Medical Science Monitor Basic Research最新文献_第9页

MicroRNA-32 Regulates Development and Progression of Hepatocellular Carcinoma by Targeting ADAMTS9 and Affects Its Prognosis. MicroRNA-32通过靶向ADAMTS9调控肝细胞癌的发生发展并影响其预后

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-11-05 DOI: 10.12659/MSMBR.910522

Shengmian Li, Tingting Li, Xiaoming Li, Yue Yao, Xiaojia Jiang, Lianmei Zhao, Wei Guo

{"title":"MicroRNA-32 Regulates Development and Progression of Hepatocellular Carcinoma by Targeting ADAMTS9 and Affects Its Prognosis.","authors":"Shengmian Li, Tingting Li, Xiaoming Li, Yue Yao, Xiaojia Jiang, Lianmei Zhao, Wei Guo","doi":"10.12659/MSMBR.910522","DOIUrl":"https://doi.org/10.12659/MSMBR.910522","url":null,"abstract":"BACKGROUND MicroRNA-32 (miR-32) induces cell proliferation and metastasis in hepatocellular carcinoma (HCC), but the detailed mechanisms of miR-32 in regulating oncogenesis and development of HCC have not been clarified. The aim of this study was to investigate the effects of miR-32 on HCC and its clinical pathological significance, as well as to determine the functional connection between miR-32 and ADAMTS9 in HCC. MATERIAL AND METHODS Quantitative RT-PCR was used to assess the expression levels of miR-32 in HCC tissues, adjacent non-cancerous tissues, and liver cancer cell lines. In vitro cell proliferation, migration, and invasion assays were performed to confirm the biological functions of miR-32. Quantitative RT-PCR, Western blot analysis, and luciferase reporter assays were used to evaluate the role of miR-32 in the regulation of ADAMTS9. RESULTS miR-32 was highly expressed in HCC tissues compared with corresponding adjacent non-cancerous tissues. Over-expression of miR-32 was also found in 3 human liver cancer cell lines: SMMC-7721, Huh7, and HepG2. Moreover, increasing expression of miR-32 in HCC tissues was related to shorter overall survival. In vitro over-expression of miR-32 promoted cell proliferation, migration, and invasion; however, the under-expression of miR-32 revealed the opposite effects. Dual-luciferase reporter assay indicated that miR-32 can directly bind to the 3'-UTR of ADAMTS9. Western blot analysis showed that over-expression of miR-32 decreased expression of ADAMTS9 protein. Rescue tests further verified the connection between miR-32 and ADAMTS9. CONCLUSIONS Our data indicate that miR-32 accelerates progression in HCC by targeting ADAMTS9, and the abnormal expression of miR-32 is correlated with prognosis and could become a potential therapeutic target.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"177-187"},"PeriodicalIF":2.8,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/07/medscimonitbasicres-24-177.PMC6237041.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36645185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Association of Serum T cell Immunoglobulin Domain and Mucin-3 and Interleukin-17 with Systemic Lupus Erythematosus. 血清T细胞免疫球蛋白结构域、黏素-3和白细胞介素-17与系统性红斑狼疮的关系。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-10-23 DOI: 10.12659/MSMBR.910949

Lairun Jin, Ran Bai, Jun Zhou, Wei Shi, Liang Xu, Jun Sheng, Hui Peng, Yuelong Jin, Hui Yuan

{"title":"Association of Serum T cell Immunoglobulin Domain and Mucin-3 and Interleukin-17 with Systemic Lupus Erythematosus.","authors":"Lairun Jin, Ran Bai, Jun Zhou, Wei Shi, Liang Xu, Jun Sheng, Hui Peng, Yuelong Jin, Hui Yuan","doi":"10.12659/MSMBR.910949","DOIUrl":"https://doi.org/10.12659/MSMBR.910949","url":null,"abstract":"BACKGROUND Previous studies have shown that T cell immunoglobulin domain and mucin-3 (Tim-3) and interleukin-17 (IL-17) are implicated in the development of several autoimmune diseases. However, it is unclear whether these proteins contribute to the pathogenesis of systemic lupus erythematosus (SLE). The purpose of this study was to evaluate SLE patient serum Tim-3 and IL-17 levels, and to assess correlations between these proteins and major clinical parameters of SLE. MATERIAL AND METHODS Overall, 55 SLE patients and 55 healthy controls were recruited in a case-control study. Serum Tim-3 and IL-17 levels were quantified using an enzyme-linked immunosorbent assay (ELISA) kit. RESULTS Serum Tim-3 and IL-17 levels in SLE patients were significantly elevated relative to healthy controls (all P<0.05). Serum Tim-3 levels were significantly lower in SLE patients with nephritis than in those SLE without nephritis (P<0.05), while no statistically significant correlation between serum IL-17 and nephritis was detected (P>0.05). Serum Tim-3 with IL-17 levels were positively correlated in SLE patients (rs=0.817, P<0.01); however, no statistically significant correlation was found between serum Tim-3 or IL-17 levels and systemic lupus erythematosus disease activity index (SLEDAI) scores in those with SLE (all P>0.05). In addition, serum Tim-3 was associated with central lesions in SLE patients, while there were no significant correlations between serum Tim-3 or IL-17 levels and other SLE clinical parameters. CONCLUSIONS Increased serum Tim-3 and IL-17 levels and their clinical associations in SLE patients suggest their possible role in this disease.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"168-176"},"PeriodicalIF":2.8,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/5b/medscimonitbasicres-24-168.PMC6213872.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36608702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Contribution of Physical and Motor Characteristics to Functional Performance in Children and Adolescents with Down Syndrome: A Preliminary Study. 唐氏综合症儿童和青少年的身体和运动特征对功能表现的影响：初步研究。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-10-16 DOI: 10.12659/MSMBR.910448

Samire Beqaj, Esmira E T Tërshnjaku, Merita Qorolli, Vujica Zivkovic

{"title":"Contribution of Physical and Motor Characteristics to Functional Performance in Children and Adolescents with Down Syndrome: A Preliminary Study.","authors":"Samire Beqaj, Esmira E T Tërshnjaku, Merita Qorolli, Vujica Zivkovic","doi":"10.12659/MSMBR.910448","DOIUrl":"10.12659/MSMBR.910448","url":null,"abstract":"BACKGROUND Down syndrome (DS) is the most frequent genetic mental disability. Individuals with DS experience a variety of physical, motor, and functional challenges throughout the lifespan. However, the inter-relatedness between these domains is relatively unexplored in children with DS. This study aimed to determine which physical and motor characteristics contribute to functional performance in children and adolescents with DS. It also investigated the relationship between physical, motor, and functional domains. MATERIAL AND METHODS We enrolled 44 children and adolescents with DS, ages 3-18 years, in this cross-sectional study. The participants were assessed for functional skills (PEDI-CAT), gross motor skills (GMFM-88), balance (PBS), fine motor skills (Nine-hole peg test), grip strength (hand-held Jamar dynamometer), and body mass index (BMI). Descriptive statistics, Pearson's correlation, and stepwise linear regression were employed for statistical analysis. RESULTS Fine motor skills and grip strength were found to be significant predictors of functional performance. All measures, except BMI, were significantly correlated with each other. The participants scored below standard values in all 4 domains of PEDI-CAT, with the social/cognitive skills being most impaired, while mobility proficiency was found to be participants' strongest asset. CONCLUSIONS This study demonstrated fine motor skills and grip strength to be predictors of functional performance in children and adolescents with DS. It also showed a high level of inter-relatedness between the variables of physical, motor, and functional domains in this population.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"159-167"},"PeriodicalIF":2.8,"publicationDate":"2018-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/33/medscimonitbasicres-24-159.PMC6199818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36631445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study. 子宫内膜增生患者DNA修复基因(XPD, XRCC4和XRCC1)多态性:一项初步研究

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-10-02 DOI: 10.12659/MSMBR.911041

Ebru Öztürk, Sacide Pehlivan, Ozcan Balat, Mete Gurol Ugur, Huseyin Caglayan Ozcan, Suna Erkılıç

{"title":"DNA Repair Gene (XPD, XRCC4, and XRCC1) Polymorphisms in Patients with Endometrial Hyperplasia: A Pilot Study.","authors":"Ebru Öztürk, Sacide Pehlivan, Ozcan Balat, Mete Gurol Ugur, Huseyin Caglayan Ozcan, Suna Erkılıç","doi":"10.12659/MSMBR.911041","DOIUrl":"https://doi.org/10.12659/MSMBR.911041","url":null,"abstract":"BACKGROUND In this study, we aimed to evaluate the association between endometrial hyperplasia and DNA repair gene (XPD, XRCC4, and XRCC1) polymorphisms. MATERIAL AND METHODS There were 114 cases enrolled in the study in 4 groups: simple endometrial hyperplasia (SH) (Group 1), complex endometrial hyperplasia without atypia (CH) (Group 2), complex atypical endometrial hyperplasia (CAH) (Group 3), and normal endometrium (NE) (Group 4). Of these cases, 37 cases had SH, 36 cases had CH, 16 cases had CAH, and 25 cases had NE. To evaluate an association between atypia and DNA repair genes, we consider a group that included both SH and CH, the endometrial hyperplasia without atypia cases (Group 5). Genomic DNA was isolated from paraffin-embedded endometrial tissue collected from the Pathology Department of Gaziantep University Medical School. Polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) method was used for evaluating of XPD (-751), XRCC4 (-1394 and a variable number of tandem repeats in intron 3), and XRCC1 (-399) genes. RESULTS We observed a notable distinction in patients having endometrial hyperplasia without atypia (the SH+CH group) and the CAH group in terms of XPD (-751) gene polymorphisms. A notable contrast was observed in patients with endometrial hyperplasia without atypia (the SH+CH group) and the NE group in terms of XRCC4 (VNTR intron 3) polymorphisms (P=0.026, P=0.018, respectively). CONCLUSIONS It was evident the DNA repair gene XPD and XRCC4 polymorphisms had a role in the pathophysiology of endometrial hyperplasia.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"146-150"},"PeriodicalIF":2.8,"publicationDate":"2018-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.12659/MSMBR.911041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36540807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial Protective Effects of Nicorandil on Rats with Type 2 Diabetic Cardiomyopathy. 尼可地尔对2型糖尿病心肌病大鼠心肌的保护作用。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-09-28 DOI: 10.12659/MSMBR.910974

Meng Zhang, Huizhen Zhang, Chun Liu, Xuehui Li, Mingying Ling, Zhihao Wang, Yanqiu Xing

{"title":"Myocardial Protective Effects of Nicorandil on Rats with Type 2 Diabetic Cardiomyopathy.","authors":"Meng Zhang, Huizhen Zhang, Chun Liu, Xuehui Li, Mingying Ling, Zhihao Wang, Yanqiu Xing","doi":"10.12659/MSMBR.910974","DOIUrl":"https://doi.org/10.12659/MSMBR.910974","url":null,"abstract":"BACKGROUND Diabetic cardiomyopathy (DCM) is a common but underestimated cause of heart failure in patients with diabetes. This study investigated the myocardial-protective effects of nicorandil (Nic) on rats with DCM. MATERIAL AND METHODS A total of forty-seven 180-220 g male Wistar rats were randomly divided into 4 groups: a control group (control, n=8), a DCM group (DCM, n=13), a nicorandil-pretreated DCM group (Nic1, n=13), and a nicorandil-treated DCM group (Nic2, n=13). A rat model of type 2 diabetes was induced by high-fat and high-sugar diet and intraperitoneal injection of streptozotocin (STZ). Nicorandil (3 mg/kg/d) was orally administrated to rats in the Nic1 group starting at week 4. Nicorandil (3 mg/kg/d) was orally administrated only after the induction of diabetes in the Nic2 group. The serum lipoids, plasma glucose, insulin levels, heart weight index, serum creatine kinase (CK), lactate dehydrogenase (LDH) levels, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) were analyzed in all groups. RESULTS The DCM group showed increased heart weight index, serum LDH, CK, and MDA content and decreased serum SOD activity, as compared with the control group (P<0.05). The DCM-induced increases in heart weight index, serum LDH, CK, and MDA content and decrease in serum SOD activity were attenuated in both Nic1 and Nic2 groups (P<0.05). However, there was no significant difference between Nic1 and Nic2 groups (P>0.05). CONCLUSIONS Nicorandil has protective effects on cardiac hypertrophy in DCM rats through increased SOD activity and decreased MDA content. Therefore, nicorandil may be a therapeutic method for diabetic patients with DCM.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"141-145"},"PeriodicalIF":2.8,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/7b/medscimonitbasicres-24-141.PMC6178877.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36532040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Chromosomal Processes in Mind-Body Medicine: Chronic Stress, Cell Aging, and Telomere Length. 身心医学中的染色体过程:慢性压力、细胞老化和端粒长度。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-09-17 DOI: 10.12659/MSMBR.911786

Tobias Esch, Richard M Kream, George B Stefano

引用次数: 15

Health Education Using Telephone and WeChat in Treatment of Symptomatic Uterine Myoma with High-Intensity Focused Ultrasound. 电话及微信健康教育在高强度聚焦超声治疗症状性子宫肌瘤中的应用。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-09-06 DOI: 10.12659/MSMBR.911040

Qian Zou, Guangyu Zhang, Yan Liu

{"title":"Health Education Using Telephone and WeChat in Treatment of Symptomatic Uterine Myoma with High-Intensity Focused Ultrasound.","authors":"Qian Zou, Guangyu Zhang, Yan Liu","doi":"10.12659/MSMBR.911040","DOIUrl":"https://doi.org/10.12659/MSMBR.911040","url":null,"abstract":"BACKGROUND Adopting modern communication methods in traditional healthcare services is a trend of modern medicine. In this study we explored the value of telephone and WeChat in health education on uterine myoma by high-intensity focused ultrasound (HIFU). MATERIAL AND METHODS A total number of 426 patients diagnosed with symptomatic uterine myoma from April 2017 to September 2017 were selected and randomly divided into a routine preoperative education group (175 patients) and a telephone/WeChat preoperative health education group (251 patients). The patients in the routine preoperative education group received routine preoperative education, whereas those in the telephone/WeChat preoperative health education group received telephone/WeChat preoperative health education. Patients were evaluated before and after treatment. RESULTS Compared with the routine preoperative education group, the patients in telephone/WeChat preoperative health education group had less preoperative and postoperative anxiety, less postoperative pain, and higher treatment satisfaction (P<0.05). CONCLUSIONS Health education using telephone and WeChat preoperatively can reduce preoperative and postoperative anxiety, postoperative pain, and early postoperative inflammatory response in patients with uterine myoma, and can improve treatment satisfaction.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"127-133"},"PeriodicalIF":2.8,"publicationDate":"2018-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/2a/medscimonitbasicres-24-127.PMC6139111.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36466399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Physical Fitness and Its Relationship to Plasma Leptin, Leptin Soluble Receptor, and Free Leptin Index in a Saudi Population: A Comparison Between Diabetic and Non-Diabetic Individuals. 沙特人群中体质及其与血浆瘦素、瘦素可溶性受体和游离瘦素指数的关系:糖尿病和非糖尿病个体的比较

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-08-09 DOI: 10.12659/MSMBR.910573

Hana Alzamil, Laila Aldokhi, Syed Shahid Habib

{"title":"Physical Fitness and Its Relationship to Plasma Leptin, Leptin Soluble Receptor, and Free Leptin Index in a Saudi Population: A Comparison Between Diabetic and Non-Diabetic Individuals.","authors":"Hana Alzamil, Laila Aldokhi, Syed Shahid Habib","doi":"10.12659/MSMBR.910573","DOIUrl":"https://doi.org/10.12659/MSMBR.910573","url":null,"abstract":"BACKGROUND Low physical activity is considered to be a risk factor for type 2 diabetes mellitus (T2DM). One theory suggest that leptin resistance is involved in the pathophysiology of impaired glucose metabolism. In this study we aimed to assess the correlation of physical fitness scores (PFS) with serum total leptin (TL), serum leptin soluble receptor (LSR), and free leptin index (FLI) in a group of Saudi patients with T2DM. MATERIAL AND METHODS This cross-sectional study involved 115 subjects: 52 healthy control subjects and 63 patients with T2DM. All subjects underwent body composition analysis. Blood samples were analyzed for fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), serum total leptin (TL), and serum leptin soluble receptor (LSR). Based on ideal body composition and our previous studies, physical fitness scores (PFS) were recorded for each subject. RESULTS In patients with T2DM, levels of LSR were positively correlated with PFS (r=0.281, p=0.025), while the levels of TL (r=-0.425, p=0.001) and FLI (r=-0.439, p=0.001) were negatively correlated with PFS. In control subjects, TL and FLI levels were negatively correlated (r=-0.612, p=0.001and r=-0.543, p=0.001 respectively) with PFS. In linear regression analysis, after adjustment for age and BMI, TL and FLI were independent predictors of PFS. CONCLUSIONS Serum TL and FLI were negatively correlated while LSR was positively correlated with PFS in patients with T2DM. Therefore, they may be important biomarkers for predicting the outcomes of physical fitness and exercise programs.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"113-119"},"PeriodicalIF":2.8,"publicationDate":"2018-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.12659/MSMBR.910573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36381965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Increased Mental Well-Being and Reduced State Anxiety in Teachers After Participation in a Residential Yoga Program. 教师参加住宿瑜伽计划后心理健康水平提高，状态焦虑减少。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-07-31 DOI: 10.12659/MSMBR.909200

Shirley Telles, Ram Kumar Gupta, Abhishek Kumar Bhardwaj, Nilkamal Singh, Prabhat Mishra, Deepak Kumar Pal, Acharya Balkrishna

{"title":"Increased Mental Well-Being and Reduced State Anxiety in Teachers After Participation in a Residential Yoga Program.","authors":"Shirley Telles, Ram Kumar Gupta, Abhishek Kumar Bhardwaj, Nilkamal Singh, Prabhat Mishra, Deepak Kumar Pal, Acharya Balkrishna","doi":"10.12659/MSMBR.909200","DOIUrl":"10.12659/MSMBR.909200","url":null,"abstract":"BACKGROUND Reducing stress in the workplace improves mental health. Teaching is of social importance, but it may receive inadequate recognition and rewards. The present study compared mental well-being and state anxiety in primary school teachers who practiced 15 days of yoga in a residential setting with those who continued their usual routine. MATERIAL AND METHODS We enrolled 236 primary school teachers to participate in the study. We assigned 118 primary school teachers (group mean ±S.D., age 41.5±6.0 years, 74 females) to the experimental group; they underwent 15 days of yoga training for 6 hours/day) in a residential yoga center. The non-yoga control group (group mean ±S.D., age 42.3±6.0 years, 79 females) consisted of 118 teachers who continued with their normal teaching routine. RESULTS After 15 days in the residential yoga program, there was an increase in overall mental well-being (p<.001) and lower state anxiety (p<.01) (repeated-measures ANOVA, followed by post hoc multiple comparison tests). At baseline, the non-yoga control group had higher levels of state anxiety, presumably related to their remaining in the workplace. CONCLUSIONS The study was a 15-day, comparative, controlled trial. The results show that after 15 days of participation in the residential yoga program, primary school teachers increased all aspects of mental well-being and had reduced state anxiety.","PeriodicalId":18491,"journal":{"name":"Medical Science Monitor Basic Research","volume":"24 ","pages":"105-112"},"PeriodicalIF":2.8,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/5a/medscimonitbasicres-24-105.PMC6083945.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36355762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Micro-Hospital: 5G Telemedicine-Based Care. 微医院:基于5G远程医疗的医疗。

IF 2.8

Medical Science Monitor Basic Research Pub Date : 2018-07-14 DOI: 10.12659/MSMBR.911436

George B Stefano, Richard M Kream

引用次数: 23