Minerva cardioangiologica最新文献

{"title":"Abluminus DES: a step forward in the fight against diabetes?","authors":"L. Asmarats, Osama Shoeib, B. Cortese","doi":"10.23736/S0026-4725.20.05565-6","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05565-6","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"48 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78045502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extrasystolic arrhythmia: is it an additional risk factor of atherosclerosis?","authors":"O. Germanova, Y. Shchukin, V. Germanov, G. Galati, A. Germanov","doi":"10.23736/S0026-4725.20.05490-0","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05490-0","url":null,"abstract":"BACKGROUND\u0000Extrasystolic arrhythmia is not included in the list of risk factors of atherosclerosis. The aim of investigation is to determine the relationship between atherosclerosis of main arteries and extrasystolic arrhythmia.\u0000\u0000\u0000METHODS\u0000We included 286 patients in our investigation. We performed 24-hours ECG monitoring, blood lipids analysis, transthoracic echocardiography, ultrasound Doppler of brachiocephalic arteries, abdominal aorta branches, lower extremities arteries, renal arteries. If prescribed we performed stress echocardiography, transesophageal echocardiography, coronary angiography, renal arteries angiography, pancerebral angiography. So the investigation was made for the active revealing of atherosclerotic signs. The main parameters of heart biomechanics and main arteries kinetics we calculated using apexcardiography and sphygmography and included: speed, acceleration, power, work in each phase of the cardiocycle by apexcardiography, as well as in period of prevalence of inflow over outflow and in period of prevalence of outflow over inflow in sphygmography. All the patients were divided into two main groups according to the quantity of extrasystoles per 24 hours: 1 group - less than 3000, 2 group -3000 extrasystoles and more per 24 hours.\u0000\u0000\u0000RESULTS\u0000We determined that the atherosclerotic process was more advanced and more often in the group 2. The atherosclerosis was more severe in patients with extrasystoles before the mitral valve opening and in fast ventricles' filling phase in cardiocycle. The main parameters of heart biomechanics and main arteries kinetics (speed, acceleration, power, work) calculated by apexcardiography and sphygmography increased with the further tendency: if earlier extrasystole appears in cardiocycle, than more changes were observed. Analyzing the methods of physics for fluid movement - Newton equation for liquids and Reynold number - we demonstrated that in extrasystolic arrhythmia in first post-extrasystolic wave there are the conditions for the turbulent blood flow that can cause the onset and progressing of atherosclerotic process.\u0000\u0000\u0000CONCLUSIONS\u0000Extrasystolic arrhythmia is an additional risk factor of main arteries atherosclerosis. Especially this thesis is fair for the extrasystoles that appear in cardiocycle before the mitral valve opening and in fast ventricles' filling phase.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83220183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized trial of flow-mediated dilation to prevent radial artery spasm during transradial approach.","authors":"E. Zencirci, Aycan Esen Zencirci, A. Değirmencioğlu","doi":"10.23736/S0026-4725.20.05463-8","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05463-8","url":null,"abstract":"BACKGROUND\u0000Although transradial approach has been increasingly preferred for percutaneous coronary interventions, radial artery spasm (RAS) is still one of the major disadvantage. Flow-mediated dilation (FMD) is a well-known method for assessing endothelial function through dilation. The aim of this study was to investigate the efficacy of prepuncture flow mediated dilation in preventing RAS during transradial approach.\u0000\u0000\u0000METHODS\u0000The present study prospectively included 222 consecutive patients who underwent transradial coronary intervention. Patients were 1:1 randomized into two groups who underwent prepuncture FMD and who did not (FMD [+] and FMD [-], respectively).\u0000\u0000\u0000RESULTS\u0000In FMD [+] group the incidence of RAS was lower (5.4% vs 16.2%, p=0.009). Multivariate logistic regression analysis demonstrated that female sex, more than two catheter usage and transradial approach without prepuncture FMD independently predicted RAS (odds ratio (OR): 4.66, 95% confidence interval [CI]: 1.8-12.06, p=0.001, OR: 5.73, 95%CI: 2.01-16.39, p=0.001, and OR: 5.01, 95% CI: 1.74-14.48, p=0.003; respectively). However, access site crossover number was very low in both groups and not different between groups.\u0000\u0000\u0000CONCLUSIONS\u0000Prepuncture FMD can significantly reduce RAS during transradial coronary interventions. Thus, prepuncture FMD can be used as a simple adjunctive method to prevent RAS.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89482268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncoupling Protein 2 as genetic risk factor for systemic lupus erythematosus: association with malondialdehyde levels and intima media thickness.","authors":"Caterina M Gambino,&nbsp;Giulia Accardi,&nbsp;Anna Aiello,&nbsp;Calogero Caruso,&nbsp;Ciriaco Carru,&nbsp;Bruno G Gioia,&nbsp;Giuliana Guggino,&nbsp;Sergio Rizzo,&nbsp;Angelo Zinellu,&nbsp;Marcello Ciaccio,&nbsp;Giuseppina Candore","doi":"10.23736/S0026-4725.20.05225-1","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05225-1","url":null,"abstract":"<p><strong>Background: </strong>Increased oxidative stress potentially leads to accelerated atherosclerosis and, consequently, cardiovascular diseases, the main cause of death in systemic lupus erythematous (SLE). To gain insight into these mechanisms, we studied the association of uncoupling protein (UCP) 2 genetic variants, gene involved in the mitochondrial production of reactive oxygen species, and oxidative stress with SLE and the presence of atherosclerosis.</p><p><strong>Methods: </strong>Genetic analysis of the UCP2 -866G/A and UCP2 Ins/Del polymorphisms was performed in 45 SLE patients and 36 healthy controls by RFLP-PCR. Oxidation status was determined by measuring malondialdehyde (MDA) levels. Presence of subclinical atherosclerosis was investigated by evaluation of intima-media thickness using echo-color-Doppler carotid ultrasound examination.</p><p><strong>Results: </strong>Allelic and genotypic frequencies of the SNPs analysed were evaluated by gene count. Significant association was found between UCP2-866A allele and susceptibility for SLE (P=0.001). Higher levels of MDA were found significantly increased in SLE patients (MDA, 5.05±3.36 µmol/L) compared to normal controls (MDA, 2.79±0.89 µmol/L) (P<0.0001).</p><p><strong>Conclusions: </strong>Our results suggest that -866G/A UCP2 polymorphism is associated with SLE causing increased ROS production that, in turn, results in increased MDA levels responsible of accelerated atherosclerosis.</p>","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":" ","pages":"609-618"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38008643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic factors of cardiovascular diseases.","authors":"Alexander M Markin,&nbsp;Alexander N Orekhov","doi":"10.23736/S0026-4725.20.05559-0","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05559-0","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":" ","pages":"599-601"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38698466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric oxide/cGMP signaling pathway and potassium channels contribute to hypotensive effects of nothofagin.","authors":"Claudio H da Silva,&nbsp;Rhanany A Palozi,&nbsp;Priscila de Souza,&nbsp;Camila L de Almeida,&nbsp;Valdir Cechinel-Filho,&nbsp;Emerson L Lourenço,&nbsp;Arquimedes Gasparotto","doi":"10.23736/S0026-4725.20.05243-3","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05243-3","url":null,"abstract":"<p><strong>Background: </strong>Nothofagin is a mono-C-glycoside of 4,2',4',6'-tetrahydroxy-dihydrochalcone that is commonly found in Aspalathus linearis, Nothofagus fusca, and Leandra dasytricha. A wide range of biological effects has been attributed to nothofagin, including antioxidant, diuretic, renoprotective, antiplatelet, and antithrombotic effects. Although nothofagin is pharmacologically active, its effects on blood pressure remain unknown. In the present study, we investigated whether nothofagin causes acute and prolonged hypotension in male Wistar rats, and we investigated the molecular mechanisms that underlie these hemodynamic effects.</p><p><strong>Methods: </strong>Hypotensive effects of nothofagin (0.3, 1, and 3 mg/kg) were evaluated after acute intraduodenal administration and after 7 days of oral treatment. Using pharmacological antagonists and inhibitors, we explored the involvement of the prostaglandin/cyclic adenosine monophosphate and nitric oxide/cyclic guanosine monophosphate pathways and K⁺ channels in nothofagin-induced hypotension.</p><p><strong>Results: </strong>Acute and prolonged nothofagin administration significantly decreased systolic blood pressure and mean arterial pressure in Wistar rats. Pretreatment with N(G)-nitro-L-arginine methyl ester, methylene blue, and tetraethylammonium prevented the hypotensive effect of nothofagin.</p><p><strong>Conclusions: </strong>These results show that nothofagin induces a hypotensive response in Wistar rats, and this effect depends on K⁺ channel opening in smooth muscle cells through nitric oxide signaling.</p>","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"68 6","pages":"602-608"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10398515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter-2 inhibitors in heart failure patients: an appraisal of recent cardiovascular outcome trials.","authors":"Duygu Kocyigit,&nbsp;Alime S Kocyigit,&nbsp;Muzna Hussain","doi":"10.23736/S0026-4725.20.05398-0","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05398-0","url":null,"abstract":"<p><p>Although initially introduced as a novel oral glucose-lowering agent class, cumulative evidence from randomized controlled trials (RCTs) have led sodium-glucose cotransporter-2 inhibitors (SGLT2i) to become a component of primary and secondary prevention from atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Dapagliflozin, one of the agents of this class, was investigated in 2019 in patients with heart failure (HF) independent of being diagnosed with T2DM at baseline. Since then, many other studies are being undertaken in this class of drugs. Herein, we aimed to review the RCTs, their subgroup and post-hoc analyses that examined the effects of SGLT2i on cardiovascular outcomes (including HF-related outcomes) in patients diagnosed with HF that were published until June 2020. We also summarized the ongoing trials that aim to assess the impact of SGLT2i on cardiovascular outcomes in patients with HF and listed available guideline recommendations regarding the use of SGLT2i for cardiovascular disease management.</p>","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":" ","pages":"629-651"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38493878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time restricted feeding: old tools, new packaging?","authors":"Hayley E Billingsley,&nbsp;Dave L Dixon,&nbsp;Graham Gipson,&nbsp;Antonio Abbate,&nbsp;Salvatore Carbone","doi":"10.23736/S0026-4725.20.05253-6","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05253-6","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":" ","pages":"539-541"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37778626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-alcoholic fatty liver disease and heart valve disease: a neglected link.","authors":"Annachiara Pingitore,&nbsp;Camillo Autore,&nbsp;Mariangela Peruzzi,&nbsp;Elena Cavarretta","doi":"10.23736/S0026-4725.20.05161-0","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05161-0","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":" ","pages":"542-544"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37685724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast FFR plus intracoronary injection of nitroglycerine accurately predicts FFR for coronary stenosis functional assessment.","authors":"A. Gutiérrez-Barrios, I. Noval-Morillas, S. Camacho-Freire, Enrique Puche-García, L. Gheorghe, Etel Silva, Inara Alarcon-Lastra, D. Cañadas-Pruaño, A. Gómez-Menchero, G. Calle-Pérez, J. Díaz-Fernández, R. Vázquez-García","doi":"10.23736/S0026-4725.20.05354-2","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05354-2","url":null,"abstract":"BACKGROUND\u0000FFR is the \"gold standard\" for assessing the physiological significance of coronary disease. In the last decade, several alternative adenosine-free indexes have been proposed in order to facilitate the dissemination of the functional evaluation of coronary stenosis. Our aim was to investigate whether radiographic contrast plus intracoronary nitroglycerin (cFFR-NTG) can predict functional assessment of coronary stenosis offering superior diagnostic agreement with FFR compared to non-hyperemic indexes and contrast mediated FFR (cFFR).\u0000\u0000\u0000METHODS\u0000329 lesions evaluated with pressure wire in 266 patients were prospectively included in this multicenter study.\u0000\u0000\u0000RESULTS\u0000The ROC curves for cFFR-NTG using a FFR≤0.80 showed a higher accuracy in predicting FFR (AUC 0.97) than resting Pd/Pa (AUC 0.90, p<0.01) and cFFR (AUC 0.93.5, p<0.01). A significant (p<0.01) strong correlation was found between FFR and the four analyzed indexes: Pd/Pa(r=0.78); iFR/RFR (r=0.73); cFFR(r=0.89) and cFFR-NTG(r=0.93). cFFR-NTG showed the closest agreement at Bland-Altman analysis. The cFFR-NTG cut off value >0.84 showed the highest negative predictive value (88%), specificity (91%), sensitivity (94%) and accuracy (92%) of the studied indexes.\u0000\u0000\u0000CONCLUSIONS\u0000Submaximal hyperemic adenosine-free indexes are an efficient alternative to adenosine for the physiological assessment of epicardial coronary disease. The most accurate index in predicting the functional significance of coronary stenosis using FFR as reference was cFFRNTG.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89938514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}