VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-03-28 DOI:10.12659/MSMBR.914570

Xian-Jie Wu, Jing Jing, Zhong-Fa Lu, Min Zheng

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引用次数: 7

Abstract

BACKGROUND Recent research reports that VEGFR-2 is expressed in the whole hair follicle, sebaceous glands, eccrine sweat glands, and epidermis. However, phosphorylated VEGFR-2 was not found, and it could not be ascertained whether the activated form of VEGFR-2 actually participates in the biological control of epidermal appendages. In this study we aimed to determine whether the VEGFR-2 pathway is directly involved in the daily regulation of epidermal appendages biology. MATERIAL AND METHODS In this study, we investigated the expression of phosphorylation of VEGFR-2 by immunohistochemical analysis in the epidermis and epidermal appendages in normal human scalp skin. RESULTS Immunohistochemical analysis revealed phosphorylation of VEGFR-2 in a whole hair follicle, mainly in the infundibulum basal layer, hair cortex, and medulla in the isthmus, and matrix in the hair bulb. Phosphorylated VEGFR-2 also was found in the sebaceous glands, eccrine sweat glands, and epidermis. CONCLUSIONS Therefore, we suggest that VEGFR-2 activation is involved in routine regulation of human epidermal appendages.

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人体头皮的毛囊、皮脂腺、汗腺和表皮中VEGFR-2处于激活状态:磷酸化VEGFR-2的原位免疫组织化学研究

最近的研究报道，VEGFR-2在整个毛囊、皮脂腺、汗腺和表皮中表达。但未发现磷酸化的VEGFR-2，也无法确定激活形式的VEGFR-2是否真的参与了表皮附属物的生物调控。在本研究中，我们旨在确定VEGFR-2通路是否直接参与表皮附属物生物学的日常调节。材料与方法在本研究中，我们通过免疫组化分析研究了VEGFR-2磷酸化在正常人头皮表皮和表皮附属物中的表达。结果免疫组织化学分析显示，VEGFR-2在整个毛囊中磷酸化，主要在毛囊基底层、毛皮质、峡部髓质和毛球基质中磷酸化。在皮脂腺、汗腺和表皮中也发现了磷酸化的VEGFR-2。因此，我们认为VEGFR-2的激活参与了人表皮附属物的常规调控。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.