of whom 10 were subsequently diagnosed with critical CAD and received appropriate interventions. The positive predictive value of ESE was 0.77. Comparatively, athletes with WMA had significantly higher CV risk scores. No major adverse CV events (MACE) were reported during the 43.9-month follow-up.</p><p><strong>Conclusions: </strong>ESE is an effective third-line diagnostic tool in master athletes, demonstrating a high diagnostic yield for identifying significant CAD. Its integration into routine CV screening for master athletes can enhance the detection of underlying pathologies, potentially leading to timely and life-saving interventions.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum uric acid and prognosis in coronary bifurcation lesions treated with drug-eluting stents.","authors":"Attilio Lauretti, Iginio Colaiori, Francesco Versaci","doi":"10.23736/S2724-5683.25.06866-8","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06866-8","url":null,"abstract":"","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercholesterolemia and cardiovascular disease: the dilemma of effective treatment for target achievement according to guidelines and national healthcare policies and a call to action.","authors":"Laura A Dalla Vecchia, Francesco DE Stefano, Maurizio Bussotti, Cosmo Godino, Marco Bernardi, Luigi Spadafora, Edvige Palazzo Adriano, Pasquale Guarini, Roberto F Pedretti","doi":"10.23736/S2724-5683.25.06704-3","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06704-3","url":null,"abstract":"<p><p>The burden of cardiovascular disease (CVD) remains a worldwide challenge. CVDs, in particular atherosclerotic CVD, are still an important cause of mortality and morbidity. The increase in life expectancy is a further determining factor in the epidemiology of CVDs in some countries, such as Italy, which increases the urgency of intervening on modifiable risk factors. Among these, hypercholesterolemia is present in a significant percentage of CVD patients. A linear relationship between the risk of acute events and the plasma level of low-density lipoproteins cholesterol (LDL-C) is well known. The reduction of LDL-C levels leads to a decrease in mortality and morbidity. The overall recommendation is to treat hypercholesterolemia intensively and as early as possible. Statins, ezetimibe, bempedoic acid, pro-protein convertase subtilisin/kexin 9 inhibitors (i.e., the monoclonal antibodies alirocumab and evolocumab, or the small interfering RNA inclisiran) are all available for reaching LDL-C targets according to risk profile. While the real-world data confirm the safety of currently recommended LDL-C targets, data on their actual achievement are discouraging, less than half of patients on therapy reach the LDL-C targets recommended by the most recent ESC/EAS Guidelines. The causes of this critical discrepancy are multiple, arising from the various components that characterize the complex relationship between patient and physician within the healthcare system. A call to action is needed. Doctors should be continuously updated on the latest evidence, follow recommendations and engage the patient in the therapeutic process. Regular monitoring of the effects of the prescribed therapy, also through e-health and telemedicine tools, is essential, as well as changing therapy when LDL-C is not adequately controlled. Finally, health systems should align with guidelines and promote good clinical practices, overcoming a silo system, to impact outcomes in terms of overall sustainability.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of percutaneous coronary intervention in spontaneous coronary artery dissection: between Scylla and Charybdis.","authors":"Marco Lombardi, Jorge Chavez-Solsol, Pablo Salinas, Enrico Cerrato, Rocco Vergallo, Italo Porto, Ferdinando Varbella, Nieves Gonzalo, Javier Escaned, Fernando Macaya-Ten","doi":"10.23736/S2724-5683.24.06680-8","DOIUrl":"https://doi.org/10.23736/S2724-5683.24.06680-8","url":null,"abstract":"<p><p>Spontaneous coronary artery dissection (SCAD) is a distinct and increasingly recognized cause of acute coronary syndromes, primarily affecting young and middle-aged women with few cardiovascular risk factors. While SCAD often resolves spontaneously with conservative management, percutaneous coronary intervention (PCI) is sometimes necessary, especially in patients with ongoing ischemia or high-risk anatomical features. This review summarizes the current state of knowledge regarding the interventional approach in SCAD, emphasizing the rationale for conservative treatment, and the indications for and challenges associated with PCI. It also provides practical recommendations, particularly highlighting technical aspects of PCI in SCAD, the critical role of intracoronary imaging, and the modality and timing of post-PCI surveillance.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tribute to the 60 years of angioplasty celebrating January 16th, 1964's first angioplasty by Charles Dotter: voices from the past, messages to build the future.","authors":"Jean Marco, Chiara DE Biase, Luigi Spadafora, Emanuele Barbato, Davide Capodanno, Francesco Saia, Salvatore DE Rosa, Elad Asher, Mattia Galli, Marco Bernardi, Pierre Sabouret","doi":"10.23736/S2724-5683.25.06571-8","DOIUrl":"https://doi.org/10.23736/S2724-5683.25.06571-8","url":null,"abstract":"<p><p>Charles T. Dotter is a recognized pioneer of interventional cardiology as much as the inventor of the angioplasty balloon himself, Andreas R. Grüntzig. Yet, despite Dotter's pioneering role in developing transluminal angioplasty, a recent survey revealed a significant lack of awareness among younger interventional cardiologists and fellows about his contributions, contrasting sharply with their familiarity with Grüntzig. We thereby shed light on Dotter's innovations and the reasons behind his relative obscurity in contemporary discourse, urging the medical community to embrace the lessons from his journey for future success. We explicitly focus on Dotter's early achievements, including his groundbreaking work in 1964, where he performed the first transluminal angioplasty, laying the groundwork for what would become a cornerstone in vascular intervention and creating the eponymous Dotter effect. Despite the initial resistance and skepticism, Dotter's methods eventually found their way to Europe, influencing Grüntzig and leading to the development of the balloon catheter. We also meticulously trace the evolution of angioplasty from Dotter's early experiments to Grüntzig's refinement of the technique and its application in coronary arteries, underscoring the pivotal moments and challenges encountered along the way. Dotter's obscurity stems from a combination of factors, including his confrontational approach and the reluctance of the medical establishment to embrace his radical ideas. Indeed, Dotter's story offers invaluable lessons on the importance of teamwork, perseverance, and the need for a supportive community to foster innovation in medicine.</p>","PeriodicalId":18668,"journal":{"name":"Minerva cardiology and angiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}