Ministry of Science and Technology, Vietnam最新文献

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Quantification of catalpol in root of Rehmannia glutinosa varieties 19 collected in Phu Tho province by high-performance liquid chromatography 用高效液相色谱法定量测定富都省采集的地黄 19 号品种根中的梓酚含量
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).20-24
Thanh Loan Pham
{"title":"Quantification of catalpol in root of Rehmannia glutinosa varieties 19 collected in Phu Tho province by high-performance liquid chromatography","authors":"Thanh Loan Pham","doi":"10.31276/vjst.66(3).20-24","DOIUrl":"https://doi.org/10.31276/vjst.66(3).20-24","url":null,"abstract":"The active ingredient catalpol in the Rehmannia glutinosavariety 19 roots is an important chemical component. Catalpol has hypoglycemia, diuretic, and laxative effects; it is used to support the treatment of diabetes, ischemic cerebral, and dementia, and it is regulated by Vietnamese Pharmacopoeia V (2017) as a marker to check the quality of medicinal herbs. This study aimed to develop a procedure for quantifying catalpol in the root of Rehmannia glutinosa varieties 19 by high-performance liquid chromatography (HPLC) to evaluate the quality of medicinal herbs. The research results have selected suitable chromatographic conditions using the Gemini C18 column (250x4.6 mm, 5 μm), detector at 210 nm, mobile phase acetonitrile - phosphoric acid 0.1%, and flow rate at 0.6 ml/min. The peak area and catalpol concentration have a strong linear correlation with r=0.9999, Y = 21887X + 26213. The procedure has good accuracy and repeatability with a relative standard deviation (RSD) <2%. Quantitative results of catalpol in the root of the R. glutinosa varieties 19 reached 1.25%. The HPLC method is suitable for quantifying catalpol in the root of R. glutinosa varieties 19.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140382208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphology, anatomy, and quantitative determination of corosolic acid in Lagerstroemia calyculata Kurz in the Southeast region, Vietnam 越南东南地区 Lagerstroemia calyculata Kurz 的形态学、解剖学和科罗索酸的定量测定
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).25-30
Minh Tu To, Thi Xuyen Do, Thi Tuyet Hoang, Van Truong Phan, Minh Tu Dang, Thanh Huyen Pham
{"title":"Morphology, anatomy, and quantitative determination of corosolic acid in Lagerstroemia calyculata Kurz in the Southeast region, Vietnam","authors":"Minh Tu To, Thi Xuyen Do, Thi Tuyet Hoang, Van Truong Phan, Minh Tu Dang, Thanh Huyen Pham","doi":"10.31276/vjst.66(3).25-30","DOIUrl":"https://doi.org/10.31276/vjst.66(3).25-30","url":null,"abstract":"Objectives: To describe the morphological characteristics, anatomy (stem, leaves), and quantify the corosolic acid in the leaves of Lagerstroemia calyculata Kurz collected in the Southeast region, Vietnam. Subjects and methods: Using the comparative morphological method to determine the scientific name of species. Studying the microscopic characteristics of Lagerstroemia calyculataKurz according to the research method of N. Ba (2009) [1] and quantifying the content of corosolic acid in the leaves according to the United States Pharmacopeia 2017 (USP 40), with adjustments to suit the conditions of the laboratory. Results: Lagerstroemia calyculata Kurz is tree, deciduous, height 30-35 m, smooth bark. Leaves lanceolate, lateral veins 9-11 pairs, hairy. Inflorescence paniculate, small white flowers. Capsules ovoid, 6-valved. Seeds are numerous, brown, and smooth. The stem has a bicollateral vascular bundle, conduction tissue arranged continuously, double phloem pillars and leaf veins exposed on both sides. The outer epidermis has multicellular stellate hairs. Scattered in soft tissue there are crystalline particles. Stomata are present only on the underside of leaves. The quantification of corosolic acid in three leaf samples of Lagerstroemia calyculata Kurz was from 0.05 to 0.12%. Conclusions: This study has detailed morphological, anatomical characteristics, and quantitative determination of corosolic acid in three leaf samples of Lagerstroemia calyculata Kurz collected in the Southeast region.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140382536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of solid-phase extraction materials from ion liquids for the analysis of carbamate pesticide 应用离子液体固相萃取材料分析氨基甲酸酯类农药
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).45-54
Van Duy Le, Thai The Nguyen, Hoang Phuong Tran, Anh Mai Nguyen
{"title":"Application of solid-phase extraction materials from ion liquids for the analysis of carbamate pesticide","authors":"Van Duy Le, Thai The Nguyen, Hoang Phuong Tran, Anh Mai Nguyen","doi":"10.31276/vjst.66(3).45-54","DOIUrl":"https://doi.org/10.31276/vjst.66(3).45-54","url":null,"abstract":"In this study, ionic liquid immobilised onto silica gel material SiO2-(CH2)3-N(Oct)3Br was successfully synthesised and characterised by Fourier-transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). This material was applied as the stationary phase of solid-phase extraction for the enrichment of trace amounts of carbamate pesticides in water. The cartridge was eluted with 5 ml of acetonitrile (ACN), blow-dried with nitrogen gas, and re-dissolved in ACN:H2O (40:60, v/v) and analysed by high-performance liquid chromatography - ultraviolet (HPLC-UV) at 210 and 245 nm. Within this process, elution of the cartridge with 5 ml of acetonitrile (ACN) was followed by nitrogen gas blow-drying and subsequent re-dissolution in ACN:H2O (40:60, v/v), culminating in analysis by HPLC-UV at 210 and 245 nm. Optimisation of conditions facilitated the analysis of carbamate pesticides, with the limit of quantitation (LOQ)ranging from 0.36-2.00 μg/l for tap water and 0.4-3.5 μg/l for river water. Furthermore, the method exhibited favourable repeatability, with a relative standard deviation (RSD) of less than 10%, thereby meeting the Association of Official Analytical Collaboration (AOAC) standards.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of geomechanical changes in faulted rock mass around underground structures subjected to earthquakes 预测受地震影响的地下结构周围断层岩体的地质力学变化
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).13-19
Q. Nguyen, Ngoc Hue Nguyen, Quang Minh Nguyen, V. Nguyen, Tuan Minh Tran
{"title":"Prediction of geomechanical changes in faulted rock mass around underground structures subjected to earthquakes","authors":"Q. Nguyen, Ngoc Hue Nguyen, Quang Minh Nguyen, V. Nguyen, Tuan Minh Tran","doi":"10.31276/vjst.66(3).13-19","DOIUrl":"https://doi.org/10.31276/vjst.66(3).13-19","url":null,"abstract":"Faults are a type of geological structure that often leads to geological disasters in underground structures under normal conditions and especially when earthquakes occur, thereby requiring careful study.This article introduces some numerical simulation results on the seismic wave propagation process, on changes in stress and displacement states in the rock mass with a small fault of a dip angle of 45o, around a circular cross-section tunnel, using the discrete element method (Universal distinct element Code - UDEC). Three cases are simulated: a) The tunnel is located in the hanging wall rock, the fault is located 10m from the centre of the tunnel on the vertical axis; b) The fault runs through the centre of the tunnel and c) The tunnel is located in the footing wall rock, the fault is located 10m from the centre of the tunnel on the vertical axis. The results obtained show a very clear influence of the position and location of the fault on the geomechanical changes in the rock mass around the tunnel, contributing to the reasonable design of tunnels subjected to earthquakes.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140383436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of TiO2 by hydrothermal method using deep eutectic solvent for application in dye-sensitised solar cell 利用深共晶溶剂通过水热法合成 TiO2,以应用于染料敏化太阳能电池
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).06-12
Doan Thanh Thuy Nguyen, De Nguyen, Huynh Trung Le Ly, Tuyet Phuong Nguyen
{"title":"Synthesis of TiO2 by hydrothermal method using deep eutectic solvent for application in dye-sensitised solar cell","authors":"Doan Thanh Thuy Nguyen, De Nguyen, Huynh Trung Le Ly, Tuyet Phuong Nguyen","doi":"10.31276/vjst.66(3).06-12","DOIUrl":"https://doi.org/10.31276/vjst.66(3).06-12","url":null,"abstract":"Raw TiO2 powder from a commercial source was used as a precursor in the hydrothermal process with deep eutectic solvent (DES) of choline chloride and urea with a molar ratio of 1:2 at different temperatures and interval times. The synthesised TiO2 was further utilised to produce diffracting TiO2 paste for application in dye-sensitised solar cells (DSCs) to improve the power conversation efficiency of devices. The TiO2 product analysed by X-ray diffraction (XRD) showed a similar phase and crystallinity to the raw material. However, scanning electron microscope (SEM) images showed that the hydrothermal TiO2 product had less particle aggregation than the raw one. The particle size was exceedingly 100 nm. The TiO2 pastes were prepared with a mixture of ethyl acetate and terpineol at volume ratios of 3:7 and 4:6. The paste was suitable to make thin films by the screen-printing method as a diffusion layer in cells. DSC devices using the TiO2 produced by the hydrothermal process with DES at 140oC for 18, 24, and 36 hours, respectively, enhanced the power conversion efficiency by 6.7-6.9%, which was higher than the ones using raw TiO2 by about 7%. Therefore, TiO2 powder modified by the hydrothermal process in DES solvent has great potential for application in DSC manufacture.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research and development of a predictive system for fall armyworm early warning on maize crop 研究和开发玉米作物秋季虫害预警预测系统
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).38-44
Thi Diep Hoang, Thi Anh Duong Nguyen, Kien Thai Duong Nguyen, Duy Vu Nguyen, Thi Quynh Trang Luu, Thi Thu Phuong Tran, Minh Trien Pham
{"title":"Research and development of a predictive system for fall armyworm early warning on maize crop","authors":"Thi Diep Hoang, Thi Anh Duong Nguyen, Kien Thai Duong Nguyen, Duy Vu Nguyen, Thi Quynh Trang Luu, Thi Thu Phuong Tran, Minh Trien Pham","doi":"10.31276/vjst.66(3).38-44","DOIUrl":"https://doi.org/10.31276/vjst.66(3).38-44","url":null,"abstract":"The rapid increase in fall armyworms (FAW, Spodoptera frugiperda) in recent years has posed major challenges to maize growers around the globe. To keep larval density below the economic threshold, we need interdisciplinary agricultural solutions like plant protection epidemiology, the Internet of Things, and scientific data techniques for early detection, monitoring, forecasting, and making informed decisions. Pest control should be planned ahead of time to prevent indiscriminate pesticide spraying, waste, and a negative effect on the environment. In this study, the authors plan to create a comprehensive iFAWcast software system that will automatically predict, alert, and gather research data on fall armyworms on maize crops in Vietnam. The system is comprised of three major components: (i) An automatic forecasting and alerting tool for fall armyworm outbreaks on the web platform; (ii) An agriculture reporting, forecasting, alerting, and user management tool on the web platform; and (iii) A mobile app that provides forecasting and alerting services on fall armyworms to farmers based on their geographical location. The iFAWcast system includes a central computation that dynamically updates weather forecasts from the Visual Crossing API and the OpenWeatherMap API, as well as a formula for the effective cumulative temperature based on the characteristics of fall armyworms on maize crops in Vietnam. The developed system was tested using data collected straight from the field, yielding extremely accurate and dependable results.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of NBS-LRR gene-specific microsatellite markers for passion fruit Passiflora edulis Sims 为西番莲开发 NBS-LRR 基因特异性微卫星标记
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).31-37
Duc Trung Tran, Thi Thu Hang Nguyen, Thu Huong Dao, Hong Linh Ta, Thi Lan Hoa Nguyen, Thanh Huyen Pham, Thi Hue Huong Tran, Hoang Nguyen
{"title":"Development of NBS-LRR gene-specific microsatellite markers for passion fruit Passiflora edulis Sims","authors":"Duc Trung Tran, Thi Thu Hang Nguyen, Thu Huong Dao, Hong Linh Ta, Thi Lan Hoa Nguyen, Thanh Huyen Pham, Thi Hue Huong Tran, Hoang Nguyen","doi":"10.31276/vjst.66(3).31-37","DOIUrl":"https://doi.org/10.31276/vjst.66(3).31-37","url":null,"abstract":"The chromosome-level genome assembly of passion fruit (Passiflora edulis Sims) has facilitated computational analyses in developing novel informative SSR markers for genetics and breeding research. In this study, in-silico analysis was conducted to discover potential microsatellite loci and to design specific primers from the sequences of the characterised nucleotide-binding site - leucine-rich repeats (NBS-LRR) gene family of passion fruit, and a genotyping experiment was performed to validate the novel simple sequence repeat (SSR) markers.In total, 497 microsatellite loci were detected from 161 passion fruit NBS-LRR genes, of which 383 loci were qualified for primer generation. Forty-six SSR markers were selected for polymorphism verification, targeting 35 NBS-LRR genes that showed potential gene expression in response to biotic and abiotic stresses. From that, 25 SSR markers showed consistent polymorphic alleles among different passion fruit genotypes via PCR-PAGE analysis. These novel NBS-LRR-specific SSR markers might provide valuable tools for fortifying research on germplasm evaluation, genetic mapping, and molecular breeding for disease-resistant passion fruit varieties.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of nuclear shell structure in neutron-rich nuclei N=32 and N=34 富中子核 N=32 和 N=34 的核壳结构演变
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-25 DOI: 10.31276/vjst.66(3).01-05
Cong Cuong Do, D. L. Bui, Duc Ton Nguyen
{"title":"Evolution of nuclear shell structure in neutron-rich nuclei N=32 and N=34","authors":"Cong Cuong Do, D. L. Bui, Duc Ton Nguyen","doi":"10.31276/vjst.66(3).01-05","DOIUrl":"https://doi.org/10.31276/vjst.66(3).01-05","url":null,"abstract":"This paper presents an overview of the experimental setup to study the structure of unstable nuclear isotopes in the region from 47Cl to 63V of the SEASTAR 3 project and the evolution of shell structure in neutron-rich nuclei N=32 and N=34. The first excited energies of Cl, Ar, and K isotopes around N=32, N=34 obtained from the SEASTAR 3 project were determined. The evolution of shell structure in neutron-rich nuclei N=32 và N=34 is explained by the contribution of tensor forces in addition to central and spin-orbit forces. The appearance of new magic neutron N=34 in 54Ca is explained due to proton-neutron tensor force that pulls neutron 0f5/2 lower than 1p1/2 level, leading to not only causes the spin inversion of neutrons at 1p1/2 and 0f5/2 levels and enlarges an energy gap between these levels. The change of proton and neutron energy levels in Cl, Ar, and K isotopes around N=32, N=34 driven by tensor force was also discussed in this article.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of several deubiquitinase and tyrosine phosphatase genes involved in inflammatory response in lymphoma 参与淋巴瘤炎症反应的几种去泛素酶和酪氨酸磷酸酶基因的表达
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-15 DOI: 10.31276/vjste.66(1).90-95
N. Giang, Nguyen Trong Ha, Nguyen Thi Xuan
{"title":"Expression of several deubiquitinase and tyrosine phosphatase genes involved in inflammatory response in lymphoma","authors":"N. Giang, Nguyen Trong Ha, Nguyen Thi Xuan","doi":"10.31276/vjste.66(1).90-95","DOIUrl":"https://doi.org/10.31276/vjste.66(1).90-95","url":null,"abstract":"Lymphoma represents a heterogeneous group of cancers affecting the lymphatic system, encompassing non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). The majority of NHL cases originate from B cells. HL is characterized by the presence of rare Hodgkin and Reed-Sternberg cells. Within the context of the inflammatory response, two SH2 domain-containing protein tyrosine phosphatases (SHPs), namely SHP-1 and SHP-2, serve as negative regulators. Deubiquitinating enzymes (DUBs) play a crucial role in inhibiting NF-κB activation in response to various stimuli. This study focuses on the DUBs OTUB1, OTUB2, and Cezanne. Blood samples were collected from 50 NHL patients, 26 HL patients, and 50 healthy individuals. Quantitative RT-PCR was employed to assess the mRNA expression of OTUB1, OTUB2, Cezanne, SHP-1,and SHP-2, while ELISA was used to determine IL-6 and CA125 concentrations. The results revealed that the mRNA level of OTUB1 was significantly downregulated in NHL patients but not in HL patients. Notably, Cezanne expression was downregulated in lymphoma patients, with significantly lower levels observed in HL compared to NHL patients. Furthermore, SHP-1 mRNA expression was significantly lower in the NHL group compared to the HL group or healthy individuals. Conversely, SHP-2 gene expression was upregulated in NHL patients but remained unchanged in HL patients. In conclusion, these findings highlight significant differences in the expressions of DUB and SHP genes and the inflammatory response in lymphoma patients. This study provides a foundation for further investigation into the roles of DUBs and tyrosine phosphatases in regulating the functional activation of lymphoma cells.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of direct C-3 difluoromethylation reaction for application in synthesis of quinoline-related drugs 开发直接 C-3 二氟甲基化反应,用于合成喹啉相关药物
Ministry of Science and Technology, Vietnam Pub Date : 2024-03-15 DOI: 10.31276/vjste.66(1).53-58
Thanh Tung Truong, John Nielsen
{"title":"Development of direct C-3 difluoromethylation reaction for application in synthesis of quinoline-related drugs","authors":"Thanh Tung Truong, John Nielsen","doi":"10.31276/vjste.66(1).53-58","DOIUrl":"https://doi.org/10.31276/vjste.66(1).53-58","url":null,"abstract":"Fluorine holds a prominent position within the realm of drug discovery and development, substantiated by its presence in approximately 25% of drugs approved by the US Food and Drug Administration (FDA). Consequently, the advancement of new fluorination reactions stands as a pivotal area in medicinal chemistry. In particular, the monofluoro-, difluoromethyl-, and trifluoromethyl- are three groups that appear most frequently in drug structure. Quinoline, owing to its privileged structural status, plays a crucial role in drug design and synthesis. Various approaches have been documented for the direct difluoromethylation of the C-2 and C-4 positions of the quinoline ring. However, achieving direct C-3 difluoromethylation has remained an elusive objective. In this study, we introduce a novel method for effecting the direct difluoromethylation at the C-3 position of the quinoline ring.Comprehensive characterizations, including 1H-NMR, 13C-NMR, and 19F-NMR for all compounds are performed. We believe that this novel method will open a new way to access the hitherto untapped C-3-difluoromethylation active compounds.","PeriodicalId":18650,"journal":{"name":"Ministry of Science and Technology, Vietnam","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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