Military Medical Research最新文献

{"title":"FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury.","authors":"Mi Zhou, Yang-Wu-Yue Liu, Yu-Hang He, Jing-Yu Zhang, Hao Guo, Hao Wang, Jia-Kui Ren, Yi-Xun Su, Teng Yang, Jia-Bo Li, Wen-Hui He, Peng-Jiao Ma, Man-Tian Mi, Shuang-Shuang Dai","doi":"10.1186/s40779-024-00523-w","DOIUrl":"10.1186/s40779-024-00523-w","url":null,"abstract":"<p><strong>Background: </strong>Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI). However, the heterogeneity, multifunctionality, and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly understood.</p><p><strong>Methods: </strong>Using the combined single-cell transcriptomics, metabolomics, and proteomics analysis from TBI patients and the TBI mouse model, we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral tests. We also characterized the underlying mechanisms both in vitro and in vivo through molecular simulations, signaling detections, gene expression regulation assessments [including dual-luciferase reporter and chromatin immunoprecipitation (ChIP) assays], primary cultures or co-cultures of neutrophils and oligodendrocytes, intracellular iron, and lipid hydroperoxide concentration measurements, as well as forkhead box protein O1 (FOXO1) conditional knockout mice.</p><p><strong>Results: </strong>We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse model. Infiltration of these FOXO1^high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI, aggravating acute brain inflammatory damage and promoting late TBI-induced depression. In the acute stage, FOXO1 upregulated cytoplasmic Versican (VCAN) to interact with the apoptosis regulator B-cell lymphoma-2 (BCL-2)-associated X protein (BAX), suppressing the mitochondrial translocation of BAX, which mediated the antiapoptotic effect companied with enhancing interleukin-6 (IL-6) production of FOXO1^high neutrophils. In the chronic stage, the \"FOXO1-transferrin receptor (TFRC)\" mechanism contributes to FOXO1^high neutrophil ferroptosis, disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein, which contributes to the progression of late depression after TBI.</p><p><strong>Conclusions: </strong>FOXO1^high neutrophils represent a novel neutrophil phenotype that emerges in response to acute and chronic TBI, which provides insight into the heterogeneity, reprogramming activity, and versatility of neutrophils in TBI.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"20"},"PeriodicalIF":16.7,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cells: potential carriers or agents for drug delivery to the central nervous system.","authors":"Shan-Shan Zhang, Ruo-Qi Li, Zhong Chen, Xiao-Ying Wang, Aaron S Dumont, Xiang Fan","doi":"10.1186/s40779-024-00521-y","DOIUrl":"10.1186/s40779-024-00521-y","url":null,"abstract":"<p><p>Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous system (CNS) remains a challenge mainly due to the obstruction from brain barriers. Immune cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug delivery. Herein, we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood-brain barrier. We subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS, as well as recent progress in rationally engineering immune cell-based DDS for CNS diseases. Finally, we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"19"},"PeriodicalIF":21.1,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10979586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140318676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure","authors":"Xiu-Yun Liu, Jing-Jing Mu, Jian-Ge Han, Mei-Jun Pang, Kuo Zhang, Wen-Qian Zhai, Nan Su, Guang-Jian Ni, Zhi-Gang Guo, Dong Ming","doi":"10.1186/s40779-024-00522-x","DOIUrl":"https://doi.org/10.1186/s40779-024-00522-x","url":null,"abstract":"&lt;p&gt;Dear Editor,&lt;/p&gt;&lt;p&gt;The primary objective of the letter is to emphasize the importance of personalized management of arterial blood pressure (ABP) in the context of off-pump coronary artery bypass grafting (CABG) surgery. Coronary artery disease, a leading global cause of mortality, necessitates a substantial number of cardiac surgeries, with approximately 400,000 CABG operations conducted annually in the United States. Postoperative heart failure (HF) is a common occurrence after CABG surgery, with readmission rates within 30 d due to HF ranging from 12 to 16%. Researchers have highlighted the critical role of HF management before, during and after CABG surgery, identifying hemodynamic instability, perioperative myocardial injury, and low cardiac output syndrome as predictive factors for postoperative HF. In 2023, Han et al. [1] found that factors such as pulse index failure and composite grafting are independent predictors of CABG failure. Additionally, a study reported by Loncar et al. [2] revealed a significant relationship between reduced cerebral blood flow (CBF) and the severity of HF in elderly males. Moreover, Hartono et al. [3] pointed out that perioperative myocardial injury and pre-existing left ventricular systolic dysfunction can contribute to post-CABG HF. In the surgical setting, the reduction of mean arterial pressure (MAP) to minimize collateral bleeding and enhance surgical visualization often leads to low systemic perfusion. Currently, the prevailing approach in CABG surgeries involves a uniform MAP management strategy, typically targeting a range of 60 to 70 mmHg for most patients. However, given the varying clinical backgrounds of patients and their diverse tolerance to low MAP levels, there is an urgent need for personalized MAP management during CABG surgery to ensure adequate blood flow and prevent postoperative complications.&lt;/p&gt;&lt;p&gt;The brain maintains stable perfusion through cerebral autoregulation (CA), which allows it to regulate CBF despite changes in ABP. Rhee et al. [4] have previously demonstrated that under severe hypoperfusion, the body may prioritize protecting the brain over peripheral organs such as the kidneys. By inducing continuous blood loss in piglets, they observed a reduction in kidney blood flow preceding a decrease in CBF. Previous studies by our researchers and others have established a correlation between low blood pressure and reduced cerebral perfusion during CABG and postoperative complications, including delirium, acute kidney injury, major morbidity, and operative mortality [5,6,7]. However, the specific MAP target most strongly associated with HF remains unknown. Therefore, the hypothesis of our current study is that low MAP and reduced cerebral perfusion to the brain might be a strong indicator of systemic ischemia and HF.&lt;/p&gt;&lt;p&gt;Various parameters have been developed to monitor intraoperative CA in real-time, including cerebral oxygen saturation index (COx), which is determined by the corr","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"4 1","pages":""},"PeriodicalIF":21.1,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking","authors":"Man-Xiu Xie, Ren-Chun Lai, Yi-Bin Xiao, Xi Zhang, Xian-Ying Cao, Xiao-Yu Tian, An-Nan Chen, Zi-Yi Chen, Yan Cao, Xiao Li, Xiao-Long Zhang","doi":"10.1186/s40779-024-00520-z","DOIUrl":"https://doi.org/10.1186/s40779-024-00520-z","url":null,"abstract":"Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is documented in the endocytosis pathway. However, the role of EndoA2 in the regulation of mechanical sensitivity and its underlying mechanisms are currently unclear. Male and female C57BL/6 mice (8–12 weeks) and male cynomolgus monkeys (7–10 years old) were used in our experiments. Nerve injury-, inflammatory-, and chemotherapy-induced pathological pain models were established for this study. Behavioral tests of touch, mechanical pain, heat pain, and cold pain were performed in mice and nonhuman primates. Western blotting, immunostaining, co-immunoprecipitation, proximity ligation and patch-clamp recordings were performed to gain insight into the mechanisms. The results showed that EndoA2 was primarily distributed in neurofilament-200-positive (NF200+) medium-to-large diameter dorsal root ganglion (DRG) neurons of mice and humans. Loss of EndoA2 in mouse NF200+ DRG neurons selectively impaired the tactile and mechanical allodynia. Furthermore, EndoA2 interacted with the mechanically sensitive ion channel Piezo2 and promoted the membrane trafficking of Piezo2 in DRG neurons. Moreover, as an adaptor protein, EndoA2 also bound to kinesin family member 5B (KIF5B), which was involved in the EndoA2-mediated membrane trafficking process of Piezo2. Loss of EndoA2 in mouse DRG neurons damaged Piezo2-mediated rapidly adapting mechanically activated currents, and re-expression of EndoA2 rescued the MA currents. In addition, interference with EndoA2 also suppressed touch sensitivity and mechanical hypersensitivity in nonhuman primates. Our data reveal that the KIF5B/EndoA2/Piezo2 complex is essential for Piezo2 trafficking and for sustaining transmission of touch and mechanical hypersensitivity signals. EndoA2 regulates touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking in sensory neurons. Our findings identify a potential new target for the treatment of mechanical pain.","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"115 1","pages":""},"PeriodicalIF":21.1,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140106874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss.","authors":"Hui-Yang Lei, Gui-Lin Pi, Ting He, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang, Ying Yang","doi":"10.1186/s40779-024-00512-z","DOIUrl":"10.1186/s40779-024-00512-z","url":null,"abstract":"<p><strong>Background: </strong>Episodic memory loss is a prominent clinical manifestation of Alzheimer's disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain unclear. Therefore, further investigation is necessary.</p><p><strong>Methods: </strong>We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis, social behavioural tests, hippocampal electrophysiology, immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and iGABASnFR. Additionally, we utilized optogenetics and administered ursolic acid (UA) via oral gavage to examine the effects of these agents on social memory in mice.</p><p><strong>Results: </strong>The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1 (vCA1) under both physiological conditions and AD-like tau pathology. As tau progressively accumulated, vCA1, especially its excitatory and parvalbumin (PV) neurons, were fully filled with mislocated and phosphorylated tau (p-Tau). This finding was not observed for dorsal hippocampal CA1 (dCA1). The overexpression of human tau (hTau) in excitatory and PV neurons mimicked AD-like tau accumulation, significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within vCA1. Photoactivating excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social memory. Notably, 1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB (TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social memory.</p><p><strong>Conclusion: </strong>This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau accumulation. Notably, our novel findings regarding the efficacy of UA in reducing tau load and targeting the vCA1 microcircuit may provide a promising strategy for treating AD in the future.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"16"},"PeriodicalIF":21.1,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging roles of ADP-dependent glucokinase in prostate cancer.","authors":"Xu Zhang","doi":"10.1186/s40779-024-00518-7","DOIUrl":"10.1186/s40779-024-00518-7","url":null,"abstract":"","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"15"},"PeriodicalIF":21.1,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD.","authors":"Tao-Hu Zhou, Xiu-Xiu Zhou, Jiong Ni, Yan-Qing Ma, Fang-Yi Xu, Bing Fan, Yu Guan, Xin-Ang Jiang, Xiao-Qing Lin, Jie Li, Yi Xia, Xiang Wang, Yun Wang, Wen-Jun Huang, Wen-Ting Tu, Peng Dong, Zhao-Bin Li, Shi-Yuan Liu, Li Fan","doi":"10.1186/s40779-024-00516-9","DOIUrl":"10.1186/s40779-024-00516-9","url":null,"abstract":"<p><strong>Background: </strong>Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD patients.</p><p><strong>Methods: </strong>This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD group. The radiomic features of the whole lung volume were extracted. Least absolute shrinkage and selection operator (LASSO) logistic regression was applied for feature selection and radiomic signature construction. A radiomic nomogram was established by combining the radiomic score and clinical factors. Receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA) were used to evaluate the predictive performance of the radiomic nomogram in the training, internal validation, and independent external validation cohorts.</p><p><strong>Results: </strong>Eighteen radiomic features were collected from the whole lung volume to construct a radiomic model. The area under the curve (AUC) of the radiomic model in the training, internal, and independent external validation cohorts were 0.888 [95% confidence interval (CI) 0.869-0.906], 0.874 (95%CI 0.844-0.904) and 0.846 (95%CI 0.822-0.870), respectively. All were higher than the clinical model (AUC were 0.732, 0.714, and 0.777, respectively, P < 0.001). DCA demonstrated that the nomogram constructed by combining radiomic score, age, sex, height, and smoking status was superior to the clinical factor model.</p><p><strong>Conclusions: </strong>The intuitive nomogram constructed by CT-based whole-lung radiomic has shown good performance and high accuracy in identifying COPD in this multicenter study.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"14"},"PeriodicalIF":21.1,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10877876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139906019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration.","authors":"Ying-Ying Li, Shuai-Fei Ji, Xiao-Bing Fu, Yu-Feng Jiang, Xiao-Yan Sun","doi":"10.1186/s40779-024-00519-6","DOIUrl":"10.1186/s40779-024-00519-6","url":null,"abstract":"<p><p>Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic transitions. The field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical properties. However, a comprehensive understanding of the underlying mechanisms remains somewhat elusive, limiting the broader application of these innovations. In this review, we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised skin. The first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for regeneration. The second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity, facilitating efficient cellular reprogramming and, consequently, promoting the regeneration of skin appendages. In summary, the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing, coupled with the restoration of multiple skin appendage functions.</p>","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"13"},"PeriodicalIF":21.1,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADP-dependent glucokinase: the ancient, archaeal key to prostate cancer.","authors":"Marcin M Kamiński","doi":"10.1186/s40779-024-00514-x","DOIUrl":"10.1186/s40779-024-00514-x","url":null,"abstract":"","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"10"},"PeriodicalIF":21.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRAS^G12D.","authors":"Qiang Cai, Quazi T H Shubhra","doi":"10.1186/s40779-024-00515-w","DOIUrl":"10.1186/s40779-024-00515-w","url":null,"abstract":"","PeriodicalId":18581,"journal":{"name":"Military Medical Research","volume":"11 1","pages":"9"},"PeriodicalIF":21.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}