Melatonin Research最新文献_第7页

Rationale for the continued use of melatonin to combat the delta variant of SARS-CoV-2 继续使用褪黑素来对抗SARS-CoV-2的δ变体的理由

Melatonin Research Pub Date : 2021-09-30 DOI: 10.32794/mr112500107

R. Reiter, D. Cardinali, R. L. Neel, Alberto Domínguez Rodríguez, Gregory M. Brown, J. Tesarik

引用次数: 2

Protective effect of melatonin in atherosclerotic cardiovascular disease: A comprehensive review 褪黑素对动脉粥样硬化性心血管疾病的保护作用:综述

Melatonin Research Pub Date : 2021-09-30 DOI: 10.32794/mr112500102

M. Datta, R. Majumder, A. Chattopadhyay, D. Bandyopadhyay

引用次数: 2

An insight into the ameliorative effects of melatonin against chromium induced oxidative stress and DNA damage: a review 褪黑素对铬诱导的氧化应激和DNA损伤的改善作用:综述

Melatonin Research Pub Date : 2021-09-30 DOI: 10.32794/mr112500101

P. Ghosh, T. Dey, A. Chattopadhyay, D. Bandyopadhyay

{"title":"An insight into the ameliorative effects of melatonin against chromium induced oxidative stress and DNA damage: a review","authors":"P. Ghosh, T. Dey, A. Chattopadhyay, D. Bandyopadhyay","doi":"10.32794/mr112500101","DOIUrl":"https://doi.org/10.32794/mr112500101","url":null,"abstract":"Chromium (Cr), a ubiquitous metal, has become a potent pollutant due to global industrialization, leading to pollution of air, water, and food that impacts human health. The most stable forms of Cr are Cr(III) and Cr(VI) (the major product of industrial activities). Cr(III) is a micronutrient essential for maintaining normal blood glucose and lipid profiles in our body but it can also form Cr (III)-DNA adducts. In addition, it directly produces reactive oxygen species (ROS) via Fenton and Haber-Weiss reactions; leading to tissue injuries. Cr (VI) has the capacity to generate Cr(V), Cr (IV), and Cr(III), respectively under suitable conditions. These intermediates also damage to biological macromolecules by interactions with several enzymatic and non-enzymatic antioxidants. For example, Cr(III) can make double DNA strands breaking to inhibit DNA replication, induce DNA oxidation, and DNA adducts formation. All of these lead to the development of malignancy. Melatonin, a potent radical scavenger as well as a metal chelator, effectively chelates Cr(VI) and prevents DNA oxidative damage. Melatonin can upregulate the gene expression of several antioxidant enzymes, and thereby, maintains cellular integrity from the oxidative stress. Thus, melatonin can be a prime molecule to protect against Cr(VI) induced cytotoxicity and genotoxicity. This review aims to highlight the potential benefits of melatonin on Cr(VI) induced oxidative stress and DNA damage.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76785260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Could melatonin be an adjunct therapy for post-TB lung disease? 褪黑素可以作为结核病后肺病的辅助治疗吗?

Melatonin Research Pub Date : 2021-09-30 DOI: 10.32794/mr112500103

G. Maarman

引用次数: 1

Melatonin: an ancient note in a contemporary wrap 褪黑素:披着现代外衣的古老音符

Melatonin Research Pub Date : 2021-09-30 DOI: 10.32794/mr112500105

Adrita Banerjee, A. Chattopadhyay, D. Bandyopadhyay

{"title":"Melatonin: an ancient note in a contemporary wrap","authors":"Adrita Banerjee, A. Chattopadhyay, D. Bandyopadhyay","doi":"10.32794/mr112500105","DOIUrl":"https://doi.org/10.32794/mr112500105","url":null,"abstract":"At the beginning of life, natural selection is and still the principal driving force for the evolution of all organisms to adapt in the particular environments of the earth. As a result, ultimately neither the strongest, nor the supreme intelligent but the most adaptable species win the race. Not only the organisms, but also the elements which are necessary for survival of them also undergo extreme evolution. These include DNA, proteins and other biochemical moleculesAt the beginning of life, natural selection is and still the principal driving force for the evolution of all organisms to adapt in the particular environments of the earth. As a result, ultimately neither the strongest, nor the supreme intelligent but the most adaptable species win the race. Not only the organisms, but also the elements which are necessary for survival of them also undergo extreme evolution. These include DNA, proteins and other biochemical molecules. However, melatonin, an indoleamine, presents in the early life form remains unchanged in its structure from unicellular organisms to mammals. When it was discovered, it was considered to be a neuronal hormone produced exclusively in the pineal gland of vertebrates. The latter discovery of its presence in primitive bacteria drives the melatonin research in different directions. Its primary function is serving as an antioxidant in all organisms. Its chemical structure is perfect to scavenge free radicals and thus, this molecule is preserved from bacteria to mammals. However, this molecule acquired many additional functions during evolution. These include circadian regulation, immuno-enhancement, oncostatic, anti-inflammatory and anti-aging activities. In the review, we are trying to present hypothetical and most plausible chronological events in the functional evolvements of melatonin during the process of evolution.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76327252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A combination of melatonin and moderate-intensity aerobic exercise improves pancreatic beta-cell function and glycemic homeostasis in type 2 diabetic model of animals 褪黑素和中等强度有氧运动的结合改善2型糖尿病模型动物胰腺β细胞功能和血糖稳态

Melatonin Research Pub Date : 2021-09-27 DOI: 10.32794/mr112500106

Eduardo Almeida Leite, P. R. Gomes, E. A. Vilas-Boas, A. C. Munhoz, L. C. Motta-Teixeira, José Sinésio Silva Júnior, A. Carpinelli, J. Cipolla Neto

{"title":"A combination of melatonin and moderate-intensity aerobic exercise improves pancreatic beta-cell function and glycemic homeostasis in type 2 diabetic model of animals","authors":"Eduardo Almeida Leite, P. R. Gomes, E. A. Vilas-Boas, A. C. Munhoz, L. C. Motta-Teixeira, José Sinésio Silva Júnior, A. Carpinelli, J. Cipolla Neto","doi":"10.32794/mr112500106","DOIUrl":"https://doi.org/10.32794/mr112500106","url":null,"abstract":"Nocturnal melatonin secretion is important for preservation of ß-cell mass and function. Knowing that type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia caused by the elevated resistance of peripheral tissues to insulin, reduction in pineal melatonin and disturbances of insulin secretion by pancreatic ß-cells. In this context, exercise is considered one of the most valuable non-pharmacological approaches for treatment of T2DM. Considering the beneficial role of melatonin on glycemic metabolism in physical exercise, we investigated the effects of moderate-intensity aerobic exercise plus melatonin on glycemic homeostasis, the morphology and architecture of pancreas in spontaneous T2DM animals [Goto-Kakizaki (GK) rats]. The results confirmed that melatonin alone reduced the mass of epididymal white adipose tissue (WAT); however, only the combination of melatonin and physical exercise significantly reduced caloric intake, body weight, WAT and improved glucose tolerance and insulin sensitivity in T2DM rats. This combination also reduced apoptosis of cells in pancreatic islets. We observed either melatonin or the combination was able to reduce insulinemia. However, only the combination improved the morphology of the pancreatic islets. Thus, we conclude that in GK rats, melatonin plays a crucial role in the functionality of the pancreas to improve insulin sensitivity of peripheral tissues and, consequently, to maintain the glucose homeostasis. In addition, the combination is more efficiency to improve glucose tolerance and integrity of pancreatic islets in GK rats than melatonin alone.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88485480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin receptor-mediated attenuation of excitotoxic cell death in cultured spinal cord slices 褪黑素受体介导的脊髓切片兴奋毒性细胞死亡衰减

Melatonin Research Pub Date : 2021-04-30 DOI: 10.32794/mr11250098

A. Haque, D. Shields, Arabinda Das, A. Varma, R. Reiter, N. Banik

{"title":"Melatonin receptor-mediated attenuation of excitotoxic cell death in cultured spinal cord slices","authors":"A. Haque, D. Shields, Arabinda Das, A. Varma, R. Reiter, N. Banik","doi":"10.32794/mr11250098","DOIUrl":"https://doi.org/10.32794/mr11250098","url":null,"abstract":"Recent studies suggest ex vivo modeling of neuronal injury is a robust approach for the mechanistic study of neurodegeneration. Melatonin, an indolamine, is a versatile molecule with antioxidative, antiapoptotic, neuroprotective, and anti-inflammatory properties. While melatonin has been studied as a therapeutic agent for spinal cord injury (SCI) related neuronal cell loss, its actions in organotypic slice cultures approximating SCI effects are less well understood. The actions of melatonin were therefore examined following exposure of cultured rat spinal cord slices to glutamate excitotoxicity. Exposure to glutamate (500 μM) for 4 hours induced neuronal degeneration that was prevented by 0.5 μM melatonin (applied immediately or 4 hours following glutamate exposure). Decreased internucleosomal DNA fragmentation, Bax:Bcl-2 and calpain:calpastatin ratios, caspase 8, 9 and 3 activities in slice cultures were measured following melatonin treatment. Melatonin receptor (MTR1, MTR2) mRNA levels were increased in the melatonin treated spinal cord slices. To confirm melatonin receptor-mediated protection, slice cultures were treated with 10 or 25 μM luzindole (melatonin receptor antagonist) at 0 and 4 hours, respectively, after glutamate exposure. Luzindole significantly decreased the ability of melatonin to prevent cell death in the sliced culture model. These results suggest melatonin receptors may provide a pathway for therapeutic applications to prevent penumbral neuron loss following SCI. ","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77873485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin as a prospective metabolic regulator in pathologically altered cardiac energy homeostasis 褪黑素在病理改变的心脏能量稳态中作为一种潜在的代谢调节剂

Melatonin Research Pub Date : 2021-04-30 DOI: 10.32794/MR11250097

Swaimanti Sarkar, A. Chattopadhyay, D. Bandyopadhyay

{"title":"Melatonin as a prospective metabolic regulator in pathologically altered cardiac energy homeostasis","authors":"Swaimanti Sarkar, A. Chattopadhyay, D. Bandyopadhyay","doi":"10.32794/MR11250097","DOIUrl":"https://doi.org/10.32794/MR11250097","url":null,"abstract":"A constant energy supply is indispensable for the relentlessly working heart. The unique metabolic flexibility of the cardiac tissue enables it to maintain its energy requirement under variable physiological conditions. However, some physiopathological statuses including aging, ischemia-reperfusion injury, diabetic cardiomyopathy, pathological cardiac hypertrophy, and heart failure frequently cause cardiac dysfunction and detrimental metabolic alteration. If the ATP supply fails to match the requirement of a working heart, the heart loses its functional capacity, resulting in slower recovery. A decrease in energy generation is often the ramifications of myocardial mitochondrial dysfunction and oxidative stress. Melatonin, a broad-spectrum antioxidant molecule has an appreciable role in the maintenance of metabolic homeostasis― from a single cell to an entire organism. Melatonin has the capacity to reduce ROS generation, preserve mitochondrial stability, and restore a robust mitochondrial function for unabated ATP production in cardiac tissues. Additionally, melatonin can promote carbohydrate and fat metabolism to further improve the ATP production in heart. In cardiac cells, melatonin upregulates GLUT4 expression either by impeding oxidative stress or by enhancing AMPK activation which accelerates fatty acid oxidation by upregulating PPAR-α and CPT-1α. Melatonin plays a pivotal role in the maintenance of calcium homeostasis in cardiomyocytes by obviating oxidative stress-mediated disruption of SERCA and NCX proteins. A possible role of melatonin to convert the Warburg effect to oxidative metabolism in pathological cardiac events has been recently contemplated. The current review will discuss the possible role of melatonin protecting against cardiac metabolic imbalances under pathological states.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80966307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Does the melatonin supplementation decrease the severity of the outcomes in COVID-19 patients? A mini review of observational data in the in vivo and in vitro studies 补充褪黑激素是否会降低COVID-19患者预后的严重程度?对体内和体外研究的观察性数据进行简要回顾

Melatonin Research Pub Date : 2021-04-21 DOI: 10.32794/MR11250099

M. Gholizadeh, Faezeh Abaj, H. Hasani, A. Mirzababaei, K. Mirzaei

{"title":"Does the melatonin supplementation decrease the severity of the outcomes in COVID-19 patients? A mini review of observational data in the in vivo and in vitro studies","authors":"M. Gholizadeh, Faezeh Abaj, H. Hasani, A. Mirzababaei, K. Mirzaei","doi":"10.32794/MR11250099","DOIUrl":"https://doi.org/10.32794/MR11250099","url":null,"abstract":"The Coronavirus Disease 2019 (COVID-19) is a global pandemic and there is no specific treatment for reducing the severity of this disease up to date. The majority of the treatments remain supportive and empirical. The aim of present study is to assess the relationship between melatonin supplementation and its effect on the severity of the outcomes in covid-19 patients. All published studies up to April 4 of 2021 were searched by using the databases of PubMed, ISI Web of Science, SCOPUS and Google Scholar. Finally, 201 studies have been acquired. After screening titles, abstracts and justifying the inclusion criteria, eight studies were finally selected in our study. Four studies were observational and case series with total 216,792 participants. Three studies performed on laboratory in the molecular level and one was carried out in mice. The results have suggested that melatonin decreases the severity of the outcomes of COVID-19 patients in their early stage or even in their critical conditions. Furthermore, the melatonin decreases pneumonia and reduces the ground glass lung damage observed in the image findings. Also, it plays an important role as anti-inflammatory, anti-viral and antioxidant activities. Melatonin inhibits the main protease of sares-cov-2 virus and decreases the viral load in molecular level. Regarding the in vivo studies, melatonin is more effective for reducing acute lung injury than other treatments. Although, further clinical studies are required.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79261675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Melatonin promotes gastric healing by modulating the components of matrix metalloproteinase signaling pathway: a novel scenario for gastric ulcer management 褪黑素通过调节基质金属蛋白酶信号通路的成分促进胃愈合:胃溃疡治疗的新方案

Melatonin Research Pub Date : 2021-03-30 DOI: 10.32794/mr11250092

R. Majumder, M. Datta, A. Chattopadhyay, D. Bandyopadhyay

{"title":"Melatonin promotes gastric healing by modulating the components of matrix metalloproteinase signaling pathway: a novel scenario for gastric ulcer management","authors":"R. Majumder, M. Datta, A. Chattopadhyay, D. Bandyopadhyay","doi":"10.32794/mr11250092","DOIUrl":"https://doi.org/10.32794/mr11250092","url":null,"abstract":"Over the past few decades, since the induction of antibiotics and proton pump inhibitors (PPI) as a therapeutic tool in controlling gastropathy, a substantial decline in the incidence of gastric ulcer and its related manifestations has been achieved globally. However, there are a lot of skeptics on the steady rise in the list of complications following long-term use of these drugs, especially in chronic and elderly patients. Hence, the search for a sustainable cure for these gastropathies has never actually ended; this let us consider that melatonin, an endogenous antioxidant, might have a utility in this respect. Although researchers have linked melatonin with accelerated post ulcerative wound healing, many of these studies have failed to identify the confounding factors and plausible healing mechanisms. In this review, we attempt to identify the underline mechanisms as to the protective effects of melatonin on a variety of gastropathies. Based on the evidence, we select the matrix metalloproteinases (MMPs) to be the main targets of melatonin. MMPs play a key role in maintaining the balance between extracellular matrix degradation and tissue remodeling, therefore, they act as the integral connection between the ulcer manifestation and healing. Thus, gastric ulceration occurs where this balance is disrupted. Melatonin can preserve this balance during the onset of gastric ulcers. In this review, we have also discussed the effects of melatonin on the different isoforms of MMPs and their roles in gastric ulceration, respectively. We hope that this will bestow us with a better understanding of the development of the gastric ulcer, as well as its cure.","PeriodicalId":18604,"journal":{"name":"Melatonin Research","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84997576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1