Marmara Pharmaceutical Journal最新文献_第5页

Antidiabetic effects of Salvia triloba and Thymus praecox subsp. skorpilii var. skorpilii in a rat model of streptozotocin/nicotinamide-induced diabetes 三叶鼠尾草和提前胸腺的抗糖尿病作用。链脲佐菌素/烟酰胺诱导的糖尿病大鼠模型中的鼻毛变异

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.8

M. Cam, S. Yildiz, B. Ertaş, A. Acar, T. Taşkın, L. Kabasakal

{"title":"Antidiabetic effects of Salvia triloba and Thymus praecox subsp. skorpilii var. skorpilii in a rat model of streptozotocin/nicotinamide-induced diabetes","authors":"M. Cam, S. Yildiz, B. Ertaş, A. Acar, T. Taşkın, L. Kabasakal","doi":"10.12991/MPJ.2017.8","DOIUrl":"https://doi.org/10.12991/MPJ.2017.8","url":null,"abstract":"Some Salvia and Thymus species of Lamiaceae family come into prominence with strong antidiabetic effects. Compared to the other species, there are limited studies on antidiabetic activity of Salvia triloba (ST) and Thymus praecox subsp. skorpilii var. skorpilii (TPS). The aim of this study was to adjust the dosage and to determine the antidiabetic effects of methanol extracts of ST and TPS in streptozotocin/nicotinamide-induced diabetic rats. Type II diabetes mellitus (T2DM) was induced by a single intraperitoneal (i.p.) injection of streptozotocin (STZ) dissolved in 0.1 M cold citrate buffer (pH 4.5) at a dose of 55 mg/kg/body weight (b.w.) and nicotinamide (100 mg/kg/b.w.) was given prior to STZ injection. For adjusting dosage, oral glucose tolerance test (OGTT) was used while insulin tolerance test (ITT), OGTT, blood glucose levels and animal weights were used to evaluate the antidiabetic effects of ST and TPS. According to the OGTT, the most effective doses for ST and TPS were 200 mg/kg and 100 mg/kg, respectively. At the end of three weeks, blood glucose levels of control goup reached to 462.50 mg/dl, whereas ST and TPS-treated groups blood glucose levels decreased less than 200.00 mg/dl. In conclusion, the present study suggests that both of ST and TPS methanolic extracts may be of therapeutic benefit in diabetes and thus need to further studies.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"8 1","pages":"818-827"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82136606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Synthesis and evaluation of novel 2-[(1,2,4-triazol-3-yl)thio]acetamide derivatives as potential serum paraoxonase-1 (PON1) activators 新型2-[(1,2,4-三唑-3-酰基)硫]乙酰胺衍生物作为血清对氧磷酶-1 (PON1)潜在活化剂的合成与评价

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.19

L. Yurttaş, Kaan Küçükoğlu, H. Nadaroğlu, Z. Kaplancıklı

{"title":"Synthesis and evaluation of novel 2-[(1,2,4-triazol-3-yl)thio]acetamide derivatives as potential serum paraoxonase-1 (PON1) activators","authors":"L. Yurttaş, Kaan Küçükoğlu, H. Nadaroğlu, Z. Kaplancıklı","doi":"10.12991/MPJ.2017.19","DOIUrl":"https://doi.org/10.12991/MPJ.2017.19","url":null,"abstract":"Coronary artery disease and low-density lipoprotein (LDL) levels in the blood have long been known to be associated with peripheral vascular diseases. Paraoxonase-1 (PON1) enzyme is related to serum levels of high-density lipoprotein (HDL) and protects LDL from oxidation which may result in development of microvascular disease in diabetes. The enzyme has a major role in the prevention of atherosclerosis besides antioxidant properties. Additionally, PON1 is important in the detoxification of organophosphate insecticides from the body. In this study, we aimed to synthesize highly active new compounds which can be a drug candidate and evaluate their effects on PON1 activity. Nine novel triazole compounds bearing thioacetamide moiety (5a-i) were synthesized and their in vitro PON1 activity was investigated. The PON1 enzyme was purified from human serum using ammonium sulfate precipitation method. Also, it was further purified using Sepharose 4B-L-tyrosine- 1-naphthylamine affinity chromatography. Among the synthesized triazole compounds, 5b, 5c, 5f and 5h have been determined to increase PON1 activity, remarkably. Compounds 5b, 5c, 5f and 5h bearing 5-nitrothiazole, benzothiazole, 6-ethoxybenzothiazole and 6-florobenzothiazole moieties could be considered to proceed in vivo investigations which is a further stage for a drug candidate.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"77 1","pages":"967-977"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77816315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac 羧甲基罗望子胶和壳聚糖互穿网络对乙酰氯芬酸的持续递送

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.20

K. Mali, S. Dhawale, R. Dias, V. Havaldar, Pankaj R Kavitake

{"title":"Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac","authors":"K. Mali, S. Dhawale, R. Dias, V. Havaldar, Pankaj R Kavitake","doi":"10.12991/MPJ.2017.20","DOIUrl":"https://doi.org/10.12991/MPJ.2017.20","url":null,"abstract":"The aim of present investigation was to characterize carboxymethyl tamarind gum (CMTG) based interpenetrating networks (IPNs) of aceclofenac for site specific sustained delivery. The drug loaded IPNs were prepared by using chitosan and CMTG as polymers and gluteraldehyde as crosslinking agent. The IPNs were characterized by Attenuated total reflectance- Fourier transform infrared (ATR-FTIR) spectroscopy, thermal analysis, X-ray powder diffraction and solid state 13C-nuclear magnetic resonance spectroscopy. The prepared IPNs were evaluated for the drug entrapment efficiency and equilibrium swelling. The drug release from IPNs was studied in 0.1NHCl for 2h followed by phosphate buffer pH 6.8 for further 10h and compared with commercial tablet. The results of ATR-FTIR and thermal analysis for blank IPNs indicated intercalation of polymeric chains of crosslinked CMTG and chitosan. The results of solid state characterization revealed that the aceclofenac is compatible with IPNs. Entrapment efficiency of IPNs was found to be increased with increase in crosslinker concentration as well as amount of CMTG. The equilibrium swelling study indicated pH dependent swelling of IPNs. The drug release by IPNs showed sustained release of aceclofenac upto 12h while commercial formulation showed fast release within 8h. From the results, it can be concluded that the IPNs of CMTG and chitosan has potential in development of site specific sustained drug delivery.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"55 5 1","pages":"771-782"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83553145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Akılcı ilaç kullanımı ilkeleri doğrultusunda diş hekimliğinde kişisel analjezik listesi oluşturulması

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/mpj.2017.1

Ahmet Akıcı, İpek Kirmizi, Gökhan Göçmen

{"title":"Akılcı ilaç kullanımı ilkeleri doğrultusunda diş hekimliğinde kişisel analjezik listesi oluşturulması","authors":"Ahmet Akıcı, İpek Kirmizi, Gökhan Göçmen","doi":"10.12991/mpj.2017.1","DOIUrl":"https://doi.org/10.12991/mpj.2017.1","url":null,"abstract":"Hekimin hastayla karsilasmadan once hazirlik yaparak, ilgili endikasyona yonelik kendi kisisel ilac listesini olusturmasi ve bu dogrultuda hastalarinin ilacla tedavisini duzenlemesi beklenir. Hekimin bu yaklasimi benimsemesi, akilci ilac kullaniminin (AIK) gerekliliklerinden birisidir. Analjezikler, dis hekimlerinin (DH) en sik receteledigi ilac gruplari arasinda yer alir. Bu yazida, “DH’lerin AIK ilkelerine uygun ilac secimini nasil yapmasi gerektigi” uzerinde durulmaktadir. Bu islemin daha kolay anlasilmasi icin dis hekimliginde “kisisel analjezik listesi” (KAL) secimi ozelinde konunun ayrintilarina yer verilmistir. KAL secimi, analjeziklere ait klinik farmakoloji bilgisinden yararlanarak “etkililik, guvenlilik, uygunluk ve maliyet”ten olusan 4 secim olcutu kullanilarak yapilir. Bu sayede alternatifleri arasindan en iyiler belirlenir. Boylece DH’nin receteleyecegi ilaclara ait bilmesi gereken bilgi yuku ciddi olcude hafifler. Piyasada mevcut cok sayidaki analjezigi ilgilendiren bilgi yukunden kurtulur. Sadece KAL’daki sinirli sayidaki ilaca ait bilgileri iyice ogrenmesi kolaylasir. Bu yontem sayesinde az sayidaki ilaci iyi bilen bir DH, pratikte hem receteye yazacagi ilaci isabetle ve kolaylikla belirler, hem de bu ilacla ilgili hastasina verecegi bilgileri daha kolay aklinda tutar ve bunu daha rahat hayata gecirir. Dolayisiyla, KAL siralamasina sahip olan bir DH, analjezik tedavisini basarili bir seklide duzenleme imkânina kavusur. Analjezik ozelinde kazanilacak bu akilci yaklasimin “transfer etkisi” yoluyla antibiyotik secimi basta olmak uzere dis hekimliginde ihtiyac hissedilen diger ilac/ urun gruplarinin seciminde de benimsenmesi beklenir.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"293 1","pages":"730-740"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79521902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gel permeation chromatographic method for drug protein binding studies 凝胶渗透色谱法用于药物蛋白结合研究

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.17

M. Bhatia, S. Jadhav, Santosh S. Kumbhar

{"title":"Gel permeation chromatographic method for drug protein binding studies","authors":"M. Bhatia, S. Jadhav, Santosh S. Kumbhar","doi":"10.12991/MPJ.2017.17","DOIUrl":"https://doi.org/10.12991/MPJ.2017.17","url":null,"abstract":"The estimation of individual plasma protein in free and bound form with analytes has importance in pharmacokinetics study. Albumins and globulins are most abundantly found in plasma and plays crucial role in plasma protein binding. The present communication deals with the development of gel permeation chromatographic method for the estimation of plasma protein binding studies for ketoprofen, tapentadol and furaltadone. The method was developed using WATER system with Ultrahydrogel column (7.8 x 300 mm i.d.), refractive index detector (1.00 to 1.75 RIU) and Rheodyne injection valve fitted with a 20μl sample loop using 0.1% sodium nitrate as a mobile phase. The method was developed by studying binding above drugs with most of plasma proteins. These complexes have shown linearity in range of 100 to 300μg/ml of these drugs. The developed method has been validated using USFDA guidelines. The developed bioanalytical method is accurate, precise, and selective and sensitive for quantification of plasma proteins bound drugs. The further optimization of method using other standard plasma proteins will explore its applicability in pharmacokinetic and biopharmaceutical studies of most of drugs.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"50 1","pages":"938-948"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80122252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The therapeutic effects of olive leaf extract on Leishmania major infection in BALB/c mice 橄榄叶提取物对BALB/c小鼠重大利什曼原虫感染的治疗作用

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.6

F. Kheirandish, H. Mahmoudvand, A. Khamesipour, F. Ebrahimzadeh, F. Behrahi, S. Rezaei, B. Delfan

引用次数: 6

Phytochemical composition and antifeedant activity of five Vincetoxicum taxa against Spodoptera littoralis and Leptinotarsa decemlineata 五种长春花毒属植物化学成分及其对沿海夜蛾和细蛾的拒食活性

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.28

S. Güzel, R. Pavela, A. Ilcim, G. Kökdil

{"title":"Phytochemical composition and antifeedant activity of five Vincetoxicum taxa against Spodoptera littoralis and Leptinotarsa decemlineata","authors":"S. Güzel, R. Pavela, A. Ilcim, G. Kökdil","doi":"10.12991/MPJ.2017.28","DOIUrl":"https://doi.org/10.12991/MPJ.2017.28","url":null,"abstract":"Five Vincetoxicum taxa (V. canescens subsp. canescens, V. canescens subsp. pedunculata, V. fuscatum subsp. fuscatum, V. fuscatum subsp. boissieri and V. parviflorum) were investigated for insect antifeedant activity against Spodoptera littoralis and Leptinotarsa decemlineata. At a dose of 500 μg/cm2, 12 extracts were 100 % feeding deterrent, while 6 extracts showed 86.3- 99.3 % antifeedant activity. The effective doses (ED50) of the total ethanol extract from V. canescens subsp. pedunculata and of the methanol: dichloromethane (1:1) extract from V. parviflorum were 12, and 18 μg/cm2, respectively, against S. littoralis, and that of the total ethanol extract from V. fuscatum subsp. fuscatum was 25 μg/cm2 against L. decemlineata. The dichloromethane extracts of V. parviflorum and V. canescens subsp. pedunculata inhibited the growth of S. littoralis with ED50 values of 0.08 and 0.09 mg/g, respectively, and their LD50 values for larval mortality were 1.07 and 1.03 mg/g, respectively. Phytochemical analysis revealed the presence of cardiotonic glycosides, sugars, flavonoids and alkaloids in all investigated taxa. In the dichloromethane and methanol:dichloromethane (1:1) extracts, phenanthroindolizidine alkaloids were detected by LC/MS/MS.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"145 1","pages":"872-880"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73439355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

A validated HPLC method for simultaneous estimation of Melatonin and Octyl Methoxycinnamate in combined pharmaceutical applications 高效液相色谱法测定复方药物中褪黑素和甲氧基肉桂酸辛酯的含量

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.16

Gulcin Arslan Azizoglu, E. Azizoğlu, S. T. Tanrıverdi, Ö. Özer

{"title":"A validated HPLC method for simultaneous estimation of Melatonin and Octyl Methoxycinnamate in combined pharmaceutical applications","authors":"Gulcin Arslan Azizoglu, E. Azizoğlu, S. T. Tanrıverdi, Ö. Özer","doi":"10.12991/MPJ.2017.16","DOIUrl":"https://doi.org/10.12991/MPJ.2017.16","url":null,"abstract":"A simple, fast and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Melatonin and Octyl Methoxycinnamate. Melatonin has become an attractive substrate in sunscreen formulations because of its high antioxidant and photo-protection properties. Octyl methoxycinnamate is one of the chemical UV filter that can be found most of the sunscreen formulations up to 7.5 % according Food and Drug Administration. The aim of the present study was to develop and validate a High-Performance Liquid Chromatography method for the determination of Melatonin and Octyl Methoxycinnamate in combined pharmaceutical or cosmetic applications. As a model of combined pharmaceutical applications, a microemulsion consisting of Melatonin and Octyl Methoxycinnamate was also prepared and characterized in terms of droplet size, pH and viscosity. The separation was performed with a Waters XTerra RP C18 (5 μm, 4.6 x 150 mm). All HPLC assays were performed with 10 μl injection volume, mobile phase consisting of acetonitrile and water, using gradient elution starting at 20% and ending at 90% of acetonitrile with a flow rate of 1.5 ml min-1.The eluent was monitored with UV detection at 222 nm for Melatonin and 306 nm for Octyl Methoxycinnamate. The method was validated according to ICH guidelines. Validation parameters were specificity, accuracy, precision (repeatability and reproducibility), linearity, limit of detection (LOD) and limit of quantification (LOQ). Analytical method development results indicated that the LOD values were 0.132 and 0.049 μg/ml; LOQ values were 0.4 and 0.15 μg/ml and assay exhibited a linear range of 0.5- 60 μg/ml for Melatonin and Octyl Methoxycinnamate, respectively.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"14 1","pages":"921-930"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77020887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Analgesic and anti-inflammatory activity of crude leaf and bark extract of Lantana Camara 山楂叶和树皮粗提取物的镇痛和抗炎活性

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.7

Shripad Bairagi, I. Pathan, N. Nema

引用次数: 11

Synthesis and antibacterial activity of hnew hydrazide-hydrazones derived from Benzocaine 苯佐卡因衍生新型肼腙的合成及抗菌活性研究

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.34

M. Han, Güler Gürol, T. Yildirim, S. Kalayci, F. Şahin, Ş. Küçükgüzel

引用次数: 6