Analgesic and anti-inflammatory activity of crude leaf and bark extract of Lantana Camara

Abstract

The purpose of present study was to investigate the analgesic and anti-inflammatory activity of Lantana camara (Verbenaceae) leaf and bark extract. The methanol extract of Lantana camara (MELC) was screened for possible analgesic activity by acetic acid, hot plate and anti-inflammatory activity by carrageenan and histamine induced paw edema. The result showed that, MELC (100 mg/kg and 200 mg/kg) leaf and bark possessed significant (P <0.01 and P <0.05) anti-inflammatory response and 200 mg/kg dose of MELC leaf and bark showed more significant (P <0.01) analgesic activity as compared to the 100 mg/kg dose. Preliminary phytochemical screening result shows the presence of several phytochemicals which may responsible for its anti-inflammatory and analgesic actions. The results indicate the MELC showed great potential for analgesic and anti-inflammatory activity and may be useful for the medical purpose.