Middle East Journal of Digestive Diseases最新文献

{"title":"Change of Expression of Ki 67, P53, and Cyclin D1 Immunoreactivity after <i>Helicobacter pylori</i> Eradication in Patients with Chronic Gastritis and Intestinal Metaplasia.","authors":"Seyed Mohammad Valizadeh Toosi, Somayeh Sheidaei","doi":"10.34172/mejdd.2025.444","DOIUrl":"10.34172/mejdd.2025.444","url":null,"abstract":"<p><strong>Background: </strong>We investigated the impact of <i>Helicobacter pylori</i> eradication on the expression of Ki67, p53, and cyclin D1 in patients diagnosed with chronic gastritis and intestinal metaplasia, utilizing the immunohistochemistry (IHC) method.</p><p><strong>Methods: </strong>The immunoexpression of Ki67, p53, and cyclin D1 in the gastric mucosa was analyzed in 26 patients with chronic gastritis, intestinal metaplasia, and confirmed <i>H. pylori</i> infection, as well as 10 patients with normal gastric histology and no <i>H. pylori</i> infection. The assessments were performed both before and after <i>H. pylori</i> eradication.</p><p><strong>Results: </strong>Successful eradication of <i>H. pylori</i> resulted in a significant reduction in the immunoexpression of Ki67, p53, and cyclin D1 in the majority of patients compared to pre-treatment. High immunoreactivity for Ki67, p53, and cyclin D1 was observed before eradication in 13 (50%), 4 (15.4%), and 9 (34.6%) patients, respectively. Following <i>H. pylori</i> eradication, none of the patients exhibited high immunoreactivity for these markers. Additionally, negative immunoreactivity for Ki67, p53, and cyclin D1 was noted in 21 (80.7%), 21 (80.7%), and 12 (46.1%) patients, respectively, with statistically significant P values of 0.005, 0.02, and 0.004.</p><p><strong>Conclusion: </strong>The eradication of <i>H. pylori</i> in patients with chronic gastritis and intestinal metaplasia leads to a significant regression in the immunoreactivity of Ki67, p53, and cyclin D1. This suggests the potential for reversing precancerous changes in the gastric mucosa through timely treatment.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 4","pages":"282-286"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatitis Manifestation and Mimicking Gallstone Symptoms Caused by Fasciola Hepatica: A Case Report.","authors":"Zahra Bigdeli Shamloo, Ahmad Hormati, Amir Anushiravani","doi":"10.34172/mejdd.2025.435","DOIUrl":"10.34172/mejdd.2025.435","url":null,"abstract":"<p><p>Fasciola hepatica is a parasitic trematode that infects humans, typically through the consumption of contaminated water or raw vegetables. The infection progresses through acute and chronic phases, with the latter often presenting as jaundice, cholangitis, pancreatitis, and cholecystitis due to bile duct obstruction. We report the case of a 53-year-old Iranian woman who experienced persistent eosinophilia, nausea, right upper quadrant and epigastric pain, and occasional chills for one year. Imaging revealed a dilated common bile duct (CBD) with sludge, and endoscopic retrograde cholangiopancreatography (ERCP) successfully identified and extracted five live Fasciola hepatica parasites. This case illustrates the vital role of early recognition and intervention in fascioliasis, as timely endoscopic management can prevent severe complications. Increased awareness among clinicians, especially in regions where the disease is uncommon, is essential to ensure prompt diagnosis and effective treatment of this often-overlooked infection.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"226-229"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Serum Anti-tissue Transglutaminase Level Predict Duodenal Histopathology and Clinical Manifestations of Celiac Disease in Adults?","authors":"Reza Gholamrezaei, Atefeh Vaezi, Fatemeh Maghool, Nahid Jamali, Mohammad Hassan Emami","doi":"10.34172/mejdd.2025.429","DOIUrl":"10.34172/mejdd.2025.429","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion. This study aimed to evaluate the correlation between anti-tTG antibodies and histopathology, as classified by the Marsh system, and clinical manifestations.</p><p><strong>Methods: </strong>This retrospective cross-sectional study analyzed the records of 346 patients with confirmed CD from 2010 to 2021. Anti-tTG levels, clinical manifestations, body mass index (BMI), and pathological results were reviewed.</p><p><strong>Results: </strong>This study included 346 patients (mean age 26.5±16.6 years; 56.4% female). Most patients (53.2%) had atypical CD, and normal BMI was prevalent (57.1%). Common symptoms included anxiety (70.2%), fatigue/weakness (64.2%), borborygmi (53.2%), abdominal pain (51.2%), and bloating (46.8%). Disease severity analysis revealed 75.1% had Marsh III, while 15.9% had normal/Marsh I and 9.0% had Marsh II. Anti-tTG levels were significantly higher in advanced Marsh classes (Marsh III: 169.27±180.17 vs. normal/Marsh I: 70.94±116.45, <i>P</i><0.001) and in typical CD (180.44±216.22) compared to atypical CD (126.20±121.72, <i>P</i>=0.005). Diarrhea, arthralgia, and osteoporosis/osteomalacia showed significant correlations with anti-tTG levels (<i>P</i><0.05). ROC analysis for anti-tTG in diagnosing Marsh II or higher yielded an AUC of 0.733.</p><p><strong>Conclusion: </strong>Anti-tTG demonstrated moderate diagnostic accuracy for advanced duodenal damage, highlighting its utility as a biomarker in CD. Larger studies are needed to validate these findings further.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"183-189"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-Resistant Nausea and Vomiting: A Challenge in Clinical Practice.","authors":"Roya Rafaiee, Raheleh Rafaiee, Alireza Bakhshipour","doi":"10.34172/mejdd.2025.437","DOIUrl":"10.34172/mejdd.2025.437","url":null,"abstract":"","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"233-235"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Resistance Identification Among the Patients with <i>Helicobacter pylori</i> Infection: A Cross-sectional Study from Iran.","authors":"Fatemeh Hasanvand, Javid Sisakhtpour, Mohamadreza Salehi, Khalil Pestehei, Sepideh Khodaparast","doi":"10.34172/mejdd.2025.427","DOIUrl":"10.34172/mejdd.2025.427","url":null,"abstract":"<p><strong>Background: </strong>The successful treatment of <i>Helicobacter pylori</i> infection is warranted only by using appropriate antimicrobial agents determined after performing antibiotic susceptibility tests. Determining the susceptibility profile of antibiotics currently used against <i>H. pylori</i> in each geographical region can be very practically beneficial for all drug prescribers.</p><p><strong>Methods: </strong>In this cross-sectional study, we aim to identify the frequency of four antibiotics mainly referred to in the battle against <i>H. pylori</i> strains isolated from gastric biopsy specimens of 260 patients with dyspepsia referred to the gastroenterology clinics in Lorestan between 2020 and 2022, marking the first report from Iran. After culturing 260 gastric biopsy samples, <i>H. pylori</i> strains were identified using standard diagnostic methods.</p><p><strong>Results: </strong>The prevalence of antibiotic resistance among <i>H. pylori</i> isolates was reported using the antibiotic disc diffusion method with metronidazole, clarithromycin, amoxicillin, and tetracycline discs. Moreover, the minimum inhibitory concentration (MIC) of tetracycline-resistant <i>H. pylori</i> strains, screened by the diffusion disc method, was determined using the E-test method. Out of 260 biopsy samples, 187 (72%) samples (male: 42%, female: 58%) were <i>H. pylori</i> positive. The prevalence of antibiotic resistance rates among 187 isolates of <i>H. pylori</i> was as follows: metronidazole (87.7%, n = 166), clarithromycin (63.1%, n = 118), amoxicillin (39%, n = 73), and tetracycline (34.2%, n = 64), accordingly. Antibiotic resistance among <i>H. pylori</i> isolates was higher than expected, especially for amoxicillin and tetracycline, which is a concerning issue.</p><p><strong>Conclusion: </strong>Consequently, considering the central role of the antibiotic susceptibility profile in experimental therapy, it is recommended that determining the resistance pattern of the bacterium in all parts of Iran can lead to an effective treatment regimen.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submucosal Tunnelling Endoscopic Resection for Oesophageal Duplication Cyst: A Case Report.","authors":"Srinu Deshidi, Gaurav Mahajan, Viswanath Kamisetty, Spoorthi Kolla, Venu Gongati, Gongala Harshavardhan Reddy, Bhaskar Kante, Sreekanth Appasani","doi":"10.34172/mejdd.2025.436","DOIUrl":"10.34172/mejdd.2025.436","url":null,"abstract":"<p><p>Oesophageal duplication cysts are rare congenital anomalies of the foregut. Although frequently asymptomatic, these cysts may cause symptoms like dysphagia, chest pain, or respiratory issues if they grow large enough to compress adjacent structures. Endoscopic ultrasound is essential for accurate diagnosis, and though surgical resection remains the conventional therapy for symptomatic cysts, advanced endoscopic techniques are increasingly recognized as effective, less invasive alternatives. We report the case of a 40-year-old man who presented with dysphagia to solids for 3 months. Upper gastrointestinal endoscopy revealed a large submucosal lesion with fluctuation sign positive, and EUS demonstrated a 4×6.5 cm anechoic to hypoechoic lesion arising above the muscularis propria, likely an oesophageal duplication cyst. The patient underwent successful submucosal tunnelling endoscopic resection (STER) of a cystic lesion under general anaesthesia. This case highlights the feasibility and efficacy of STER as a minimally invasive treatment option for oesophageal duplication cysts.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"230-232"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Plant-Based Diet and Gallstone Disease: A Case-Control Study.","authors":"Mohammad Hossein Ebrahimizadeh, Ava Kheirizadeh, Azita Hekmatdoost, Moloud Ghorbani, Amir Sadeghi, Zahra Yari","doi":"10.34172/mejdd.2025.430","DOIUrl":"10.34172/mejdd.2025.430","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have emphasized the role of plant-based diets in reducing the risk of gallstone disease (GD) by reducing oxidative stress and inflammation. This study aimed to investigate the association between plant-based diet indices and GD risk.</p><p><strong>Methods: </strong>189 patients with newly diagnosed GD and 342 healthy controls participated in this case-control study. To assess overall adherence to a plant-based diet, three indices were calculated based on dietary data from the food frequency questionnaire: the plant-based dietary index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uhPDI). The association between plant-based diet indices and the risk of GD was assessed using logistic regression models.</p><p><strong>Results: </strong>A significant and inverse association was observed between PDI and the risk of GD, with an odds reduction of 48% in the crude model, 56% when adjusted for age and sex, and 59% when adjusted for additional confounders. Similar results were obtained for hPDI. Increasing the hPDI was associated with a 53% (in the crude model) to 67% (in the full adjusted model) reduction in the odds of GD. While increasing uhPDI was associated with an increased odds of GD. In the crude model, the highest uhPDI score increased the odds of the disease by 70%, and in the final model, the increase in odds reached 2.2-fold.</p><p><strong>Conclusion: </strong>Our study revealed that a healthy plant-based diet is associated with a reduced risk of GD, whereas an unhealthy plant-based diet may contribute to a greater susceptibility to disease, emphasizing the importance of diet quality in plant-based nutritional approaches. Further studies are needed to confirm these findings.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"190-195"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Correlation Between Fecal Microbiota Profiles and Clinical Presentation in Pediatric Patients with Celiac Disease.","authors":"Nastaran Asri, Mohadeseh Mahmoudi Ghehsareh, Fahimeh Sadat Gholam-Mostafaei, Mehdi Azizmohammad Looha, Hamidreza Houri, Somayeh Jahani-Sherafat, Mohammad Rahmanian, Mostafa Rezaei Tavirani, Mohammad Rostami-Nejad","doi":"10.34172/mejdd.2025.428","DOIUrl":"10.34172/mejdd.2025.428","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease (CD) is an immune-mediated disorder triggered by gluten in genetically susceptible individuals, often presenting with diverse gastrointestinal and non-gastrointestinal symptoms. Emerging evidence suggests that alterations in gut microbiota composition may influence disease manifestation and clinical outcomes. We investigated the correlation between gut microbiota profiles and clinical features in pediatric patients with CD.</p><p><strong>Methods: </strong>38 pediatric patients (mean age 10.24 years) with confirmed CD were enrolled from August 2021 to September 2022. We had the data on the relative abundance of various fecal microbiota from our previous study, and collected their clinical and demographic data through questionnaires. Genotyping of human leukocyte antigens (HLA)-DQ2 and HLA-DQ8 alleles was performed.</p><p><strong>Results: </strong>Significant correlations were found between gut microbiota and both gastrointestinal (GI) and non-GI symptoms. Enterobacteriaceae and <i>Streptococcus</i> were positively associated with diarrhea (OR: 5.23 and OR: 3.46), whereas deltaproteobacteria showed a negative correlation (OR: 0.07). Betaproteobacteria and <i>Staphylococcus</i> were linked to vomiting (OR: 0.05 and OR: 12.59). Firmicutes and Actinobacteria correlated with weight loss (OR: 2.73 and OR: 16.21), and Verrucomicrobia inversely correlated with fatigue (OR: 0.36). The prevalent HLA genotype DQ2 was correlated positively with Betaproteobacteria (OR: 14.82) and <i>Prevotella</i> (OR: 5.05), while <i>Veillonella</i> showed a negative correlation with HLA-DQ2 (OR: 0.43).</p><p><strong>Conclusion: </strong>Overall, the analysis revealed distinct microbiota patterns influenced by symptom presentation and HLA-DQ genotypes, underscoring the need for further research into the therapeutic potential of modifying gut microbiota in managing CD.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"175-182"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining Upper Limit of Alanine Aminotransferase in Iranian Cohort Population Using Ultrasound Screening for Liver Diseases.","authors":"Behnam Ahmadi, Farhad Naleini, Mehdi Moradinazar, Bita Anvari","doi":"10.34172/mejdd.2025.426","DOIUrl":"10.34172/mejdd.2025.426","url":null,"abstract":"<p><strong>Background: </strong>Alanine aminotransferase (ALT) has a variable normal range according to race and ethnicity. So, the upper normal level of ALT localized for the Iranian population was determined in the Ravansar Non-Communicable Disease (RaNCD) cohort population by re-evaluation of high-risk people.</p><p><strong>Methods: </strong>A cohort population with normal ALT results based on the current kit was checked for a history of liver diseases. After excluding them, the remaining population was included in the distribution diagram of individuals with apparently healthy livers. Participants whose ALT values were in the 90th to 100th percentile were re-evaluated by ultrasonography (US) and a checklist of liver disease. Patients identified as having liver disease or those with other abnormal liver enzymes were excluded, and the 95th percentile was extracted from the distribution diagram of the remaining population.</p><p><strong>Results: </strong>After excluding liver disease, among 8046 participants of RaNCD, US and re-evaluation were performed in 543 high-risk individuals. Liver disease was diagnosed in 74.6% by US. The most common liver disease was metabolic dysfunction-associated steatotic liver disease (MASLD), accounting for 69.7%. Grade 2 or 3 of MASLD was found in 23.2%. After excluding patients with abnormal liver enzymes and liver disease, the 95th percentile of ALT was 29 U/L in women (sensitivity: 53%, specificity: 82%) and 36 U/L in men (sensitivity: 28%, specificity: 90%).</p><p><strong>Conclusion: </strong>The calculated 95th percentile was lower than the routine cut-off value of the current kit in both sexes. Generalizability is a significant advantage of our results, provided by the lack of exclusion of patients with metabolic risk factors and the use of US to exclude MASLD.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"158-166"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Pandemic Virtual Teaching Self-Efficacy: Insights from Medical Educators at Shiraz University of Medical Sciences, Iran.","authors":"Ali Reza Rezvani, Nahid Zarifsanaiey, Parviz Shahmirzalou, Manoosh Mehrabi, Leila Rahmati, Ali Reza Safarpour","doi":"10.34172/mejdd.2025.431","DOIUrl":"10.34172/mejdd.2025.431","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic has highlighted the importance of teacher self-efficacy in online instruction, with virtual teaching models associated with lower efficacy scores compared to in-person formats. This study assessed the self-efficacy of faculty members at Shiraz University of Medical Sciences (SUMS) in online teaching, with a focus on the impact of demographic factors and specialty areas on virtual teaching efficacy post-COVID-19.</p><p><strong>Methods: </strong>This cross-sectional analytic study was conducted between July 2023 and August 2024, on 203 clinical faculty members from Shiraz University of Medical Sciences. Participants included professors with at least one year of clinical experience and who were actively teaching in one of the university's hospitals. The Teachers' Sense of Self-Efficacy Scale (TSES), developed by Tanchan-Moran and Hoy, was used to assess self-efficacy. The instrument was translated from English to Farsi using forward-backward translation methods. Internal consistency and validity were confirmed. Descriptive statistics, one-way ANOVA, t-tests, and chi-square tests were used to analyze the data.</p><p><strong>Results: </strong>The average (SD) work experience of participants was 15.11 (8.89) years, with most being male, married, and working in the medical field. The internal consistency of TSES was excellent (Cronbach's alpha is 0.94). The average (SD) self-efficacy score of participants was 56.17 (14.62), with a minimum score of 22 and a maximum score of 110. Additionally, no significant regression relationships were found between demographic factors (sex, work experience, field of activity, and marital status) and the self-efficacy score. Approximately 70% of the faculty members reported a moderate to high self-efficacy in virtual teaching.</p><p><strong>Conclusion: </strong>This study provides valuable insights into the self-efficacy of SUMS faculty members in online education following the COVID-19 pandemic. While the study recommends that overall self-efficacy levels are moderately high, there is an ongoing need for continued investment in faculty development programs and support to confirm effective online teaching practices and address the evolving needs of medical education.</p>","PeriodicalId":18517,"journal":{"name":"Middle East Journal of Digestive Diseases","volume":"17 3","pages":"196-203"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12958311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}