{"title":"A two-stage clustering technique for automatic biaxial gating of flow cytometry data","authors":"M. Pouyan, V. Jindal, J. Birjandtalab, M. Nourani","doi":"10.1109/BIBM.2015.7359736","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359736","url":null,"abstract":"Measurement of various markers of single cells using flow cytometry has several biological applications. These applications include improving our understanding of behavior of cellular systems, identifying rare cell populations and personalized medication. A common critical issue in the existing methods is approximation of the number of cellular populations which heavily affects the accuracy of results. In this work, we propose a novel technique to estimate the number of dominant subtypes and identify them in flow cytometry datasets. Our experimentation on 42 flow cytometry datasets indicates high performance and accurate clustering (F-measure > 91%) in identifying the main cellular populations.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132765140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Nonnegative Matrix Factorization and atomic deconvolution","authors":"Kazufumi Ito, A. K. Landi","doi":"10.1109/BIBM.2015.7359923","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359923","url":null,"abstract":"The Nonnegative Matrix Factorization is an unsupervised maching learning technique that finds a representation of measured data in terms of two low-rank factors. It has recently gained popularity in various applications as a feature selection and dimension reduction tool, e.g. text mining, signal processing, and image processing. Thus, the nonnegative matrix factorization is an increasingly important tool in big data analysis as data continues to grow not only in size but also in complexity. In this paper, we advance the NMF analysis in the case of the convolution. That is, the two factors have the clear roles of convolution kernel and signal. Specifically, for the case of the point-spread function, atoms are the weights that describe the kernel. Using proper atoms, we develop a method for the blind deconvolution based on an NMF representation so that we obtain an estimate of the signal and the kernel. In addition, with Magnetic Resonance Imaging (MRI). Specifically, we extend the idea of the two factors to the Fourier transform and develop a coordinate-descent method in order to determine phases.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133109938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiyao Wang, Yuanfang Ren, M. Hasan, A. Ay, Tamer Kahveci
{"title":"Construction of signaling networks with incomplete RNAi data","authors":"Qiyao Wang, Yuanfang Ren, M. Hasan, A. Ay, Tamer Kahveci","doi":"10.1109/BIBM.2015.7359674","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359674","url":null,"abstract":"Methods for constructing signaling networks from reference networks and single gene knockdown RNAi experiments have been proposed in recent years. All of these studies assume that the RNAi data is complete. However, RNAi experiments are usually noisy and more importantly have a considerable amount of missing data (i.e., a subset of the gene knockdowns is missing). In this paper, we address the signaling network construction problem with incomplete RNAi data. We develop two new methods for constructing a network topology which is closest to the reference network and consistent with the given incomplete RNAi data. Our experiments on real and synthetic datasets demonstrate that these methods produce accurate results and they are efficient. For real Wnt networks, our methods produce results with high accuracy in less than 100 ms.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"255 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131274966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On using Compressed Sensing and peak detection method for the Dynamic Instability parameters estimation for Microtubules modeled in three states","authors":"Shantia Yarahmadian, V. Menon, V. Rezania","doi":"10.1109/BIBM.2015.7359718","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359718","url":null,"abstract":"Recent studies has revealed that Microtubules (MTs) exhibit three transition states of growth, shrinkage and pause states. In this paper, we use Trichotomous Markov Noise (TMN) as a framework for studying MTs dynamics in its three transition states. We then apply Compressed Sensing (CS) to the experimental data of MT length and apply peak detection in the wavelet domain to efficiently detect the three transition states of MTs. One of the novelties of our method is in detecting the peaks and encoding them simultaneously in the wavelet domain without having the need to do further processing after decoding stage. Experimental results show that using CS in conjunction with wavelets provides better compression and reconstruction performance comparing to the traditional sampling schemes. Dynamic Instability parameters of MTs are estimated and are shown to closely approximate original MT data for lower sampling rates.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127059581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manar D. Samad, Jonna Bobzien, J. Harrington, K. Iftekharuddin
{"title":"Analysis of facial muscle activation in children with autism using 3D imaging","authors":"Manar D. Samad, Jonna Bobzien, J. Harrington, K. Iftekharuddin","doi":"10.1109/BIBM.2015.7359704","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359704","url":null,"abstract":"Autism Spectrum Disorder (ASD) impairs an individual's non-verbal skills including natural and contextual facial expressions. Such impairments may manifest as odd facial expressions (facial oddity) based on subjective evaluations of facial images. A few studies conducted on individuals with ASD have focused on the physiology of facial muscle usage by employing eletrophysiological sensors in response to visual stimuli. The sensors are placed directly on the face and may inhibit or limit the spontaneous facial response which may be too subtle for subjective human evaluations. This study uses a non-intrusive 3D facial imaging sensor that captures detailed geometric information of the face to facilitate quantification and detection of subtle changes in facial expression based on the physiology of facial muscle. A novel computer vision and data mining approach is developed from curve-based geometric feature of 3D facial data to discern the changes in the facial muscle actions. A pilot study is conducted with sixteen subjects (8 subjects with ASD and 8 typically-developing controls) where 3D facial images have been captured in response to visual stimuli involving 3D facial expressions. Statistical analyses reveal a significantly asymmetric facial muscle action in subjects with ASD compared to the typically-developing controls. This study demonstrates feasibility of using non-intrusive facial imaging sensor data in evaluating possible physiology-based impairments.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127386278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Cao, Sisi Zeng, F. Shen, Chuandi Pan, Chengshui Chen, Thanh Nguyen, J. Chen
{"title":"Predictive and preventive models for diabetes prevention using clinical information in electronic health record","authors":"Ni Cao, Sisi Zeng, F. Shen, Chuandi Pan, Chengshui Chen, Thanh Nguyen, J. Chen","doi":"10.1109/BIBM.2015.7359799","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359799","url":null,"abstract":"In this work, we constructed diabetes predictive models using electronic health record data, which could potentially have better preventive power than other diabetes predictive models known according to our knowledge. Diabetes is one of the most common, costly and complicated diseases all over the world, including China. To tackle the complexity of diabetes, electronic health record has been widely used to support physicians in integrated care. However, diabetes predictive models using electronic health record may lack of preventive power when the clinical measurements directly related to diabetes diagnosis criteria are used. To overcome this limitation, we did not use glucose, insulin, C-peptide and HbA1C clinical measurements in classifying diabetes patients. We used decision-table and support vector machine algorithm to build predictive models. As the result, our decision-table-based model achieves accuracy of 0.879, AUC of 0.921, precision of 0.898 and recall of 0.904, which is comparable with any known definition to diabetes. Our support-vector-machine-based model achieves accuracy of 0.660, AUC of 0.584, precision of 0.652 and recall of 0.939. We also found 37 measurements significantly associated to diabetes, which are not directly related to diabetes diagnosis criteria.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114865709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emna Ben Abdallah, M. Folschette, O. Roux, M. Magnin
{"title":"Exhaustive analysis of dynamical properties of Biological Regulatory Networks with Answer Set Programming","authors":"Emna Ben Abdallah, M. Folschette, O. Roux, M. Magnin","doi":"10.1109/BIBM.2015.7359694","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359694","url":null,"abstract":"The combination of numerous simple influences between the components of a Biological Regulatory Network (BRN) often leads to behaviors that cannot be grasped intuitively. They thus call for the development of proper mathematical methods to delineate their dynamical properties. As a consequence, formal methods and computer tools for the modeling and simulation of BRNs become essential. Our recently introduced discrete formalism called the Process Hitting (PH), a restriction of synchronous automata networks, is notably suitable to such study. In this paper, we propose a new logical approach to perform model-checking of dynamical properties of BRNs modeled in PH. Our work here focuses on state reachability properties on the one hand, and on the identification of fixed points on the other hand. The originality of our model-checking approach relies in the exhaustive enumeration of all possible simulations verifying the dynamical properties thanks to the use of Answer Set Programming.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121961459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hui-Hui Wang, Jia-Ming Liu, Mingyu You, Guozheng Li
{"title":"Audio signals encoding for cough classification using convolutional neural networks: A comparative study","authors":"Hui-Hui Wang, Jia-Ming Liu, Mingyu You, Guozheng Li","doi":"10.1109/BIBM.2015.7359724","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359724","url":null,"abstract":"Cough detection has considerable clinical value, which can provide an objective basis for assessment and diagnosis of respiratory diseases. Motivated by the great achievements of convolutional neural networks (CNNs) in recent years, we adopted 5 different ways to encode audio signals as images and treated them as the input of CNNs, so that image processing technology could be applied to analyze audio signals. In order to explore the optimal audio signals encoding method, we performed comparative experiments on medical dataset containing 70000 audio segments from 26 patients. Experimental results show that RASTA-PLP spectrum is the best method to encode audio signals as images with respect to cough classification task, which gives an average accuracy of 0.9965 in 200 iterations on test batches and a F1-score of 0.9768 on samples re-sampled from the test set. Therefore, the image processing based method is shown to be a promising choice for the process of audio signals.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126183625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saeed Mehrang, E. Helander, M. Pavel, A. Chieh, I. Korhonen
{"title":"Outlier detection in weight time series of connected scales","authors":"Saeed Mehrang, E. Helander, M. Pavel, A. Chieh, I. Korhonen","doi":"10.1109/BIBM.2015.7359896","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359896","url":null,"abstract":"In principle, connected sensors allow effortless long-term self-monitoring of health and wellness that can help maintain health and quality of life. However, data collected in the “wild” may be noisy and contain outliers, e.g., due to uncontrolled sources or data from different persons using the same device. The removal of the “outliers” is therefore critical for accurate interpretation of the data. In this paper we study the detection and elimination of outliers in self-weighing time series data obtained from connected weight scales. We examined three techniques: (1) a method based on autoregressive integrated moving average (ARIMA) time series modelling, (2) median absolute deviation (MAD) scale estimate, and (3) a method based on Rosner statistics. We applied these methods to both a data set with real outliers and a clean data set corrupted with simulated outliers. The results suggest that the simple MAD algorithm and ARIMA performed well with both test sets while the Rosner statistics was significantly less effective. In addition, the ARIMA approach appeared to be significantly less sensitive to long periods of missing data than MAD and Rosner statistics.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127293067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative utility of time and frequency HRV domains for automated classification of exercise exertion levels","authors":"I. Jeong, J. Finkelstein","doi":"10.1109/BIBM.2015.7359817","DOIUrl":"https://doi.org/10.1109/BIBM.2015.7359817","url":null,"abstract":"Exercise exertion results in activation of sympathetic nervous system. Heart rate variability (HRV) has been used to analyze activity of sympathetic nervous system (ANS). However, approaches to use HRV for exercise exertion analysis were not explored systematically. The main goal of this study was to develop classification algorithms to determine level of exercise exertion in real time and to compare potential of HRV time domain parameters versus HRV frequency domain parameters versus combined time and frequency parameter set. Discriminant analysis was used to identify optimal parameter sets and to develop algorithms for classification of exercise exertion levels. Time-domain HRV parameters demonstrated higher classification accuracy (95.6%) as compared to frequency-domain parameters (82.2%). Combing HRV parameters from time and frequency domains improves classification accuracy (97.8%). Our results suggested that HRV analysis can be used to automatically classify exercise exertion levels. Future studies should focus on more granular approach in identifying different stages of exercise process. Evaluation of classification algorithms should be based on larger sample of diverse representatives of different age, sex and health condition groups.","PeriodicalId":186217,"journal":{"name":"2015 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130121038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}